Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Methyl-5-(thien-2-yl)-1H-pyrazole-3-carboxylic acid

N±-(2,4-Dinitrophenyl)-L-arginine is a bioactive chemical that has been shown to have potential use in the treatment of cervical cancer. This compound has been shown to have optical imaging properties and can be used as a probe for the evaluation of cervical cancer. The geranyl group on this compound is responsible for its antibacterial activity. N±-(2,4-Dinitrophenyl)-L-arginine has also been shown to inhibit the growth of bacteria by binding to bacterial DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. This compound has also been shown to inhibit uptake of d-pinitol by cells, which may be due to its ability to bind to cell surface receptors or heptacosane, an antitumor agent.

Versatile small molecule scaffold

1,6-Naphthyridin-4-yl-4-boronic acid

Versatile small molecule scaffold

2-Amino-5-bromo-6-methyl-3-nitropyridine

6-(Difluoromethyl)nicotinaldehyde

Versatile small molecule scaffold

4-(Ethoxycarbonylamino)butanoic acid is a derivatization reagent that contains a carbamate function. It is used for the analysis of haptens and other compounds in gc-ms methods. The reactivity and recovery of 4-(ethoxycarbonylamino)butanoic acid are dependent on the type of compound being analyzed, but it can be used to derivatize carboxylic acids with electron-withdrawing groups such as esters or ketones. This derivatization agent has been shown to have cross-reactivity with amines, which may lead to false positive results.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

N-(2-Bromobenzyl)oxetan-3-amine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(3-Amino-6-nitro-1-benzofuran-2-yl)(4-fluorophenyl)methanone

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Acetyl-2-methylquinoxaline-13C6 is a functionalized aldehyde that has been synthesized from 3-chloroacetyl-2-methylquinoxaline. It has been shown to have antitubercular activity, which may be due to its ability to inhibit the synthesis of DNA and RNA by inhibiting protein synthesis. 3-Acetyl-2-methylquinoxaline-13C6 also has exciplex properties, which are formed in the presence of amines and xylene. This compound can be used as an intermediate in organic synthesis.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(1H-Indazol-4-yl)acetic acid is a cation that has been shown to have pharmacological activity. It is hydrolyzable and is used as an anti-inflammatory agent. This compound also decarboxylates and hydrolyzes, which are processes that produce carboxyl and fluoro groups. (1H-Indazol-4-yl)acetic acid has been shown to be an anti-inflammatory agent, with effects against inflammation in the central nervous system. This drug also inhibits the production of inflammatory cytokines, including tumor necrosis factor alpha (TNFα), interleukin 1β (IL1β), and IL6.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(2,3-Dichlorophenyl)piperidine hydrochloride

2-(1,2-Benzothiazol-3-yl)acetic acid is a plant hormone that is found in the indole-3-acetic acid family of plant hormones. It is one of the auxins and it has been shown to promote germination and root growth. Auxins have also been shown to be involved in the development of vascular tissue and other aspects of plant growth. 2-(1,2-Benzothiazol-3-yl)acetic acid has been isolated from Pisum sativum L., Lycopersicon esculentum, and Esculentum.

6-Bromo-8-(trifluoromethoxy)quinolin-4(1H)-one

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5,6-Difluoro-1H-1,3-benzodiazol-2-amine is a nucleoside analogue that inhibits the synthesis of viral DNA by competitively inhibiting the incorporation of dATP into viral DNA. It has been shown to be active against herpes simplex virus type 1 and 2 and varicella zoster virus. 5,6-Difluoro-1H-1,3-benzodiazol-2-amine is selective for infected cells because it does not inhibit cellular DNA synthesis. This antiviral agent has also been found to be effective in treating infections caused by cytomegalovirus (CMV) and adenovirus.

Versatile small molecule scaffold

5-Fluoro-1-methyl-1H-indazole-6-carboxaldehyde

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Iodo-3-methylbenzonitrile is a reactive inhibitor that has been shown to inhibit the catalytic domains of protein kinases. 2-Iodo-3-methylbenzonitrile binds to the ATP binding site and competitively inhibits ATP binding, which prevents phosphorylation of proteins and subsequent activation of the kinase. This drug has been shown to be effective against a number of protein kinases with diverse structures and selectivity profiles. The crystal structure for 2-iodo-3-methylbenzonitrile was determined by X-ray crystallography, revealing a planar molecule with two iodine atoms in close proximity to one another.

Versatile small molecule scaffold

6,6-Dimethyl-3-azabicyclo[3.1.0]hexane is an oxidative biotechnology that targets chitin and carbohydrate in microorganisms and biofuels. The advancements in this field are now due to the discovery of peroxides, which can be used as a source of hydrogen peroxide. This compound has been shown to have antimicrobial properties against various microorganisms, including fungi, bacteria, and yeast. 6,6-Dimethyl-3-azabicyclo[3.1.0]hexane also has the ability to generate active enzymes that can break down peroxides into non-toxic materials such as water or oxygen gas. These compounds have been shown to be effective in environmentally clean applications such as wastewater treatment and decontamination of soil contaminated by oil spills or radioactive waste disposal sites.

(3R)-Trichloromethyl-cis-Tetrahydropyrrolo[1,2-c]oxazol-1-one

5-Chloro-3-{[2-(trifluoromethyl)phenyl]methyl}-1,2,4-thiadiazole

Applications Labelled 3-(3,4-Dimethoxyphenyl)propanoic Acid (D460730), one of the novel circulating coffee metabolites in human plasma. References Clifford, M., et al.: J. Sci. Food Agric., 80, 1033 (2000), Mateos, R., et al.: J. Agric. Food Chem., 54, 8724 (2006), Wong, C., et al.: J. Nutr. Biochem., 21, 1060 (2010),

Versatile small molecule scaffold

Versatile small molecule scaffold

5-(Dimethylaminomethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

2-(Chloromethyl)-1,3-benzoxazole

6-(Bis-BOC-Amino)-5-methylpyridin-3-ol

2-[(3-Aminophenyl)sulfonyl]ethanol (DASPE) is a reactive compound that is used for the removal of copper from wastewater. The DASPE molecule binds to the copper ion and forms a complex, which can be removed by desorption. The reaction time for this process depends on the concentration of chloride ions in the wastewater, which affects the stability of the DASPE molecule. The DASPE molecule has been shown to be effective in removing copper from wastewater that contains chloride ions at concentrations below 10g/L. This compound also has an oxidizing property, which can be exploited in derivatisation reactions.

4-(Benzyloxy)-2-chlorobenzaldehyde is an aldehyde that can be used for the synthesis of organic compounds. It is made from 2-chloro-4-hydroxybenzaldehyde, which is synthesized from hydroxybenzaldehyde, oxime, and benzyl alcohol. The product has been shown to react with riboflavin and a second reagent in the presence of palladium to form a chromatographic column. 4-(Benzyloxy)-2-chlorobenzaldehyde reacts with 6-chlorouracil to form an oxirane ring. This reaction can also be used to synthesize tulobuterol, which is a β2-agonist. 4-(Benzyloxy)-2-chlorobenzaldehyde reacts with ribose in the presence of hydroxy to produce glucose and 2-(6'-hydroxypurinomethyl)riboflavin as a byproduct.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Formyl-1H-indazole-5-carboxylic acid

Versatile small molecule scaffold

7-Hydroxy-4-oxo-4H-chromene-2-carboxylic acid is a molecule that is found in the human body. It has been shown to have cationic polymer activity and to inhibit the growth of bacteria by binding to the hydroxyl group of DNA. 7-Hydroxy-4-oxo-4H-chromene-2-carboxylic acid has potent inhibitory activity against Gram positive and Gram negative bacteria, including Mycobacterium tuberculosis and Staphylococcus aureus. This compound can be used as an antibiotic for bacterial infections due to its ability to bind with high concentrations of the hydroxyl group on DNA.

Versatile small molecule scaffold

4-Amino-2-bromo-5-nitropyridine

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(Dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold