Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Methyl-1H-pyrazole-4-carboxaldehyde

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(2,5-Dimethyl-1H-pyrrol-1-yl)benzonitrile

Versatile small molecule scaffold

Versatile small molecule scaffold

N-(3-Aminopropyl)-n-dodecylpropane-1,3-diamine, also called N,N-bis(3-aminopropyl)dodecylamine and laurylamine dipropylenediamine, is dodecylamine substituted with 2 propylamine units. Laurylamine dipropylenediamine is a non-ionic surfactant, antimicrobial agent, preservative, emulsifying agent, dispersing agent, corrosion inhibitor and an anti-static agent used in hair products.

Versatile small molecule scaffold

Versatile small molecule scaffold

diexo-3-(9H-Fluoren-9-ylmethoxycarbonylamino)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

6-Methyl-2-oxo-5-phenyl-1,2-dihydropyridine-3-carbonitrile

2-Azetidinecarboxylic acid, 1-methyl-, (2S)-

Versatile small molecule scaffold

2,3-Dichloroquinoxaline

1-Benzyl-4-piperidine-carboxaldehyde is a polymorphic compound with two crystalline forms: the α form and β form. The α form has a molecular weight of 174.2 g/mol and the β form has a molecular weight of 178.3 g/mol. Both forms are soluble in organic solvents but not in water. It is insoluble in hydrochloric acid, n-hexane, and acetonitrile. It is stable at room temperature but unstable at temperatures above 60°C. 1-Benzyl-4-piperidinecarboxaldehyde is an inhibitor of liver function, which may be due to its inhibition of CYP450 enzymes or other unknown mechanisms that lead to haemodynamic effects such as hypotension and tachycardia.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(Chloromethyl)-5-phenylisoxazole

Versatile small molecule scaffold

1-(Cyclopropylsulfonyl)piperidine-4-carbonitrile

Methyl 5-hydroxypyrazine-2-carboxylate

Versatile small molecule scaffold

2-[4-Chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetohydrazide is a hydrazide that has potent antifungal activity. It is an imidazole derivative and works by inhibiting the synthesis of ergosterol, which is an important component of fungal cell membranes. 2-[4-Chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetohydrazide has been shown to have antiinflammatory activity, as well as inhibitory effects on acid production in the stomach. Elemental analysis shows that this compound contains carbon, hydrogen, oxygen, nitrogen, chlorine and fluorine.

2-Pyrrolidone

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Chloro-2-methoxytoluene is a chlorinated aromatic compound that belongs to the group of organic compounds. It has been shown to be biologically active, with a reaction rate of 20% in filtration experiments. This compound reacts with pseudomonad bacteria, producing fluorescing products that are visible under UV light. 5-Chloro-2-methoxytoluene is metabolized by soil bacteria and chlorine, which is used as a carbon source. The molecule can be immobilized on an electrode surface and used for the detection of chloride ions in water samples.

2-Formylcinnamic acid is a metabolite of cinnamic acid that is formed by the oxidation of cinnamoyl-CoA. It is a colorless solid with a melting point of about 116 degrees Celsius. 2-Formylcinnamic acid has been shown to be an intermediate in the formation of phthalic acid and naphthalene from cinnamic acid. These compounds are used in the production of plasticizers, dyes, and pesticides. 2-Formylcinnamic acid can also be produced as a result of photochemical reactions in the atmosphere. It can be used to detect gaseous molecules such as ozone, nitric oxide, sulfur dioxide, and methane by absorbing light at different wavelengths. The reaction products are determined by gas chromatography/mass spectrometry or multichannel analysis with particle detection.

Versatile small molecule scaffold

2-Chloro-5-methoxyquinoline is a quinoline derivative that binds to the protein kinase. This binding prevents the phosphorylation of tyrosine residues in proteins, thereby inhibiting protein synthesis and cell division. 2-Chloro-5-methoxyquinoline has been shown to inhibit cancer cell growth by binding to the tumor suppressor protein p53, which is mutated in many cancers. It also inhibits the activity of kinases involved in the cell cycle, including cyclin D1 and cdk4, which are important for G1 phase progression. These activities may be responsible for its effects on cancer cells.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Methoxy-2-naphthaldehyde is a molecule that belongs to the group of organic compounds called aldehydes. It is an oxidizing agent with molecular weight of 92.13 g/mol and chemical formula CH 3 COCH 2 OH. The oxidation of 3-methoxy-2-naphthaldehyde is catalyzed by the enzyme aldehyde oxidase, which converts it into 3-hydroxy-2-naphthaldehyde. This reaction requires NAD+ as cofactor and produces NADH, which can be used in other reactions such as glycolysis or the citric acid cycle. The intramolecular hydrogen bond between the carbon atom in carbonyl group and the oxygen atom in hydroxyl group stabilizes this molecule. 3-Methoxy-2-naphthaldehyde has low energy photophysical properties and can be used as a signal transducer for functional groups, such as phenols and am

Versatile small molecule scaffold

Versatile small molecule scaffold

(2E)-3-(1,3,5-Trimethyl-1H-pyrazol-4-yl)acrylic acid

(2-Oxo-2,3-dihydro-1H-indol-3-yl)acetic acid

2-(2-Chlorophenyl)-4-(trifluoromethyl)-1H-imidazole

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(2-Iodoethyl)-2-methyl-1,3-dioxolane

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(5-Chloro-4-(difluoromethoxy)pyridin-2-yl)methanol

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(Cyclopropylmethoxy)pyridine-3-boronic acid

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Applications 5’-Cholesteryl-TEG Phosphoramidite is used in the synthesis of immunostimulatory oligonucleotides for in vivo cell modification for immunotherapy. References Liu, H. et al.: Angew. Chem. Int. Ed., 50, 7052 (2011);

Versatile small molecule scaffold