Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(2-Carbamoylpyridin-4-yl)acetic acid

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,5-Dibromopyridin-3-amine

2,6,6-Trimethyl-4,5,6,7-tetrahydro-1-benzofuran-4-one

Versatile small molecule scaffold

1-(7-Nitro-1,1,3,3,6-pentamethylindan-5-yl)-1H-pyrrole

Versatile small molecule scaffold

Versatile small molecule scaffold

3,4-Difluorophthalic anhydride

Versatile small molecule scaffold

5-Bromo-2-chloroisonicotinamide

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Formyl-6-(methoxycarbonyl)-1H-indole, N-BOC protected

Versatile small molecule scaffold

3,4,5-Trichloro-2,6-dimethylpyridine (3,4,5-TCP) is a chemical compound that is used as a hyperpolarizer in magnetic resonance imaging. Hyperpolarization is a process that increases the polarization of nuclear spins and can be achieved by using 3,4,5-TCP as an agent to transfer the electron spin from one molecule to another. This process is reversible and efficient. This agent binds to ligands such as parahydrogen or iridium complexes and transfers the electron spin efficiently. 3,4,5-TCP has been shown to be effective for catalyzing reactions with nuclei such as Iridium or Rhodium.

4-Chloro-3-methoxy-2-methylpyridine N-oxide

3,4-Diethyl-3-hexanol is a chemical compound that is used as an ophthalmic agent. It is a colorless or white solid. 3,4-Diethyl-3-hexanol has been shown to be an antiviral agent that blocks the virus from entering the cells of the body. It also prevents the virus from replicating its genetic material and spreading throughout the body. This drug can be used in infants, pregnant women, and adults. 3,4-Diethyl-3-hexanol binds to plasma proteins and may interfere with levothyroxine metabolism in some cases. It has been shown to have no adverse effects on dihedral angles or boceprevir activity and has low toxicity levels in rats.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(6-Chloropyridine-3-sulfonamido)propanoic acid is a research tool that has been used in the study of protein interactions, ion channels, and cell biology. It has shown to inhibit the activity of several receptor types and peptides. 3-(6-Chloropyridine-3-sulfonamido)propanoic acid has also been studied as a potential therapeutic agent for the treatment of various diseases such as asthma, cancer, diabetes, and Parkinson's disease.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Oxo-2H-chromene-3-carboxamide is a coumarin derivative that inhibits mitochondrial membrane potential and is used as an inhibitor of cardiac hypertrophy. It also has inhibitory effects on the activity of mitochondria, which are important for maintaining the balance between ATP production and consumption in cells. 2-Oxo-2H-chromene-3-carboxamide is used to treat cancer and inflammatory diseases, such as arthritis and asthma. This drug can be administered by injection or orally. The oral bioavailability of 2-Oxo-2H-chromene-3-carboxamide is about 60% and has a half life of 3 hours.

2-Chloro-5-(methylaminomethyl)pyridine

Versatile small molecule scaffold

3-Phenylimidazolidine-2,4-dione

Acryloylglycine is a versatile compound that acts as an inhibitor for various processes. It inhibits the synthesis of fatty acids by blocking the activity of key enzymes involved in their production. Additionally, acryloylglycine has been found to inhibit the binding of antibodies to glycoproteins, thus preventing immune responses mediated by these interactions. Furthermore, it has been shown to inhibit the growth of certain bacteria and has potential as an antibiotic agent. Acryloylglycine also plays a role in research as it can be used as a building block for the synthesis of other compounds, such as acid ethyl ester or oligosaccharides. Lastly, acryloylglycine has been investigated for its effects on dopamine receptors and its potential in modulating neurotransmitter activity.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Phenylazepane

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1H-Pyrazolo[3,4-d]pyrimidine-4,6-diol

Versatile small molecule scaffold

1-(3-Carboxypropionyl)naphthalene is a drug that belongs to the class of reactive drugs. It is a prodrug that is metabolized by cytochrome P450 enzymes to 1-(3-carboxypropionyl)naphthoquinone (1CPRNQ). Its main mechanism of action is through binding to magnesium, which induces cell membrane permeability and results in apoptosis. 1-(3-Carboxypropionyl)naphthalene has shown an antibody response to eye disorders and cardiovascular diseases, as well as anti-angiogenic properties. It also has been shown to inhibit the proliferation of tumor cells and induce leukocyte antigen expression.

trans-4-(4-Morpholinyl)cyclohexanol

Versatile small molecule scaffold

N-Methyl-N-phenylprop-2-enamide is a perfluorinated compound with acrylate functional groups. It is a monomer that can react with other compounds to form polymers. It has been shown to be useful in the production of polyacrylates, which are used in industrial and medical applications. NMPEA has a bond cleavage reaction when it reacts with triphosgene, which can lead to the formation of acrylonitrile and chlorobenzene. This type of reaction also exhibits hydrogen bonding interactions and can be activated by an amide or an alcohol.

Versatile small molecule scaffold

Versatile small molecule scaffold

5,7-Dimethyl-3-oxo-2-phenyl-3H-4λ5-[1,2]diazolo[1,2-a]pyrazol-4-ylium-1-olate

Bicyclo[4.1.0]heptan-5-one is a naturally occurring heterocyclic compound with a bicyclic structure, consisting of a six-membered ring with two additional carbon atoms in the form of an additional ring fused to the first ring. The compound has been used as a synthetic intermediate and has been studied for its capability to inhibit protein synthesis by interrupting peptide bonds during the formation of proteins. Bicyclo[4.1.0]heptan-5-one has also been studied as a possible drug candidate for the treatment of cancer and HIV infection, due to its ability to bind to DNA and RNA and inhibit their synthesis. Bicyclo[4.1.0]heptan-5-one can be synthesized from cyclopropanes, which are obtained by homologation of allyl alcohols or by hydroboration followed by oxidation of alkenes or alkynes.br>

Versatile small molecule scaffold

3-(1H-Imidazol-2-yl)propanoic acid hydrochloride is a potent inhibitor of the GABA transporter. It is an imidazole derivative with a 3-substituted propanoic acid moiety and a protonated imidazole ring. The compound inhibits the GABA transporter, which is responsible for transporting GABA into presynaptic neurons and glia cells. This inhibitory effect blocks the function of the transporter proteins, leading to decreased levels of GABA in the brain, which leads to increased levels of gaba in the synapse. 3-(1H-Imidazol-2-yl)propanoic acid hydrochloride has been shown to have potent inhibitory effects on a number of other neurotransmitter transporters, including glutamate and glycine transporters.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Octahydrocyclopenta[c]pyrrole is a potent inhibitor of the enzyme borohydride reductase, which is an enzyme that catalyzes the reduction of borane to borohydride. Borohydride reductase is essential for the production of hydrogen, which is used for many biological processes including the synthesis of nicotinic acetylcholine and dopamine. Octahydrocyclopenta[c]pyrrole has been shown to have potent inhibitory activity against hydroxyl group-containing enzymes such as iridoid glucoside and potassium ion-dependent enzymes such as borohydride reductase. This inhibition may be due to its structural similarity to these substrates.

N-[(3S)-Piperidin-3-yl]pyrrolidine-1-carboxamide hydrochloride

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Amino-4-hydroxypyridine

Versatile small molecule scaffold

2,2,3,3-Tetramethylcyclopropyl)methanol is a reagent that is used in the synthesis of insecticides and in the preparation of other organic compounds. It is prepared by reacting phosphorus with chlorinating agents such as thionyl chloride or phosphoryl chloride. This chemical can also be synthesized from halogenated alkanes by catalytic chlorination. 2,2,3,3-Tetramethylcyclopropyl)methanol has been employed as a Grignard reagent and Wittig reaction catalyst.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold