Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1H-Pyrazolo[3,4-d]pyrimidine-4,6-diol

Versatile small molecule scaffold

1-(3-Carboxypropionyl)naphthalene is a drug that belongs to the class of reactive drugs. It is a prodrug that is metabolized by cytochrome P450 enzymes to 1-(3-carboxypropionyl)naphthoquinone (1CPRNQ). Its main mechanism of action is through binding to magnesium, which induces cell membrane permeability and results in apoptosis. 1-(3-Carboxypropionyl)naphthalene has shown an antibody response to eye disorders and cardiovascular diseases, as well as anti-angiogenic properties. It also has been shown to inhibit the proliferation of tumor cells and induce leukocyte antigen expression.

trans-4-(4-Morpholinyl)cyclohexanol

Versatile small molecule scaffold

N-Methyl-N-phenylprop-2-enamide is a perfluorinated compound with acrylate functional groups. It is a monomer that can react with other compounds to form polymers. It has been shown to be useful in the production of polyacrylates, which are used in industrial and medical applications. NMPEA has a bond cleavage reaction when it reacts with triphosgene, which can lead to the formation of acrylonitrile and chlorobenzene. This type of reaction also exhibits hydrogen bonding interactions and can be activated by an amide or an alcohol.

Versatile small molecule scaffold

Versatile small molecule scaffold

5,7-Dimethyl-3-oxo-2-phenyl-3H-4λ5-[1,2]diazolo[1,2-a]pyrazol-4-ylium-1-olate

Bicyclo[4.1.0]heptan-5-one is a naturally occurring heterocyclic compound with a bicyclic structure, consisting of a six-membered ring with two additional carbon atoms in the form of an additional ring fused to the first ring. The compound has been used as a synthetic intermediate and has been studied for its capability to inhibit protein synthesis by interrupting peptide bonds during the formation of proteins. Bicyclo[4.1.0]heptan-5-one has also been studied as a possible drug candidate for the treatment of cancer and HIV infection, due to its ability to bind to DNA and RNA and inhibit their synthesis. Bicyclo[4.1.0]heptan-5-one can be synthesized from cyclopropanes, which are obtained by homologation of allyl alcohols or by hydroboration followed by oxidation of alkenes or alkynes.br>

Versatile small molecule scaffold

3-(1H-Imidazol-2-yl)propanoic acid hydrochloride is a potent inhibitor of the GABA transporter. It is an imidazole derivative with a 3-substituted propanoic acid moiety and a protonated imidazole ring. The compound inhibits the GABA transporter, which is responsible for transporting GABA into presynaptic neurons and glia cells. This inhibitory effect blocks the function of the transporter proteins, leading to decreased levels of GABA in the brain, which leads to increased levels of gaba in the synapse. 3-(1H-Imidazol-2-yl)propanoic acid hydrochloride has been shown to have potent inhibitory effects on a number of other neurotransmitter transporters, including glutamate and glycine transporters.

Versatile small molecule scaffold

Versatile small molecule scaffold