Moduladores GABA
Os moduladores de GABA são compostos que influenciam a função dos receptores de GABA (ácido gama-aminobutírico), os principais receptores inibitórios de neurotransmissores no sistema nervoso central. Estes moduladores podem aumentar ou inibir a atividade GABAérgica, afetando a excitabilidade neuronal e a transmissão sináptica. Os moduladores de GABA são cruciais no tratamento e estudo de vários distúrbios neurológicos e psiquiátricos, incluindo ansiedade, epilepsia e insônia. Na CymitQuimica, oferecemos uma ampla gama de moduladores de GABA para apoiar sua pesquisa em neurociência, farmacologia e neuroterapêutica.
Produtos da "Moduladores GABA"
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Phenazepam-d5
CAS:Produto ControladoApplications A benzodiazepine drug, which is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety. References Ogiso, T., et al.: Chem. Pharm. Bull., 37, 446 (1989), Gu, Q., et al.: J. Med. Chem., 36, 1001 (1993), Bekhterev, V.N., et al.: Pharm. Chem. J., 42, 95 (2008),Fórmula:C152H4H6BrClN2OCor e Forma:NeatPeso molecular:353.63N-Demethyl Olanzapine-d8
CAS:Produto ControladoApplications A labelled metabolite of Olanzapine.Fórmula:C162H8H10N4SCor e Forma:NeatPeso molecular:306.46Delorazepam (100 ug/mL in Methanol)
CAS:Produto ControladoFórmula:C15H10Cl2N2OCor e Forma:Single SolutionPeso molecular:305.168-Fluoro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylic acid
CAS:Fórmula:C13H10FN3O3Pureza:99%Cor e Forma:SolidPeso molecular:275.23524-Boc-7-Bromo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Cor e Forma:SolidPeso molecular:327.221984863281251H-1,4-Benzodiazepine-2,5-dione, 3,4-dihydro-
CAS:Fórmula:C9H8N2O2Pureza:97%Cor e Forma:SolidPeso molecular:176.17202N-Desmethyl Clozapine-d8
CAS:Produto ControladoApplications A major labelled metabolite of clozapine. A potent and selective 5-HT2C serotonin receptor antogonist. References Kuoppamaki, M. et al.: Eur. J. Pharm. Mol. Pharm. Sect., 245, 179 (1993), Olessen, O.V., et al.: J. Chromatog., 622, 39 (1993), Pirmohamed, M., et al.: J. Pharmacol. Exp. Ther., 272, 984 (1995)Fórmula:C172H8H9ClN4Cor e Forma:Light YellowPeso molecular:320.85(S)-Methyl 3-(7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanoate
CAS:Pureza:97.0%Peso molecular:402.24798583984375Zopiclone N-Oxide
CAS:Impurity Zopiclone EP Impurity A Applications Eszopiclone impurity A. References Vire, J.C., et al.: Talanta, 40, 313 (1993), Sha, Yu., et al.: Molecules, 13, 1817 (2008),Fórmula:C17H17ClN6O4Cor e Forma:White To Light BrownPeso molecular:404.812-Propylglutaric Acid
CAS:Produto ControladoApplications A metabolite of Valproic Acid. References McLean, M.J., et al.: J. Pharmacol. Exp. Ther., 237, 1001 (1986), Lee, R.D., et al.: J. Pharm. Sci., 78, 667 (1989), Mergen, F., et al.: J. Pharm. Pharmacol., 43, 815, (1991)Fórmula:C8H14O4Cor e Forma:NeatPeso molecular:174.192-Propanone, 1-[4,5-dihydro-2-(4-methyl-1-piperazinyl)-4-thioxo-3H-1,5-benzodiazepin-3-ylidene]-, (1Z)-
CAS:Fórmula:C17H20N4OSPureza:97%Cor e Forma:SolidPeso molecular:328.43199-Amino-1,2,3,4-tetrahydro-1,4-benzodiazepin-5-one
CAS:Fórmula:C9H11N3OPureza:95%Cor e Forma:SolidPeso molecular:177.20311-Methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS:Pureza:95.0%Cor e Forma:SolidPeso molecular:190.201995849609383-Hydroxy Bromazepam 1.0 mg/mL in Methanol
CAS:Produto ControladoFórmula:C14H10BrN3O2Cor e Forma:ColourlessPeso molecular:332.15Flumazenil (Ro 15-1788)
CAS:Fórmula:C15H14FN3O3Pureza:95%Cor e Forma:SolidPeso molecular:303.28836319999994Ref: IN-DA005JF1
1g300,00€5gA consultar25gA consultar50gA consultar5mg44,00€10mg54,00€100mg82,00€250mg139,00€Allobarbital
CAS:Produto ControladoApplications Allobarbital is a barbiturate derivative that is primarily used as an anticonvulsant. Allobarbital also shows hypnotic activity and is used to boost the activity of analgesic drugs. Studies show that Allobarbital is an effective promoters of hepatocarcinogenesis. Allobarbital is a Controlled Substance. References Tateoka, Y. et al.: Yakug. Zas., 106, 504 (1986); Crawford, J.M. et al.: Neuropharmacology, 9, 31 (1970); Rice, J.M. et al.: Carcinogenesis, 15, 395 (1994);Fórmula:C10H12N2O3Cor e Forma:WhitePeso molecular:208.214-Methyl-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepine
CAS:Pureza:95%Peso molecular:162.235992431640621'-Hydroxy Triazolam (1.0 mg/mL in DMSO)
CAS:Produto ControladoFórmula:C17H12Cl2N4OCor e Forma:Single SolutionPeso molecular:359.215H-1-Benzazepin-5-one, 7-chloro-1,2,3,4-tetrahydro-
CAS:Fórmula:C10H10ClNOPureza:97%Cor e Forma:SolidPeso molecular:195.6455Zaleplon-D5
CAS:Produto ControladoApplications Selective non-benzodiazepine GABAA receptor agonist. References Allen, D., et al.: Eur. J. Clin. Pharmacol., 45, 313 (1993), Beer, B., et al.: J. Clin. Pharmacol., 34, 335 (1994), Rosen, A.S., et al.: Biopharm. Drug Dispos., 20, 171 (1999), Elie, R., et al.: J. Clin. Psychiatry, 60, 536 (1999), Heydorn, W.E., et al.: Expert Opin. Invest. Drugs, 9, 841 (2000)Fórmula:C172H5H10N5OCor e Forma:Off White SolidPeso molecular:310.36Chlordiazepoxide-d5
CAS:Produto ControladoApplications Controlled substance (depressant). Anxiolytic. Prototype of the benzodiazepine anxiolytics. References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 15 (1972), Greenblatt, D.J., et al.: Clin. Pharmacokinet., 3, 381 (1978),Fórmula:C162H5H9ClN3OCor e Forma:NeatPeso molecular:304.797-methyl-5-phenyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one
CAS:Pureza:95.0%Peso molecular:252.31700134277344Talbutal
CAS:Produto ControladoApplications A stuctural isomer of Butalbital (B690100). A short to intermediate-acting barbiturate that act as nonselective depressants of the central nervous system (CNS). Sedative, hypnotic. Controlled Substance. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Nielsen, C.J. et al.: Pharmacol., 26, 371 (1925); Lien, E.J. et al.: Acta Pharmac. Jug., 34, 123 (1984);Fórmula:C11H16N2O3Cor e Forma:NeatPeso molecular:224.264-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione
CAS:Pureza:95.0%Peso molecular:190.201995849609388-Amino-4-Boc-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Peso molecular:263.341003417968751,3-Dimethyl Barbituric Acid
CAS:Produto ControladoApplications 1,3-Dimethyl Barbituric Acid (Urapidil Impurity 4) is a derivative of Barbituric acid (B118650). All of the barbituric acid derivatives which have been reported to have pronounced hypnotic activity are disubstituted in the 5-position. References Gupta, K., et al.: Eur. J. Med. Chem., 17, 448 (1982), Weber, L., et al.: Curr. Med. Chem., 9, 2085 (2002), Skiles, J., et al.: Curr. Med. Chem., 11, 2911 (2004),Fórmula:C6H8N2O3Cor e Forma:NeatPeso molecular:156.14Ref: IN-DA00EB3S
Produto descontinuadoClobazam-d5
CAS:Produto ControladoApplications Labelled Clobazam (C582500). Benzodiazepine psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types. An anxiolytic; anticonvulsant. Controlled substance (depressant). References Gastaut, H., et al.: Epilepsia, 20, 437 (1979), Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990), Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993),Fórmula:C16H8D5ClN2O2Cor e Forma:Off White PowderPeso molecular:305.77nor-Flurazepam
CAS:Produto ControladoImpurity Flurazepam USP Related Compound F Applications The major human metabolite of Flurazepam. Controlled substance.Flurazepam USP Related Compound F. References Ochs, H.R., et al.: Pharmacology, 36, 166 (1988); Capello, S., et al.: Drug Metab. Dispos., 18, 190 (1990);Fórmula:C15H10ClFN2OCor e Forma:White To Off-WhitePeso molecular:288.705-Allyl-6-imino-5-(1-methyl-2-pentynyl)hydrouracil-13C,15N2
Produto ControladoFórmula:C12CH17NN2O2Cor e Forma:NeatPeso molecular:250.2710-Hydroxy-10,11-dihydrocarbamazepine
CAS:Produto ControladoFórmula:C15H14N2O2Cor e Forma:NeatPeso molecular:254.28Rufinamide USP Related Compound B
CAS:Produto ControladoFórmula:C11H9F2N3O2Cor e Forma:NeatPeso molecular:253.20Secobarbital
CAS:Produto ControladoApplications Barbiturates are being widely used as antiepileptics, hypnotics, and anesthetics.Controlled substance. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Inaba, T., et al.: Clin. Pharm. Ther., 20, 439 (1976), Sun, S., et al.: J. Pharm. Sci., 66, 477 (1977), Coudore, F., et al.: J .Anal. Toxicol., 17, 109 (1993), Ferslew, K., et al.: J. Forensic Sci., 40, 245 (1995),Fórmula:C12H18N2O3Cor e Forma:WhitePeso molecular:238.282,3,4,5-Tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Cor e Forma:Solid, White to yellow/orange crystalline powderPeso molecular:148.20899963378906Diazepam-13C,d3
CAS:Produto ControladoApplications Labelled Diazepam, an anxiolytic; muscle relaxant (skeletal); anticonvulsant.Diazepam is a Controlled substance (depressant). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 79 (1972), Mandelli, M., et al.: Clin. Pharmacokinet., 3, 72 (1978), Bertilsson, L., et al.: Pharmacol. Ther., 45, 85 (1990), Murray, J.B., et al.: J. Psychol., 124, 655 (1990), Pellock, J.M., et al.: Drug Saf., 27, 383 (2004),Fórmula:C1513CH10D3ClN2OCor e Forma:NeatPeso molecular:288.7510H-Thieno[2,3-b][1,5]benzodiazepin-4-amine, 2-methyl-,monohydrochloride
CAS:Fórmula:C12H12ClN3SPureza:95%Cor e Forma:SolidPeso molecular:265.7618Pinazepam
CAS:Produto ControladoApplications Pinazepam is a is a benzodiazepine. Pinazepam possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Pinazepam is less toxic than Diazepam. This is a contolled substance (depressant). Anxiolytic. References Bertoncelli, V., et al.: Clin. Ter., 94, 641 (1980); Miyaguchi, H., et al.: Forensic Sci. Int., 157, 57 (2006), ElSohly, M., et al.: J. Anal. Toxicol., 32, 547 (2008), Vogliardi, S., et al.: Anal. Bioanal. Chem., 2011, 400, 51 (2011),Fórmula:C18H13ClN2OCor e Forma:NeatPeso molecular:308.76Zolazepam Hydrochloride
CAS:Produto ControladoApplications A sedative and anesthetic agent. References Winters, W., et al.: Neuropharmacology, 11, 303 (1972), Genevois, J., et al.: Rec. Med. Vet.,164, 289 (1988),Fórmula:C15H15FN4O·ClHCor e Forma:NeatPeso molecular:322.77Clozapine
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C18H19ClN4Cor e Forma:Crystalline powder, YellowPeso molecular:326.83
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