Moduladores GABA
Os moduladores de GABA são compostos que influenciam a função dos receptores de GABA (ácido gama-aminobutírico), os principais receptores inibitórios de neurotransmissores no sistema nervoso central. Estes moduladores podem aumentar ou inibir a atividade GABAérgica, afetando a excitabilidade neuronal e a transmissão sináptica. Os moduladores de GABA são cruciais no tratamento e estudo de vários distúrbios neurológicos e psiquiátricos, incluindo ansiedade, epilepsia e insônia. Na CymitQuimica, oferecemos uma ampla gama de moduladores de GABA para apoiar sua pesquisa em neurociência, farmacologia e neuroterapêutica.
Produtos da "Moduladores GABA"
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EMEDASTINE FUMARATE
CAS:Fórmula:C25H34N4O9Pureza:98%Cor e Forma:SolidPeso molecular:534.55885999999993-AMINO-1-METHYL-5-PHENYL-1H-BENZO[E][1,4]DIAZEPIN-2(3H)-ONE
CAS:Pureza:95.0%Cor e Forma:SolidPeso molecular:265.31600952148447-Fluoro-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione
CAS:Pureza:95.0%Peso molecular:208.192001342773442-[[(2-Amino-5-nitrophenyl)(2-chlorophenyl)methylene]amino]acetic Acid
Fórmula:C15H12ClN3O4Cor e Forma:Neat7-Bromo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS:Pureza:97.0%Cor e Forma:SolidPeso molecular:255.07099914550786-Amino-5-ethyl-5-(1-methylbutyl)-2,4(3H,5H)-pyrimidinedione
CAS:Produto ControladoApplications 6-Amino-5-ethyl-5-(1-methylbutyl)-2,4(3H,5H)-pyrimidinedione is an impurity of Pentobarbital (P276000), an sedative and hypnotic.Fórmula:C11H19N3O2Cor e Forma:WhitePeso molecular:225.298-Fluoro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Peso molecular:166.199005126953124-Boc-7,8-Dimethoxy-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Peso molecular:308.377990722656253-Amino-4-(2-chlorophenyl)-6-nitroquinolin-2(1H)-one
CAS:Fórmula:C15H10ClN3O3Pureza:98%Cor e Forma:SolidPeso molecular:315.7112Mesocarb
CAS:Produto ControladoApplications Mesocarb is a CNS stimulant that acts as a dopamine reuptake inhibitor. Mesocarb is a psychotropic drug. Mesocarb is used to counteract the sedative effects of benzodiazepine drugs. References Gainetdinov, R.R. et al.: Eur. J. Pharmacol., 340, 53 (1997); Kholodov, L.E. et al.: Khim.-Farmat. Zhur., 7, 50 (1973); Valueva, L.N. et al.: Zhur. Nevropatol. Psikh. S. S. Korsak., 82, 1212 (1982);Fórmula:C18H18N4O2Cor e Forma:NeatPeso molecular:322.36Bromazepam-d4
CAS:Produto ControladoApplications Controlled substance (depressant). Anxiolytic. Labelled Bromazepam. References Schwartz, M.A., et al.: J. Pharm. Sci., 62, 1776 (1973), Chalmers, P., et al.: Anesthesia, 39, 370 (1984), Hassan, M.M., et al.: Anal. Profiles Drug Subs., 16, 1 (1987),Fórmula:C142H4H6BrN3OCor e Forma:NeatPeso molecular:320.18Olanzapine (1mg/ml in Acetonitrile)
CAS:Fórmula:C17H20N4SCor e Forma:Single SolutionPeso molecular:312.43Flumazenil Carboxylic Acid
CAS:Applications Flumazenil carboxylic acid is a derivative of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine. References Brogden, R. & Goa, K.: Drugs, 35, 448 (1988); Klotz, U. & Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)Fórmula:C13H10FN3O3Cor e Forma:White To Off-WhitePeso molecular:275.24Clonazepam-d4 (1.0 mg/mL in Methanol)
CAS:Produto ControladoFórmula:C152H4H6ClN3O3Cor e Forma:Single SolutionPeso molecular:319.74Ketazolam
CAS:Produto ControladoStability Unstable in Solution Applications A psychotropic benzodiazepine derivative with hypnotic and anxiolytic properties. Controlled Substance. References Sethy, V.H. et al.: Naun.-Schmeid. Atch. Pharmacol., 301, 157 (1978); Moore, S. et al.: Curr. Therap. Res., 29, 704 (1981); Gutierrez, S.F. et al.: Cien. Pharmac., 5, 37 (1995);Fórmula:C20H17ClN2O3Cor e Forma:Off White CrystallinePeso molecular:368.81Ketazolam-13C,d3
CAS:Produto ControladoApplications A labelled psychotropic benzodiazepine derivative with hypnotic and anxiolytic properties. Controlled Substance. References Sethy, V.H. et al.: Naun.-Schmeid. Atch. Pharmacol., 301, 157 (1978); Moore, S. et al.: Curr. Therap. Res., 29, 704 (1981); Gutierrez, S.F. et al.: Cien. Pharmac., 5, 37 (1995);Fórmula:C1913CH14D3ClN2O3Cor e Forma:NeatPeso molecular:372.827-Chloro-1-methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-4-amine
CAS:Applications An impurity of Alprazolam (A575650). The major degradation product in Alprazolam tablets during their stability assay. References Nudelman, N., et al.: J. Pharm. Sci., 91, 1274 (2002), Marin, A., et al.: Anal. Chem., 77, 471 (2005),Fórmula:C17H13ClN4Cor e Forma:White To Off-WhitePeso molecular:308.76Tilivalline
CAS:Applications Tilivalline, is a metabolite from Klebsiella oxytoca. Tilivalline, is shown to be cytotoxin, and the key event causing Antibiotic-Associated Hemorrhagic Colitis. References Mori, Sh., et al.: Tetrahedron, 47, No.27, 5051 (1991); Nagasaka, T., et al.: Tetrahedron Lett., 14, 1871 (1989);Fórmula:C20H19N3O2Cor e Forma:Light BrownPeso molecular:333.38Pyrrolidin-2-one (2-Pyrrolidone)
CAS:Produto ControladoFórmula:C4H7NOCor e Forma:NeatPeso molecular:85.102,3,4,5-Tetrahydro-1H-1,4-benzodiazepine, 95%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C9H12N2Pureza:95%Cor e Forma:Yellow with orange to pale brown, Crystals or powder or crystalline powder or lumpy solidPeso molecular:148.217-Amino Clonazepam
CAS:Produto ControladoApplications The major metabolite of Clonazepam (C587080). References Clark, D., et al.: Drugs, 29, 342 (1985), Colmenero, J., et al.: Antimicrob. Agents Chemother., 38, 2798 (1994), Grant, D., et al.: Pharmacology, 61, 204 (2000), Negrusz, A., et al.: Anal. Bioanal. Chem., 376, 1198 (2003),Fórmula:C15H12ClN3OCor e Forma:YellowPeso molecular:285.73Cloxazolam
CAS:Produto ControladoApplications Cloxazolam is a benzodiazepine derivative with anxiolytic, hypnotic and antihypertensive properties used as an anti-anxiety drug. It is metabolized into the active metabolite Delorezepam (D230675). Controlled Substance. References Oliveira-Silva, D. et al.: Biomed. Chrom., 23, 1266 (2009); Kamioka, T. et al.: Psychopharmacol., 52, 17 (1977); Fischer-Cornelssen, K.A. et al.: Arzneim.-Forsch., 31, 1757 (1981);Fórmula:C17H14Cl2N2O2Cor e Forma:NeatPeso molecular:349.21Nimetazepam-d3
CAS:Produto ControladoApplications Labelled Nimetazepam (N477800). Sedative, hypnotic. Controlled substance. References Inaba, et al.: Chem. Pharm. Bull., 19, 722 (1971), Sakai, S., et al.: Arzneim.-Forsch., 22, 534 (1972),Fórmula:C16H10D3N3O3Cor e Forma:NeatPeso molecular:298.318-Chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS:Produto ControladoFórmula:C17H12ClFN4Cor e Forma:NeatPeso molecular:326.765-(2-Bromophenyl)-7-fluoro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Flubromazepam Isomer)
CAS:Fórmula:C15H10BrFN2OPirenzepine, Dihydrochloride
CAS:Produto ControladoApplications An antiulcerative. Tricyclic gastric-acid inhibitor. References Eberlein, W., et al.: Arzneimittel-Forsch., 27, 356 (1977), Hellerr, G., et al.: Verh. Deut. Ges. Inn. Med., 84, 991 (1978), Carmine, A.A., et al.: Drugs, 30,85 (1985), El-Obeid, H.A., et al.: Anal. Profiles Drug Subs., 16, 445 (1987), Homon, C.A., et al.: Ther. Drug Monit., 9, 236 (1987),Fórmula:C19H21N5O2·2ClHCor e Forma:NeatPeso molecular:424.324-Amino-2-methyl-10H-thieno[2,3-b][1,5]-benzodiazapine, Hydrochloride
CAS:Produto ControladoImpurity Olanzapine Impurity 6 HCl Applications Intermediate in the preparation of Olanzapine (O253750). Olanzapine Impurity 6 HCl. References Calligaro, D., et al.: Bioorg. Med. Chem. Lett., 7, 25 (1997),Fórmula:C12H11N3S·ClHCor e Forma:NeatPeso molecular:265.76Sultiame 100 µg/mL in Acetonitrile
CAS:Fórmula:C10H14N2O4S2Cor e Forma:Single SolutionPeso molecular:290.362-Bromo-2'-(2-chlorobenzoyl)-4'-nitroacetanilide
CAS:Produto ControladoFórmula:C15H10BrClN2O4Cor e Forma:NeatPeso molecular:397.61N-Descarboxymethyl-N-carboxyethyl Lacosamide (Impurity)
CAS:Produto ControladoApplications N-Descarboxymethyl-N-carboxyethyl Lacosamide is an impurity of Lacosamide (L098500), an anticonvulsant drug that enhances sodium channel slow inactivation, and is used to treat patients with epilepsy. References Doty, P., et al.: Neurotherapeutics, 4, 145 (2007); Perucca, E., et al.: Nat. Rev. Drug Discov., 7, 973 (2008); Sake, J., et al.: CNS Drugs, 24, 1055 (2010)Fórmula:C14H20N2O3Cor e Forma:NeatPeso molecular:264.327-Amino Nimetazepam
CAS:Produto ControladoApplications A metabolite of Nimetazepam. Controlled substance. References Nishikawa, M., et al.: Forensic Sci. Int., 66, 149 (1994), Katagi, M., et al.: J. Anal. Toxicol., 24, 354 (2000),Fórmula:C16H15N3OCor e Forma:NeatPeso molecular:265.31Lixivaptan
CAS:Produto ControladoApplications Drug used in the treatment and prevention of cardiovascular diseases. References Lo, R., et al.: Curr. Clin. Pharmacol., 3, 156 (2008), Ghali, J., et al.: Cardiol., 111, 147 (2008),Fórmula:C27H21ClFN3O2Cor e Forma:NeatPeso molecular:473.93Phenobarbital
CAS:Produto ControladoApplications This is a controlled substance (depressant). Anticonvulsant; sedative; hypnotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Chao, M.K.C., et al.: Anal. Profiles Drug Subs., 7, 359 (1978),Fórmula:C12H12N2O3Cor e Forma:White To Off-WhitePeso molecular:232.247-Amino Clonazepam-d4
CAS:Produto ControladoApplications A labelled major metabolite of Clonazepam (C587080). References Clark, D., et al.: Drugs, 29, 342 (1985), Colmenero, J., et al.: Antimicrob. Agents Chemother., 38, 2798 (1994), Grant, D., et al.: Pharmacology, 61, 204 (2000), Negrusz, A., et al.: Anal. Bioanal. Chem., 376, 1198 (2003),Fórmula:C152H4H8ClN3OCor e Forma:Yellow To Light Orange ColourPeso molecular:289.754-Hydroxy Midazolam (100 μg/mL in methanol)
CAS:Produto ControladoFórmula:C18H13ClFN3OCor e Forma:Single SolutionPeso molecular:341.77Phenazepam
CAS:Produto ControladoApplications A benzodiazepine drug, which is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety. References Ogiso, T., et al.: Chem. Pharm. Bull., 37, 446 (1989), Gu, Q., et al.: J. Med. Chem., 36, 1001 (1993), Bekhterev, V.N., et al.: Pharm. Chem. J., 42, 95 (2008),Fórmula:C15H10BrClN2OCor e Forma:Light YellowPeso molecular:349.61
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