Moduladores GABA
Os moduladores de GABA são compostos que influenciam a função dos receptores de GABA (ácido gama-aminobutírico), os principais receptores inibitórios de neurotransmissores no sistema nervoso central. Estes moduladores podem aumentar ou inibir a atividade GABAérgica, afetando a excitabilidade neuronal e a transmissão sináptica. Os moduladores de GABA são cruciais no tratamento e estudo de vários distúrbios neurológicos e psiquiátricos, incluindo ansiedade, epilepsia e insônia. Na CymitQuimica, oferecemos uma ampla gama de moduladores de GABA para apoiar sua pesquisa em neurociência, farmacologia e neuroterapêutica.
Produtos da "Moduladores GABA"
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3-Hydroxy Prazepam
CAS:Produto ControladoApplications 3-Hydroxy-prazepam is a metabolite of Prazepam (P702250), a benzodiazepine commonly prescribed to treat anxiety. References Kingstone, E.,et al.: Curr. Ther. Res. Clin. E., 8, 159 (1966); Lemoine, P., et al.: Pharmacopsychiatry, No vol. given, No pp. given, (1991);Fórmula:C19H17ClN2O2Cor e Forma:NeatPeso molecular:340.808-Bromo-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one
CAS:Pureza:97.0%Peso molecular:241.087997436523447-Hydroxy-furo[3,4-b]pyrazin-5-one, 70%
CAS:Produto ControladoApplications 7-Hydroxy-furo[3,4-b]pyrazin-5-one is a derivative of 6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one (C379925) which is an impurity of Eszopiclone (E889150), a nonbenzodiazepine hypnotic agent used as a treatment for insomnia. References Gottesmann, C., et al.: Eur. J. Neurosci., 10, 409 (1998), Yoshimoto, M., et al.: Eur. Neuropsychopharmacol., 9, 29 (1999),Fórmula:C6H4N2O3Pureza:70%Cor e Forma:NeatPeso molecular:152.11Eszopiclone
CAS:Produto ControladoApplications Eszopiclone is the active stereoizomer of Zopiclone and belongs to the class of drug known as cyclopyrrones. It is a nonbenzodiazepine hypnotic agent used as a treatment for insomnia.This is a controlled substance (depressant) in the US but not in Canada. References Gottesmann, C., et al.: Eur. J. Neurosci., 10, 409 (1998), Yoshimoto, M., et al.: Eur. Neuropsychopharmacol., 9, 29 (1999),Fórmula:C17H17ClN6O3Cor e Forma:Off WhitePeso molecular:388.812,2-Dipropylpentanoic Acid
CAS:Produto ControladoFórmula:C11H22O2Cor e Forma:NeatPeso molecular:186.29Pridinol Methanesulfonate Salt
CAS:Produto ControladoApplications Used as an antiparkinsonian agent and as an anticholinergic. References Duperray, B., et al.: Eur. J. Drug Metab. Pharmacokinet., 2, 121 (1977),Fórmula:C20H25NO·CH4O3SCor e Forma:White To Off-WhitePeso molecular:391.521’-Hydroxy Midazolam (100 ug/mL in methanol)
CAS:Produto ControladoFórmula:C18H13ClFN3OCor e Forma:Single SolutionPeso molecular:341.77Talbutal-d5
CAS:Produto ControladoApplications A labelled stuctural isomer of Butalbital (B690100). A short to intermediate-acting barbiturate that act as nonselective depressants of the central nervous system (CNS). Sedative, hypnotic. Controlled Substance. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Nielsen, C.J. et al.: Pharmacol., 26, 371 (1925); Lien, E.J. et al.: Acta Pharmac. Jug., 34, 123 (1984);Fórmula:C11H11D5N2O3Cor e Forma:NeatPeso molecular:229.294-Hydroxy Triazolam
CAS:Produto ControladoStability Light Sensitive Applications A metabolite of Triazolam (T767380). References Gall, M., et al.: J. Med. Chem., 21, 1290 (1978), Jones, H., et al.: Drug Metab. Dispos., 32, 973 (2004), Hallifax, D., et al.: Drug Metab. Dispos., 33, 1852 (2005).Fórmula:C17H12Cl2N4OCor e Forma:NeatPeso molecular:359.21Barbituric Acid-13C,15N2
CAS:Produto ControladoApplications Parent compound of barbiturate drugs. References Luo, Y., et al.: J. Med. Chem., 53, 3846 (2010), Tomasic, T., et al.: Eur. J. Med. Chem., 45, 1667 (2010), Gilbert, A., et al.: Bioorg. Med. Chem. Lett., 20, 636 (2010),Fórmula:C313CH415N2O3Cor e Forma:NeatPeso molecular:131.075H-Dibenzo[b,f]azepine (Iminostilbene)
CAS:Produto ControladoFórmula:C14H11NCor e Forma:NeatPeso molecular:193.24Methylbarbital
CAS:Produto ControladoApplications Methylbarbital is a barbituate which displays anticonvulsant/antiepileptic activity. References Lien, E. et al.: J. Pharm. Sci.., 68, 463 (1979); Kesselheim, A. et al.: Drugs, 70, 605 (2010);Fórmula:C9H14N2O3Cor e Forma:WhitePeso molecular:198.221-Methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
CAS:Pureza:98%Peso molecular:250.30099487304688Pentobarbital
CAS:Produto ControladoApplications Pentobarbital is a narcotic and sedative barbiturate drug formerly used to relieve insomnia. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Schafer, E.W., et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972), Woster, P.S., et al.: Clin. Pharm., 9, 762 (1990), Evans, A.T., et al.: J. Am. Vet. Med. Assoc., 203, 664 (1993),Fórmula:C11H18N2O3Cor e Forma:NeatPeso molecular:226.27Allobarbital-d10
CAS:Produto ControladoApplications Labelled Allobarbital, a barbiturate derivative that is primarily used as an anticonvulsant. Allobarbital also shows hypnotic activity and is used to boost the activity of analgesic drugs. Studies show that Allobarbital is an effective promoters of hepatocarcinogenesis. Allobarbital is a Controlled Substance. References Tateoka, Y. et al.: Yakug. Zas., 106, 504 (1986); Crawford, J.M. et al.: Neuropharmacology, 9, 31 (1970); Rice, J.M. et al.: Carcinogenesis, 15, 395 (1994);Fórmula:C10D10H2N2O3Cor e Forma:White To Off-WhitePeso molecular:218.275Clozapine N-Oxide
CAS:Produto ControladoImpurity CLOZAPINE N-OXIDE IMPURITY Applications Clozapine N-Oxide is a 5-HT2 antagonist. It is a major metabolite of clozapine (C587500) that can be monitored by HPLC. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Baldessarini, E., et al.: Neuropsychopharmacol., 9, 117 (1993); Lin, G., et al.: J. Pharm. Sci, 83, 1412 (1994); Roth, B.L., et al.: J. Pharmacol. Exp. Ther., 268, 1403 (1994)Fórmula:C18H19ClN4OCor e Forma:Light Yellow To YellowPeso molecular:342.82Valproic Acid EP Impurity E
CAS:Produto ControladoFórmula:C5H11NOCor e Forma:NeatPeso molecular:101.15Clorazepic Acid Ethyl Ester
CAS:Produto ControladoApplications Clorazepic Acid Ethyl Ester is an ethyl ester of Clorazepic Acid (C587365, Dipotassium Salt) which is an anxiolytic. References Cone, E., et al.: J. Pharm. Sci., 73, 243 (1984), Maurer, H., et al.: J. Anal. Toxicol., 25, 237 (2001), Beyer, J., et al.: Ther. Drug Monit., 27, 151 (2005)Fórmula:C18H15ClN2O3Cor e Forma:White To Light YellowPeso molecular:342.78Flubromazepam (7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one)
CAS:Produto ControladoFórmula:C15H10BrFN2OMidazolam-d6 (1mg/ml in Acetonitrile)
CAS:Produto ControladoFórmula:C18D6H7ClFN3Cor e Forma:Single SolutionPeso molecular:331.806-Amino-5-ethyl-5-(1-methylbutyl)-2,4(3H,5H)-pyrimidinedione-d5
CAS:Produto ControladoFórmula:C11D5H14N3O2Cor e Forma:NeatPeso molecular:230.3187-bromo-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
CAS:Pureza:95.0%Peso molecular:315.1700134277344Desmethyldiazepam-D5 (Nordazepam-D5), 0.1mg/ml in Methanol
CAS:Produto ControladoFórmula:C152H5H6ClN2OAlphenal
CAS:Produto ControladoApplications Barbituric Acid (B118650) derivative with anti-convulsive properties. Controlled Substance. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Carissime, M. et al.: Farmac. Edi. Sci., 17, 390 (1962); Harvey, D.J. et al.: Drug. Metab. Disp., 5, 527 (1977);Fórmula:C13H12N2O3Cor e Forma:NeatPeso molecular:244.25Pirenzepine-d8 Dihydrochloride
CAS:Produto ControladoFórmula:C19H15D8Cl2N5O2Cor e Forma:NeatPeso molecular:432.37Flurazepam Dihydrochloride
CAS:Produto ControladoApplications Flurazepam Dihydrochloride is used as an sedative, hypnotic. This is a controlled substance (depressant). References Sternbach, L.H., et al.: J. Med. Chem., 8, 815 (1965); Schwartz, et al.: J. Med. Chem., 11, 770, (1968); Armagnac, et al.: Therapie, 26, 439 (1971); Ganjali, M., et al.: Curr. Pharm. Anal., 5, 28 (2009);Fórmula:C21H23ClFN3O·2ClHCor e Forma:Light Orange Colour To YellowPeso molecular:460.808-Chloro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Cor e Forma:SolidPeso molecular:182.649993896484385-Phenyl-5-ethyl-2-thiobarbituric Acid-d5
CAS:Produto ControladoApplications Phenobarbital derivative. References Foltz, R.L., et al.: Biochem. Med., 6, 294 (1972),Fórmula:C122H5H7N2O2SCor e Forma:NeatPeso molecular:253.33Thiobutabarbital
CAS:Produto ControladoApplications Anesthetic. References DesJarlais, R., et al.: J. Med. Chem ., 31, 722 (1988), Woo, Y., et al.: Toxicol. Lett., 79, 219 (1995), Blundell, T., et al.: Nature, 384, 23 (1996),Fórmula:C10H16N2O2SCor e Forma:NeatPeso molecular:228.31(S)-5-(4-Hydroxyphenyl)-5-ethylhydantoin
CAS:Produto ControladoFórmula:C11H12N2O3Cor e Forma:NeatPeso molecular:220.22Phenobarbital N-beta-D-Glucuronide
CAS:Produto ControladoApplications A metabolite of Phenobarbital (P316760). References Soine, W.H., et al.: Drug Metab. Dispos., 12, 792 (1984), Soine, W.H., et al.: J. Pharmac. Sci., 80, 99 (1991),Fórmula:C18H20N2O9Cor e Forma:NeatPeso molecular:408.359(2-Amino-5-nitrophenyl)(2-chlorophenyl)methanone
CAS:Produto ControladoFórmula:C13H9ClN2O3Cor e Forma:NeatPeso molecular:276.68Cyanoguanidine-15N4
CAS:Produto ControladoStability Hygroscopic Applications Labelled Cyanoguanidine (C981350). A guanidine derivative used in the synthesis of barbiturates. References Kumar, U., et al.: Curr. Sci., 79, 224 (2000), Di, H., et al.: Biol. Fertil. Soils, 2006, 42, 472 (2006),Fórmula:C2H415N4Cor e Forma:White To Light BeigePeso molecular:88.0536Loprazolam
CAS:Produto ControladoApplications Sedative, hypnotic. Controlled substance (depressant). References Agar, J.R., et al.: J. Med. Chem., 20, 1035 (1977), Clark, B.G., et al.: Drugs, 31, 500 (1986),Fórmula:C23H21ClN6O3Cor e Forma:YellowPeso molecular:464.90Pregabalin Methyl Ester Hydrochloride
CAS:Produto ControladoFórmula:C9H19NO2·ClHCor e Forma:NeatPeso molecular:209.71Lormetazepam
CAS:Produto ControladoApplications An analog of Lorazepam (L469850). Sedative, hypnotic.Controlled substance (depressant). References Nudelman, A., et al.: J. Pharma. Sci., 63, 1886 (1974), Humpel, M., et al.: Eur. J. Drug Metab. Pharmacokinet., 4, 237 (1979), Girkin, R., et al.: Xenobiotica, 10, 401 (1980),Fórmula:C16H12Cl2N2O2Cor e Forma:Light Yellow To Light GreenPeso molecular:335.18Lorazepam Acetate ((3RS)-7-Chloro-5-(2-chlorophenyl)-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl Acetate)
CAS:Produto ControladoFórmula:C17H12Cl2N2O3ALLYL ISOPROPYL ACETYLUREA
CAS:Fórmula:C9H16N2O2Pureza:98%Cor e Forma:SolidPeso molecular:184.23554000000001
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