Fonte Botânica

Deoxyshikonin and dodecyl gallate show significantly synergic antimicrobial activity with penicillin in vivo and in vitro, and can effectively reduce nasopharyngeal and lung colonization caused by different penicillin-resistant pneumococcal serotypes. Deoxyshikonin exerts very good radical scavenging activities toward ABTS+ but shows moderate inhibition of DPPH·, and shows cytotoxic activities. Deoxyshikonin may be a new drug candidate for wound healing and treatment of lymphatic diseases.

Pelargonidin-3-O-sophoroside is a specialized flavonoid glycoside, which is derived from certain plant sources. It is primarily isolated from various fruits and flowers where it contributes to pigmentation, specifically imparting hues such as red and pink. The compound functions through its role as a pigment by absorbing specific wavelengths of light, which can protect the plant tissues from excess UV radiation and attract pollinators. In addition to its role in pigmentation, pelargonidin-3-O-sophoroside exhibits antioxidant properties by scavenging free radicals. This can help in protecting cells from oxidative stress and potential damage. Its antioxidant activity makes it of interest in research related to oxidative stress-related conditions and in developing natural antioxidant therapies. Applications of pelargonidin-3-O-sophoroside are primarily focused on basic and applied plant research, particularly in understanding anthocyanin biosynthesis, plant breeding, and developing cultivars with desirable pigmentation traits. Additionally, due to its antioxidant properties, it is investigated in the context of dietary supplements and natural preservatives for food products, albeit primarily in research settings.

Tuberostemonine has antitussive activity, acts in part as an open-channel blocker at the crayfish neuromuscular junction; it also exhibits relatively higher intestinal permeabilities.

Wogonoside has anticoagulant, anti-inflammatory, anti-angiogenic and anticancer effects, it may exert its anti-inflammatory effect via dual inhibition of NF-κB and NLRP3 inflammasome. Wogonoside induced autophagy through the MAPK-mTOR pathway, it inhibited LTB 4 production at the concentration of 100 uM.

Tubuloside A has anti-inflammatory, antioxidative and hepatoprotective activities. Tubuloside A shows stronger free radical scavenging activities than alpha-tocopherol on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine/xanthine oxidase (XOD) generated superoxide anion radical (O2-.).

Sinensetin is a polymethoxylated flavonoids in citrus fruit, as a novel antiangiogenesis agent, has potential for anti-carcinogenesis, antitumor, and cardiovascular protective activity.

Momordicoside L is a triterpenoid saponin, which is a class of chemical compounds predominantly found in plants. It is derived from Momordica charantia, commonly known as bitter melon, a plant which has been traditionally utilized in various medicinal practices. The mode of action of Momordicoside L involves its capacity to influence cellular pathways, particularly through the modulation of glucose metabolism and potential anti-inflammatory effects. This is achieved via the interaction with specific cellular receptors, thereby impacting signal transduction processes. The applications of Momordicoside L are primarily in the realm of biomedical research, where its potential therapeutic benefits are being explored. It is investigated for its possible roles in the management of metabolic disorders, including diabetes, given its effects on glucose homeostasis. Additionally, preliminary studies indicate its utility in modulating inflammatory responses, making it a candidate for further research in inflammatory diseases. Thus, Momordicoside L serves as an intriguing subject for scientific investigation due to its multifaceted biological activities and potential health benefits.

Astragaloside III can effectively reduce cancer cell survival in vitro and inhibit the tumor growth in vivo, the potential mechanism is the induction of cell apoptosis signaling pathways, suggests that it provides a new therapeutic tool to treat breast cancer.

p-Vinylphenyl O-[b-D-apiofuranosyl-(1-6)]-b-D-glucopyranoside is a glycoside compound, which is typically derived from plant sources. It is characterized by its unique structure, comprising a phenolic moiety linked to a disaccharide sugar chain. Glycosides like this one are commonly found in nature and are known for their diverse roles in plant metabolism and potential biological activities. The mode of action of p-Vinylphenyl O-[b-D-apiofuranosyl-(1-6)]-b-D-glucopyranoside involves its interaction with specific cellular targets, which may include enzymes or receptor sites, influencing various biochemical pathways. Such actions can lead to a variety of biological effects, depending on the specific interactions and the system in which they occur. This compound is of interest in scientific research for its potential applications in pharmacology and biochemistry. Researchers explore its use as a model compound to study glycosidic bonds and investigate its potential therapeutic properties. Additionally, it serves as a tool in understanding plant-derived bioactive compounds, contributing to fields such as drug discovery and natural product research.

Benzoylmesaconine (BEN, an aconitine derivative extracted from heated-Aconiti tuber) induces the generation of CD4+ T cells antagonistic to type 2 T cells (BEN-CD4+ T cells), the combination therapy of IL-12 (an inducer of type 1 T cell responses) and BEN (an inhibitor of type 2 T cell responses) may protect TI-mice from severe HSV-1 infection.

Gypenoside XLIX is a saponin compound, which is derived from the plant Gynostemma pentaphyllum, commonly known as Jiaogulan. This plant is a valuable source of various gypenosides, which are structurally similar to ginsenosides found in ginseng. Gypenoside XLIX acts primarily through modulating cellular pathways, including antioxidative, anti-inflammatory, and apoptotic processes. It interacts with cell signaling mechanisms, potentially influencing metabolic and cardiovascular health. Gypenoside XLIX is being studied for its wide-ranging pharmacological applications. Research has shown that it may possess neuroprotective and cardioprotective effects, making it a focus in studies related to neurodegenerative diseases and myocardial ischemia. Additionally, its role in enhancing immune function and promoting cellular homeostasis opens avenues for further exploration in cancer research. While studies are ongoing, its multifaceted actions suggest potential in therapeutic interventions and preventative healthcare strategies.