Fonte Botânica

Germacrone, a natural product isolated from Rhizoma curcuma, can inhibit the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway.

Clinodiside A is a triterpenoid saponin, which is a type of secondary metabolite found in certain marine sponges. The source of this compound is primarily marine organisms, particularly sponges in the genus Cliona. Clinodiside A operates through various biochemical pathways, including disrupting cell membrane integrity and inducing apoptosis in certain cell types. This mode of action is particularly relevant in the context of inhibiting cancer cell proliferation and providing antitumor activities. The uses and applications of Clinodiside A extend to research areas focused on developing novel therapeutic agents. Scientists explore its potential in drug development due to its bioactive properties, especially its anticancer and antiviral capabilities. Research into Clinodiside A also explores its role as a natural product in studying marine chemical ecology and its implications in biotechnology related to marine-sourced pharmaceuticals. These attributes make Clinodiside A a compound of interest in ongoing scientific investigations into marine-derived bioactive substances.

Pinoresinol diglucopyranoside is a lignan glycoside, which is a type of polyphenolic compound. It is predominantly sourced from various plant species, including flaxseeds, sesame seeds, and olives. This compound is distinguished by its intricate glycosidic linkages, which play a crucial role in its biological activity. As an antioxidant, pinoresinol diglucopyranoside functions by neutralizing free radicals, thus reducing oxidative stress in cells. Its mode of action involves modulating biochemical pathways and interacting with specific cellular receptors to exert protective effects against cellular damage. In research settings, pinoresinol diglucopyranoside has attracted attention for its potential applications in nutraceuticals and pharmaceuticals. It is studied for its cardiovascular benefits, potential anti-cancer properties, and role in regulating lipid metabolism. Its ability to modulate inflammatory responses further underscores its significance in developing therapeutic agents aimed at chronic conditions. Given its biological activities, pinoresinol diglucopyranoside continues to be a subject of interest for scientists exploring natural compounds with health-promoting qualities.

Onjisaponin B, derived from Radix Polygalae, can enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells.

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Gypenoside I is a saponin compound, which is a natural product sourced from the medicinal plant Gynostemma pentaphyllum, also known as Jiaogulan. This plant is native to Asia and has been used in traditional medicine due to its wide range of purported health benefits. The mode of action of Gypenoside I involves its interaction with various biological pathways, particularly those related to oxidative stress and metabolic regulation. It is known to exhibit antioxidant properties, which help in scavenging free radicals, and may influence pathways that regulate glucose and lipid metabolism. The uses and applications of Gypenoside I are primarily in the field of experimental and therapeutic research. It is investigated for its potential adaptogenic effects, which may help in improving resilience to stress. Moreover, studies have suggested its role in modulating immune function, providing cardiovascular protection, and possibly offering neuroprotective benefits. Research continues to explore its pharmacological efficacy and safety profile in various in vitro and in vivo models, aiming to better understand its potential therapeutic applications.

Atractylone has inhibitory effects on mast cell-mediated allergic reactions, it regulates the degranulation of mast cell, proves its potential in the treatment of mast cell-mediated allergic reactions.

Liquiritigenin, an aglycone of liquiritin in G. radix , exerts cytoprotective effects against heavy metal-induced toxicity in vitro, can protect the liver from acute injuries induced by APAP or from APAP-induced severe injuries during GSH deficiency.

Notoginsenoside R1(NR1) is the main ingredient with cardiovascular activity in Panax notoginseng, which has some neuronal protective, antihypertensive,antioxidant, anti-inflammatory, antiapoptotic, and immune-stimulatory activities. NR1 can counteract endotoxin-induced activation of endothelial cells in vitro and endotoxin-induced lethality in mice in vivo. NR1 inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways, it attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation.

Mesaconitine increases the [Ca2+]i level in endothelial cells by influx of Ca2+ from extracellular spaces, suggests that mesaconitine-induced Ca2+ influx and activation of nitric-oxide synthase in endothelial cells and, thus, induced vasorelaxation in rat aorta.

Pinoresinol diglucoside is a putative α-glucosidase inhibiting compound, has antihypertensive activity. It is a heat shock factor 1 inducer, increased expression of HSF1 by a factor of 1.041 at 3 μM.