Fonte Botânica

(-)-Epicatechin gallate can effectively stimulates osteoblast differentiation, it has antioxidative effect against lipid peroxidation when phospholipid bilayers are exposed to aqueous oxygen radicals.

Mogroside IVa is a triterpene glycoside, which is a type of natural sweetening compound, derived primarily from the fruit of Siraitia grosvenorii, commonly known as monk fruit. The compound is extracted from the fruit through a meticulous process that ensures the preservation of its natural properties. The mode of action of Mogroside IVa involves its interaction with taste receptors on the tongue, where it delivers intense sweetness, often several hundred times sweeter than sucrose, without providing caloric value. Additionally, studies suggest that this mogroside exhibits antioxidant activities, potentially neutralizing free radicals and protecting against cellular damage. Mogroside IVa has various applications, predominantly in the food and beverage industry as a natural low-calorie sweetener. Researchers are also exploring its potential therapeutic uses due to its antioxidant capacity, investigating its role in managing conditions such as obesity, diabetes, and other metabolic disorders. Its role in novel drug formulations and nutraceuticals is of considerable interest, owing to its dual functionality as both a sweetener and an antioxidant.

Gentiopicroside has been developed into a novel traditional Chinese drug named gentiopicroside injection, and it was approved for the treatment of acute jaundice and chronic active hepatitis by SFDA.Gentiopicroside has analgesic, smooth muscle relaxing, antibacterial, and free radical scavenging activities, it exerts anti-inflammatory effects on experimental acute colitis through attenuating the expression levels of TNF-α, IL-1β, IL-6, iNOS and COX-2.

Quercetin, a member of the flavonoids family, is one of the most prominent dietary antioxidants. It is ubiquitously present in foods including vegetables, fruit, tea and wine as well as countless food supplements and is claimed to exert beneficial health effects. This includes protection against various diseases such as osteoporosis, certain forms of cancer, pulmonary and cardiovascular diseases but also against aging.

4'-Demethylepipodophyllotoxin is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly.

11-oxo-Mogroside V is a natural sweetener, which is a type of mogroside, sourced primarily from the fruit of Siraitia grosvenorii, commonly known as monk fruit or Luo Han Guo. This compound is part of a group of triterpene glycosides, which are responsible for the intense sweetness of monk fruit extracts, being up to several hundred times sweeter than sucrose. The mode of action of 11-oxo-Mogroside V involves its interaction with taste receptors, specifically binding to sweet taste receptor cells and triggering sweetness perception without the caloric contribution of traditional sugars. Moreover, it exhibits potent antioxidant properties, providing potential health benefits due to its capacity to scavenge free radicals and reduce oxidative stress. In terms of applications, 11-oxo-Mogroside V is predominantly used in the food and beverage industry as a non-caloric sweetening agent. It is particularly valuable in the development of reduced-calorie, low-glycemic index products, making it beneficial in managing conditions like diabetes and obesity. Additionally, its antioxidant activity makes it a candidate of interest for nutraceutical formulations aimed at supporting overall health and wellness.