Padrões sobre hidrocarbonetos policíclicos aromáticos (HPAs)

Applications 7,12-Dimethylbenz[a]anthracene is a highly potent carcinogen that is activated by microsomal enzymes to a diol epoxide metabolite that binds covalently to DNA in mammalian cells, leading ultimately to tumor induction. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Huggins, C., et al.: Proc. Nat. Acad. Sci. U.S.A., 58, 2253 (1967); Dipple, A., et al.: N. Cancer Res., 43, 4123 (1983)

Applications Benz[a]anthracene-7,12-dione is a polycyclic aromatic hydrocarbon that is present in the emission soot of biomass fuels combustion. Benz[a]anthracene-7,12-dione is an urban air contaminant and also a potential mutagen & carcinogen. References Durant, J., et al.: Mutat. Res., Gen. Toxicol., 371, 123 (1996); Salamone, M., et al.: Env. Int., 2, 37 (1979); Wu, W., et al.: J. Env. Sci. Health A., A37, 579 (2002)

Applications 5-Chloroacenaphthenone is a chlorinated derivative of 1-Acenphthenone (A130755). 1-Acenaphthenone is a product of the photolysis (and microbial metabolism) of acenaphthene, a polycyclic hydrocarbon that has potential to act as polyploidizing agents in plants. References Kostoff, D.: Nature, 142, 753 (1938); Reyes, C., et al.: J. Photochem. Photobio. A, 112, 277 (1998); Schocken, M. & Gibson, D.: Appl. Environ. Microb., 48, 10 (1984)

Applications 6-Bromobenzo{a}pyrene is the polycyclic aromatic hydrocarbons with significant contribution to inhalation cancer risk. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wang, J., et al.: Environ. Sci. Technol., 46, 9745-9752 (2012)

Stability Air Sensitive Applications 2-AMINOANTHRACENE (cas# 613-13-8) is a useful research chemical.

Applications Dibenz[a,h]anthracene is a polycyclic aromatic hydrocarbon (PAH) and a known carcinogen. Dibenz[a,h]anthracene has produced positive results in bacterial DNA damage and mutagenicity assays and in mammalian cell DNA damage, mutagenicity and cell transformation assays. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Farmer, P.B. et al.: Mutat. Res. Re. Mutat. Res., 544, 397 (2003); Leadon, S. et al.: Carcinogenesis, 16, 3021 (1995); Andrews, A.W. et al.: Mutat. Res., 51, 311 (1978); Kaden, D.A. et al.: Cancer Res., 39, 4152 (1979);

Applications Polycyclic aromatic hydrocarbons as carcinogenic agents. References Hansen, B., et al.: Environ. Toxicol. Chem., 18, 772 (1999), Czub, G., et al.: Environ. Sci. Technol., 38, 2406 (2004),

Applications An active metabolite from inhalation and dermal exposure to polycyclic aromatics hydrocarbons found in hot mix asphalt paving workers. DBC is the most potent tumorigen that has been identified to date. Dibenzo[def,p]chrysene (DBC) is a carcinogen and should be handled with caution. References Anderson, L., et al.: Toxicol. Appl. Pharmacol., 199, 85 (2004), Yu, Z., et al.: Cancer Res., 66, 755 (2006), Shen, J., et al.: Toxicol. Sci., 95, 313 (2007),