Padrões sobre hidrocarbonetos policíclicos aromáticos (HPAs)

Applications 7-Hydroxybenzo[a]pyrene is a metabolite of Benzopyrene (BaP), a carcinogenic component of tobacco smoke implicated in lung cancer. References Li, F.,et al.: Environ. Toxicol. Pharmacol., 32, 373 (2011); Hayakawa, K., et al.: Polycyclic. Aromatic. Compound., 28, 382 (2008); Webb, L., et al.: Environ. Toxicol. Pharmacol., 21, 224 (2006);

Applications 1,8-Dichloronaphthalene (CAS# 2050-74-0) is a useful research chemical compound.

Applications 1,3,6-Trichloropyrene is a chlorinated polycyclic aromatic hydrocarbon and micropollutant found in the environment. References Puzyn, T., et al.: J. Environ. Sci. Heal. A., A38, 1761 (2003)

Applications Dibenzo[e,l]pyrene is a polycyclic aromatic hydrocarbon (PAH). It is an isomer of Dibenzo[a,l]pyrene (D416945) which is confirmed to be highly carcinogenic. Dibenzo[e,l]pyrene is also used as a standard in determination of polycyclic aromatic hydrocarbons (PAH’s). References Wei, S., et al.: J. Environ. Monitor., 13, 2568 (2011); Anderson, L., et al.: Toxicol. Appl. Pharmacol., 199, 85 (2004), Yu, Z., et al.: Cancer Res., 66, 755 (2006), Shen, J., et al.: Toxicol. Sci., 95, 313 (2007); Schubert, P., et al.: Analyt. Chem.m 75, 234 (2003)

Applications Labelled analogue of Dibenzo[a,i]pyrene, a polycyclic aromatic hydrocarbon (PAH) with potent carcinogenic activity. Dibenzo[a,i]pyrene was shown to induce DNA adduction, tumorigenicity as well as Ki-ras oncogene mutations in strain A/J mouse lung. Dibenzo[a,i]pyrene has been shown to be present in cigarette smoke condensate and in automobile exhaust gas in small quantities. References Prahalad, A.K. et al.: Carcinogenesis, 18, 1955 (1997); Wynder, E.L. et al.: Nature, 192, 1092 (1961); Homburger, F. et al.: J. Nat. Cancer Inst., 44, 357 (1970);

Applications 1,4-Dibromonaphthalene is used in the annelation of PAHs. Also used in the synthesis of novel, orally active dual NK1/NK2 antagonists. References Bernstein, P. et al.: Bioorg. Med. Chem. Lett., 11, 2769 (2001); Wegner, H. et al.: J. Org. Chem., 68, 883 (2003);