Padrões sobre hidrocarbonetos policíclicos aromáticos (HPAs)

Applications Labelled Dibenzo[a,l]pyrene (D416945). An active metabolite from inhalation and dermal exposure to polycyclic aromatics hydrocarbons in hot mix asphalt paving workers. DBC is the most potent tumorigen that has been identified to date. Dibenzo[def,p]chrysene (DBC) is a carcinogen and should be handled with appropriate caution. References Anderson, L., et al.: Toxicol. Appl. Pharmacol., 199, 85 (2004), Yu, Z., et al.: Cancer Res., 66, 755 (2006), Shen, J., et al.: Toxicol. Sci., 95, 313 (2007),

Applications 3-Nitroacenaphthene is an impurity of Acenaphthene (D448330), which is a polycyclic aromatic hydrocarbon as carcinogenic agent. References Liu, Y., et al.: J. Med. Chem., 57, 5203 (2014);

Applications Naphtho[2,3-e]pyrene is a polycyclic aomatic hydrocarbon (PAH) with carcinogenicity. Naphtho[2,3-e]pyrene is one of the C24H14 PAH that displayed mutagenicity in human cells expressing CYP1A1. References Yan, L.S.: Carcinogenesis6, 1 (1985); Durant, J.L. et al.: Mutat. Res. Gen. Toxicol. Environ. Mutagen., 446, 1 (1999);