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4-Amino-2-chloro-6,7-dimethoxyquinazoline (4ACDMQ) is a synthetic compound that has been used as a chemical intermediate. The chemical structure of 4ACDMQ is similar to that of the natural amino acid tryptophan. It is synthesized by reacting phosphorus pentachloride with 2,6,7-trimethoxyquinazoline in the presence of hydroxide solution and hexamethylphosphoramide. 4ACDMQ has been shown to be an inhibitor of ubiquitin proteasome system and has been used in functional studies on this system. The reaction yield for 4ACDMQ can be increased by using sodium hydroxide solution or n-dimethyl formamide as a solvent. Functional assays have shown binding properties for 4ACDMQ to proteins such as ubiquitin and proteasome subunits.

Please enquire for more information about NUC-7738 including the price, delivery time and more detailed product information at the technical inquiry form on this page

NPS-ALX-4A is a drug, which has been shown to have cognition-enhancing effects in mice. It is a 5-HT6 receptor antagonist and can be used as an animal model for human cognitive disorders. NPS-ALX-4A was administered orally to control mice and the animals were tested for learning and memory. The study showed that NPS-ALX-4A improved spatial memory in the mouse model. This drug has not been tested on humans, but it has shown cognitive benefits in the mouse model with no significant side effects.

Impurity Salicylic Acid Related Compound A Applications Acetylsalicylic Acid Impurity A. References Walter, M., et al.: Eur. J. Biochem., 1996, 239, 281 (1996), Bantignies, B., et al.: Plant Mol. Biol., 42, 871 (2000), Bais, H., et al.: J. Biol. Chem., 278, 32413 ( 2003), Finkler, C., et al.: Genetica, 124, 117 (2005),

Please enquire for more information about 5-Chloro-N-4-pyridinyl-2,1-benzisothiazole-3-carboxamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Labelled Sulfasalazine (S699084). An anti-inflammatory (gastrointestinal). Sulfasalazine has been used in granulomatous colitis. References Schroder, H., et al.: Clin. Pharmacol. Ther.,13, 539 (1972), McDonnell, J.P., et al.: Anal. Profiles Drug Subs., 5, 515 (1976), Klotz, U., et al.: Clin. Pharmacokinet.,10, 285 (1985),

3-(Dimethylamino)-1-(2-thienyl)propanone hydrochloride is a sulfoxide that is used as a solvent. It has been used in the synthesis of benzylsulfoxides and solvents for the manufacture of pharmaceuticals. 3-(Dimethylamino)-1-(2-thienyl)propanone hydrochloride is also a potent compound, which is structurally similar to benzene but with an additional methyl group. 3-(Dimethylamino)-1-(2-thienyl)propanone hydrochloride has been used in the synthesis of melphalan and elemental analysis. The chloride group on its structure makes it soluble in water and organic solvents such as acetonitrile. 3-(Dimethylamino)-1-(2-thienyl)propanone hydrochloride can be synthesized by reacting nitric acid with 2-aminothiophenol and dimethylanil

Applications An anticonvulsant. Inhibits glutamate release, possible through inhibition of Sodium, Potassium and Calcium currents. Used in treatment of bipolar depression. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Miller, A.A., et al.: Epilepsia, 27, 483 (1986), Grunze, et al.: Neuropsychobiology, 38, 131 (1998), Calabrese, J.R., et al.: J. Clin. Psychiatry, 60, 79 (1999),