APIs para pesquisa e impurezas

9-Hydroxymethyl-10-carbamoylacridan is an active metabolite of carbamazepine. It is a potent competitive inhibitor of the enzyme acetylcholinesterase, which leads to increased levels of acetylcholine in the human brain and causes decreased seizure threshold. 9-Hydroxymethyl-10-carbamoylacridan can be found in wastewater and it has been detected in the water supply and in human serum. 9-Hydroxymethyl-10-carbamoylacridan is also present in human urine and can be detected by high performance liquid chromatography (HPLC). This compound has been shown to cause epileptic seizures in humans.

Rosuvastatin anhydro lactone is a pure chemical compound that is used as an analytical reference standard for high-performance liquid chromatography (HPLC) for the determination of purity and identification of impurities in pharmaceuticals. It is also utilized as a drug development, API impurity, and HPLC standard. Rosuvastatin anhydro lactone is a metabolite of rosuvastatin and is chemically designated as C22H29NO3. The CAS number for rosuvastatin anhydro lactone is 1246665-85-9.

Sterebin E is an analog of a kinase inhibitor that has shown promising anticancer activity. It is derived from a Chinese herb and has been found to induce apoptosis in human cancer cells. Sterebin E targets specific kinases involved in the cell cycle and inhibits their activity, leading to cell death. This compound has been shown to have potent inhibitory effects on various protein kinases, making it a promising candidate for the development of new cancer therapies. In addition, Sterebin E has been found in urine samples from cancer patients, suggesting that it may be a useful biomarker for tumor diagnosis and prognosis.

Applications Semisynthetic antibiotic. Antibacerial (tuberculostatic). References Furesz, et al.: Antibiot. Chemother., 16, 316 (1970), Gallo, G.G., et al.: Anal. Profiles Drug Subs., 5, 467 (1976),

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Applications An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lopaschuk, G., et al.: Mol. Cell. Biochem., 88, 175 (1989), Reinauer, H., et al.: J. Clin. Chem .Clin. Biochem., 28, 335 (1990),

Impurity Clobetasol Propionate EP Impurity G / Betamethasone EP Impurity B Applications Clobetasol (Clobetasol Propionate EP Impurity G) is a topical corticosteroid. Glucocorticoid; anti-inflammatory. References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),

Applications A metabolite of Camostat. It is a pollen protease inhibitor for prevention and control of allergy. References Senochuki, K., et al.: J. Med. Chem., 38, 2521 (1995)

Applications A sulfonylurea hypoglycemic agent. Used as an antidiabetic. References Ratheiser, K., et al.: Arzneim.-Forsch., 43, 856, (1993),

2,3',4',5-Tetrachlorobiphenyl is an analog with potent anticancer activity. It has been shown to induce apoptosis in human cancer cells and inhibit tumor growth in Chinese hamsters. This compound is also a potent inhibitor of protein kinases, including those involved in the regulation of cell growth and differentiation. Additionally, it has been found to enhance the activity of other kinase inhibitors such as tolvaptan. 2,3',4',5-Tetrachlorobiphenyl may be useful for developing new therapies for cancer treatment.