APIs para pesquisa e impurezas

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Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile (TMBDAC) is an impurity standard and a metabolite of the drug product. It is an analytical standard for HPLC. Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile is a high purity research and development chemical that can be custom synthesized to meet specific needs. This synthetic compound has shown potential as a niche metabolite in metabolism studies. CAS No. 120511-84-4.

Ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate is a custom synthesis. It is a metabolite of the drug product, ethyl 2-(5-isopropenyl-4-methylphenoxy)propanoate. Its CAS number is 157356-73-5.

Tirzepatide Impurity

Applications A 16-membered ring macrolide antibiotic used in ophthalmology as well as other medical fields. References Matsui, K. et al.: J. Inter. Cytokin Res., 24, 197 (2004); Schmalreck, A.F. et al.: Antiinfect Drugs Chemother., 14, 225 (1996); Tokuda, H. et al.: Chemother., 21, 887 (1973);

Applications Sulfisoxazole is a sulfonamide based antibacterial that exhibits activity against wide spectrum of gram-negative and gram-positive bacterium. References O’Shea, R., et al.: J. Medn. Chem., 51, 2871 (2008); Hawser, S., et al.: Biochem. Pharmacol., 71, 941 (2006);

7 S-Cefdinir is an oral cephalosporin antibiotic that binds to penicillin-binding proteins in the bacterial cell wall by competitive inhibition. This binding prevents the formation of an antibiotic-inhibitor complex with transpeptidase and transpeptidase, which are enzymes involved in peptidoglycan synthesis. 7 S-Cefdinir also inhibits pentapeptide cross-linking, which is necessary for the formation of peptidoglycan chains. 7 S-Cefdinir has bactericidal activity against a wide range of bacteria and acts as an antibacterial agent. It is active against erythromycin-resistant strains of Streptococcus pneumoniae and Mycoplasma pneumoniae, but not against methicillin-resistant Staphylococcus aureus (MRSA).

Nicergoline EP Impurity B is a metabolite of nicergoline, a drug product. It has been synthesized for use as an impurity standard for analytical and pharmacopoeia purposes. Nicergoline EP Impurity B is not found in nature and has been shown to be metabolically stable in vitro. It can be used as a reference substance for the determination of nicergoline concentrations in human plasma samples.

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Applications Maslinic Acid is an apoptosis inducer in lung cancer cells, occuring under normoxic and hypoxic conditions. References Hsia, T. et al.: Molecules., 19, 19892 (2014);