Angiogenesis
Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.
Subcategories of "Angiogenesis"
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Products of "Angiogenesis"
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Tranilast
CAS:Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment ofFormula:C18H17NO5Purity:100% - 99.90%Color and Shape:White With Light Yellow Crystalline PowderMolecular weight:327.33Ref: TM-T2690
5mg43.00€10mg55.00€25mg66.00€50mg93.00€100mg119.00€200mg175.00€500mg298.00€1mL*10mM (DMSO)55.00€Itacnosertib
CAS:Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.Formula:C26H28N8OPurity:99.38%Color and Shape:SolidMolecular weight:468.555-Amino-2-methylbenzenesulfonamide
CAS:Controlled ProductStability Hygroscopic Applications 5-Amino-2-methylbenzenesulfonamide is an intermediate for the synthesis of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR. References Harris, P.A., et al.: J. Med. Chem., 51, 4632 (2008); Petrow, V., et al.: J. Pharmacy. Pharmacol., 12, 705 (1960);Formula:C7H10N2O2SColor and Shape:NeatMolecular weight:186.23HIF-2α-IN-3
CAS:HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.Formula:C12H6ClN5O5Purity:98.11%Color and Shape:SolidMolecular weight:335.66Ref: TM-T11562
1mg115.00€5mg274.00€10mg432.00€25mg845.00€50mg1,293.00€100mg1,768.00€1mL*10mM (DMSO)303.00€THS-044
CAS:THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activityFormula:C11H12F3N3O3Purity:100%Color and Shape:SolidMolecular weight:291.23N-(4-Chloro-2-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine
CAS:Controlled ProductApplications N-(4-Chloro-2-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an intermediate in the synthesis of 5-((2-((2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-4-yl)amino)-2-methylbenzenesulfonamide Hydrochloride (D474433) which is an impurity of Pazopanib (P210925), which is an oral angiogenesis inhibitor targeting VEGFR and PDGFR. References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),Formula:C14H14ClN5Color and Shape:NeatMolecular weight:287.75EHop-016
CAS:EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.Formula:C25H30N6OPurity:100% - 99.86%Color and Shape:SolidMolecular weight:430.55Ref: TM-T2427
5mg48.00€10mg73.00€25mg127.00€50mg213.00€100mg334.00€200mg492.00€500mg787.00€1mL*10mM (DMSO)52.00€HIF-1α-IN-2
CAS:HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.Formula:C21H19N3OSPurity:98.45%Color and Shape:SolidMolecular weight:361.46FGFRs-IN-1
FGFRs-IN-1 (Compound A16) is an orally active inhibitor targeting FGFR1/2/3/4, with IC50 values of 2.3, 7, 11, and 163 nM respectively. It also inhibits VEGFR1/2/3, Abl, and Flt3, with IC50 values of 61, 176, 112, 26, and 353 nM. The compound shows weak inhibition of CYP enzymes. FGFRs-IN-1 reduces the expression of α-SMA and collagen I, and it inhibits epithelial-mesenchymal transition (EMT) in A549 cells stimulated by TGF-β1. Additionally, FGFRs-IN-1 demonstrates anti-inflammatory activity in mouse models of lung fibrosis induced by Bleomycin and liver fibrosis induced by CCl4.Formula:C28H26Cl2N4O3Color and Shape:SolidMolecular weight:537.44tert-Butyl (2,6-Dioxopiperidin-3-yl)carbamate
CAS:Controlled ProductApplications tert-Butyl (2,6-Dioxopiperidin-3-yl)carbamate is an intermediate in the synthesis of Thalidomide-d4 (T338852), a labelled Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. References D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994); Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993); Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)Formula:C10H16N2O4Color and Shape:NeatMolecular weight:228.25AG1557
CAS:AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).Formula:C16H14IN3O2Purity:98.61% - 99.23%Color and Shape:SolidMolecular weight:407.21Tyrosine kinase-IN-9
CAS:Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.Formula:C20H14ClN3O3Color and Shape:SolidMolecular weight:379.796TZEP7
CAS:TZEP7 functions as an EGFR kinase inhibitor in cancer cells. It exhibits cytotoxicity and induces apoptosis within these cells. TZEP7 downregulates the anti-apoptotic protein Bcl-2, upregulates the pro-apoptotic protein Bax, and increases caspase levels. This compound holds potential for research in anticancer drug development.Formula:C27H19ClFNSColor and Shape:SolidMolecular weight:443.963Endoxifen (Z-isomer)
CAS:Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.Formula:C25H27NO2Purity:99.81%Color and Shape:SolidMolecular weight:373.49rac cis-3-((tert-Butyldimethylsilyl)oxy)-1-(4-nitrophenyl)cyclopentanecarboxamide
CAS:Controlled ProductApplications (1S,3S)-3-((tert-Butyldimethylsilyl)oxy)-1-(4-nitrophenyl)cyclopentanecarboxamide is an impurity in the synthesis of metabolites of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).Formula:C18H28N2O4SiColor and Shape:NeatMolecular weight:364.51CA IX/VEGFR-2-IN-3
CAIX/VEGFR-2-IN-3 (Compound 6i) is an inhibitor of Carbonic Anhydrase IX and VEGFR-2, with IC50 values of 41 and 48 nM, respectively. It exhibits anticancer activity by inhibiting the growth of MCF-7 breast cancer cells (IC50 of 22.33 μM) and mouse fibroblast cell line 3T3, where cell viability is reduced to below 40% at a concentration of 100 μM. This compound is applicable for research in the field of cancer treatment.Formula:C19H16ClN3O5S2Molecular weight:465.93EGFR-TK-IN-5
EGFR-TK-IN-5 (Compound NCE 2) is a thiazolyl pyrazoline derivative with significant inhibitory activity and stability against EGFR. It is applicable in tumor research.Formula:C26H20ClFN4OSColor and Shape:SolidMolecular weight:490.98MK-886 Sodium Salt
CAS:Controlled ProductFormula:C27H33ClNO2S·NaColor and Shape:NeatMolecular weight:494.06N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine
CAS:Controlled ProductApplications N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine is a degredation product of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR. References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009), Patel, P. et al.: J. Mass. Spec., 50, 918 (2015);Formula:C14H16N6Color and Shape:NeatMolecular weight:268.32EGFR-IN-147
CAS:EGFR-IN-147 (compound ID-5841161) is a potent EGFR inhibitor, demonstrating a 14% inhibition rate at a concentration of 1μM. It holds promise for cancer research applications.Formula:C13H13N5OColor and Shape:SolidMolecular weight:255.275
