Apoptosis

Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cell

DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.

Benufutamab (GEN1029) is an agonistic antibody targeting death receptor 5 (DR5) with anti-tumor activity, used in the study of solid tumors.

SCR130 (1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-) 是基于 SCR7 的 DNA 非同源末端连接抑制剂,可诱导细胞凋亡并,具有抗癌活性。 它特异性依赖连接酶 IV,抑制 DNA 的末端连接。

Alphitolic acid from Potentilla freyniana Bornm is an HMGCS2 inhibitor with anti-inflammatory and anti-cancer activity.

Rosiglitazone maleate (BRL 49653) is an oral antidiabetic and potential anticancer agent.

BIX selectively induces BiP/GRP78 and ER chaperone, preventing cell death in neurons and retinas.

Applications Gliotoxin is a sulfur-containing mycotoxin produced by species of fungi and pathogens of humans. Gliotoxin exhibits inhibitory activities against histone H3K9 methyltransferase, a key enzyme in the regulation of transcriptional activity by writing epigenetic marks. Gliotoxin also exhibits immunosuppressive properties by causing apoptosis of cells of the immune system. In addition, various studies suggests Gliotoxin may also be a potential anti-inflammatory, antibiotic, antifungal and antiviral agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Takahashi, M., et al.: J. Antibiotics., 65, 263 (2012); Li., Y.G., et al.: Biochem. Biophy. Rsch. Commun., 422, 85 (2012); Zhang, H.C., et al.: Applied, Mech. Mater., 178, 783 (2012); Scharf, D.H., et al.: Appl. Microbiol. Biotechnol., 93, 467 (2012);

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat CASP2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat CASP2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat CASP2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat CASP2 in the samples is then determined by comparing the OD of the samples to the standard curve.

TAT-NEP1-40 TFA, a blood-brain barrier-permeable peptide, safeguards PC12 cells against oxygen and glucose deprivation (OGD) and fosters neurite outgrowth.

Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and

Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Pig CLU. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Pig CLU. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Pig CLU, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Pig CLU in the samples is then determined by comparing the OD of the samples to the standard curve.

MCL-1/BCL-2-IN-2 is a selective Mcl-1 and Bcl-2 inhibitor with potential antitumor activity for tumor research.

MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.

Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.

TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay.

CDK4/6/HDAC-IN-1 (Compound N14) is a dual-target inhibitor of CDK4/6 and HDAC, with IC50 values of 7.23 nM for CDK4, 13.20 nM for CDK6, 55.66 nM for HDAC1, and 48.38 nM for HDAC6. It induces apoptosis and G0/G1 phase arrest through the HDAC-p21-CDK signaling pathway and can inhibit hepatocellular carcinoma.

p53-MDM2-IN-1 (Example 30), an inhibitor targeting the p53-MDM2/X protein interaction, exhibits a K i value of 23.35 µM.

Applications A labelled Tamoxifen; a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen (H954725) are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells. References Sutherland, R., et al.: Nature, 267, 434 (1977); Lerner, L., et al.: Cancer Res., 50, 4177 (1990); Love, R., et al.: J. Clin. Oncol., 20 2559 (2002);

Ragifilimab (INCAGN-1876), a GITR-targeting agonist antibody, may treat advanced solid tumors.

3',6-Disinapoylsucrose (Disinapoyl sucrose) shows the neuroprotective effect and antidepressive activity in rats.

BAM 7 is a direct and specific activator of proapoptotic Bax (EC50: 3.3 μM).

SDU-071 is a BRD4-p53 inhibitor, suppressing MDA-MB-231 cell proliferation, inducing cell cycle arrest and apoptosis.

Pectolinarin is a Cirsium isolate with anti-inflammatory activity.

Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent.

Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.

T-1101 tosylate (TAI-95 tosylate) is an inhibitor of Hec1/Nek2, with antitumor activity.

RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme cancer stem cells (EC50: ≤500 nM).

Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer.

Onvansertib (NMS-1286937) is a PLK1 inhibitor with high selectivity and oral activity. Onvansertib has antitumor activity. Cost-effective and quality-assured.

Patulin (Claviform) is a mycotoxin produced by a variety of molds commonly found in rotting apples, including Aspergillus and Penicillium.

ST1074, a dual inhibitor of CerS2 and CerS4, promotes apoptosis and is applicable in cancer research [1].

Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.

Cabozantinib S-malate (XL184) is the salt form of cabozantinib, an orally bioavailable, small molecule RTK inhibitor with potential antineoplastic activity.

Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.

Mitotane (NCI-C04933) is a derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex.

CRI9 effectively inhibits the c-MET/PI3K/Akt/mTOR axis, suppressing the proliferation of hepatocellular carcinoma (HCC) cells. This compound exhibits potent cytotoxicity against HCC cells and induces apoptosis.

Vitamin K4 (Menadiol Diacetate) is a vitamin medicine for the treatment of blood coagulation disorders that caused by the lack of VK4.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse MASP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse MASP1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse MASP1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse MASP1 in the samples is then determined by comparing the OD of the samples to the standard curve.

Fosinopril sodium: ACE inhibitor prodrug for hypertension, becomes active metabolite fosinoprilat.

YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1.

Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/L

Zileuton (A 64077) inhibits 5-lipoxygenase, reduces leukotrienes, aids bronchodilation, lessens mucus/edema, and helps manage asthma symptoms.

Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis.

FG-3019 (Pamrevlumab), a human antibody, targets CTGF, potentially treating idiopathic pulmonary fibrosis.

STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor

Antiproliferative agent-59 (Compound 14u) acts as an inhibitor of tubulin polymerization. Demonstrating anticancer activity in Huh7, SGC-7901, and MCF-7 cell lines, this compound achieves IC50 values of 0.03, 0.18, and 0.13 μM, respectively. Additionally, it arrests the cell cycle at the G2/M phase and induces apoptosis in Huh7 cells. In a xenograft mouse model utilizing Huh7 cells, Antiproliferative agent-59 exhibits antitumor effects against hepatocellular carcinoma without significant toxicity.