Mdm2
Mdm2 inhibitors target the Mdm2 protein, which is an E3 ubiquitin ligase that negatively regulates the tumor suppressor p53. Mdm2 promotes the degradation of p53, thereby preventing apoptosis in cells that should undergo cell death. Inhibiting Mdm2 stabilizes p53, enhancing its tumor-suppressing activity and promoting apoptosis in cancer cells. Mdm2 inhibitors are crucial in cancer research and therapy, particularly for cancers with intact p53 pathways. At CymitQuimica, we provide high-quality Mdm2 inhibitors to support your research in cancer biology, apoptosis, and therapeutic development.
Products of "Mdm2"
Sort by
SAR405838
CAS:MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.Formula:C29H34Cl2FN3O3Purity:98.04%Color and Shape:SolidMolecular weight:562.5Ref: TM-T6585
1mg49.00€2mg90.00€5mg133.00€10mg213.00€25mg419.00€50mg617.00€100mg879.00€500mg1,776.00€p53-MDM2-IN-1
CAS:p53-MDM2-IN-1 (Example 30), an inhibitor targeting the p53-MDM2/X protein interaction, exhibits a K i value of 23.35 µM.Formula:C23H20ClN3O3Purity:98.3%Color and Shape:SoildMolecular weight:421.88SJ-172550
CAS:SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).Formula:C22H21ClN2O5Purity:99.87%Color and Shape:SolidMolecular weight:428.87Ref: TM-T16888
2mg44.00€5mg65.00€10mg96.00€25mg185.00€50mg354.00€100mg607.00€500mg1,264.00€1mL*10mM (DMSO)72.00€SP-141
CAS:SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.Formula:C22H16N2OPurity:98.01%Color and Shape:SolidMolecular weight:324.38MG-277
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.Formula:C41H42Cl2FN5O5Purity:98%Color and Shape:SolidMolecular weight:774.71PK11007
CAS:PK11007 is an anti-p53 drug.Formula:C15H11ClFN5O3S2Purity:≥98%Color and Shape:SolidMolecular weight:427.86p53-Mdm2 inhibitor 4
CAS:p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.Formula:C23H20FN3O3Purity:99.63%Color and Shape:SoildMolecular weight:405.42RO8994
CAS:RO8994: potent MDM2 spiroindolinone inhibitor, IC50: 20 nM (proliferation), 5 nM (binding).Formula:C31H31Cl2FN4O4Purity:99.31% - 99.44%Color and Shape:SolidMolecular weight:613.51Ref: TM-T3517
1mg40.00€2mg52.00€5mg87.00€10mg127.00€25mg230.00€50mg364.00€100mg540.00€1mL*10mM (DMSO)105.00€Milademetan
CAS:Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, and can be used to study solid tumors.Formula:C30H34Cl2FN5O4Purity:100%Color and Shape:SolidMolecular weight:618.53Ref: TM-T12040
1mg170.00€5mg518.00€10mg753.00€25mg1,035.00€50mg1,454.00€100mg1,882.00€1mL*10mM (DMSO)35.00€MX69
CAS:MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.Formula:C27H26N2O4SPurity:97.27% - 99.57%Color and Shape:SolidMolecular weight:474.57Ref: TM-T3653
1mg37.00€2mg52.00€5mg79.00€10mg119.00€25mg227.00€50mg368.00€100mg547.00€500mg1,198.00€1mL*10mM (DMSO)82.00€XI-006
CAS:NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and regulates MDM2, an E3 ligase.Formula:C11H13N5O4Purity:99.12%Color and Shape:SolidMolecular weight:279.25Ref: TM-T6610
1mg56.00€2mg81.00€5mg119.00€10mg187.00€25mg432.00€50mg638.00€100mg908.00€500mg1,825.00€1mL*10mM (DMSO)114.00€MD-224
CAS:MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.Formula:C48H43Cl2FN6O6Purity:100% - 99.07%Color and Shape:SolidMolecular weight:889.8Ref: TM-T11980
1mg70.00€5mg153.00€10mg274.00€25mg467.00€50mg655.00€100mg932.00€200mg1,283.00€1mL*10mM (DMSO)166.00€Brigimadlin
CAS:Brigimadlin (BI 907828) is an orally active and highly potent antagonist of the E3 ubiquitin-protein ligase MDM2-p53 with antitumor activity.Formula:C31H25Cl2FN4O3Purity:98.17%Color and Shape:SolidMolecular weight:591.46CP-31398 dihydrochloride
CAS:CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines.Formula:C22H28Cl2N4OPurity:98.23%Color and Shape:SolidMolecular weight:435.4Ref: TM-T21648
5mg49.00€10mg74.00€25mg134.00€50mg207.00€100mg339.00€200mg470.00€1mL*10mM (DMSO)58.00€
