Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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LY3143921 hydrate
CAS:LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].Formula:C16H14FN5O2Purity:98.43%Color and Shape:SolidMolecular weight:327.31CDK2-IN-39
CAS:CDK2-IN-39 (compound 4) is a CDK2 inhibitor.Formula:C14H15N3O4SColor and Shape:SolidMolecular weight:321.352COH29
CAS:COH29 is an oral RNR-blocking thiazole that may reduce DNA synthesis and promote apoptosis, with potential cancer-treating properties.Formula:C22H16N2O5SPurity:97.04% - 98.92%Color and Shape:SolidMolecular weight:420.44Ref: TM-T3157
1mg37.00€2mg52.00€5mg79.00€10mg119.00€25mg217.00€50mg354.00€100mg590.00€1mL*10mM (DMSO)87.00€5'-Azido-5'-deoxythymidine
CAS:5'-Azido-5'-deoxythymidine is a nucleoside analog with potential anti-tuberculosis activity and an inhibitor of TMPKmt in Mycobacterium tuberculosis.Formula:C10H13N5O4Purity:99.85%Color and Shape:SolidMolecular weight:267.24NSC23005 Sodium
CAS:NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.Formula:C13H16NNaO4SPurity:99.64%Color and Shape:SolidMolecular weight:305.32Ref: TM-T3589
1mg47.00€2mg59.00€5mg93.00€10mg115.00€25mg245.00€50mg437.00€100mg625.00€1mL*10mM (DMSO)93.00€CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H27FN4O4Purity:98%Color and Shape:SolidMolecular weight:442.48BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
CAS:BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1)/programmed cell death ligand 1 (Formula:C41H45Cl3N4O5Purity:98%Color and Shape:SoildMolecular weight:780.18TASIN-1 Hydrochloride
CAS:TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncatedFormula:C18H29ClN2O3SPurity:99.84%Color and Shape:SolidMolecular weight:388.95Ref: TM-T24855
1mg78.00€5mg143.00€10mg197.00€25mg335.00€50mg477.00€100mg662.00€200mg892.00€1mL*10mM (DMSO)150.00€Abemaciclib methanesulfonate
CAS:Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).Formula:C27H32F2N8·CH4O3SPurity:98.69% - 99.44%Color and Shape:SolidMolecular weight:602.7CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Formula:C24H22FN7O2Color and Shape:SolidMolecular weight:459.48WRN inhibitor 12
CAS:WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.Formula:C33H33ClF3N9O5Color and Shape:SolidMolecular weight:728.12Cilengitide TFA
CAS:Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.Formula:C29H41F3N8O9Color and Shape:SolidMolecular weight:702.68WAY-322243
CAS:WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer's disease.Formula:C18H18N2O2SPurity:99.47%Color and Shape:SoildMolecular weight:326.41TP-353
CAS:TP-353 (EOS-61973) is a CDK7 inhibitor.Formula:C35H30FNO3Purity:99.12%Color and Shape:SolidMolecular weight:531.62Ref: TM-T22440
1mg59.00€2mg80.00€5mg108.00€10mg187.00€25mg341.00€50mg472.00€100mg652.00€200mg899.00€1mL*10mM (DMSO)158.00€CDK12/13 ligand 1
CAS:ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.Formula:C26H26BrN5OColor and Shape:SolidMolecular weight:504.42D-I03
CAS:D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM.Formula:C23H36N6SPurity:99.04%Color and Shape:SolidMolecular weight:428.64Ref: TM-T10936
1mg37.00€2mg52.00€5mg77.00€10mg126.00€25mg283.00€50mg390.00€100mg567.00€1mL*10mM (DMSO)85.00€NY2267
CAS:NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethylFormula:C38H43N3O6Purity:99.16% - 99.27%Color and Shape:SolidMolecular weight:637.76Ref: TM-T9093
1mg87.00€5mg187.00€10mg298.00€25mg525.00€50mg747.00€100mg1,017.00€1mL*10mM (DMSO)264.00€WEE1-IN-11
CAS:WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.Formula:C26H29FN8OS2Color and Shape:SolidMolecular weight:552.69Blinatumomab
CAS:Blinatumomab (AMG-10,MT-103) is a CD19/CD3 bispecific B-cell and T-cell binding antibody that in acute lymphoblastic leukemia and non-Hodgkin's lymphoma.Color and Shape:LiquidAPE1-IN-1
CAS:APE1-IN-1 is a purine/pyrimidine-free endonuclease 1 inhibitor with potential antitumor activity that enhances the toxicity of alkylating agents on cancer cellsFormula:C19H21N3OS2Purity:98.50%Color and Shape:SolidMolecular weight:371.52Plogosertib
CAS:Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.Formula:C34H48N8O3Purity:99.15% - 99.85%Color and Shape:SolidMolecular weight:616.797P18IN003
CAS:P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion ofFormula:C17H16N2O3Purity:98.77%Color and Shape:SolidMolecular weight:296.32AM5992
CAS:AM5992 (example 195) is a potent CDK4 and CDK6 inhibitor (CDK4, IC50= 0.013 μM). AM5992 can be used for the research of CDK4-mediated disorders.Formula:C27H33FN8OPurity:98%Color and Shape:SoildMolecular weight:504.6Synstatin (92-119)
CAS:Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 andFormula:C133H207N35O46Purity:98%Color and Shape:SolidMolecular weight:3032.27GLPG0187
CAS:GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).Formula:C29H37N7O5SPurity:100% - 99.70%Color and Shape:SolidMolecular weight:595.71P18IN011
CAS:P18IN011 (P18IN011 - CAS 77408-67-4 - Calbiochem) is a novel inhibitor of p18(INK4C).Formula:C15H12N2O5SPurity:97.63%Color and Shape:SolidMolecular weight:332.33Ref: TM-T8576
1mg88.00€5mg170.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)178.00€Ethynylcytidine
CAS:Ethynylcytidine is a nucleoside antimetabolite.Formula:C11H13N3O5Purity:98%Color and Shape:SolidMolecular weight:267.24TMX-3013
CAS:TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.Formula:C17H14BrFN6O3SColor and Shape:SolidMolecular weight:481.3UMK57
CAS:UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,Formula:C17H17N3SPurity:99.81%Color and Shape:SolidMolecular weight:295.4PD-1/PD-L1-IN-32
PD-1/PD-L1-IN-32 (compound A56) is a potent inhibitor of PD-1/PD-L1, displaying pronounced anticancer activity with an IC50 value of 2.4 nM.Purity:98%Color and Shape:Odour SolidTMPyP4 tosylate
CAS:TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.Formula:C72H66N8O12S4Purity:99.11% - 99.85%Color and Shape:SolidMolecular weight:1363.6GSK4418959
CAS:GSK4418959 (IDE275) is an oral, non-covalent, reversible, and selective WRN helicase inhibitor.inhibits ATPase and DNA unwinding functions. MSI-H.Formula:C31H30F4N4O5SColor and Shape:SoildMolecular weight:646.65AVG-233
CAS:AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.Formula:C26H22ClN5O3Purity:99%Color and Shape:SolidMolecular weight:487.94GW8510
CAS:GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.Formula:C21H15N5O3S2Purity:99.32%Color and Shape:SolidMolecular weight:449.51Ref: TM-T24125
1mg52.00€5mg97.00€10mg169.00€25mg329.00€50mg537.00€100mg868.00€200mg1,169.00€1mL*10mM (DMSO)111.00€IMMH 010 maleate
CAS:IMMH 010 maleate (YPD-30 maleate) is a programmed cell death ligand 1 inhibitor used in the study of neurological disorders and advanced malignant solid tumors.Formula:C36H36BrClN2O9Color and Shape:SoildMolecular weight:756.04NCGC00029283
CAS:NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μMFormula:C18H12FN3O3Purity:99.6%Color and Shape:SolidMolecular weight:337.3Ref: TM-T40823
1mg111.00€2mg163.00€5mg264.00€10mg432.00€25mg747.00€50mg1,103.00€100mg1,539.00€1mL*10mM (DMSO)283.00€Docosanoic acid
CAS:Docosanoic acid (Behenic Acid) is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.Formula:C22H44O2Purity:100%Color and Shape:Waxy Solid Liquid Othersolid PelletslargecrystalsMolecular weight:340.58N6-Methyladenine
CAS:N6-Methyladenine (6-(Methylamino)Purine) is a modified purine commonly found in genomes of prokaryotes, protists, and plants.Formula:C6H7N5Purity:98.35%Color and Shape:SolidMolecular weight:149.15Vaccarin
CAS:Vaccarin, a key flavonoid glycoside in Vaccariae semen, undergoes methylation, hydroxylation, glycosylation, and deglycosylation.Formula:C32H38O19Purity:99.16% - 99.97%Color and Shape:SolidMolecular weight:726.63Poloxin-2
CAS:Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.Formula:C16H15NO3Purity:99.59%Color and Shape:SolidMolecular weight:269.3Ref: TM-T25969
1mg333.00€5mg922.00€10mg1,140.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,664.00€2′-C-Methyl-6-O-methylinosine
CAS:6-MeO-9-(2-C-methyl-β-D-ribofuranosyl)purine is a hypoxanthine analog used in tumor disease research.Formula:C12H16N4O5Purity:99.09%Color and Shape:SolidMolecular weight:296.28Abrilumab
CAS:Abrilumab (MEDI-7183) is a fully human monoclonal antibody against α4β7 that inhibits the α4β7 integrin.Color and Shape:LiquidXPW1
CAS:XPW1 is a CDK9 inhibitor with antitumor activity, inhibits DNA repair procedures, and can be used for the research of clear cell renal cell carcinoma.Formula:C36H39ClFN7O2Purity:98.08%Color and Shape:SoildMolecular weight:656.19Peldesine
CAS:Peldesine (BCX 34), an oral purine nucleoside phosphorylase blocker, halts T-cell growth; used in CTCL, psoriasis, HIV research. IC50: 800 nM.Formula:C12H11N5OPurity:99.27% - 99.95%Color and Shape:SolidMolecular weight:241.25Ref: TM-T12399
1mg114.00€5mg274.00€10mg439.00€25mg727.00€50mg1,017.00€100mg1,378.00€500mg2,737.00€1mL*10mM (DMSO)303.00€Kinesore
CAS:Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.Formula:C20H16Br2N4O4Purity:97.24%Color and Shape:SolidMolecular weight:536.17Ref: TM-T15663
2mg43.00€5mg66.00€10mg94.00€25mg159.00€50mg230.00€100mg346.00€200mg520.00€1mL*10mM (DMSO)74.00€c-Myc inhibitor 12
Compound 67h, also known as c-Myc inhibitor 12, is a potent inhibitor of c-Myc, exhibiting a pEC50 value of 6.4 [1].Formula:C22H24N6OPurity:98%Color and Shape:SolidMolecular weight:388.478-Azaguanine
CAS:8-Azaguanine (SK 1150) is a purine analogue with potential antineoplastic activity.Formula:C4H4N6OPurity:100% - 99.89%Color and Shape:White To Off-White Crystalline PowderMolecular weight:152.11Clofarabine-5'-diphosphate
CAS:Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formula:C10H13ClFN5O9P2Color and Shape:SolidMolecular weight:463.64MC180295
CAS:MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.Formula:C17H18N4O3SPurity:99.84%Color and Shape:SolidMolecular weight:358.41Ref: TM-T5533
1mg56.00€5mg131.00€10mg187.00€25mg319.00€50mg449.00€100mg638.00€200mg842.00€1mL*10mM (DMSO)143.00€2'-Deoxycytidine hydrochloride
CAS:2'-Deoxycytidine hydrochloride is an important deoxyribonucleoside analog and protects mice from the lethal toxicity of cytosine arabinoside(araC).Formula:C9H14ClN3O4Purity:98.96%Color and Shape:White To Off-White Crystalline PowderMolecular weight:263.68GW406108X
CAS:GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.Formula:C20H11Cl2NO4Purity:98%Color and Shape:SolidMolecular weight:400.21Hycanthone
CAS:Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.Formula:C20H24N2O2SPurity:98.78%Color and Shape:Yellow-Orange Powder (Ntp 1992)Molecular weight:356.48Z62954982
CAS:Z62954982 (ZINC08010136) is a Rac1 inhibitor that inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary arteriesFormula:C20H21N3O5SPurity:98.28%Color and Shape:SolidMolecular weight:415.46Ref: TM-T37113
1mg38.00€5mg80.00€10mg111.00€25mg183.00€50mg269.00€100mg393.00€200mg560.00€1mL*10mM (DMSO)92.00€10058-F4
CAS:10058-F4 inhibits c-Myc-Max, blocking c-Myc target gene activation, causing cell-cycle arrest & apoptosis.Formula:C12H11NOS2Purity:98% - 99.82%Color and Shape:SolidMolecular weight:249.35Ezabenlimab
CAS:Ezabenlimab (BI-754091) is an anti-PD-1 mAb, Kd 6 nM, blocks PD-1/PD-Ls, boosts T-cell IFN-γ, inhibits tumors in vivo.Purity:95% - 95%Color and Shape:LiquidLY2334737
CAS:LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.Formula:C17H25F2N3O5Purity:98.82%Color and Shape:SolidMolecular weight:389.39Ref: TM-T4061
1mg62.00€5mg131.00€10mg205.00€25mg378.00€50mg562.00€100mg777.00€200mg1,074.00€1mL*10mM (DMSO)166.00€PF-2771
CAS:PF-2771: potent CENP-E inhibitor, IC50 of 16.1 nM, used in cancer treatment.Formula:C29H36ClN5O4Purity:98%Color and Shape:SolidMolecular weight:554.08BS-181 hydrochloride
CAS:BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.Formula:C22H32N6·HClPurity:99.21%Color and Shape:SolidMolecular weight:416.99Ref: TM-T6162
1mg37.00€2mg52.00€5mg79.00€10mg126.00€25mg274.00€50mg454.00€100mg655.00€1mL*10mM (DMSO)87.00€CD532
CAS:CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.Formula:C26H25F3N8OPurity:99.49%Color and Shape:SolidMolecular weight:522.52TC-A 2317 hydrochloride
CAS:TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Formula:C19H29ClN6OPurity:98%Color and Shape:SolidMolecular weight:392.93Alisertib
CAS:Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Formula:C27H20ClFN4O4Purity:100% - 99.82%Color and Shape:SolidMolecular weight:518.92Ref: TM-T2241
5mg55.00€10mg96.00€25mg155.00€50mg226.00€100mg354.00€200mg454.00€500mg743.00€1mL*10mM (DMSO)63.00€4μ8C
CAS:4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.Formula:C11H8O4Purity:97.48% - 98.45%Color and Shape:SolidMolecular weight:204.18CDK-IN-15
CAS:CDK-IN-15 (Compound 456) is an effective inhibitor of Cyclin A, exhibiting an IC50 value of 0.14 μM.Formula:C45H63Cl2F4N7O8Color and Shape:SolidMolecular weight:976.92GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Formula:C16H21BrClN5OPurity:97.85%Color and Shape:SolidMolecular weight:414.73Ref: TM-T27407
1mg46.00€2mg58.00€5mg85.00€10mg108.00€25mg187.00€50mg269.00€100mg376.00€200mg548.00€1mL*10mM (DMSO)87.00€CDK9-IN-2
CAS:CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Formula:C23H25ClFN5Purity:99%Color and Shape:SolidMolecular weight:425.93Ref: TM-T14918
1mg88.00€5mg187.00€10mg281.00€25mg487.00€50mg705.00€100mg998.00€1mL*10mM (DMSO)207.00€Emzadirib
CAS:Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.Formula:C27H40N4O6S2Purity:99.79%Color and Shape:SolidMolecular weight:580.7610074-A4
CAS:10074-A4 is a c-Myc binding compound that associates with c-Myc370-409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features fromFormula:C18H14Cl2N2O3SPurity:98.01%Color and Shape:SolidMolecular weight:409.29Ref: TM-T9628
1mg71.00€5mg135.00€10mg197.00€25mg335.00€50mg480.00€100mg662.00€200mg892.00€1mL*10mM (DMSO)156.00€BI-1950
CAS:BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Formula:C32H26Cl2FN7O3Purity:98%Color and Shape:SolidMolecular weight:646.5MYCi975
CAS:MYCi975 (NUCC-0200975) is an orally active inhibitor of MYC.Formula:C25H16Cl2F6N2O2Purity:99.3% - 99.58%Color and Shape:SolidMolecular weight:561.3AG-024322
CAS:AG-024322 is a pan-CDK inhibitor with antitumor activity, induces apoptosis, and can be used in the study of metabolic diseases.Formula:C23H20F2N6Purity:98.53%Color and Shape:SolidMolecular weight:418.44TG003
CAS:TG003 is a Clk1/Sty inhibitor that inhibits Clk1 and Clk4, suppresses cancer cell growth, and induces apoptosis.Formula:C13H15NO2SPurity:99.46%Color and Shape:SolidMolecular weight:249.33Ref: TM-T60367
1mg50.00€5mg97.00€10mg159.00€25mg281.00€50mg465.00€100mg558.00€200mg810.00€1mL*10mM (DMSO)170.00€PHA-680632
CAS:PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.Formula:C28H35N7O2Purity:98.20%Color and Shape:SolidMolecular weight:501.62T4 UvsX Recombinase
T4 UvsX Recombinase initiates DNA replication on double-stranded templates by catalyzing synapsis with a homologous primer single strand.Purity:98%Color and Shape:Odour SoliddGTP
CAS:dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, andFormula:C10H16N5O13P3Purity:99.9%Color and Shape:SolidMolecular weight:507.18Avotaciclib hydrochloride
Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, includingFormula:C13H12ClN7OPurity:98%Color and Shape:SolidMolecular weight:317.73RI-2
CAS:RI-2, a potent RAD51 inhibitor, has a 44.17 μM IC50 and selectively blocks human HR repair.Formula:C21H18Cl2N2O4Purity:98.85% - 99.86%Color and Shape:SolidMolecular weight:433.28Ref: TM-T2628
1mg73.00€2mg97.00€5mg160.00€10mg281.00€25mg435.00€50mg640.00€100mg910.00€1mL*10mM (DMSO)170.00€CDK9-IN-29
CAS:CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.Formula:C29H33F2N5O4Purity:98%Color and Shape:SolidMolecular weight:553.6PD-1/PD-L1-IN-50
Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.Color and Shape:Odour SolidBMS-8
CAS:BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.Formula:C27H28BrNO3Purity:99.06%Color and Shape:SolidMolecular weight:494.42Ref: TM-T26859
1mg39.00€5mg84.00€10mg131.00€25mg269.00€50mg432.00€100mg638.00€200mg909.00€1mL*10mM (DMSO)96.00€Reversine
CAS:Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formula:C21H27N7OPurity:98% - 99.75%Color and Shape:SolidMolecular weight:393.49Ref: TM-T1825
1mg38.00€2mg49.00€5mg70.00€10mg88.00€25mg164.00€50mg224.00€100mg393.00€1mL*10mM (DMSO)70.00€10074-G5
CAS:10074-G5 is an inhibitor of c-Myc-Max dimerization.Formula:C18H12N4O3Purity:97.22% - 99.67%Color and Shape:SolidMolecular weight:332.31Ref: TM-T3686
2mg42.00€5mg63.00€10mg88.00€25mg142.00€50mg225.00€100mg396.00€200mg565.00€500mg900.00€1mL*10mM (DMSO)69.00€9-Isopropylolomoucine
CAS:9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.Formula:C17H22N6OPurity:100%Color and Shape:SolidMolecular weight:326.4Ref: TM-T23589
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€1mL*10mM (DMSO)642.00€PD-1/PD-L1-IN-27
CAS:PD-1/PD-L1-IN-27: potent anti-cancer, IC50 134nM, minimal T cell harm, boosts CD8+ T cells, reduces fatigue.Formula:C44H35NO6Purity:98%Color and Shape:SolidMolecular weight:673.75Gantofiban
CAS:Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.Formula:C21H29N5O6Purity:99.21%Color and Shape:SolidMolecular weight:447.48CAN508
CAS:CAN508: potent CDK9/T1 inhibitor; IC50 0.35 μM, Cdk2/E; Ki 13.3 μM, IC50 20 μM; 38x selective; antitumor.Formula:C9H10N6OPurity:98.65%Color and Shape:SolidMolecular weight:218.22H-Gly-Arg-Gly-Asp-Asn-Pro-OH
CAS:RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) is a integrin-ligand interactions inhibitor.Formula:C23H38N10O10Purity:100%Color and Shape:SolidMolecular weight:614.61CDK9 ligand 3
CAS:CDK9ligand 3 is a ligand for CDK9 and can be utilized in the synthesis of PROTAC degraders, specifically PROTAC CDK9degrader-11.Formula:C18H18BrCl2N5O3Color and Shape:SolidMolecular weight:503.177MLN0905
CAS:MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).Formula:C24H25F3N6SPurity:97.17% - 98%Color and Shape:SolidMolecular weight:486.56Cdk5 Substrate acetate
Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.Formula:C55H103N15O14Purity:96.21%Color and Shape:SolidMolecular weight:1198.5R-10015
CAS:R-10015, potent LIMK inhibitor with 38 nM IC50 for LIMK1, targets ATP pocket, and serves as a broad-spectrum HIV antiviral.Formula:C20H19ClN6O2Purity:98.68%Color and Shape:SolidMolecular weight:410.86Ref: TM-T12609
1mg75.00€5mg170.00€10mg256.00€25mg423.00€50mg562.00€100mg792.00€200mg1,074.00€1mL*10mM (DMSO)182.00€PD-1/PD-L1-IN-52
PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.Color and Shape:Odour SolidAKI603
CAS:AKI603: Aurora A kinase blocker; IC50 12.3 nM; targets BCR-ABL-T315I resistance; halts leukemia cell growth.Formula:C19H23N9O2Purity:99.81%Color and Shape:SolidMolecular weight:409.45Ref: TM-T64338
1mg66.00€5mg145.00€10mg212.00€25mg380.00€50mg562.00€100mg792.00€200mg1,064.00€1mL*10mM (DMSO)160.00€Triazavirin
CAS:Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.Formula:C5H7N6NaO5SPurity:99.55%Color and Shape:SolidMolecular weight:286.2DNA Gyrase-IN-13
CAS:DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.Formula:C15H21N3O3SColor and Shape:SolidMolecular weight:323.41Quarfloxin
CAS:Quarfloxin (CX-3543), a fluoroquinolone, inhibits neuroblastoma with nanomolar IC50, disrupting nucleolin and G-quadruplex DNA.Formula:C35H33FN6O3Purity:99.77%Color and Shape:SolidMolecular weight:604.67Ref: TM-T16703
1mg119.00€5mg169.00€10mg264.00€25mg487.00€50mg652.00€100mg847.00€1mL*10mM (DMSO)234.00€LY3295668
CAS:LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Formula:C24H26ClF2N5O2Purity:99.44%Color and Shape:SolidMolecular weight:489.95iRGD peptide
CAS:iRGD peptide: 9-amino acid cyclic compound (CRGDKGPDC), found through phage display in mice with tumors.Formula:C35H57N13O14S2Purity:98.77%Color and Shape:SolidMolecular weight:948.04XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurity:99.07%Color and Shape:SolidMolecular weight:437.54Ref: TM-T17267
1mg56.00€2mg78.00€5mg99.00€10mg149.00€25mg258.00€50mg393.00€100mg582.00€1mL*10mM (DMSO)110.00€Sasanlimab
CAS:Sasanlimab (PF-06801591), a humanized IgG4-κ antibody, selectively targets PD-1 and is primarily produced in Chinese Hamster Ovary (CHO) cells [1].Purity:98%Color and Shape:Liquid(2S,3R)-Voruciclib
CAS:(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.Formula:C22H19ClF3NO5Purity:98%Color and Shape:SolidMolecular weight:469.84
