Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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HNC-1664
CAS:HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.Formula:C12H13FIN3O3Color and Shape:SolidMolecular weight:393.153AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1(IC50=5 nM), is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Formula:C17H19FN4O2SPurity:98.96% - 99.19%Color and Shape:SolidMolecular weight:362.42Ref: TM-T6093
1mg38.00€2mg49.00€5mg81.00€10mg96.00€25mg177.00€50mg280.00€100mg449.00€1mL*10mM (DMSO)88.00€WBC100
CAS:WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc glue degrader that targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathwayFormula:C25H33NO7Purity:98%Color and Shape:SolidMolecular weight:459.53SB-218078
CAS:SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM).Formula:C24H15N3O3Purity:98%Color and Shape:SolidMolecular weight:393.39Lusianthridin
CAS:Lusianthridin is a natural product from Dendrobium venustum.Formula:C15H14O3Purity:99.11% - 99.11%Color and Shape:SolidMolecular weight:242.27ddTTP trisodium
Dideoxythymidine triphosphate trisodium (ddTTP), a 2',3'-dideoxyribonucleoside 5'-triphosphate (ddNTP), functions as a chain-elongation inhibitor of DNAFormula:C10H14N2Na3O13P3Purity:98%Color and Shape:SolidMolecular weight:532.11Danofloxacin mesylate
CAS:Danofloxacin mesylate (CP 76136-27) is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.Formula:C19H20FN3O3·CH4O3SPurity:99.73%Color and Shape:Crystalline SolidMolecular weight:453.48SMN-C2
CAS:SMN-C2, a SMN2 gene splicing regulator, is an RNA-binding ligand that regulates pre-mRNA splicing and has potential for studying spinal muscular atrophy.Formula:C24H27N5O2Purity:99.01%Color and Shape:SolidMolecular weight:417.5NSC 23766
CAS:NSC 23766 is a Rac1 GTPase inhibitor by targeting GEFs, inhibiting cell proliferation.NSC23766 competitively inhibits M2 mAChR-induced Rac1 activation.Formula:C24H35N7Purity:99.49%Color and Shape:SolidMolecular weight:421.58Gentisin
CAS:Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity.Formula:C14H10O5Purity:95.34%Color and Shape:SolidMolecular weight:258.23GFB-12811
CAS:GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.Formula:C22H23F4N5OPurity:98.88%Color and Shape:SolidMolecular weight:449.44L-Uridine
CAS:L-Uridine, an RNA component from Poria cocos fungus, is a D-uridine enantiomer with antiviral potential and a phosphate acceptor.Formula:C9H12N2O6Purity:99.57%Color and Shape:SolidMolecular weight:244.2LFM-A13
CAS:LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR,Formula:C11H8Br2N2O2Purity:99.9%Color and Shape:SolidMolecular weight:360qsl-304
QSL-304 is a DNA gyrase B inhibitor that serves as an antibacterial agent, exhibiting an IC50 of 31.23 mg/mL against Staphylococcus aureus SA-P2003 [1].Formula:C11H9NO4S2Purity:98%Color and Shape:SolidMolecular weight:283.32Tetrapeptide
CAS:Tetrapeptide, an α-MSH analogue, stimulates melanin production and mitigates DNA damage by attenuating reactive oxidative species generation and augmenting DNAFormula:C32H40N10O5Purity:98%Color and Shape:SolidMolecular weight:644.72CDK9-IN-10
CAS:CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2.Formula:C22H16O5Purity:99.8%Color and Shape:SolidMolecular weight:360.36Methotrexate metabolite
CAS:DAMPA, active metabolite of Methotrexate, is a chemotherapeutic and immunosuppressive folic acid antagonist.Formula:C15H15N7O2Purity:95.28% - 99.7%Color and Shape:SolidMolecular weight:325.33XMD-17-51
CAS:XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.Formula:C21H24N8OPurity:99.39%Color and Shape:SoildMolecular weight:404.47Pidilizumab
CAS:Pidilizumab (CT-011), a humanized IgG1κ anti-PD-1 monoclonal antibody, serves as a DLL1 antagonist with potential applications in researching hematologicPurity:98%Color and Shape:LiquidLZ9
CAS:LZ9 is an ATP-competitive inhibitor of CDK1 and CDK2, with potential applications in colorectal cancer (CRC) research.Formula:C17H11F3N4O2Color and Shape:SolidMolecular weight:360.29Carmofur
CAS:Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.Formula:C11H16FN3O3Purity:98.59% - 99.48%Color and Shape:SolidMolecular weight:257.265-Ethynyluridine
CAS:5-Ethynyluridine marks new RNA for RICK, capturing proteins on various RNAs, even nonpolyadenylated types.Formula:C11H12N2O6Purity:100%Color and Shape:SolidMolecular weight:268.22Ref: TM-T36971
5mg51.00€10mg88.00€25mg145.00€50mg250.00€100mg363.00€200mg545.00€1mL*10mM (DMSO)57.00€CDK2/4-IN-2
CAS:CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.Formula:C18H20F3N7O3S2Color and Shape:SolidMolecular weight:503.52Abemaciclib
CAS:Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.Formula:C27H32F2N8Purity:99.39% - 99.87%Color and Shape:SolidMolecular weight:506.595-(Methoxycarbonyl)methyluridine
CAS:5-(Methoxycarbonyl)methyluridine is an important modifying nucleotide in tRNAs, and the lack of the mcm5U modification leads to increased protein aggregation.Formula:C12H16N2O8Purity:99.71%Color and Shape:SolidMolecular weight:316.26GSK-1520489A
CAS:GSK-1520489A is an active PKMYT1 inhibitor.Formula:C21H23N5O3SPurity:97.25%Color and Shape:SolidMolecular weight:425.5D5B
D5B is an effective and selective PD-L1 inhibitor that has been modified with DBCO. It degrades PD-L1 in 4T1 and B16-F10 tumor cells with EC50 values of 5.4 μM and 6.2 μM, respectively. D5B can block the PD-L1/PD-1 interaction and exhibits antitumor activity.Formula:C58H66N2O12Color and Shape:SolidMolecular weight:983.15TH287 hydrochloride
CAS:TH287 inhibits MTH1 (IC50: 0.8 nM), causing DNA damage in cancer cells through oxidized dNTP incorporation, leading to cytotoxicity in mouse xenografts.Formula:C11H11Cl3N4Purity:99.5%Color and Shape:SolidMolecular weight:305.59ANI-7
CAS:ANI-7, an AhR pathway activator, selectively impedes MCF-7 breast cancer cell growth (GI50: 0.56 μM).Formula:C13H8Cl2N2Purity:99.21%Color and Shape:SolidMolecular weight:263.12CDK4/6-IN-3
CAS:CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.Formula:C25H31FN8Purity:98%Color and Shape:SolidMolecular weight:462.57Danusertib
CAS:Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Formula:C26H30N6O3Purity:97.88% - 98.44%Color and Shape:White PowderMolecular weight:474.55Ref: TM-T2094
1mg59.00€2mg85.00€5mg116.00€10mg188.00€25mg365.00€50mg555.00€100mg795.00€500mg1,605.00€1mL*10mM (DMSO)120.00€DNA polymerase-IN-2
DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, demonstrates inhibitory activity towards Taq DNA polymerase, with an IC50 value of 48.25 μM, and holdsFormula:C14H12O5SPurity:98%Color and Shape:SolidMolecular weight:292.31TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formula:C23H22Cl2FN5O3Purity:98.69%Color and Shape:SolidMolecular weight:506.36Ref: TM-T34787
1mg97.00€5mg235.00€10mg378.00€25mg748.00€50mg1,169.00€100mg1,644.00€1mL*10mM (DMSO)261.00€ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Formula:C21H25N7Purity:97.63% - ≥95%Color and Shape:SolidMolecular weight:375.47Ref: TM-T2358
1mg51.00€2mg72.00€5mg105.00€10mg159.00€25mg279.00€50mg462.00€100mg648.00€1mL*10mM (DMSO)116.00€Mefenidil
CAS:Mefenidil (McN-2378), a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.Formula:C12H11N3Purity:98.17%Color and Shape:SolidMolecular weight:197.24Volociximab
CAS:Volociximab (M200) is an IgG4 monoclonal antibody targeting the α5β1 integrin , with antiangiogenic, antitumor and anticancer activity, inhibits the growth of rabbit VX2 tumors and is used to study solid tumors.Purity:95%Color and Shape:LiquidPKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Formula:C24H26FN5O2Color and Shape:SolidMolecular weight:435.49MKC3946
CAS:MKC3946 is an effective and soluble IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines.Formula:C21H20N2O3SPurity:99.65%Color and Shape:SolidMolecular weight:380.46Ref: TM-TQ0101
1mg66.00€5mg170.00€10mg265.00€25mg444.00€50mg653.00€100mg929.00€1mL*10mM (DMSO)157.00€ML216
CAS:ML216 (CID-49852229) inhibits BLM helicase (IC50: 1.8 μM), 28-fold selective over RECQ1, RECQ5, and UvrD (IC50s > 50 μM).Formula:C15H9F4N5OSPurity:98.12%Color and Shape:SolidMolecular weight:383.323'-Deoxy-3'-fluoroguanosine
CAS:3'-Deoxy-3'-fluoroguanosine is a nucleoside phosphorylase inhibitor that inhibits RNA replication by binding replons.Formula:C10H12FN5O4Purity:99.33%Color and Shape:SolidMolecular weight:285.23CHK1-IN-4
CAS:CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.Formula:C18H18BrN7O2Purity:98%Color and Shape:SolidMolecular weight:444.29Butylparaben sodium
CAS:Butylparaben sodium significantly impacts the later phases of spermatogenesis in the testes by impairing hormonal regulation and/or RNA and protein synthesis [1Formula:C11H13NaO3Purity:98%Color and Shape:SolidMolecular weight:216.21MSC2530818
CAS:MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).Formula:C18H17ClN4OPurity:98.93%Color and Shape:SolidMolecular weight:340.81Ref: TM-TQ0266
1mg66.00€5mg144.00€10mg230.00€25mg509.00€50mg735.00€100mg1,026.00€1mL*10mM (DMSO)159.00€Lucanthone
CAS:Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1).Formula:C20H24N2OSPurity:99.92%Color and Shape:Yellow Crystals From Alcohol SolidMolecular weight:340.48Ref: TM-T4569
1mg56.00€2mg80.00€5mg126.00€10mg188.00€25mg400.00€50mg592.00€100mg837.00€1mL*10mM (DMSO)140.00€BIO-1211
CAS:BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).Formula:C36H48N6O9Purity:99.33%Color and Shape:SolidMolecular weight:708.8Mps1-IN-2
CAS:Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.Formula:C26H36N6O3Purity:96.24% - 99.75%Color and Shape:SolidMolecular weight:480.6CDK12-IN-5
CAS:CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.Formula:C18H15F5N8OPurity:99.37%Color and Shape:SolidMolecular weight:454.36Ref: TM-T40290
1mg165.00€5mg399.00€10mg645.00€25mg1,320.00€50mg2,080.00€100mg2,822.00€1mL*10mM (DMSO)439.00€Cdc7-IN-5
CAS:Cdc7-IN-5: potent Cdc7 serine-threonine kinase inhibitor, critical for starting DNA replication.Formula:C25H23N3O5Purity:97.15%Color and Shape:SolidMolecular weight:445.47Ref: TM-T10727
1mg96.00€5mg227.00€10mg376.00€25mg620.00€50mg847.00€100mg1,169.00€1mL*10mM (DMSO)250.00€COH1
CAS:COH1 is a ribonucleotide reductase (RR) inhibitor utilized in research pertaining to cancer, mitochondrial diseases, and neurodegenerative disorders [1].Formula:C11H10N2O3SPurity:98%Color and Shape:SolidMolecular weight:250.27Bexotegrast
CAS:Bexotegrast (PLN-74809) is an αvβ6 and αvβ1 integrin inhibitor with antifibrotic properties for the study of idiopathic pulmonary fibrosis (IPF).Formula:C27H36N6O3Purity:99.53%Color and Shape:SolidMolecular weight:492.61Indatuximab
Indatuximab is a chimeric antibody targeting CD13, used in the synthesis of ADC compound Indatuximab ravtansine.Color and Shape:LiquidMolecular weight:145.5 kDaHPH-15
CAS:HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.Formula:C19H31N3S4Color and Shape:SolidMolecular weight:429.735-Fluorouridine
CAS:5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine.Formula:C9H11FN2O6Purity:99.53% - 99.76%Color and Shape:White PowderMolecular weight:262.19ML264
CAS:ML264 (CID-51003603) is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer.Formula:C17H21ClN2O4SPurity:99.33% - 99.45%Color and Shape:SolidMolecular weight:384.88CDK2-IN-30
CAS:CDK2-IN-30 (Formula (I)) is a CDK2 inhibitor with an IC50 of ≤20 nM, utilized primarily in tumor research.Formula:C18H25N7O3SColor and Shape:SolidMolecular weight:419.502-Fluoroadenine
CAS:2-Fluoroadenine (NSC-27364) has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for anticancer studies.Formula:C5H4FN5Purity:99.49%Color and Shape:White To Light Yellow Crystal PowderMolecular weight:153.12BS194
CAS:BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.Formula:C20H27N5O3Purity:99.85%Color and Shape:SolidMolecular weight:385.463,4-Dihydroxybenzylamine hydrobromide
CAS:3,4-Dihydroxybenzylamine hydrobromide inhibits DNA polymerase and melanoma growth, varying with tyrosinase activity.Formula:C7H10BrNO2Purity:97.28%Color and Shape:Light Beige Crystalline PowderMolecular weight:220.06BMS-688521
CAS:BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory activity.Formula:C26H19Cl2N5O4Purity:98.87%Color and Shape:SolidMolecular weight:536.37Ref: TM-T14676
1mg183.00€5mg464.00€10mg655.00€25mg1,169.00€50mg1,539.00€100mg1,882.00€1mL*10mM (DMSO)547.00€LY3405105
CAS:LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-Formula:C26H39N7O3Purity:98.01%Color and Shape:SolidMolecular weight:497.63IMT1
CAS:IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.Formula:C21H21NO4Purity:98.07% - 98.14%Color and Shape:SolidMolecular weight:351.4Ref: TM-T8841
1mg81.00€5mg170.00€10mg301.00€25mg563.00€50mg805.00€100mg1,111.00€1mL*10mM (DMSO)188.00€PHI-101
CAS:PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.Formula:C19H19FN4O2SPurity:99.40%Color and Shape:SolidMolecular weight:386.44Ref: TM-T81490
1mg173.00€5mg437.00€10mg702.00€25mg1,406.00€50mg2,262.00€100mg3,600.00€1mL*10mM (DMSO)469.00€SEL120-34A HCl
CAS:SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectivelyFormula:C15H19Br2ClN4Purity:98.13% - 99.75%Color and Shape:SolidMolecular weight:450.6(S)-GNA-T-phosphoramidite
CAS:(S)-GNA-T-phosphoramidite is a nucleoside analog commonly used in the synthesis of other active compounds.Formula:C38H47N4O7PPurity:99.35%Color and Shape:SolidMolecular weight:702.78AZD-5438
CAS:AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).Formula:C18H21N5O2SPurity:99.73% - 99.87%Color and Shape:SolidMolecular weight:371.46BUR1
CAS:BUR1 is a Saccharomyces cerevisiae cyclin-dependent kinase (CDK) and is homologous to mammalian Cdk9, which functions in transcriptional elongation.Formula:C16H17N5Purity:90%Color and Shape:SolidMolecular weight:279.34Obtustatin triacetate
Obtustatin triacetate, a 41-residue non-RGD disintegrin isolated from the venom of Vipera lebetina obtusa, serves as a potent and selective inhibitor of theFormula:C184H284N52O57S8·3C2H4O2Purity:99.51%Color and Shape:SolidMolecular weight:4573.21MYC-RIBOTAC
MYC-RIBOTAC, a ribonuclease-targeting chimera (RIBOTAC) specific to the MYC internal ribosome entry site (IRES), comprises an MYC mRNA-binding element tetheredFormula:C55H58N10O11SPurity:98%Color and Shape:SolidMolecular weight:1067.17Lerociclib dihydrochloride
CAS:Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/Formula:C26H36Cl2N8OPurity:97.40%Color and Shape:SolidMolecular weight:547.52CCT241533 hydrochloride
CAS:CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H28ClFN4O4Purity:97.13%Color and Shape:SolidMolecular weight:478.95Ref: TM-T10718L
1mg73.00€2mg96.00€5mg159.00€10mg240.00€25mg515.00€50mg852.00€100mg1,264.00€500mg2,547.00€1mL*10mM (DMSO)170.00€DMT-dU-CE Phosphoramidite
CAS:DMT-dU-CE Phosphoramidite is a nucleoside molecule commonly used for the synthesis and sequencing of DNA.Formula:C39H47N4O8PPurity:97.58%Color and Shape:SolidMolecular weight:730.79BMS-1001
CAS:BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction(IC50 : 2.25 nM, in a homogenous time-resolved fluorescence binding assay).Formula:C35H34N2O7Purity:98.43%Color and Shape:SolidMolecular weight:594.7Abciximab
CAS:Abciximab: chimeric antibody, anti-platelet, blocks glycoprotein IIb/IIIa, vitronectin, Mac-1.Purity:SDS-PAGE:95.2%;SEC-HPLC:95.9%Color and Shape:LiquidMolecular weight:95.18 kDaVotoplam HCl
CAS:Votoplam HCl is a systemically acting gene splicing regulator that down-regulates the levels of huntingtin protein, which to inhibit Huntington's disease (HD).Formula:C21H26ClN9OPurity:99.49%Color and Shape:SoildMolecular weight:455.94
