Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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CDK9-IN-9
CAS:CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).Formula:C22H23F2N5O2SPurity:98%Color and Shape:SolidMolecular weight:459.51GSK-923295
CAS:GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).Formula:C32H38ClN5O4Purity:96.22% - 98.02%Color and Shape:SolidMolecular weight:592.13Ref: TM-T2039
1mg49.00€2mg70.00€5mg97.00€10mg168.00€25mg331.00€50mg510.00€100mg737.00€1mL*10mM (DMSO)136.00€Poloxin
CAS:Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).Formula:C18H19NO3Purity:99.19%Color and Shape:SolidMolecular weight:297.35GSK 3008348 hydrochloride
CAS:GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.Formula:C29H37N5O2xHClPurity:99.54%Color and Shape:SolidMolecular weight:0LY2812223
CAS:LY2812223: selective mGlu2 agonist; binds mGlu2/mGlu3 (Ki=144/156 nM).Formula:C10H12N4O4SPurity:98%Color and Shape:SolidMolecular weight:284.29(R)-Enitociclib
CAS:(R)-Enitociclib, an enantiomer of BAY-1251152, is a CDK9 inhibitor with anticancer activity.Formula:C19H18F2N4O2SPurity:98.82%Color and Shape:SoildMolecular weight:404.43CX-5461
CAS:CX5461 is an orally rRNA synthesis inhibitor that inhibits Pol I-driven rRNA transcription. CX5461 has antitumor activity. Cost-effective and quality-assured.Formula:C27H27N7O2SPurity:95.44% - 99.25%Color and Shape:SolidMolecular weight:513.61IRE1α kinase-IN-1
CAS:IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM.Formula:C26H26ClFN8Purity:99.18%Color and Shape:SolidMolecular weight:504.99Ref: TM-T9564
1mg116.00€5mg283.00€10mg452.00€25mg707.00€50mg1,017.00€100mg1,406.00€1mL*10mM (DMSO)311.00€CRT0044876
CAS:CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.Formula:C9H6N2O4Purity:98.27% - 98.98%Color and Shape:Brown PowderMolecular weight:206.15INCB086550
CAS:INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Formula:C41H39N7O4Purity:98.21%Color and Shape:SolidMolecular weight:693.79Cdc7-IN-1
CAS:Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.Formula:C21H16ClN3O4Color and Shape:SolidMolecular weight:409.82BVDU 5′-Triphosphate
CAS:BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase.Formula:C11H16BrN2O14P3Purity:98%Color and Shape:SolidMolecular weight:573.08Tirofiban hydrochloride monohydrate
CAS:Tirofiban(MK383) hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist. Cost-effective and quality-assured.Formula:C22H39ClN2O6SPurity:95.83% - 99.94%Color and Shape:White SolidMolecular weight:495.07S-Gem
CAS:S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR.Formula:C13H15F2N3O6S2Purity:98%Color and Shape:SolidMolecular weight:411.4CBFβ Inhibitor
CAS:CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.Formula:C12H14N2OSPurity:96.50%Color and Shape:SolidMolecular weight:234.32Leucettinib-92
CAS:Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μMFormula:C21H22N4OSPurity:98%Color and Shape:SolidMolecular weight:378.49Poly(A) polymerase
CAS:Poly(A) polymerase enzymatically adds a polyadenosine tail of 20-200 adenine bases to the 3' end of RNA, a process that involves integrating ATP as AMP.Purity:98%Color and Shape:Solid5-Fluoroorotic acid
CAS:5-Fluoroorotic acid is an inhibitor of thymidylate synthase.Formula:C5H3FN2O4Purity:100% - 99.7%Color and Shape:White To Pale Yellow PowderMolecular weight:174.09MU147
CAS:MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.Formula:C19H13N3O3SColor and Shape:SolidMolecular weight:363.39Deoxythymidine triphosphate
CAS:Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.Formula:C10H14N2Na3O14P3Purity:96.00%Color and Shape:White Amorphous PowderMolecular weight:548.11PFM03
CAS:PFM03 is a endonuclease inhibitor that specifically blocks Mre11,reduce MRN endonuclease activity, blocking hMRN-mediated endonucleotomy and nuclear exocytosis.Formula:C14H15NO2S2Purity:98.20% - 99.98%Color and Shape:SolidMolecular weight:293.4TC-S 7005
CAS:TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).Formula:C21H17N3O3Purity:99.68%Color and Shape:SolidMolecular weight:359.38Ref: TM-T17008
1mg57.00€2mg84.00€5mg125.00€10mg188.00€25mg354.00€50mg532.00€100mg712.00€500mgTo inquire1mL*10mM (DMSO)138.00€Metarrestin
CAS:Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis.Formula:C31H30N4OPurity:99.45%Color and Shape:SolidMolecular weight:474.6Ref: TM-T12006
1mg40.00€2mg52.00€5mg88.00€10mg144.00€25mg298.00€50mg512.00€100mg740.00€500mg1,539.00€RG7800 tetrahydrochloride
RG7800 hydrochloride is an orally active modulator of SMN2 splicing, exhibiting EC50 values of 23 nM for SMN2 splicing and 87 nM for SMN protein production.Formula:C24H32Cl4N6OPurity:98%Color and Shape:SolidMolecular weight:562.362'-Deoxy-N4-methylcytidine
CAS:2’-Deoxy-N4-methylcytidine (N(3)-Methyl-2'-deoxycytidine) is a purine nucleoside analog with potential antitumor activity for the study of apoptosis.Formula:C10H15N3O4Purity:99.61%Color and Shape:SolidMolecular weight:241.24HMN-176
CAS:HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).Formula:C20H18N2O4SPurity:98.92% - 98.99%Color and Shape:SolidMolecular weight:382.43Ref: TM-T3643
1mg43.00€2mg56.00€5mg88.00€10mg119.00€25mg188.00€50mg350.00€100mg522.00€500mg1,130.00€1mL*10mM (DMSO)79.00€SGC-CLK-1
CAS:SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.Formula:C19H15F3N6O2Color and Shape:SolidMolecular weight:416.36APY29
CAS:APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.Formula:C17H16N8Purity:96.51% - 98.46%Color and Shape:SolidMolecular weight:332.36Ref: TM-T3654
2mg43.00€5mg65.00€10mg96.00€25mg177.00€50mg301.00€100mg543.00€500mg1,130.00€1mL*10mM (DMSO)71.00€Budigalimab
CAS:Budigalimab (ABBV 181) is a humanized monoclonal antibody targeting PD-1 with potential antitumor activity.Purity:95% - 95%Color and Shape:LiquidHomouridine
CAS:Homouridine, an analogue of uridine, functions as an intermediate in the synthesis of MMP-2 inhibitor (compound I, IC50 = 150 μM).Formula:C10H14N2O6Purity:98%Color and Shape:SolidMolecular weight:258.23CDK5-IN-3
CAS:CDK5-IN-3 is a selective and potent CDK5 inhibitor that inhibits CDK5/p25 and CDK2/CycA, and can be used in the study of cancer.Formula:C22H26N4OPurity:98.21%Color and Shape:SolidMolecular weight:362.47Avelumab
CAS:Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody. Avelumab shows potential antibody-dependent cell-mediated cytotoxicity.Purity:95% - 98.3% (SEC-HPLC)Color and Shape:LiquidMolecular weight:143.8 kDaDatelliptium chloride
CAS:Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride shows anti-tumor activities.Formula:C23H28ClN3OPurity:98%Color and Shape:SolidMolecular weight:397.94CK7
CAS:CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.Formula:C14H12N6O2SPurity:98.07%Color and Shape:SolidMolecular weight:328.35Ref: TM-T9615
1mg52.00€5mg120.00€10mg187.00€25mg376.00€50mg588.00€100mg905.00€200mg1,216.00€1mL*10mM (DMSO)139.00€Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formula:C26H31FN7O6PPurity:99.63%Color and Shape:SolidMolecular weight:587.54Simurosertib
CAS:Simurosertib (TAK-931) is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM).Formula:C17H19N5OSPurity:99.82% - 99.93%Color and Shape:SolidMolecular weight:341.43Ref: TM-T12642L
1mg74.00€2mg96.00€5mg180.00€10mg250.00€25mg465.00€50mg677.00€100mg938.00€1mL*10mM (DMSO)187.00€Acrixolimab
CAS:Acrixolimab is a humanized IgG4-κ monoclonal antibody that selectively targets PD-1 [1] [2].Purity:98%Color and Shape:Liquid6-Thioinosine
CAS:6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.Formula:C10H12N4O4SPurity:97.74%Color and Shape:SolidMolecular weight:284.29Ref: TM-T7621
2mg51.00€5mg85.00€10mg119.00€25mg150.00€50mg188.00€100mg283.00€200mg432.00€1mL*10mM (DMSO)99.00€Natalizumab
CAS:Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Purity:98.00%Color and Shape:LiquidMolecular weight:N/AKJ Pyr 9
CAS:KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).Formula:C22H15N3O4Purity:98.07% - ≥98%Color and Shape:SolidMolecular weight:385.37Ref: TM-T15665
2mg39.00€5mg57.00€10mg81.00€25mg145.00€50mg279.00€100mg510.00€200mg683.00€500mg1,064.00€1mL*10mM (DMSO)63.00€DNA Gyrase-IN-9
DNA Gyrase-IN-9 (compound 4j), an antibacterial agent, selectively targets DNA gyrase.Formula:C26H18ClN3O2Purity:98%Color and Shape:SolidMolecular weight:439.89IXA6
CAS:IXA6 is an IRE1/XBP1s agonist with potential vasoprotective activity for the study of neurodegenerative diseases such as Parkinson's disease.Formula:C22H20ClN3O3SPurity:98.63%Color and Shape:SolidMolecular weight:441.93CW-069
CAS:CW-069 (IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.Formula:C23H21IN2O3Purity:97.52% - 98.59%Color and Shape:SolidMolecular weight:500.33Ref: TM-T6209
1mg43.00€5mg90.00€10mg125.00€25mg216.00€50mg306.00€100mg432.00€500mg938.00€1mL*10mM (DMSO)89.00€DNA Gyrase-IN-8
CAS:DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].Formula:C19H14BrN5OPurity:98%Color and Shape:SolidMolecular weight:408.25Cdc7-IN-7
CAS:Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.Formula:C21H22N4O5Purity:99.25%Color and Shape:SolidMolecular weight:410.42ZIM
CAS:ZIM, from 4-Aminoantipyrine, induces DNA and chromosomal damage, cell death, and phagocytosis, with potential in cancer therapy.Formula:C20H19N3O3Purity:99.13%Color and Shape:SolidMolecular weight:349.38Ref: TM-T72024
5mg39.00€10mg58.00€25mg105.00€50mg170.00€100mg271.00€200mg398.00€1mL*10mM (DMSO)52.00€Pyrintegrin
CAS:Pyrintegrin: β1-integrin agonist, boosts embryonic stem cell survival, and podocyte protection, improves cell-matrix adhesion.Formula:C23H25N5O3SPurity:97.81%Color and Shape:SolidMolecular weight:451.54Ref: TM-T16695
1mg82.00€2mg96.00€5mg159.00€10mg226.00€25mg435.00€50mg648.00€100mg924.00€200mg1,225.00€1mL*10mM (DMSO)168.00€Senexin B
CAS:Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).Formula:C27H26N6OPurity:99.67%Color and Shape:SolidMolecular weight:450.53Ref: TM-T8430
1mg97.00€2mg131.00€5mg188.00€10mg305.00€25mg487.00€50mg655.00€100mg905.00€1mL*10mM (DMSO)215.00€GDC-0575
CAS:GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).Formula:C16H20BrN5OPurity:≥95%Color and Shape:SolidMolecular weight:378.27CCT-251921
CAS:CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Formula:C21H23ClN6OPurity:97.74%Color and Shape:SolidMolecular weight:410.9Ref: TM-T14901
1mg95.00€5mg221.00€10mg324.00€25mg548.00€50mg785.00€100mg1,074.00€1mL*10mM (DMSO)202.00€PROTAC CDK9/CycT1 Degrader-2
PROTAC CDK9/CycT1 Degrader-2 inhibits CDK9 with an IC50 of 45 nM [1].Formula:C30H36N4O6S2Purity:98%Color and Shape:SolidMolecular weight:612.76BMS-1001 hydrochloride
CAS:BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effectFormula:C35H35ClN2O7Purity:97.36%Color and Shape:SolidMolecular weight:631.11Ref: TM-T10565
1mg56.00€5mg127.00€10mg197.00€25mg401.00€50mg645.00€100mg1,026.00€200mg1,378.00€1mL*10mM (DMSO)172.00€ZCL278
CAS:ZCL278 is a selective Cdc42 GTPase inhibitor.Formula:C21H19BrClN5O4S2Purity:96.29% - 99.72%Color and Shape:SolidMolecular weight:584.89Ref: TM-T1855
5mg50.00€10mg79.00€25mg136.00€50mg221.00€100mg310.00€200mg497.00€500mg805.00€1mL*10mM (DMSO)79.00€CID 5951923
CAS:CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.Formula:C16H18N2O7SPurity:100.00%Color and Shape:SolidMolecular weight:382.39Barasertib-HQPA
CAS:Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.Formula:C26H30FN7O3Purity:98.43% - 99.29%Color and Shape:SolidMolecular weight:507.56TH588
CAS:TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.Formula:C13H12Cl2N4Purity:96.05% - 99.82%Color and Shape:SolidMolecular weight:295.17AAPK-25
CAS:AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Formula:C21H13Cl2N3O2SPurity:97.79%Color and Shape:SolidMolecular weight:442.32Ref: TM-T10215
1mg95.00€5mg202.00€10mg303.00€25mg550.00€50mg825.00€100mg1,198.00€1mL*10mM (DMSO)233.00€Palbociclib monohydrochloride
CAS:Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6, with no inhibition against a panel of 36 additional protein kinasesFormula:C24H29N7O2·HClPurity:100% - 99.91%Color and Shape:SolidMolecular weight:483.99JSH-150
CAS:JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Formula:C24H33ClN6O2SPurity:100% - 99.96%Color and Shape:SolidMolecular weight:505.08LIMK-IN-22j
CAS:LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Formula:C20H21BrN8Purity:99.17%Color and Shape:SolidMolecular weight:453.34Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Formula:C27H40N8O7Purity:98% - 99.8%Color and Shape:SolidMolecular weight:588.66Ref: TM-T2494
1mg49.00€2mg70.00€5mg96.00€10mg160.00€25mg274.00€50mg439.00€100mg632.00€1mL*10mM (DMSO)137.00€Mirvetuximab
CAS:Mirvetuximab, a monoclonal antibody targeting FOLR1/FRα, treats ovarian and FRα-positive cancers, often paired with platinum-based drugs.Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:148 kDa (average)Ispinesib
CAS:Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplasticFormula:C30H33ClN4O2Purity:98% - 98.59%Color and Shape:SolidMolecular weight:517.06Ref: TM-T2103
1mg39.00€2mg50.00€5mg79.00€10mg118.00€25mg210.00€50mg339.00€100mg557.00€500mg1,216.00€1mL*10mM (DMSO)89.00€CDK8/19-IN-1
CAS:CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).Formula:C19H18N4O4S2Purity:98%Color and Shape:SolidMolecular weight:430.5Werner syndrome RecQ helicase-IN-1
CAS:Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomachFormula:C31H31ClF3N9O5Purity:98.74% - 99.62%Color and Shape:SolidMolecular weight:702.08Ref: TM-T72107
1mg60.00€5mg125.00€10mg177.00€25mg296.00€50mg502.00€100mg803.00€500mg1,795.00€1mL*10mM (DMSO)822.00€CDK12-IN-E9
CAS:CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.Formula:C24H30N6O2Color and Shape:SolidMolecular weight:434.53Folinic Acid Calcium Salt Pentahydrate
CAS:Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.Formula:C20H21CaN7O7·5H2OPurity:100% - 99.17%Color and Shape:Yellowish-White To Yellow PowderMolecular weight:601.58NITD-2
CAS:NITD-2 is a DENV RdRp inhibitor with poor cell membrane penetration; no vaccine or antiviral for DENV exists.Formula:C23H19N3O4SPurity:98.03% - 99.46%Color and Shape:SolidMolecular weight:433.48Ref: TM-T8886
1mg74.00€5mg170.00€10mg274.00€25mg472.00€50mg655.00€100mg944.00€200mg1,264.00€1mL*10mM (DMSO)188.00€GP-82996
CAS:GP-82996 (CINK4) inhibits CDK4/6; IC50s: 1.5 μM (CDK4/D1), 5.6 μM (CDK6/D1), 25 μM (Cdk5/p35); triggers U2OS cancer cell apoptosis.Formula:C27H32N6OPurity:99.57%Color and Shape:SolidMolecular weight:456.58N6,N6-Dimethyladenosine
CAS:N6,N6-Dimethyladenosine is find in mycobacterium bovis Bacille Calmette-Guérin tRNA.Formula:C12H17N5O4Purity:98.79%Color and Shape:White PowderMolecular weight:295.29Aurora kinase inhibitor-3
CAS:Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Formula:C21H18F3N5OPurity:98.91%Color and Shape:SolidMolecular weight:413.4Ref: TM-T5524
1mg78.00€2mg97.00€5mg188.00€10mg298.00€25mg500.00€50mg710.00€100mg938.00€200mg1,311.00€1mL*10mM (DMSO)215.00€HDAC-IN-85
HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.Formula:C24H27FN4O5Color and Shape:SolidMolecular weight:470.49RG7800
CAS:RG7800 (RO6885247) has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier.Formula:C24H28N6OPurity:99.44%Color and Shape:SolidMolecular weight:416.52ART558
CAS:ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM).Formula:C21H21F3N4O2Purity:99.18%Color and Shape:SolidMolecular weight:418.41PD-1/PD-L1-IN-NP19
CAS:PD-1/PD-L1-IN-NP19: a PD-1/PD-L1 inhibitor with 12.5 nM IC50, may boost antitumor immunity.Formula:C33H31ClN2O4Purity:98%Color and Shape:SolidMolecular weight:555.06Doxifluridine
CAS:Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity.Formula:C9H11FN2O5Purity:99.47% - 99.86%Color and Shape:White SolidMolecular weight:246.192′-Deoxy-2′-fluoroguanosine
CAS:2′-Deoxy-2′-fluoroguanosine is a nucleoside analog that potently inhibits influenza virus A and B strains(EC90 <0.35 μM).Formula:C10H12FN5O4Purity:99.82%Color and Shape:SolidMolecular weight:285.23Raltitrexed
CAS:Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.Formula:C21H22N4O6SPurity:98.99% - 99.06%Color and Shape:Yellow Crystalline PowderMolecular weight:458.49SCH-1473759
CAS:SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Formula:C20H26N8OSPurity:98%Color and Shape:SolidMolecular weight:426.54Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Formula:C32H46O8Purity:97.10% - 99.33%Color and Shape:SolidMolecular weight:558.7AZD-5597
CAS:AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potentFormula:C23H28FN7OPurity:98.01%Color and Shape:SolidMolecular weight:437.51Ref: TM-T21544
1mg57.00€5mg120.00€10mg187.00€25mg416.00€50mg655.00€100mg924.00€1mL*10mM (DMSO)144.00€Sapacitabine
CAS:Sapacitabine (CS682) is a nucleoside analog precursor with anticancer activity used in the study of leukemia.Formula:C26H42N4O5Purity:98.82%Color and Shape:SolidMolecular weight:490.64T4 RNA ligase
T4 RNA ligase is an enzyme that facilitates the ligation of single-stranded DNA.Purity:98%Color and Shape:Odour SolidMonastrol
CAS:Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formula:C14H16N2O3SPurity:98.59% - 99.19%Color and Shape:SolidMolecular weight:292.35Ref: TM-T4048
1mg48.00€5mg78.00€10mg97.00€25mg188.00€50mg311.00€100mg502.00€500mg1,074.00€1mL*10mM (DMSO)87.00€Enrofloxacin
CAS:Enrofloxacin (BAY-Vp2674) is a veterinary antibacterial agent, used in poultry.Formula:C19H22FN3O3Purity:100% - 99.89%Color and Shape:Pale Yellow CrystalsMolecular weight:359.39PF-06873600
CAS:PF-06873600: oral CDK inhibitor (CDK2/4/6), Ki 0.09-0.16 nM, potential anticancer drug.Formula:C20H27F2N5O4SPurity:98.77% - 99.58%Color and Shape:SolidMolecular weight:471.52Ref: TM-T8463
1mg57.00€5mg120.00€10mg188.00€25mg354.00€50mg588.00€100mg938.00€200mg1,264.00€1mL*10mM (DMSO)131.00€Zimberelimab
CAS:Zimberelimab (GLS-010) is a humanized antibody targeting PD-1, with anticancer activity.Purity:95%Color and Shape:Liquid7-Methylguanosine
CAS:7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor (IC50 : 87.8 ± 7.5 μM).Formula:C11H16N5O5Purity:98.11%Color and Shape:SolidMolecular weight:298.282′-O-Methylcytidine
CAS:2′-O-Methylcytidine inhibits NS5B-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.Formula:C10H15N3O5Purity:99.81%Color and Shape:SolidMolecular weight:257.24Ilorasertib hydrochloride
CAS:Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Formula:C25H22ClFN6O2SPurity:98.34%Color and Shape:SolidMolecular weight:525TK216
CAS:TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.Formula:C19H15Cl2NO3Purity:97.22%Color and Shape:SolidMolecular weight:376.23(S)-Monastrol
CAS:Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formula:C14H16N2O3SPurity:98%Color and Shape:SolidMolecular weight:292.356-Mercaptopurine
CAS:6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties.Formula:C5H4N4SPurity:99.53% - 99.63%Color and Shape:Yellow Crystalline Powder SolidMolecular weight:152.18KIF18A-IN-15
CAS:KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, both with an IC50 range of 0.01-0.1 μM. These compounds inhibit the viability of OVCAR-3 cells, with IC50 values of 0.01-0.1 μM for EX36-A and 0-0.01 μM for EX36-B. KIF18A-IN-15 is applicable in research on tumors, including colon, breast, and lung cancers.Formula:C25H33F3N6O5SColor and Shape:SolidMolecular weight:586.63Voruciclib hydrochloride
CAS:Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).Formula:C22H20Cl2F3NO5Purity:98%Color and Shape:SolidMolecular weight:506.33-Methylcytidine
CAS:3-Methylcytidine as biomarkers of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.Formula:C10H15N3O5Purity:98%Color and Shape:SolidMolecular weight:257.24Kif15-IN-2
CAS:Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.Formula:C20H20N6O4SPurity:98.17%Color and Shape:SolidMolecular weight:440.48CDK1-IN-2
CAS:CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM.Formula:C17H11ClN2OPurity:98.41%Color and Shape:SoildMolecular weight:294.73Ref: TM-T64373
1mg50.00€5mg107.00€10mg170.00€25mg354.00€50mg567.00€100mg810.00€500mg1,644.00€1mL*10mM (DMSO)103.00€NU6140
CAS:NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).Formula:C23H30N6O2Purity:98.33%Color and Shape:SolidMolecular weight:422.52Ref: TM-T16359
2mg42.00€5mg64.00€10mg97.00€25mg187.00€50mg301.00€100mg437.00€200mg612.00€1mL*10mM (DMSO)71.00€Bisindolylmaleimide X hydrochloride
CAS:Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).Formula:C26H25ClN4O2Purity:98.5%Color and Shape:SolidMolecular weight:460.96
