Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
Sort by
Catumaxomab
CAS:Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.Purity:95%Color and Shape:LiquidPOL1-IN-1
CAS:POL1-IN-1 (Compound 3A) 是一种RNA 聚合酶 1 POL1抑制剂,IC50值低于 0.5 uM。 它能有效抑制A375恶性黑色素瘤细胞系中RNA 聚合酶I 的转录。Formula:C21H20N6Purity:98%Color and Shape:SolidMolecular weight:356.42Rac1 Inhibitor W56 acetate(1095179-01-3 free base)
Rac1 Inhibitor W56 acetate(1095179-01-3 free base) is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activationFormula:C76H121N19O25SPurity:98.96%Color and Shape:SolidMolecular weight:1732.95CAF-382
CAF-382 (compound B1), an analog of SNS-032, functions as a CDKL5 and pan-CDK inhibitor, exhibiting modest inhibitory activity against GSK3α/β with an affinityFormula:C16H22N4O2S2Purity:98%Color and Shape:SolidMolecular weight:366.5PD-L1-IN-3
CAS:PD-L1-IN-3 is a PD-1/PD-L1 inhibitor for the study of tumors and immune diseases.Formula:C19H15ClFN2OSPurity:99.47%Color and Shape:SoildMolecular weight:373.85DHX9-IN-2
CAS:DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.Formula:C18H16ClN3O3S2Purity:98.00%Color and Shape:SolidMolecular weight:421.92β-glycosidase-IN-1
CAS:β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.Formula:C13H23NO5Purity:98%Color and Shape:SolidMolecular weight:273.33Orotic acid
CAS:Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.Formula:C5H4N2O4Purity:99.42%Color and Shape:Crystals Physical Description White Crystals Or Crystalline Powder (Ntp 1992)Molecular weight:156.1IDD388
CAS:IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor.Formula:C16H12BrClFNO4Purity:99.56%Color and Shape:SolidMolecular weight:416.63BTYNB
CAS:BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1. MDK6620 downregulates β-TrCP1 mRNA and reduces activation of NF-κB.Formula:C12H9BrN2OSPurity:99.91% - ≥95%Color and Shape:SolidMolecular weight:309.18Ref: TM-T9033
5mg48.00€10mg63.00€25mg93.00€50mg136.00€100mg198.00€200mg309.00€500mg563.00€1mL*10mM (DMSO)50.00€Orbofiban TFA
CAS:Orbofiban TFA is an orally active GPIIb/IIIa platelet receptor antagonist with inhibitory effects on platelet aggregation for the study of unstable coronaryFormula:C19H24F3N5O6Purity:97.45% - 98.43%Color and Shape:SolidMolecular weight:475.42PLN-1474
CAS:PLN-1474 is a potent αVβ1 inhibitor with IC50 < 50 nM.Formula:C24H37N3O4Purity:99.25%Color and Shape:SoildMolecular weight:431.57Ref: TM-T60101
1mg52.00€5mg111.00€10mg180.00€25mg305.00€50mg439.00€100mg612.00€1mL*10mM (DMSO)124.00€RdRP-IN-6
RdRP-IN-6 (compound 27) is an inhibitor of RNA-dependent RNA polymerase (RdRp), exhibiting an IC90 value of 14.1 μM.Formula:C41H67N8O7PSi2Purity:98%Color and Shape:SolidMolecular weight:871.16Firategrast
CAS:Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervousFormula:C27H27F2NO6Purity:99.16%Color and Shape:SolidMolecular weight:499.5Ref: TM-TQ0291
1mg47.00€5mg87.00€10mg140.00€25mg283.00€50mg464.00€100mg747.00€200mg1,017.00€1mL*10mM (DMSO)97.00€Pacmilimab
CAS:Pacmilimab (CX-072) is a Probody immune checkpoint inhibitor targeting programmed death ligand 1 (PD-L1) with anti-tumor activity for the study of solid tumors.Purity:95% - 95%Color and Shape:LiquidNUAK1-IN-1
NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formula:C25H30N6OColor and Shape:SolidMolecular weight:430.545MLN8054
CAS:MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.Formula:C25H15ClF2N4O2Purity:98.07% - 98.26%Color and Shape:SolidMolecular weight:476.86Ref: TM-T6315
1mg52.00€2mg71.00€5mg88.00€10mg127.00€25mg233.00€50mg376.00€100mg567.00€1mL*10mM (DMSO)93.00€2,5-Di-tert-butyl-1,4-benzoquinone
CAS:2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.Formula:C14H20O2Color and Shape:SolidMolecular weight:220.31AS-0141
CAS:AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM),具有抗肿瘤活性。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶,在细胞周期中对 DNA 复制的启动至关重要。Formula:C21H22F3N5O4Purity:100%Color and Shape:SolidMolecular weight:465.43DI-87
CAS:DI-87 (TRE-515) is a novel and orally available dCK (deoxycytidine kinase) inhibitor. DI-87 binds to dCK reduces the production of dNTP inhibits tumor growth.Formula:C23H30N6O3S2Purity:99.76%Color and Shape:SolidMolecular weight:502.65Levoleucovorin Calcium
CAS:Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.Formula:C20H21N7O7·CaPurity:98.46% - ≥98%Color and Shape:White Crystalline PowderMolecular weight:511.5PROTAC CDK9 degrader-6
CAS:PROTAC CDK9 degrader-6 targets and degrades CDK9 isoforms via proteasome, with DC50 of 0.10μM and 0.14μM.Formula:C42H49Cl2N9O8Purity:98%Color and Shape:SolidMolecular weight:878.8THZ1-R
CAS:THZ1-R displays diminished activity for CDK7 inhibition(Kd:142 nM).Formula:C31H30ClN7O2Purity:98%Color and Shape:SolidMolecular weight:568.07CLK1-IN-1
CAS:CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).Formula:C24H16FN5OColor and Shape:SolidMolecular weight:409.42Teclistamab
CAS:Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.Purity:95%Color and Shape:LiquidCDK-TCIP2
DK-TCIP2 is an anticancer agent formed by linking the CDK9 inhibitor SNS-032 and the BCL6 inhibitor BI-3812. This compound exhibits anticancer activity both in vivo and in vitro, making it suitable for research in lymphoma.Formula:C52H67ClN12O8S2Color and Shape:SolidMolecular weight:1087.75SIBA
CAS:SIBA, a synthetic SAH analog, inhibits SAM-dependent transmethylation and blocks HSV-1 replication.Formula:C14H21N5O3SPurity:99.48%Color and Shape:SolidMolecular weight:339.41Ref: TM-T12908
1mg52.00€5mg94.00€10mg117.00€25mg220.00€50mg329.00€100mg469.00€200mg652.00€1mL*10mM (DMSO)104.00€(R)-Simurosertib
CAS:(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.Formula:C17H19N5OSPurity:99.64%Color and Shape:SolidMolecular weight:341.43JNJ-7706621
CAS:JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.Formula:C15H12F2N6O3SPurity:99.1% - 99.66%Color and Shape:SolidMolecular weight:394.36Ref: TM-T6126
1mg50.00€2mg66.00€5mg105.00€10mg180.00€25mg284.00€50mg520.00€100mg728.00€500mg1,473.00€1mL*10mM (DMSO)88.00€2'-Deoxy-2'-fluorocytidine
CAS:2'-Deoxy-2'-fluorocytidine is an nucleoside analog and inhibits of Crimean-Congo hemorrhagic fever virus (CCHFV) replication potently.Formula:C9H12FN3O4Purity:99.03%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:245.21Bleomycin hydrochloride
CAS:Bleomycin hydrochloride is a potent antitumor antibiotic that functions as a DNA synthesis inhibitor and DNA damaging agent.Formula:C55H84ClN17O21S3Purity:98%Color and Shape:SoildMolecular weight:1451.01(Average)Mithramycin A
CAS:Mithramycin A (Plicamycin), a DNA-binding antitumor antibiotic, is a selective specificity protein 1 (Sp1) inhibitor, which inhibits the growth of variousFormula:C52H76O24Purity:99.28%Color and Shape:Yellow PowderMolecular weight:1085.15CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Formula:C16H16F3N7OPurity:97.06% - 99.69%Color and Shape:SolidMolecular weight:379.34Ref: TM-T7080
1mg39.00€2mg51.00€5mg84.00€10mg119.00€25mg225.00€50mg369.00€100mg552.00€1mL*10mM (DMSO)92.00€DNA gyrase B-IN-3
CAS:DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against GramFormula:C14H9Cl2N3O4SPurity:98%Color and Shape:SolidMolecular weight:386.21IRES-C11
CAS:IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.Formula:C13H11Cl2NO4Purity:99.89%Color and Shape:SolidMolecular weight:316.14Ref: TM-T40419
1mg103.00€5mg246.00€10mg395.00€25mg785.00€50mg1,198.00€100mg1,853.00€200mg2,498.00€1mL*10mM (DMSO)271.00€STF-083010
CAS:STF-083010 is a selective inhibitor of the IRE1α endonuclease.Formula:C15H11NO3S2Purity:97.53% - 98.85%Color and Shape:SolidMolecular weight:317.38Ref: TM-T6681
5mg51.00€10mg80.00€25mg120.00€50mg205.00€100mg368.00€200mg555.00€500mg810.00€1mL*10mM (DMSO)58.00€ARB-272572
CAS:ARB-272572 is a PD-L1 signaling inhibitor that produces immunostimulatory activity in human primary cells.Formula:C32H36N6O4Purity:97.36% - 98.07%Color and Shape:SolidMolecular weight:568.675-Bromo-2',3',5'-tri-O-acetyluridine
CAS:5-Bromo-2',3',5'-tri-O-acetyluridine is a purine nucleoside analog that can be used to explore explore improve Parkinson's disease.Formula:C15H17BrN2O9Purity:99%Color and Shape:SolidMolecular weight:449.21(E/Z)-THZ1 2HCl
CAS:THZ1 2HCl: selective CDK7 allosteric inhibitor, IC50 3.2 nM, hinders cancer cell growth.Formula:C31H30Cl3N7O2Purity:98.33%Color and Shape:SolidMolecular weight:638.98TASIN-1
CAS:TASIN-1 is a small molecule inhibitor of mutant adenomatous polyposis coli (APC).Formula:C18H28N2O3SPurity:98.48%Color and Shape:SolidMolecular weight:352.49Ref: TM-T22632
1mg39.00€5mg84.00€10mg131.00€25mg269.00€50mg432.00€100mg638.00€500mg1,359.00€1mL*10mM (DMSO)92.00€GSK2850163
CAS:GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).Formula:C24H29Cl2N3OPurity:98.44%Color and Shape:SolidMolecular weight:446.41Phthalazinone pyrazole
CAS:Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.Formula:C18H15N5OPurity:97.03%Color and Shape:SolidMolecular weight:317.34Ref: TM-T21981
1mg64.00€2mg96.00€5mg145.00€10mg212.00€25mg353.00€50mg532.00€100mg792.00€200mg1,064.00€EHT 1864 2HCl
CAS:EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3. Cost effective and quality assured.Formula:C25H29Cl2F3N2O4SPurity:98.39% - 99.42%Color and Shape:SolidMolecular weight:581.47Ref: TM-T6483
1mg47.00€5mg92.00€10mg136.00€25mg259.00€50mg472.00€100mg677.00€200mg934.00€1mL*10mM (DMSO)107.00€(D)-PPA 1 TFA
(D)-PPA 1 TFA is a hydrolysis-resistant D-peptide antagonist and a potent PD-1/PD-L1 inhibitor, exhibiting an affinity for PD-1 of 0.51 μM and demonstratingFormula:C72H99F3N20O23Purity:98%Color and Shape:SolidMolecular weight:1669.67H1k
H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that downregulates the expression of cell cycle protein B1.Formula:C27H22N2OPurity:98.38%Color and Shape:SoildMolecular weight:390.48Nocarnickelamides B
Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.Formula:C29H42N6O9Color and Shape:SolidMolecular weight:618.68LXW7
CAS:LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (Formula:C29H48N12O12S2Purity:100%Color and Shape:SolidMolecular weight:820.89HALOFUGINONE LACTATE
CAS:HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D.Formula:C19H23BrClN3O6Purity:99.02% - 99.96%Color and Shape:SolidMolecular weight:504.8Ref: TM-T8785
2mg42.00€5mg59.00€10mg94.00€25mg130.00€50mg207.00€100mg309.00€200mg462.00€1mL*10mM (DMSO)66.00€Amsilarotene
CAS:Amsilarotene (TAC101) blocks RB phosphorylation, boosts 2 CDK inhibitors, halts cell cycle, and reduces thymidylate synthase and cyclin A levels.Formula:C20H27NO3Si2Purity:99.27%Color and Shape:SolidMolecular weight:385.6Ref: TM-T21314
1mg43.00€2mg57.00€5mg96.00€10mg140.00€25mg273.00€50mg393.00€100mg560.00€200mg757.00€1mL*10mM (DMSO)96.00€ARRY 520 hydrochloride
CAS:'ARRY 520 hydrochloride: a KSP inhibitor causing apoptosis and strong anti-proliferative effects.'Formula:C20H23ClF2N4O2SPurity:98.06% - 99.26%Color and Shape:SolidMolecular weight:456.94Ref: TM-TQ0318L
1mg59.00€5mg116.00€10mg170.00€25mg304.00€50mg437.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)149.00€
