Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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CCT129202
CAS:CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.Formula:C23H25ClN8OSPurity:98.14%Color and Shape:SolidMolecular weight:497.02Elarofiban
CAS:Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.Formula:C22H32N4O4Purity:99.94%Color and Shape:SolidMolecular weight:416.51p21PBP
p21PBP, a peptide composed of 20 amino acids, serves as an inhibitor of DNA replication. It specifically binds to the purified proliferating cell nuclear antigen (PCNA) found in extracts from tumor cells. p21PBP holds potential for use in cancer research.Formula:C112H181N37O30SColor and Shape:SolidMolecular weight:2557.93Cdk2 Inhibitor II
CAS:Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.Formula:C14H11BrN4O3SPurity:98.38%Color and Shape:SolidMolecular weight:395.23Ref: TM-T36933
1mg103.00€2mg140.00€5mg202.00€10mg305.00€25mg512.00€50mg730.00€100mg998.00€500mg1,977.00€IXA4
CAS:IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1.Formula:C24H28N4O4Purity:97.59% - 98.69%Color and Shape:SolidMolecular weight:436.5YK-2168
CAS:YK-2168 is a differentiated selective inhibitor of CDK9.Formula:C16H18ClN5Color and Shape:SolidMolecular weight:315.80PF07104091
CAS:PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation. Cost-effective and quality-assured.Formula:C19H28N6O4Purity:98.61%Color and Shape:SolidMolecular weight:404.46Ref: TM-T9712
1mg354.00€2mg518.00€5mg823.00€10mg1,206.00€25mg1,795.00€50mg2,422.00€100mg3,258.00€1mL*10mM (DMSO)914.00€2'-Fluoro-2'-Deoxyadenosine
CAS:2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP).Formula:C10H12FN5O3Purity:99.35%Color and Shape:SolidMolecular weight:269.23BMS-265246
CAS:BMS-265246 is a potent and selective CDK1/2 inhibitor.Formula:C18H17F2N3O2Purity:98.77% - 99.55%Color and Shape:SolidMolecular weight:345.34Ref: TM-T2679
1mg35.00€5mg74.00€10mg116.00€25mg221.00€50mg335.00€100mg480.00€200mg652.00€1mL*10mM (DMSO)82.00€2'-Deoxy-5,6-dihydrouridine
CAS:2'-Deoxy-5,6-dihydrouridine is a nucleoside analog that contains a dihydro group in its molecular structure,commonly used in base excision related studies.Formula:C9H14N2O5Purity:99.75%Color and Shape:SolidMolecular weight:230.229-(β-D-Xylofuranosyl)adenine
CAS:9-(β-D-Xylofuranosyl)adenine (Adenine xyloside) is an adenine nucleoside analog that is a potential smooth muscle vasodilator.9-(β-D-Xylofuranosyl)adenine hasFormula:C10H13N5O4Purity:99.55%Color and Shape:SolidMolecular weight:267.24PVZB1194
CAS:PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis throughFormula:C13H9F4NO2SPurity:98%Color and Shape:SolidMolecular weight:319.28(1S,3R,5R)-PIM447 dihydrochloride
(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).Formula:C24H25Cl2F3N4OPurity:98%Color and Shape:SolidMolecular weight:513.38(±)-Enitociclib
CAS:(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152. BAY-1251152 is highly selective inhibitor of PTEF/CDK9.Formula:C19H18F2N4O2SPurity:99.29%Color and Shape:SolidMolecular weight:404.43Ref: TM-T13467
1mg37.00€5mg88.00€10mg120.00€25mg216.00€50mg354.00€100mg567.00€200mg805.00€1mL*10mM (DMSO)87.00€CDK9 inhibitor HH1
CAS:CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.Formula:C13H15N3OSPurity:97.97%Color and Shape:SolidMolecular weight:261.34RP-6306
CAS:Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM.Cost-effective and quality-assured.Formula:C18H20N4O2Purity:98.41% - 99.28%Color and Shape:SolidMolecular weight:324.38CDK2 degrader 3
CAS:CDK2 degrader3 selectively degrades CDK2 and exhibits antitumor activity.Formula:C44H53ClN10O6SColor and Shape:SolidMolecular weight:885.47Lerociclib
CAS:Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.Formula:C26H34N8OPurity:99%Color and Shape:SolidMolecular weight:474.6360A
CAS:360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).Formula:C27H23N5O2Purity:98.68%Color and Shape:SolidMolecular weight:449.5Apcin
CAS:Apcin: potent APC/C(Cdc20) E3 ligase inhibitor, blocks substrate recognition & mitosis, synergizes with Ts-Arg-OMe.Formula:C13H14Cl3N7O4Purity:96.74%Color and Shape:SolidMolecular weight:438.65Ref: TM-T8561
1mg48.00€2mg63.00€5mg87.00€10mg140.00€25mg274.00€50mg472.00€100mg710.00€1mL*10mM (DMSO)97.00€Rosnilimab
CAS:Rosnilimab is a humanized IgG1-κ antibody that targets PD-1 [1] [2].Purity:98%Color and Shape:LiquidEHop-016
CAS:EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.Formula:C25H30N6OPurity:100% - 99.86%Color and Shape:SolidMolecular weight:430.55Ref: TM-T2427
5mg48.00€10mg73.00€25mg127.00€50mg213.00€100mg334.00€200mg492.00€500mg787.00€1mL*10mM (DMSO)52.00€YJ1206
CAS:YJ1206 is a highly potent and selective CDK12/13 PROTAC degrader oral, DNA damage and cell-cycle arrest,and inhibits the proliferation of prostate cancer cells.Formula:C49H52FN11O5Purity:97.14%Color and Shape:SolidMolecular weight:894.01MBM-17S
CAS:MBM-17S, a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM, effectively inhibits cancer cell proliferation by inducing cell cycle arrest andFormula:C36H40N6O10Purity:98%Color and Shape:SolidMolecular weight:716.74WRN inhibitor 2
CAS:WRN Inhibitor 2 (example 118), a potent inhibitor of the WRN (Werner Syndrome ATP-dependent helicase enzyme), exhibits a pIC50 value of 7.0 or greater [1].Formula:C15H11F3N2O5S2Purity:98%Color and Shape:SolidMolecular weight:420.38DMT-dG(ib) Phosphoramidite
CAS:DMT-dG(ib) Phosphoramidite can be used to synthesize DNA.Formula:C44H54N7O8PPurity:99.74%Color and Shape:SolidMolecular weight:839.92SU-9516
CAS:SU9516 is a selectively potent ATP-competitive inhibitor of CDKs.Formula:C13H11N3O2Purity:99.59%Color and Shape:SolidMolecular weight:241.25Ref: TM-T8819
1mg90.00€5mg131.00€10mg170.00€25mg248.00€50mg321.00€100mg419.00€500mg938.00€1mL*10mM (DMSO)117.00€Aaptamine
CAS:Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.Formula:C13H12N2O2Purity:98%Color and Shape:SolidMolecular weight:228.25c-Myc inhibitor 11
c-Myc inhibitor 11 (Compound 67e), a c-MYC inhibitor (p EC 50 : 6.4), exhibits high clearance, a moderate volume of distribution, and a short half-life in ratFormula:C20H22N6OPurity:98%Color and Shape:SolidMolecular weight:362.43AI-10-49
CAS:AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.Formula:C30H22F6N6O5Purity:97.14%Color and Shape:SolidMolecular weight:660.52Ref: TM-T6753
2mg40.00€5mg60.00€10mg96.00€25mg169.00€50mg245.00€100mg361.00€200mg512.00€1mL*10mM (DMSO)88.00€SR15006
CAS:SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).Formula:C16H20ClN3O4SPurity:99.78%Color and Shape:SoildMolecular weight:385.87Ref: TM-T60037
5mg39.00€10mg64.00€25mg117.00€50mg212.00€100mg316.00€200mg454.00€1mL*10mM (DMSO)62.00€SB-743921 hydrochloride
CAS:SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).Formula:C31H34Cl2N2O3Purity:95.58% - 99.70%Color and Shape:SolidMolecular weight:553.52Ref: TM-T2255
1mg42.00€5mg106.00€10mg163.00€25mg278.00€50mg429.00€100mg657.00€500mg1,501.00€1mL*10mM (DMSO)130.00€13-TP
13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.Formula:C12H19F2N6O12P3Color and Shape:SolidMolecular weight:570.23DL-Alanosine
CAS:DL-Alanosine is an amino acid analog with antitumor activity.Formula:C3H7N3O4Color and Shape:SolidMolecular weight:149.105Caracemide
CAS:Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.Formula:C6H11N3O4Purity:98.81%Color and Shape:SolidMolecular weight:189.17AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Formula:C28H32FN9O2Color and Shape:SolidMolecular weight:545.61PD-1-IN-17
CAS:PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.Formula:C13H22N6O7Purity:99.6%Color and Shape:SolidMolecular weight:374.35PD-L1-IN-2
CAS:PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity.Formula:C33H38N4O6Purity:98%Color and Shape:SolidMolecular weight:586.68Laromustine
CAS:Laromustine (VNP40101M) is a sulfonyl hydrolysis alkylation prodrug for cancer treatment with significant anticancer activity, inhibiting thioredoxin reductase.Formula:C6H14ClN3O5S2Color and Shape:SolidMolecular weight:307.785-Fluorouridine 5'-phosphate
CAS:5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.Formula:C9H12FN2O9PColor and Shape:SolidMolecular weight:342.172AS2863619 free base
CAS:AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.Formula:C16H12N8OColor and Shape:SolidMolecular weight:332.32KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Formula:C16H27Cl2N5Purity:99.79%Color and Shape:SolidMolecular weight:360.33Ref: TM-T9446
1mg96.00€2mg143.00€5mg235.00€10mg378.00€25mg630.00€50mg898.00€100mg1,216.00€1mL*10mM (DMSO)249.00€2-Keto-D-galactose
CAS:2-Keto-D-galactose inhibits DNA synthesis and inhibits the proliferation of in vitro grown Ehrlich ascites tumor cells.Formula:C6H10O6Purity:98%Color and Shape:SolidMolecular weight:178.14Zn(BQTC)
CAS:Zn(BQTC) inhibits mtDNA and nDNA, damages mitochondria/nuclei, triggers apoptosis, and targets A549R cancer cells.Formula:C30H36Cl2N5O3ZnPurity:98%Color and Shape:SolidMolecular weight:650.92Ocifisertib(CFI-400945 free base)
CAS:Ocifisertib (CFI-400945 free base) is a potent, selective and orally active inhibitor of polo-like kinase 4.Cost-effective and quality-assured.Formula:C33H34N4O3Purity:97.56% - 98.53%Color and Shape:SolidMolecular weight:534.65ATN-161 trifluoroacetate salt
CAS:ATN-161 TFA salt, a new integrin α5β1 inhibitor, curbs angiogenesis, liver metastases growth, enhances survival in mice.Formula:C25H36F3N9O10SPurity:98% - 99.98%Color and Shape:SolidMolecular weight:711.67Eciruciclib
CAS:Eciruciclib is an inhibitor of CDK with antitumor properties.Formula:C27H33FN8Purity:97.51%Color and Shape:SolidMolecular weight:488.6IBR2
CAS:IBR2 is a potent RAD51 inhibitor that disrupts DNA repair, inhibits cancer cell growth, and induces apoptosis.Formula:C24H20N2O2SPurity:96.15%Color and Shape:SolidMolecular weight:400.49Ref: TM-T11600
1mg35.00€5mg70.00€10mg111.00€25mg183.00€50mg259.00€100mg359.00€200mg532.00€1mL*10mM (DMSO)77.00€Tirofiban
CAS:Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.Formula:C22H36N2O5SPurity:99.87%Color and Shape:SolidMolecular weight:440.6Enoxacin
CAS:Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.Formula:C15H17FN4O3Purity:98.68% - 99.89%Color and Shape:Off-White To Yellow CrystalsMolecular weight:320.32
