Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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Ac-rC Phosphoramidite
CAS:Ac-rC Phosphoramidite can modify phosphodisulfide oligonucleotides.Formula:C47H64N5O9PSiPurity:99.49%Color and Shape:SolidMolecular weight:902.1Pyridostatin
CAS:Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome orFormula:C31H32N8O5Purity:98%Color and Shape:SolidMolecular weight:596.64SB273005
CAS:SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.Formula:C22H24F3N3O4Purity:99.58%Color and Shape:SolidMolecular weight:451.44Ribociclib hydrochloride
CAS:Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Formula:C23H31ClN8OPurity:98%Color and Shape:SolidMolecular weight:471PD-1/PD-L1-IN-33
CAS:PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM.Formula:C26H27N5OPurity:98%Color and Shape:SolidMolecular weight:425.53KIF18A-IN-14
CAS:KIF18A-IN-14 (Compound Example 81) is an inhibitor of KIF18A that exists in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit the viability of OVCAR-3 cells with IC50 values of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be utilized in tumor research, including studies on colon cancer, breast cancer, and lung cancer.Formula:C26H32F3N5O6SColor and Shape:SolidMolecular weight:599.62MK-5108
CAS:MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Formula:C22H21ClFN3O3SPurity:100%Color and Shape:SolidMolecular weight:461.94Farletuzumab
CAS:Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.Purity:> 95%Color and Shape:LiquidMolecular weight:145.36 kDa8-Azahypoxanthine
CAS:8-Azahypoxanthine (NSC-22709) inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase and has antimalarial properties.Formula:C4H3N5OPurity:≥98%Color and Shape:Light Yellow To Light Beige Fine CrystallineMolecular weight:137.1Ref: TM-T20102
5mg48.00€10mg66.00€25mg104.00€50mg154.00€100mg216.00€200mg324.00€1mL*10mM (DMSO)48.00€Datelliptium chloride hydrochloride
CAS:Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.Formula:C23H29Cl2N3OPurity:99.46%Color and Shape:SolidMolecular weight:434.4ZM-447439
CAS:ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.Formula:C29H31N5O4Purity:98.53% - 99.11%Color and Shape:Pale Yellow SolidMolecular weight:513.59MBM-17
CAS:MBM-17 is a potent inhibitor of NIMA-related kinase 2 (Nek2,IC50 of 3 nM).Formula:C28H28N6O2Purity:98%Color and Shape:SolidMolecular weight:480.56Dalpiciclib
CAS:Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.Formula:C25H30N6O2Purity:98.32%Color and Shape:SolidMolecular weight:446.54BVDV-IN-1
CAS:BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.Formula:C20H22N4OPurity:98.43%Color and Shape:SolidMolecular weight:334.41Ref: TM-T9103
1mg40.00€5mg90.00€10mg131.00€25mg255.00€50mg375.00€100mg535.00€200mg725.00€1mL*10mM (DMSO)90.00€KSI-3716
CAS:KSI-3716 is a c-Myc inhibitor, a bladder chemotherapy agent that blocks the formation of complexes between c-MYC/MAX and target gene promoters.Formula:C17H11BrCl2N2O2Purity:98.94%Color and Shape:SolidMolecular weight:426.09IIIM-290
CAS:IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Formula:C23H21Cl2NO5Purity:98%Color and Shape:SolidMolecular weight:462.32Rabacfosadine
CAS:Rabacfosadine (GS-9219) is a novel prodrug of PMEG, an acyclic nucleotide phosphonate, with antitumor activity for the study of lymphoma.Formula:C21H35N8O6PPurity:98.75% - 99.43%Color and Shape:SolidMolecular weight:526.53CHK1-IN-2
CAS:CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).Formula:C20H22N4OSPurity:98%Color and Shape:SolidMolecular weight:366.48THZ531
CAS:THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).Formula:C30H32ClN7O2Purity:97.17% - 99.86%Color and Shape:SolidMolecular weight:558.07Ref: TM-T4293
1mg63.00€2mg90.00€5mg111.00€10mg153.00€25mg329.00€50mg472.00€100mg687.00€500mg1,415.00€1mL*10mM (DMSO)137.00€IRE1α kinase-IN-8
CAS:IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of IRE-1α.Formula:C23H22N2O5Purity:98%Color and Shape:SolidMolecular weight:406.43SY-5609
CAS:SY-5609 (CDK7-IN-3) is a selective non-covalent CDK7 inhibitor, with weak inhibitory activity against CDK2, CDK9 and CDK12.Cost-effective and quality-assured.Formula:C23H26F3N6OPPurity:99.32% - 99.34%Color and Shape:SolidMolecular weight:490.46Ref: TM-T36038
1mg139.00€2mg200.00€5mg343.00€10mg553.00€25mgTo inquire50mgTo inquire1mL*10mM (DMSO)399.00€BRD4 Inhibitor-40
CAS:BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.Formula:C27H32N8OColor and Shape:SolidMolecular weight:484.596PD-1/PD-L1-IN-26
CAS:PD-1/PD-L1-IN-26 is a strong inhibitor with IC50 of 0.0380 μM that may boost immune response in cancer by aiding CD4+ T cell entry to tumors.Formula:C43H52N4O8Purity:98%Color and Shape:SolidMolecular weight:752.89Briciclib
CAS:Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.Formula:C19H23O10PSPurity:98% - 99.84%Color and Shape:SolidMolecular weight:474.42Ref: TM-T3207
1mg47.00€2mg57.00€5mg88.00€10mg126.00€25mg250.00€50mg376.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)87.00€8-Chloroinosine
CAS:8-Chloroinosine is a purine nucleoside analog and a metabolite of the anticancer compound 8-chloro-adenosine.Formula:C10H11ClN4O5Purity:99.37% - 99.56%Color and Shape:SolidMolecular weight:302.67H3B-968
CAS:H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonucleaseFormula:C22H18F6N4O4SPurity:98%Color and Shape:SolidMolecular weight:548.46CLT-28643
CAS:CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.Formula:C19H17N3O4Purity:99.98%Color and Shape:SolidMolecular weight:351.36CHK-IN-1
CAS:CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.Formula:C18H19ClFN5OSPurity:100%Color and Shape:SolidMolecular weight:407.891-Methylinosine
CAS:1-Methylinosine (N1-Methylinosine) is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA and has a role as a metabolite.Formula:C11H14N4O5Purity:98.13%Color and Shape:SolidMolecular weight:282.25CDK9-IN-27
CDK9-IN-27 (Compound 6a), a CDK9 inhibitor with an IC50 of 0.424 μM, induces apoptosis and S-phase cell cycle arrest.Formula:C23H18ClN5O3Purity:98%Color and Shape:SolidMolecular weight:447.87CCG-100602
CAS:CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Formula:C21H17ClF6N2O2Purity:99.58%Color and Shape:SolidMolecular weight:478.82Ref: TM-T22062
5mg38.00€10mg57.00€25mg114.00€50mg188.00€100mg303.00€200mg449.00€1mL*10mM (DMSO)43.00€Ro3280
CAS:Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Formula:C27H35F2N7O3Purity:100% - 98%Color and Shape:SolidMolecular weight:543.61CDK7-IN-31
CAS:CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.Formula:C27H32F5N6O2PColor and Shape:SolidMolecular weight:598.55SR18662
SR18662, improved ML264 derivative, inhibits KLF5 at 4.4 nM IC50; curbs colorectal cancer cell growth and triggers apoptosis.Formula:C16H19Cl2N3O4SPurity:98.97% - 99.2%Color and Shape:SolidMolecular weight:420.31Ref: TM-T22429
1mg48.00€5mg96.00€10mg160.00€25mg311.00€50mg502.00€100mg718.00€200mg938.00€500mg1,454.00€1mL*10mM (DMSO)105.00€InhA-IN-2
CAS:N-[3-(Aminomethyl)phenyl]-5-chloro-3-methyl-benzo[b]thiophene-2-sulfonamide inhibits InhA without KatG activation.Formula:C16H15ClN2O2S2Purity:98.4%Color and Shape:SolidMolecular weight:366.89Ref: TM-T9734
1mg87.00€5mg192.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€200mg1,130.00€1mL*10mM (DMSO)197.00€Y-33075
CAS:Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.Formula:C16H16N4OPurity:98%Color and Shape:SolidMolecular weight:280.32DDRI-18
CAS:DDRI-18 is an inhibitor that regulates the DNA damage response, has anticancer activity, and inhibits non-homologous end-joining (NHEJ) DNA repair.Formula:C26H20N6Purity:98%Color and Shape:SolidMolecular weight:416.48N-deacetylated BMS-202
CAS:N-deacetylated BMS-202 is an inhibitor of PD-1/PD-L1 interaction with potential anticancer activity for cancer research.Formula:C23H27N3O2Purity:98.13% - 98.13%Color and Shape:SolidMolecular weight:377.48ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Formula:C10H12N6OPurity:99.69%Color and Shape:SolidMolecular weight:232.24NUAK1-IN-2
NUAK1-IN-2 (Compound 24) is an inhibitor of NUAK1 with an IC50 of 3.162 nM, as well as an inhibitor of CDK2/4/6. It is applicable in research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formula:C24H30N6OColor and Shape:SolidMolecular weight:418.535SWS1
CAS:SWS1, a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM), displays anticancer activity by augmenting tumor-infiltrating lymphocytes and demonstrating antiFormula:C47H53ClN6O5SPurity:98%Color and Shape:SolidMolecular weight:849.48CCT251455
CAS:CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.Formula:C26H26ClN7O2Purity:99.1% - 99.1%Color and Shape:SolidMolecular weight:503.98P162-0948
CAS:P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. It reduces cell migration and the expression of EMT-related proteins in the A549 human alveolar epithelial cell line. Furthermore, P162-0948 decreases Smad phosphorylation, indicating disruption of the TGF-β/Smad signaling pathway, making it a promising compound for pulmonary fibrosis research.Formula:C20H15FN4O2Color and Shape:SolidMolecular weight:362.357Silver sulfadiazine
CAS:Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.Formula:C10H9AgN4O2SPurity:99.04% - 99.58%Color and Shape:SolidMolecular weight:357.14Vedolizumab
CAS:Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.Purity:SDS-PAGE:98.4%;SEC-HPLC:99.1%Color and Shape:LiquidMolecular weight:146.80 kDaMK-8745
CAS:MK-8745 is a potent and selective Aurora A inhibitor.Formula:C20H19ClFN5OSPurity:98.94% - 99.31%Color and Shape:SolidMolecular weight:431.913-Hydroxyxanthone
CAS:3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFormula:C13H8O3Purity:98%Color and Shape:SolidMolecular weight:212.2Pyridostatin Trihydrochloride
CAS:Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.Formula:C31H35Cl3N8O5Purity:99.69%Color and Shape:SolidMolecular weight:706.02Enocitabine
CAS:Enocitabine is a nucleoside analog.Formula:C31H55N3O6Purity:98.02%Color and Shape:SolidMolecular weight:565.78AZD4573
CAS:AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.Formula:C22H28ClN5O2Purity:99.23% - 99.63%Color and Shape:SolidMolecular weight:429.94
