Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Formula:C23H21ClN2O3Purity:98.82% - 99.35%Color and Shape:SolidMolecular weight:408.88Eg5 Inhibitor V, trans-24
CAS:Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.Formula:C26H21N3O3Purity:97.45%Color and Shape:SolidMolecular weight:423.46Ref: TM-T11155
1mg92.00€5mg205.00€10mg305.00€25mg495.00€50mg677.00€100mg905.00€200mg1,216.00€1mL*10mM (DMSO)227.00€NU6102
CAS:NU6102 is a CDK2 inhibitor with antitumor activity against CDK1/cyclinB, CDK1/CDK2, CDK4, DYRK1A , PDK1, and ROCKII, and it can be used to study rectal cancer.Formula:C18H22N6O3SPurity:99.76%Color and Shape:SolidMolecular weight:402.47CDK-IN-2
CAS:CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).Formula:C18H19ClFN3O2Purity:99.52%Color and Shape:SolidMolecular weight:363.81Ref: TM-TQ0078
1mg40.00€2mg54.00€5mg92.00€10mg145.00€25mg271.00€50mg398.00€100mg562.00€500mg1,121.00€1mL*10mM (DMSO)97.00€PTC-209 hydrobromide
CAS:PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results inFormula:C17H13Br2N5OS·HBrPurity:98%Color and Shape:SolidMolecular weight:576.1SHR5428
SHR5428 is an orally active, selective, noncovalent inhibitor of CDK7, displaying potent enzymatic inhibition (IC50 = 2.3 nM) and effectively suppressingPurity:98%Color and Shape:Odour Solid5-Aminouridine
CAS:5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA.Formula:C9H13N3O6Purity:100%Color and Shape:SolidMolecular weight:259.22LTB
LTB is a prodrug formed through the conjugation of the glycolysis inhibitor (Lonidamine) and the PD1/PDL1 blocker (BMS-1) via a thioketal bond. LTB can encapsulate the photosensitizer Chlorin e6 (Ce6), constructing a co-delivery photodynamic nanoplatfform through self-assembly (LTB-6 NPs).Formula:C53H59Cl2N3O7S2Color and Shape:SolidMolecular weight:985.09Cytembena
CAS:Cytembena is a cytostatic and a carcinogenic compound that may increase the incidence of fibroadenomas.Cytembena broadly inhibits DNA biosynthesis.Formula:C11H8BrNaO4Purity:99.53%Color and Shape:White PowderMolecular weight:307.07CDK12-IN-3
CAS:CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.Formula:C23H28F2N8OPurity:99.85%Color and Shape:SolidMolecular weight:470.52Ref: TM-T14990
1mg130.00€5mg311.00€10mg512.00€25mg1,074.00€50mg1,795.00€100mg2,375.00€1mL*10mM (DMSO)344.00€PD 407824
CAS:PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Formula:C20H12N2O3Purity:98.02%Color and Shape:SolidMolecular weight:328.32AMG 900
CAS:AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.Formula:C28H21N7OSPurity:98.35% - 98.9%Color and Shape:SolidMolecular weight:503.58Ref: TM-T6380
1mg52.00€5mg97.00€10mg166.00€25mg303.00€50mg467.00€100mg682.00€500mg1,415.00€1mL*10mM (DMSO)105.00€GSK461364
CAS:GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.Formula:C27H28F3N5O2SPurity:98.85% - 99.5%Color and Shape:SolidMolecular weight:543.6Ref: TM-T6282
1mg37.00€2mg52.00€5mg74.00€10mg124.00€25mg207.00€50mg374.00€100mg557.00€200mg797.00€500mg1,216.00€β-catenin-IN-8
CAS:β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.Formula:C15H12ClN3O2SColor and Shape:SolidMolecular weight:333.79Socazolimab
CAS:Socazolimab (ZKAB001) is a monoclonal antibody targeting PD-L1 with antitumor activity, used in studies of recurrent or metastatic cervical cancer.Purity:95%Color and Shape:LiquidPS423
CAS:PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.Formula:C25H23F3O9Purity:98.81% - 99.26%Color and Shape:SolidMolecular weight:524.442'-Deoxy-2'-fluoroarabinoadenosine
CAS:2'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analogue with extensive anti-tumor activity and can be used for the study of tumor diseases.Formula:C10H12FN5O3Purity:99.44%Color and Shape:SolidMolecular weight:269.23PMT-O9-1A
PMT-O9-1A is an effective PD-L1 degrader that reduces PD-L1 protein expression and exhibits cytotoxic properties. Additionally, PMT-O9-1A possesses anticancer activity.Formula:C22H25ClN2O4Color and Shape:SolidMolecular weight:416.90Trilaciclib hydrochloride
CAS:Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Formula:C24H32Cl2N8OPurity:98.61% - 99.69%Color and Shape:SolidMolecular weight:519.47Fadraciclib
CAS:Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).Formula:C21H31N7OPurity:99.75%Color and Shape:SolidMolecular weight:397.52Ref: TM-TQ0053
1mg48.00€5mg101.00€10mg178.00€25mg304.00€50mg437.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)111.00€KIF18A-IN-3
CAS:KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.Formula:C28H38N4O5S2Purity:98.45%Color and Shape:SolidMolecular weight:574.76Ro5-3335
CAS:Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins.Formula:C13H10ClN3OPurity:99.42% - 99.50%Color and Shape:SolidMolecular weight:259.69(S)-PF-06873600
CAS:(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.Formula:C20H27F2N5O4SPurity:98.55%Color and Shape:SolidMolecular weight:471.52Orotic acid zinc
CAS:Orotic acid zinc (Zinc Orotate) salt dihydrate is an intermediate product in pyrimidine synthesis.Formula:C10H6N4O8ZnPurity:99.13%Color and Shape:SolidMolecular weight:188.79VVD-214
CAS:VVD-214 (RO7589831) is a WRN deconjugation enzyme lethal-mutagenic inhibitor that can be used to study proliferative diseases.Formula:C20H21F2N3O4SPurity:99.24%Color and Shape:SoildMolecular weight:437.46N-Nitrosonornicotine
CAS:N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.Formula:C9H11N3OColor and Shape:SolidMolecular weight:177.2ARQ 621
CAS:ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.Formula:C28H24Cl2FN5O2Purity:98.38%Color and Shape:SolidMolecular weight:552.43Lifitegrast
CAS:Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.Formula:C29H24Cl2N2O7SPurity:99.39% - 99.66%Color and Shape:SolidMolecular weight:615.48Cdc7-IN-7c
CAS:Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.Formula:C15H17N5OSPurity:99.31% - 99.77%Color and Shape:SolidMolecular weight:315.39Ref: TM-T23867
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€1mL*10mM (DMSO)633.00€CDK12-IN-2
CAS:CDK12-IN-2 selectively inhibits CDK12 (IC50: 52 nM) with minimal effect on CDK2, CDK7, and CDK9, useful for CDK12 research.Formula:C32H32N6O2Purity:99.54%Color and Shape:SolidMolecular weight:532.64Ref: TM-T39752
1mg92.00€5mg216.00€10mg376.00€25mg620.00€50mg889.00€100mg1,198.00€1mL*10mM (DMSO)255.00€Cyclo(-RGDfK) TFA
CAS:Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).Formula:C29H42F3N9O9Purity:98.99% - 99.54%Color and Shape:SolidMolecular weight:717.69TH-257
CAS:TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).Formula:C24H26N2O3SPurity:98.23%Color and Shape:SolidMolecular weight:422.54Peresolimab
CAS:Peresolimab, a humanized IgG1-κ antibody, targets PD-1 and may activate physiological immune inhibitory pathways, thereby restoring immune homeostasis [1] [2].Purity:98%Color and Shape:Liquid10-Formyl-5,8-dideazafolic acid
CAS:10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor.Formula:C22H21N5O7Purity:96.04%Color and Shape:SolidMolecular weight:467.43CWHM-12
CAS:CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).Formula:C26H32BrN5O6Purity:98.05% - 98.5%Color and Shape:SolidMolecular weight:590.47Ref: TM-TQ0250
1mg40.00€2mg52.00€5mg88.00€10mg126.00€25mg221.00€50mg369.00€100mg550.00€1mL*10mM (DMSO)96.00€2',5-Difluoro-2'-deoxy-1-arabinosyluracil
CAS:2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepilepticFormula:C9H10F2N2O5Purity:99.94%Color and Shape:SolidMolecular weight:264.18FIT-039
CAS:FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).Formula:C17H18FN3SPurity:98.61%Color and Shape:SolidMolecular weight:315.41KWR137
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.Formula:C33H31ClF3N9O4Color and Shape:SolidMolecular weight:710.105PD-1/PD-L1-IN-31
PD-1/PD-L1-IN-31 is a potent inhibitor of PD-1/PD-L1 (IC50=2.2 nM) that enhances IFN-γ secretion and activates the immune response of peripheral bloodFormula:C24H24ClFN2O3Purity:98%Color and Shape:SolidMolecular weight:442.915'-O-DMT-N2-ibu-dG
CAS:5'-O-DMT-N2-ibu-dG is a deoxynucleoside served as a building block in oligonucleotide synthesis, with protecting groups to prevent unwanted reactions.Formula:C35H37N5O7Purity:98.71%Color and Shape:SolidMolecular weight:639.7Isoindigotin
CAS:Isoindigotin is used in the therapy of Y.Formula:C16H10N2O2Purity:97.52% - ≥95%Color and Shape:SolidMolecular weight:262.26Tislelizumab
CAS:Tislelizumab, a PD-1 receptor monoclonal antibody, reduces Fcγ interaction and T cell clearance in advanced squamous NSCLC research.Purity:95%Color and Shape:LiquidDebio-0123
CAS:Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.Formula:C26H28Cl2N6OPurity:99.52%Color and Shape:SolidMolecular weight:511.45Ref: TM-T9864
1mg95.00€5mg227.00€10mg359.00€25mg607.00€50mg868.00€100mg1,169.00€1mL*10mM (DMSO)255.00€BCH001
CAS:BCH001 is a specific small-molecule inhibitor of PAPD5.Formula:C20H15F3N2O5Purity:99.06%Color and Shape:SolidMolecular weight:420.34Human membrane-bound PD-L1 polypeptide
CAS:Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].Formula:C85H140N26O36SPurity:98%Color and Shape:SolidMolecular weight:2134.24GSK-1070916
CAS:GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Formula:C30H33N7OPurity:99.73%Color and Shape:SolidMolecular weight:507.63Adenine hydrochloride
CAS:Adenine hydrochloride (6-Aminopurine hydrochloride) is a hydrochloride salt form of adenine which is a nucleobase with a variety of roles in biochemistry.Formula:C5H5N5·HClPurity:98.86%Color and Shape:White To Light Yellow Crystal PowderMolecular weight:171.59RS-1
CAS:RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.Formula:C20H16Br2N2O3SPurity:99.72%Color and Shape:SolidMolecular weight:524.23Ref: TM-T6972
5mg51.00€10mg79.00€25mg126.00€50mg210.00€100mg354.00€200mg517.00€500mg825.00€1mL*10mM (DMSO)59.00€TREX1-IN-4
CAS:TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.Formula:C24H19ClN6O4Color and Shape:SolidMolecular weight:490.898Balamapimod
CAS:Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.Formula:C30H32ClN7OSPurity:98%Color and Shape:SolidMolecular weight:574.14
