Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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Anti-Mouse PD-1 Antibody (RMP1-14)
RMP1-14 is an IgG1-like immunoglobulin and anti-Mouse PD-1 antibody that blocks PD-1/PD-L1 signaling.Purity:14.68mg/ml - >95%Color and Shape:Odour LiquidTREX1-IN-3
CAS:TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.Formula:C24H19ClN6O4Color and Shape:SolidMolecular weight:490.898Lipustobart
CAS:Lipustobart is an IgG4-kappa humanized monoclonal antibody targeting PDCD1 (programmed cell death 1, PD1, PD-1, CD279), with immunostimulant and antineoplasticPurity:98%Color and Shape:Liquid2',3'-Isopropylideneuridine
CAS:2',3'-Isopropylideneuridine is a nucleoside derivative that has shown antiviral activity in several studies, particularly against Flaviviruses, such as HCV.Formula:C12H16N2O6Purity:99.91%Color and Shape:SolidMolecular weight:284.27N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite
CAS:N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite is an adenine nucleoside analog with potential vasodilator activity and anticancer activity.Formula:C47H52N7O7PPurity:98.59%Color and Shape:SolidMolecular weight:857.93Ref: TM-TNU1119
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€500mg3,734.00€DMT-2′Fluoro-dU Phosphoramidite
CAS:DMT-2′Fluoro-dU Phosphoramidite (2'-F-dU Phosphoramidite) can be used to modify nucleosides.Formula:C39H46FN4O8PPurity:98.45%Color and Shape:SolidMolecular weight:748.78Azelaoyl PAF
CAS:Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones.promotes the uptake of oxLDL by macrophages by upregulating CD36 expression.Formula:C33H66NO9PColor and Shape:SolidMolecular weight:651.85Polθ-IN-5
CAS:Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.Formula:C23H18ClF2N7O3SColor and Shape:SolidMolecular weight:545.95CYC-116
CAS:CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not activeFormula:C18H20N6OSPurity:96.6% - 97.59%Color and Shape:SolidMolecular weight:368.46Ref: TM-T6458
2mg39.00€5mg56.00€10mg78.00€25mg135.00€50mg217.00€100mg358.00€500mg908.00€1mL*10mM (DMSO)49.00€BAY1217389
CAS:BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).Formula:C27H24F5N5O3Purity:95.71% - 98.78%Color and Shape:SolidMolecular weight:561.5Paprotrain
CAS:Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.Formula:C16H11N3Purity:99.69%Color and Shape:SolidMolecular weight:245.28Ref: TM-T12359
5mg48.00€10mg62.00€25mg97.00€50mg169.00€100mg250.00€200mg373.00€500mg612.00€1mL*10mM (DMSO)52.00€CDK4/6-IN-2
CAS:CDK4/6-IN-2 是一种CDK4和CDK6抑制剂,IC50分别为 2.7 和 16 nM。Formula:C27H32F2N8Purity:99.47%Color and Shape:SolidMolecular weight:506.59Cytidine
CAS:Cytidine (Cytosine-1-β-D-ribofuranoside) is a pyrimidine nucleoside comprised of a cytosine bound to ribose via a beta-N1-glycosidic bond.Formula:C9H13N3O5Purity:98.80% - 99.63%Color and Shape:Physical Description White Crystalline Powder (Ntp 1992)Molecular weight:243.22T2AA
CAS:T2AA (4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol) is an inhibitor of proliferating cell nuclear antigen (PCNA) with IC50 of 1 μM for PCNA/PIP-Formula:C15H15I2NO3Purity:98.19%Color and Shape:SolidMolecular weight:511.09QR-6401
CAS:QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/Formula:C19H23N5O3Purity:98%Color and Shape:SolidMolecular weight:369.42N,N-Dimethyl-2'-O-methylcytidine
CAS:N,N-Dimethyl-2'-O-methylcytidine (N4, N4, 2'-O-Trimethylcytidine) is a purine nucleoside analogue with anti-cancer activity.Formula:C12H19N3O5Purity:99.62%Color and Shape:SolidMolecular weight:285.32'-O-Methyl-5-iodouridine
CAS:2'-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and possesses aFormula:C10H13IN2O6Purity:98.32%Color and Shape:SolidMolecular weight:384.12Deoxycytidine triphosphate
CAS:dCTP is a nucleotide used in DNA synthesis, PCR, cDNA creation, and sequencing.Formula:C9H16N3O13P3Purity:95.19%Color and Shape:SolidMolecular weight:467.16Kif15-IN-1
CAS:Kif15-IN-1 is a Kif15 inhibitor with antiproliferative and potential anticancer activity, which can be used to study gastric cancer.Formula:C20H22N4O5SPurity:99.39% - 99.39%Color and Shape:SolidMolecular weight:430.48TC-Mps1-12
CAS:TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .Formula:C17H20N6OPurity:98%Color and Shape:SolidMolecular weight:324.38N2-Methylguanosine
CAS:N2-methylguanosine is a modified nucleoside of tRNA that occurs at several specific locations in many tRNA'sFormula:C11H15N5O5Purity:97.77%Color and Shape:SolidMolecular weight:297.27PNU112455A hydrochloride
CAS:PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.Formula:C10H12ClN5O2SPurity:98.58% - 99.22%Color and Shape:SolidMolecular weight:301.75Ref: TM-T8230
2mg47.00€5mg74.00€10mg105.00€25mg182.00€50mg281.00€100mg459.00€500mg1,017.00€1mL*10mM (DMSO)84.00€L82-G17
CAS:L82-G17 is an uncompetitive LigI-selective inhibitor in human cells with utility as a probe of the catalytic activity and cellular functions of LigI.Formula:C11H9ClN4O2Purity:99.78%Color and Shape:SolidMolecular weight:264.67αVβ8-IN-1
CAS:αVβ8-IN-1 is an inhibitor of the αVβ8 integrin. It exhibits growth-suppressive activity against tumors such as EMT6, CT26, KPC, and TKCC-10. αVβ8-IN-1 is suitable for research related to idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), and various cancers.Formula:C25H32ClN5O4Color and Shape:SolidMolecular weight:502.01Pritelivir
CAS:Pritelivir (BAY 57-1293) (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).Formula:C18H18N4O3S2Purity:97.96% - 99.42%Color and Shape:SolidMolecular weight:402.49Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.Color and Shape:Odour LiquidTipiracil hydrochloride
CAS:Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI).Formula:C9H12Cl2N4O2Purity:100% - ≥95%Color and Shape:SolidMolecular weight:279.12Bimosiamose
CAS:Bimosiamose has anti-inflammatory effects[1].Formula:C46H54O16Purity:98%Color and Shape:SolidMolecular weight:862.91αvβ1 integrin-IN-1
CAS:αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.Formula:C26H34N6O6SPurity:100% - 99.74%Color and Shape:SolidMolecular weight:558.65Ref: TM-T13473
1mg115.00€5mg274.00€10mg432.00€25mg697.00€50mg938.00€100mg1,293.00€200mg1,738.00€1mL*10mM (DMSO)349.00€DHX9-IN-4
CAS:DHX9-IN-4 is an ATP-dependent RNA helicase DHX9 inhibitor used in cancer research.Formula:C21H22ClN5O4S2Purity:98.12%Color and Shape:SolidMolecular weight:508.01PDL-1 cpd 10
CAS:PDL-1 cpd 10 is a novel small molecule PD-L1 inhititor.Formula:C21H23N5O2Purity:97.08%Color and Shape:SolidMolecular weight:377.44Ref: TM-T9359
1mg55.00€5mg117.00€10mg187.00€25mg393.00€50mg562.00€100mg787.00€200mg1,035.00€1mL*10mM (DMSO)134.00€K34c hydrochloride
K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.Formula:C38H50ClN5O2Purity:100% - 99.95%Color and Shape:SoildMolecular weight:644.29Ref: TM-T41151L
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€1mL*10mM (DMSO)887.00€LP23
LP23, a non-arylmethylamine PD-1/PD-L1 inhibitor (IC 50: 16.7 nM), exhibits anti-tumor activity through the restoration of immune cell function in HepG2/JurkatFormula:C27H27N3O5SPurity:98%Color and Shape:SolidMolecular weight:505.59SCH900776
CAS:SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.Formula:C15H18BrN7Purity:96.69% - 99.6%Color and Shape:SolidMolecular weight:376.25Ref: TM-T2517
1mg52.00€2mg78.00€5mg115.00€10mg168.00€25mg283.00€50mg462.00€100mg660.00€1mL*10mM (DMSO)124.00€Lifitegrast sodium
CAS:Lifitegrast sodium (SAR-1118-023 sodium) is an integrin antagonist that reduces ocular surface inflammation and can be used to study dry eye.Formula:C29H23Cl2N2NaO7SPurity:99.33%Color and Shape:SolidMolecular weight:637.46Pembrolizumab
CAS:Pembrolizumab (MK-3475) is a humanized monoclonal antibody.Cost-effective and quality-assured.Purity:95% - 99.70%Color and Shape:LiquidMolecular weight:149 kDaART812
CAS:ART812 is an orally active inhibitor of DNA polymerase Polθ, possessing an IC50 value of 7.6 nM.Formula:C19H16ClF4N3O4Purity:99.32%Color and Shape:SolidMolecular weight:461.79Ref: TM-T40236
1mg116.00€5mg283.00€10mg452.00€25mg747.00€50mg1,103.00€100mg1,539.00€1mL*10mM (DMSO)280.00€XU1
CAS:XU1(Benzo[c][1,8]naphthyridin-6(5h)-One) is an Aurora protein kinase inhibitor used for the treatment of diseases suitable for inhibition, regulation orFormula:C12H8N2OPurity:100% - 98.97%Color and Shape:SolidMolecular weight:196.2Atuveciclib
CAS:Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Formula:C18H18FN5O2SPurity:97.29%Color and Shape:SolidMolecular weight:387.43Ref: TM-T10464L
1mg88.00€2mg120.00€5mg202.00€10mg329.00€25mg612.00€50mg817.00€100mg1,121.00€1mL*10mM (DMSO)224.00€CDK7-IN-22
CAS:CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].Formula:C22H25F3N6Purity:98%Color and Shape:SolidMolecular weight:430.47CID44216842
CAS:CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.Formula:C22H20BrN3O3SPurity:99.66%Color and Shape:SolidMolecular weight:486.38Ref: TM-T8930
2mg35.00€5mg52.00€10mg89.00€25mg167.00€50mg258.00€100mg379.00€200mg540.00€1mL*10mM (DMSO)58.00€Cidofovir
CAS:Cidofovir ((S)-HPMPC) 通过特异性抑制病毒 DNA 合成来抑制病毒复制。Formula:C8H14N3O6PPurity:99.24% - 99.76%Color and Shape:Fluffy White PowderMolecular weight:279.19Dyrk1A-IN-12
CAS:Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).Formula:C22H16FN3O2SColor and Shape:SolidMolecular weight:405.445Cytarabine hydrochloride
CAS:Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase.Formula:C9H14ClN3O5Purity:99.62%Color and Shape:White PowderMolecular weight:279.68Dihydro-5-azacytidine acetate
CAS:Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1Formula:C10H18N4O7Purity:98%Color and Shape:SolidMolecular weight:306.27N6-Methyl-2'-O-methyladenosine
CAS:N6-Methyl-2'-O-methyladenosine (N6,2′-O-Dimethyladenosine), a substrate for adiposity and obesity-related genes (FTO), is a reversible modifier compound foundFormula:C12H17N5O4Purity:99.77%Color and Shape:SolidMolecular weight:295.29Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurity:99.12%Color and Shape:SolidMolecular weight:512.46ML327
CAS:ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).Formula:C19H18N4O4Purity:99.48%Color and Shape:SolidMolecular weight:366.37Ap4dT
CAS:Ap4dT serves as an inhibitor of human adenylate kinase isozyme 1 (hAK1), effectively suppressing the synthesis of ATP and ADP, with IC50 values of 42 μM and 38 μM, respectively.Formula:C20H41N11O20P4Color and Shape:SolidMolecular weight:879.5α7β1 integrin modulator-1
CAS:α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].Formula:C23H29N3O6SPurity:98%Color and Shape:SolidMolecular weight:475.56
