Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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GW406108X
CAS:GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.Formula:C20H11Cl2NO4Purity:98%Color and Shape:SolidMolecular weight:400.21Hycanthone
CAS:Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.Formula:C20H24N2O2SPurity:98.78%Color and Shape:Yellow-Orange Powder (Ntp 1992)Molecular weight:356.48Z62954982
CAS:Z62954982 (ZINC08010136) is a Rac1 inhibitor that inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary arteriesFormula:C20H21N3O5SPurity:98.28%Color and Shape:SolidMolecular weight:415.46Ref: TM-T37113
1mg38.00€5mg80.00€10mg111.00€25mg183.00€50mg269.00€100mg393.00€200mg560.00€1mL*10mM (DMSO)92.00€10058-F4
CAS:10058-F4 inhibits c-Myc-Max, blocking c-Myc target gene activation, causing cell-cycle arrest & apoptosis.Formula:C12H11NOS2Purity:98% - 99.82%Color and Shape:SolidMolecular weight:249.35Ezabenlimab
CAS:Ezabenlimab (BI-754091) is an anti-PD-1 mAb, Kd 6 nM, blocks PD-1/PD-Ls, boosts T-cell IFN-γ, inhibits tumors in vivo.Purity:95% - 95%Color and Shape:LiquidLY2334737
CAS:LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.Formula:C17H25F2N3O5Purity:98.82%Color and Shape:SolidMolecular weight:389.39Ref: TM-T4061
1mg62.00€5mg131.00€10mg205.00€25mg378.00€50mg562.00€100mg777.00€200mg1,074.00€1mL*10mM (DMSO)166.00€PF-2771
CAS:PF-2771: potent CENP-E inhibitor, IC50 of 16.1 nM, used in cancer treatment.Formula:C29H36ClN5O4Purity:98%Color and Shape:SolidMolecular weight:554.08BS-181 hydrochloride
CAS:BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.Formula:C22H32N6·HClPurity:99.21%Color and Shape:SolidMolecular weight:416.99Ref: TM-T6162
1mg37.00€2mg52.00€5mg79.00€10mg126.00€25mg274.00€50mg454.00€100mg655.00€1mL*10mM (DMSO)87.00€CD532
CAS:CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.Formula:C26H25F3N8OPurity:99.49%Color and Shape:SolidMolecular weight:522.52TC-A 2317 hydrochloride
CAS:TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Formula:C19H29ClN6OPurity:98%Color and Shape:SolidMolecular weight:392.93Alisertib
CAS:Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Formula:C27H20ClFN4O4Purity:100% - 99.82%Color and Shape:SolidMolecular weight:518.92Ref: TM-T2241
5mg55.00€10mg96.00€25mg155.00€50mg226.00€100mg354.00€200mg454.00€500mg743.00€1mL*10mM (DMSO)63.00€4μ8C
CAS:4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.Formula:C11H8O4Purity:97.48% - 98.45%Color and Shape:SolidMolecular weight:204.18CDK-IN-15
CAS:CDK-IN-15 (Compound 456) is an effective inhibitor of Cyclin A, exhibiting an IC50 value of 0.14 μM.Formula:C45H63Cl2F4N7O8Color and Shape:SolidMolecular weight:976.92GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Formula:C16H21BrClN5OPurity:97.85%Color and Shape:SolidMolecular weight:414.73Ref: TM-T27407
1mg46.00€2mg58.00€5mg85.00€10mg108.00€25mg187.00€50mg269.00€100mg376.00€200mg548.00€1mL*10mM (DMSO)87.00€CDK9-IN-2
CAS:CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Formula:C23H25ClFN5Purity:99%Color and Shape:SolidMolecular weight:425.93Ref: TM-T14918
1mg88.00€5mg187.00€10mg281.00€25mg487.00€50mg705.00€100mg998.00€1mL*10mM (DMSO)207.00€Emzadirib
CAS:Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.Formula:C27H40N4O6S2Purity:99.79%Color and Shape:SolidMolecular weight:580.7610074-A4
CAS:10074-A4 is a c-Myc binding compound that associates with c-Myc370-409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features fromFormula:C18H14Cl2N2O3SPurity:98.01%Color and Shape:SolidMolecular weight:409.29Ref: TM-T9628
1mg71.00€5mg135.00€10mg197.00€25mg335.00€50mg480.00€100mg662.00€200mg892.00€1mL*10mM (DMSO)156.00€BI-1950
CAS:BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Formula:C32H26Cl2FN7O3Purity:98%Color and Shape:SolidMolecular weight:646.5MYCi975
CAS:MYCi975 (NUCC-0200975) is an orally active inhibitor of MYC.Formula:C25H16Cl2F6N2O2Purity:99.3% - 99.58%Color and Shape:SolidMolecular weight:561.3AG-024322
CAS:AG-024322 is a pan-CDK inhibitor with antitumor activity, induces apoptosis, and can be used in the study of metabolic diseases.Formula:C23H20F2N6Purity:98.53%Color and Shape:SolidMolecular weight:418.44TG003
CAS:TG003 is a Clk1/Sty inhibitor that inhibits Clk1 and Clk4, suppresses cancer cell growth, and induces apoptosis.Formula:C13H15NO2SPurity:99.46%Color and Shape:SolidMolecular weight:249.33Ref: TM-T60367
1mg50.00€5mg97.00€10mg159.00€25mg281.00€50mg465.00€100mg558.00€200mg810.00€1mL*10mM (DMSO)170.00€PHA-680632
CAS:PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.Formula:C28H35N7O2Purity:98.20%Color and Shape:SolidMolecular weight:501.62T4 UvsX Recombinase
T4 UvsX Recombinase initiates DNA replication on double-stranded templates by catalyzing synapsis with a homologous primer single strand.Purity:98%Color and Shape:Odour SoliddGTP
CAS:dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, andFormula:C10H16N5O13P3Purity:99.9%Color and Shape:SolidMolecular weight:507.18Avotaciclib hydrochloride
Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, includingFormula:C13H12ClN7OPurity:98%Color and Shape:SolidMolecular weight:317.73RI-2
CAS:RI-2, a potent RAD51 inhibitor, has a 44.17 μM IC50 and selectively blocks human HR repair.Formula:C21H18Cl2N2O4Purity:98.85% - 99.86%Color and Shape:SolidMolecular weight:433.28Ref: TM-T2628
1mg73.00€2mg97.00€5mg160.00€10mg281.00€25mg435.00€50mg640.00€100mg910.00€1mL*10mM (DMSO)170.00€CDK9-IN-29
CAS:CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.Formula:C29H33F2N5O4Purity:98%Color and Shape:SolidMolecular weight:553.6PD-1/PD-L1-IN-50
Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.Color and Shape:Odour SolidBMS-8
CAS:BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.Formula:C27H28BrNO3Purity:99.06%Color and Shape:SolidMolecular weight:494.42Ref: TM-T26859
1mg39.00€5mg84.00€10mg131.00€25mg269.00€50mg432.00€100mg638.00€200mg909.00€1mL*10mM (DMSO)96.00€Reversine
CAS:Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formula:C21H27N7OPurity:98% - 99.75%Color and Shape:SolidMolecular weight:393.49Ref: TM-T1825
1mg38.00€2mg49.00€5mg70.00€10mg88.00€25mg164.00€50mg224.00€100mg393.00€1mL*10mM (DMSO)70.00€10074-G5
CAS:10074-G5 is an inhibitor of c-Myc-Max dimerization.Formula:C18H12N4O3Purity:97.22% - 99.67%Color and Shape:SolidMolecular weight:332.31Ref: TM-T3686
2mg42.00€5mg63.00€10mg88.00€25mg142.00€50mg225.00€100mg396.00€200mg565.00€500mg900.00€1mL*10mM (DMSO)69.00€9-Isopropylolomoucine
CAS:9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.Formula:C17H22N6OPurity:100%Color and Shape:SolidMolecular weight:326.4Ref: TM-T23589
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€1mL*10mM (DMSO)642.00€PD-1/PD-L1-IN-27
CAS:PD-1/PD-L1-IN-27: potent anti-cancer, IC50 134nM, minimal T cell harm, boosts CD8+ T cells, reduces fatigue.Formula:C44H35NO6Purity:98%Color and Shape:SolidMolecular weight:673.75Gantofiban
CAS:Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.Formula:C21H29N5O6Purity:99.21%Color and Shape:SolidMolecular weight:447.48CAN508
CAS:CAN508: potent CDK9/T1 inhibitor; IC50 0.35 μM, Cdk2/E; Ki 13.3 μM, IC50 20 μM; 38x selective; antitumor.Formula:C9H10N6OPurity:98.65%Color and Shape:SolidMolecular weight:218.22H-Gly-Arg-Gly-Asp-Asn-Pro-OH
CAS:RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) is a integrin-ligand interactions inhibitor.Formula:C23H38N10O10Purity:100%Color and Shape:SolidMolecular weight:614.61CDK9 ligand 3
CAS:CDK9ligand 3 is a ligand for CDK9 and can be utilized in the synthesis of PROTAC degraders, specifically PROTAC CDK9degrader-11.Formula:C18H18BrCl2N5O3Color and Shape:SolidMolecular weight:503.177MLN0905
CAS:MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).Formula:C24H25F3N6SPurity:97.17% - 98%Color and Shape:SolidMolecular weight:486.56Cdk5 Substrate acetate
Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.Formula:C55H103N15O14Purity:96.21%Color and Shape:SolidMolecular weight:1198.5R-10015
CAS:R-10015, potent LIMK inhibitor with 38 nM IC50 for LIMK1, targets ATP pocket, and serves as a broad-spectrum HIV antiviral.Formula:C20H19ClN6O2Purity:98.68%Color and Shape:SolidMolecular weight:410.86Ref: TM-T12609
1mg75.00€5mg170.00€10mg256.00€25mg423.00€50mg562.00€100mg792.00€200mg1,074.00€1mL*10mM (DMSO)182.00€PD-1/PD-L1-IN-52
PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.Color and Shape:Odour SolidAKI603
CAS:AKI603: Aurora A kinase blocker; IC50 12.3 nM; targets BCR-ABL-T315I resistance; halts leukemia cell growth.Formula:C19H23N9O2Purity:99.81%Color and Shape:SolidMolecular weight:409.45Ref: TM-T64338
1mg66.00€5mg145.00€10mg212.00€25mg380.00€50mg562.00€100mg792.00€200mg1,064.00€1mL*10mM (DMSO)160.00€Triazavirin
CAS:Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.Formula:C5H7N6NaO5SPurity:99.55%Color and Shape:SolidMolecular weight:286.2DNA Gyrase-IN-13
CAS:DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.Formula:C15H21N3O3SColor and Shape:SolidMolecular weight:323.41Quarfloxin
CAS:Quarfloxin (CX-3543), a fluoroquinolone, inhibits neuroblastoma with nanomolar IC50, disrupting nucleolin and G-quadruplex DNA.Formula:C35H33FN6O3Purity:99.77%Color and Shape:SolidMolecular weight:604.67Ref: TM-T16703
1mg119.00€5mg169.00€10mg264.00€25mg487.00€50mg652.00€100mg847.00€1mL*10mM (DMSO)234.00€LY3295668
CAS:LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Formula:C24H26ClF2N5O2Purity:99.44%Color and Shape:SolidMolecular weight:489.95iRGD peptide
CAS:iRGD peptide: 9-amino acid cyclic compound (CRGDKGPDC), found through phage display in mice with tumors.Formula:C35H57N13O14S2Purity:98.77%Color and Shape:SolidMolecular weight:948.04XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurity:99.07%Color and Shape:SolidMolecular weight:437.54Ref: TM-T17267
1mg56.00€2mg78.00€5mg99.00€10mg149.00€25mg258.00€50mg393.00€100mg582.00€1mL*10mM (DMSO)110.00€Sasanlimab
CAS:Sasanlimab (PF-06801591), a humanized IgG4-κ antibody, selectively targets PD-1 and is primarily produced in Chinese Hamster Ovary (CHO) cells [1].Purity:98%Color and Shape:Liquid(2S,3R)-Voruciclib
CAS:(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.Formula:C22H19ClF3NO5Purity:98%Color and Shape:SolidMolecular weight:469.84
