Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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SR 11302
CAS:SR 11302 is an inhibitor of activator protein-1 (AP-1).Formula:C26H32O2Purity:98%Color and Shape:SolidMolecular weight:376.53Ref: TM-T23384
1mg137.00€5mg492.00€10mg797.00€25mg1,385.00€50mgTo inquire100mgTo inquire1mL*10mM (DMSO)550.00€Nedaplatin
CAS:Nedaplatin, a cisplatin derivative, induces tumor DNA damage (IC50: 94 μM) through platinum-DNA cross-links, causing apoptosis.Formula:C2H8N2O3PtPurity:100% - 98.69%Color and Shape:Straw Yellow PowderMolecular weight:303.17A-205804
CAS:A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.Formula:C15H12N2OS2Purity:98.07% - 98.52%Color and Shape:SolidMolecular weight:300.4Ref: TM-T2254
2mg44.00€5mg52.00€10mg81.00€25mg160.00€50mg271.00€100mg532.00€500mg1,169.00€1mL*10mM (DMSO)71.00€N-6-Furfurylguanosine
CAS:N-6-Furfurylguanosine (kinetin riboside) is a purine nucleoside analog with cytotoxicity, inhibiting the growth of cancer cells.Formula:C15H18N6O5Purity:99.58%Color and Shape:SolidMolecular weight:362.34Ancitabine hydrochloride
CAS:Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity.Formula:C9H12ClN3O4Purity:99.02% - 99.37%Color and Shape:White SolidMolecular weight:261.66Uridine-5-acetic acid
CAS:Uridine-5-acetic acid (5-Carboxymethyluridine) is a nucleoside formed during RNA transfer processes in yeast and wheat embryos.Formula:C11H14N2O8Purity:99.59%Color and Shape:SolidMolecular weight:302.24PolQi2
CAS:PolQi2 is a Polθ inhibitor that suppresses the helicase activity of Polθ, and when combined with AZD7648.Formula:C21H16ClN5O3SPurity:99.19%Color and Shape:SolidMolecular weight:453.9Ref: TM-T84770
1mg92.00€5mg188.00€10mg313.00€25mg603.00€50mg840.00€100mg1,169.00€200mg1,586.00€1mL*10mM (DMSO)216.00€CHK1 inhibitor
CAS:CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.Formula:C17H21BrN4OPurity:98%Color and Shape:SolidMolecular weight:377.28Saccharin 1-methylimidazole
CAS:Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.Formula:C7H5NO3S·C4H6N2Purity:98.21%Color and Shape:SolidMolecular weight:265.29THZ1
CAS:THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.Formula:C31H28ClN7O2Purity:95.09% - 99.27%Color and Shape:SolidMolecular weight:566.05Antiviral agent 36
Antiviral agent 36 (compound 27), a potent inhibitor of both dengue (DENV) and Zika (ZIKV) viruses, demonstrates replication inhibition with EC50 values of 100Formula:C30H32N4O3Purity:98%Color and Shape:SolidMolecular weight:496.6m-Se3
CAS:m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].Formula:C29H23IN2SePurity:98%Color and Shape:SolidMolecular weight:605.37CDK2-IN-4
CAS:CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A.Formula:C23H18N6O2SPurity:97.24% - 99.10%Color and Shape:SolidMolecular weight:442.49Ref: TM-T14916
1mg87.00€5mg202.00€10mg321.00€25mg550.00€50mg753.00€100mg1,074.00€1mL*10mM (DMSO)240.00€Bersiporocin
CAS:Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.Formula:C15H19Cl2N3OPurity:100% - 98.88%Color and Shape:SolidMolecular weight:328.24ON-013100
CAS:ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Formula:C19H22O7SPurity:98.27%Color and Shape:SolidMolecular weight:394.44Ref: TM-T16391
1mg50.00€5mg74.00€10mg105.00€25mg182.00€50mg283.00€100mg425.00€200mg602.00€1mL*10mM (DMSO)64.00€ICAM-1-IN-1
CAS:ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.Formula:C15H11BrN2O2SPurity:99.34%Color and Shape:SolidMolecular weight:363.23Ref: TM-T13147
1mg185.00€5mg393.00€10mg587.00€25mg935.00€50mg1,264.00€100mg1,700.00€500mg3,410.00€1mL*10mM (DMSO)432.00€CDK2-IN-40
CAS:CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.Formula:C16H21N7O2Color and Shape:SolidMolecular weight:343.384MYCi361
CAS:MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).Formula:C26H16ClF9N2O2Purity:99.52%Color and Shape:SolidMolecular weight:594.86Dimethylenastron
CAS:Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.Formula:C16H18N2O2SPurity:98.07%Color and Shape:SolidMolecular weight:302.39Ref: TM-T3118
1mg35.00€2mg48.00€5mg62.00€10mg87.00€25mg156.00€50mg235.00€100mg354.00€1mL*10mM (DMSO)67.00€Ribociclib succinate
CAS:Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Formula:C27H36N8O5Purity:99.90%Color and Shape:SolidMolecular weight:552.63Ref: TM-T15732
2mg35.00€5mg51.00€10mg73.00€25mg97.00€50mg115.00€100mg168.00€200mg271.00€500mg484.00€1mL*10mM (DMSO)64.00€HAMNO
CAS:HAMNO (NSC-111847) is a protein interaction inhibitor of replication protein A (RPA).Formula:C17H13NO2Purity:99.96%Color and Shape:SolidMolecular weight:263.29BML-259
CAS:BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.Formula:C14H16N2OSPurity:99.68%Color and Shape:SolidMolecular weight:260.35Ref: TM-T36964
5mg50.00€10mg85.00€25mg169.00€50mg279.00€100mg487.00€500mg1,035.00€1mL*10mM (DMSO)52.00€WRN inhibitor 14
WRN inhibitor 14 (compound S35) is an orally administered WRN inhibitor with anticancer properties. It effectively suppresses tumor growth in the SW48 xenograft model in BALB/c nude mice.Formula:C35H40F4N10O5Color and Shape:SolidMolecular weight:756.75Bimosiamose disodium
CAS:Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.Formula:C46H52Na2O16Purity:98%Color and Shape:SolidMolecular weight:906.888-Bromoadenosine
CAS:8-Bromoadenosine is an adenosine derivative. 8-Br-Adenosine inhibitis mitochondrial membrane potential, cytoplasmic Ca²⁺ levels, and RNA and protein synthesis.Formula:C10H12BrN5O4Purity:99.11%Color and Shape:SolidMolecular weight:346.14SEL120-34A
CAS:SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Formula:C15H18Br2N4Purity:100% - 99.7%Color and Shape:SolidMolecular weight:414.14NSAH
CAS:NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-Formula:C18H14N2O3Purity:99.27%Color and Shape:SolidMolecular weight:306.32Ref: TM-T8800
5mg70.00€10mg111.00€25mg216.00€50mg354.00€100mg567.00€500mg1,198.00€1mL*10mM (DMSO)77.00€CDK8-IN-1
CAS:CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).Formula:C11H8F3N3OPurity:97.09%Color and Shape:SolidMolecular weight:255.2Ref: TM-T10740
1mg87.00€5mg216.00€10mg311.00€25mg525.00€50mg707.00€100mg944.00€1mL*10mM (DMSO)240.00€Rifalazil
CAS:Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.Formula:C51H64N4O13Purity:98%Color and Shape:SolidMolecular weight:941.07GTSE1-IN-1
CAS:GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.Formula:C21H24FN7Color and Shape:SolidMolecular weight:393.46Rifapentine
CAS:Rifapentine (Rifapentinum) is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.Formula:C47H64N4O12Purity:95.74% - ≥98%Color and Shape:SolidMolecular weight:877.032-Methylbiphenyl-oxadiazole-NH-Ph-CHO
CAS:2-Methylbiphenyl-oxadiazole-NH-Ph-CHO functions as a PD-L1 ligand for AUTACPD-L1degrader-3. It is also applicable in the synthesis of AUTAC.Formula:C22H17N3O2Color and Shape:SolidMolecular weight:355.39Ganciclovir
CAS:Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus.Formula:C9H13N5O4Purity:99.4% - 99.55%Color and Shape:White PowderMolecular weight:255.23Werner syndrome RecQ helicase-IN-2
CAS:Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.Formula:C32H34F3N9O5Purity:99.02%Color and Shape:SolidMolecular weight:681.67Digeranyl bisphosphonate
CAS:Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.DigeranylFormula:C21H34Na4O6P2Purity:98.5%Color and Shape:SolidMolecular weight:536.4Cyclapolin 9
CAS:Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.Formula:C9H4F3N3O4SPurity:99.5%Color and Shape:SolidMolecular weight:307.21Ref: TM-T22700
1mg92.00€5mg216.00€10mg338.00€25mg540.00€50mg747.00€100mg1,017.00€500mg2,043.00€1mL*10mM (DMSO)240.00€Seliciclib
CAS:Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.Formula:C19H26N6OPurity:97.15% - 99.88%Color and Shape:White To Off-White SolidMolecular weight:354.45NVP-LCQ195
CAS:NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).Formula:C17H19Cl2N5O4SPurity:100% - 99.36%Color and Shape:SolidMolecular weight:460.33Ref: TM-TQ0068
1mg48.00€5mg97.00€10mg145.00€25mg269.00€50mg395.00€100mg563.00€200mg743.00€1mL*10mM (DMSO)99.00€Deoxyguanosine triphosphate trisodium salt
CAS:Deoxyguanosine triphosphate trisodium salt (2'-Deoxyguanosine-5'-triphosphate trisodium salt) is a nucleotide precursor for DNA synthesis in cells and can beFormula:C10H13N5Na3O13P3Purity:98.73%Color and Shape:SolidMolecular weight:573.13WRN inhibitor 18
CAS:WRN inhibitor 18 (compound 306) is an orally active inhibitor of WRN with demonstrated anticancer activity in vivo.Formula:C35H35F6N5O5SColor and Shape:SolidMolecular weight:751.747-Methylxanthine
CAS:7-Methylxanthine, a xanthine methyl derivative, prevents FDM by altering the sclera in rabbits. It's a purine in kidney stones.Formula:C6H6N4O2Purity:97.66% - 98.58%Color and Shape:SolidMolecular weight:166.14sAJM589
CAS:sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.Formula:C16H10N2OPurity:98%Color and Shape:SolidMolecular weight:246.266-Mercaptopurine hydrate
CAS:6-Mercaptopurine hydrate is a leukemia treatment; it blocks purine metabolism, affecting DNA synthesis.Formula:C5H6N4OSPurity:97.54% - 99.14%Color and Shape:Light Yellow Crystalline PowderMolecular weight:170.19Nusinersen
CAS:Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.Color and Shape:SolidMirvetuximab soravtansine
CAS:Mirvetuximab soravtansine (IMGN853) is an antibody-drug coupling that targets FRα, inhibits cell growth, and can be used to study drug-resistant ovarian cancerPurity:95%Color and Shape:LiquidButyrolactone I
CAS:Butyrolactone I (Olomoucin) inhibits CDKs, blocks cdc2 kinases, and shows antitumor activity in lung and prostate cancers.Formula:C24H24O7Purity:98%Color and Shape:SolidMolecular weight:424.44CDK4/6-IN-17
CAS:CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.Formula:C27H28F4N8Purity:98%Color and Shape:SolidMolecular weight:540.56CDK9-IN-24
CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation.Formula:C27H31N3O4Purity:98%Color and Shape:SolidMolecular weight:461.55PD-1/PD-L1-IN-34
CAS:PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1/PD-L1 interaction (IC 50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1Formula:C35H33ClN2O3Purity:98%Color and Shape:SolidMolecular weight:565.1CDK9-IN-28
PROTAC CDK9/CycT1 Degrader-1 (compounds 10), a potent CDK9 inhibitor, serves as a target protein ligand for PROTAC synthesis.Formula:C32H40N4O6S2Purity:98%Color and Shape:SolidMolecular weight:640.81
