Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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CDK9-IN-9
CAS:CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).Formula:C22H23F2N5O2SPurity:98%Color and Shape:SolidMolecular weight:459.51GSK-923295
CAS:GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).Formula:C32H38ClN5O4Purity:96.22% - 98.02%Color and Shape:SolidMolecular weight:592.13Ref: TM-T2039
1mg49.00€2mg70.00€5mg97.00€10mg168.00€25mg331.00€50mg510.00€100mg737.00€1mL*10mM (DMSO)136.00€Poloxin
CAS:Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).Formula:C18H19NO3Purity:99.19%Color and Shape:SolidMolecular weight:297.35GSK 3008348 hydrochloride
CAS:GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.Formula:C29H37N5O2xHClPurity:99.54%Color and Shape:SolidMolecular weight:0LY2812223
CAS:LY2812223: selective mGlu2 agonist; binds mGlu2/mGlu3 (Ki=144/156 nM).Formula:C10H12N4O4SPurity:98%Color and Shape:SolidMolecular weight:284.29(R)-Enitociclib
CAS:(R)-Enitociclib, an enantiomer of BAY-1251152, is a CDK9 inhibitor with anticancer activity.Formula:C19H18F2N4O2SPurity:98.82%Color and Shape:SoildMolecular weight:404.43CX-5461
CAS:CX5461 is an orally rRNA synthesis inhibitor that inhibits Pol I-driven rRNA transcription. CX5461 has antitumor activity. Cost-effective and quality-assured.Formula:C27H27N7O2SPurity:95.44% - 99.25%Color and Shape:SolidMolecular weight:513.61IRE1α kinase-IN-1
CAS:IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM.Formula:C26H26ClFN8Purity:99.18%Color and Shape:SolidMolecular weight:504.99Ref: TM-T9564
1mg116.00€5mg283.00€10mg452.00€25mg707.00€50mg1,017.00€100mg1,406.00€1mL*10mM (DMSO)311.00€CRT0044876
CAS:CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.Formula:C9H6N2O4Purity:98.27% - 98.98%Color and Shape:Brown PowderMolecular weight:206.15INCB086550
CAS:INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Formula:C41H39N7O4Purity:98.21%Color and Shape:SolidMolecular weight:693.79Cdc7-IN-1
CAS:Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.Formula:C21H16ClN3O4Color and Shape:SolidMolecular weight:409.82BVDU 5′-Triphosphate
CAS:BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase.Formula:C11H16BrN2O14P3Purity:98%Color and Shape:SolidMolecular weight:573.08Tirofiban hydrochloride monohydrate
CAS:Tirofiban(MK383) hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist. Cost-effective and quality-assured.Formula:C22H39ClN2O6SPurity:95.83% - 99.94%Color and Shape:White SolidMolecular weight:495.07S-Gem
CAS:S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR.Formula:C13H15F2N3O6S2Purity:98%Color and Shape:SolidMolecular weight:411.4CBFβ Inhibitor
CAS:CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.Formula:C12H14N2OSPurity:96.50%Color and Shape:SolidMolecular weight:234.32Leucettinib-92
CAS:Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μMFormula:C21H22N4OSPurity:98%Color and Shape:SolidMolecular weight:378.49Poly(A) polymerase
CAS:Poly(A) polymerase enzymatically adds a polyadenosine tail of 20-200 adenine bases to the 3' end of RNA, a process that involves integrating ATP as AMP.Purity:98%Color and Shape:Solid5-Fluoroorotic acid
CAS:5-Fluoroorotic acid is an inhibitor of thymidylate synthase.Formula:C5H3FN2O4Purity:100% - 99.7%Color and Shape:White To Pale Yellow PowderMolecular weight:174.09MU147
CAS:MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.Formula:C19H13N3O3SColor and Shape:SolidMolecular weight:363.39Deoxythymidine triphosphate
CAS:Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.Formula:C10H14N2Na3O14P3Purity:96.00%Color and Shape:White Amorphous PowderMolecular weight:548.11PFM03
CAS:PFM03 is a endonuclease inhibitor that specifically blocks Mre11,reduce MRN endonuclease activity, blocking hMRN-mediated endonucleotomy and nuclear exocytosis.Formula:C14H15NO2S2Purity:98.20% - 99.98%Color and Shape:SolidMolecular weight:293.4TC-S 7005
CAS:TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).Formula:C21H17N3O3Purity:99.68%Color and Shape:SolidMolecular weight:359.38Ref: TM-T17008
1mg57.00€2mg84.00€5mg125.00€10mg188.00€25mg354.00€50mg532.00€100mg712.00€500mgTo inquire1mL*10mM (DMSO)138.00€Metarrestin
CAS:Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis.Formula:C31H30N4OPurity:99.45%Color and Shape:SolidMolecular weight:474.6Ref: TM-T12006
1mg40.00€2mg52.00€5mg88.00€10mg144.00€25mg298.00€50mg512.00€100mg740.00€500mg1,539.00€RG7800 tetrahydrochloride
RG7800 hydrochloride is an orally active modulator of SMN2 splicing, exhibiting EC50 values of 23 nM for SMN2 splicing and 87 nM for SMN protein production.Formula:C24H32Cl4N6OPurity:98%Color and Shape:SolidMolecular weight:562.362'-Deoxy-N4-methylcytidine
CAS:2’-Deoxy-N4-methylcytidine (N(3)-Methyl-2'-deoxycytidine) is a purine nucleoside analog with potential antitumor activity for the study of apoptosis.Formula:C10H15N3O4Purity:99.61%Color and Shape:SolidMolecular weight:241.24HMN-176
CAS:HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).Formula:C20H18N2O4SPurity:98.92% - 98.99%Color and Shape:SolidMolecular weight:382.43Ref: TM-T3643
1mg43.00€2mg56.00€5mg88.00€10mg119.00€25mg188.00€50mg350.00€100mg522.00€500mg1,130.00€1mL*10mM (DMSO)79.00€SGC-CLK-1
CAS:SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.Formula:C19H15F3N6O2Color and Shape:SolidMolecular weight:416.36APY29
CAS:APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.Formula:C17H16N8Purity:96.51% - 98.46%Color and Shape:SolidMolecular weight:332.36Ref: TM-T3654
2mg43.00€5mg65.00€10mg96.00€25mg177.00€50mg301.00€100mg543.00€500mg1,130.00€1mL*10mM (DMSO)71.00€Budigalimab
CAS:Budigalimab (ABBV 181) is a humanized monoclonal antibody targeting PD-1 with potential antitumor activity.Purity:95% - 95%Color and Shape:LiquidHomouridine
CAS:Homouridine, an analogue of uridine, functions as an intermediate in the synthesis of MMP-2 inhibitor (compound I, IC50 = 150 μM).Formula:C10H14N2O6Purity:98%Color and Shape:SolidMolecular weight:258.23CDK5-IN-3
CAS:CDK5-IN-3 is a selective and potent CDK5 inhibitor that inhibits CDK5/p25 and CDK2/CycA, and can be used in the study of cancer.Formula:C22H26N4OPurity:98.21%Color and Shape:SolidMolecular weight:362.47Avelumab
CAS:Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody. Avelumab shows potential antibody-dependent cell-mediated cytotoxicity.Purity:95% - 98.3% (SEC-HPLC)Color and Shape:LiquidMolecular weight:143.8 kDaDatelliptium chloride
CAS:Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride shows anti-tumor activities.Formula:C23H28ClN3OPurity:98%Color and Shape:SolidMolecular weight:397.94CK7
CAS:CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.Formula:C14H12N6O2SPurity:98.07%Color and Shape:SolidMolecular weight:328.35Ref: TM-T9615
1mg52.00€5mg120.00€10mg187.00€25mg376.00€50mg588.00€100mg905.00€200mg1,216.00€1mL*10mM (DMSO)139.00€Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formula:C26H31FN7O6PPurity:99.63%Color and Shape:SolidMolecular weight:587.54Simurosertib
CAS:Simurosertib (TAK-931) is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM).Formula:C17H19N5OSPurity:99.82% - 99.93%Color and Shape:SolidMolecular weight:341.43Ref: TM-T12642L
1mg74.00€2mg96.00€5mg180.00€10mg250.00€25mg465.00€50mg677.00€100mg938.00€1mL*10mM (DMSO)187.00€Acrixolimab
CAS:Acrixolimab is a humanized IgG4-κ monoclonal antibody that selectively targets PD-1 [1] [2].Purity:98%Color and Shape:Liquid6-Thioinosine
CAS:6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.Formula:C10H12N4O4SPurity:97.74%Color and Shape:SolidMolecular weight:284.29Ref: TM-T7621
2mg51.00€5mg85.00€10mg119.00€25mg150.00€50mg188.00€100mg283.00€200mg432.00€1mL*10mM (DMSO)99.00€Natalizumab
CAS:Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Purity:98.00%Color and Shape:LiquidMolecular weight:N/AKJ Pyr 9
CAS:KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).Formula:C22H15N3O4Purity:98.07% - ≥98%Color and Shape:SolidMolecular weight:385.37Ref: TM-T15665
2mg39.00€5mg57.00€10mg81.00€25mg145.00€50mg279.00€100mg510.00€200mg683.00€500mg1,064.00€1mL*10mM (DMSO)63.00€DNA Gyrase-IN-9
DNA Gyrase-IN-9 (compound 4j), an antibacterial agent, selectively targets DNA gyrase.Formula:C26H18ClN3O2Purity:98%Color and Shape:SolidMolecular weight:439.89IXA6
CAS:IXA6 is an IRE1/XBP1s agonist with potential vasoprotective activity for the study of neurodegenerative diseases such as Parkinson's disease.Formula:C22H20ClN3O3SPurity:98.63%Color and Shape:SolidMolecular weight:441.93CW-069
CAS:CW-069 (IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.Formula:C23H21IN2O3Purity:97.52% - 98.59%Color and Shape:SolidMolecular weight:500.33Ref: TM-T6209
1mg43.00€5mg90.00€10mg125.00€25mg216.00€50mg306.00€100mg432.00€500mg938.00€1mL*10mM (DMSO)89.00€DNA Gyrase-IN-8
CAS:DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].Formula:C19H14BrN5OPurity:98%Color and Shape:SolidMolecular weight:408.25Cdc7-IN-7
CAS:Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.Formula:C21H22N4O5Purity:99.25%Color and Shape:SolidMolecular weight:410.42ZIM
CAS:ZIM, from 4-Aminoantipyrine, induces DNA and chromosomal damage, cell death, and phagocytosis, with potential in cancer therapy.Formula:C20H19N3O3Purity:99.13%Color and Shape:SolidMolecular weight:349.38Ref: TM-T72024
5mg39.00€10mg58.00€25mg105.00€50mg170.00€100mg271.00€200mg398.00€1mL*10mM (DMSO)52.00€Pyrintegrin
CAS:Pyrintegrin: β1-integrin agonist, boosts embryonic stem cell survival, and podocyte protection, improves cell-matrix adhesion.Formula:C23H25N5O3SPurity:97.81%Color and Shape:SolidMolecular weight:451.54Ref: TM-T16695
1mg82.00€2mg96.00€5mg159.00€10mg226.00€25mg435.00€50mg648.00€100mg924.00€200mg1,225.00€1mL*10mM (DMSO)168.00€Senexin B
CAS:Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).Formula:C27H26N6OPurity:99.67%Color and Shape:SolidMolecular weight:450.53Ref: TM-T8430
1mg97.00€2mg131.00€5mg188.00€10mg305.00€25mg487.00€50mg655.00€100mg905.00€1mL*10mM (DMSO)215.00€GDC-0575
CAS:GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).Formula:C16H20BrN5OPurity:≥95%Color and Shape:SolidMolecular weight:378.27CCT-251921
CAS:CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Formula:C21H23ClN6OPurity:97.74%Color and Shape:SolidMolecular weight:410.9Ref: TM-T14901
1mg95.00€5mg221.00€10mg324.00€25mg548.00€50mg785.00€100mg1,074.00€1mL*10mM (DMSO)202.00€
