Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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Dithranol
CAS:Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especiallyFormula:C14H10O3Purity:93.49% - ≥98%Color and Shape:Physical Description Lemon Yellow Leaflets Or Plates Or An Orange Powder MeltingMolecular weight:226.23Centrinone
CAS:Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).Formula:C26H25F2N7O6S2Purity:98.76%Color and Shape:SolidMolecular weight:633.65Zeltociclib
CAS:Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.Formula:C18H20F3N4O2PColor and Shape:SolidMolecular weight:412.346CDK8-IN-4
CAS:CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).Formula:C20H18N4OColor and Shape:SolidMolecular weight:330.38EN4
CAS:EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.Formula:C25H24N2O4Purity:98.51%Color and Shape:SolidMolecular weight:416.47TAME
CAS:Tosyl-L-Arginine Methyl Ester (TAME (N-4-Tosyl-L-arginine methyl ester)) is an APC inhibitor.Formula:C14H22N4O4SPurity:98%Color and Shape:SolidMolecular weight:342.41Amenamevir
CAS:Amenamevir (ASP2151) is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mLFormula:C24H26N4O5SPurity:99.00% - 99.86%Color and Shape:SolidMolecular weight:482.55Ref: TM-T4226
1mg60.00€2mg79.00€5mg124.00€10mg197.00€25mg325.00€50mg505.00€100mg730.00€500mg1,501.00€1mL*10mM (DMSO)140.00€Palmatine chloride
CAS:Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Formula:C21H22ClNO4Purity:97.9% - 99.47%Color and Shape:SolidMolecular weight:387.857Indisulam
CAS:Indisulam (E 7070) is a dual-action anticancer drug, blocking G1/S cell cycle transition by degrading cyclin E and activating p53/p21.Formula:C14H12ClN3O4S2Purity:98.68% - 99.77%Color and Shape:SolidMolecular weight:385.85Ref: TM-T4321
1mg35.00€2mg46.00€5mg66.00€10mg93.00€25mg137.00€50mg210.00€100mg314.00€1mL*10mM (DMSO)72.00€TR-14035
CAS:TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).Formula:C24H21Cl2NO5Purity:98.98%Color and Shape:SolidMolecular weight:474.33Ref: TM-T5310
1mg52.00€5mg105.00€10mg170.00€25mg298.00€50mg430.00€100mg605.00€200mg815.00€1mL*10mM (DMSO)111.00€Tegafur
CAS:Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity.Formula:C8H9FN2O3Purity:99.16% - 99.89%Color and Shape:White Crystalline PowderMolecular weight:200.17BWC0977
CAS:BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.Formula:C22H21FN6O5Color and Shape:SolidMolecular weight:468.44Mycro 3
CAS:Mycro 3 is potent and selective for c-Myc in whole cell assays.Formula:C24H17ClF2N6O4Purity:97.87% - 99.51%Color and Shape:SolidMolecular weight:526.88Ref: TM-T4367
1mg49.00€5mg99.00€10mg168.00€25mg335.00€50mg477.00€100mg662.00€200mg892.00€1mL*10mM (DMSO)116.00€TASIN-30
CAS:TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.Formula:C18H30N2O3SColor and Shape:SolidMolecular weight:354.51ITX3
CAS:ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM.Formula:C22H17N3OSPurity:99.02%Color and Shape:SolidMolecular weight:371.45GSK_WRN4
CAS:GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer researchFormula:C16H20N2O4SPurity:100%Color and Shape:SolidMolecular weight:336.41Cyclo(RGDyK) trifluoroacetate
CAS:Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Formula:C31H43F6N9O12Purity:≥95%Color and Shape:SolidMolecular weight:847.72Brr2-IN-2
Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.Formula:C21H25FN4O2Color and Shape:SolidMolecular weight:384.45Eg5-IN-1
Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.Formula:C23H16ClFN4OPurity:98.21%Color and Shape:SolidMolecular weight:418.85ASC-69
CAS:ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].Formula:C19H19N7Purity:98%Color and Shape:SolidMolecular weight:345.4T56-LIMKi
CAS:T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Formula:C19H14F3N3O3Purity:98.39% - 98.61%Color and Shape:SolidMolecular weight:389.33IMT1B
CAS:IMT1B (LDC203974) is an oral POLRMT inhibitor that curbs mtDNA expression and has anti-cancer properties.Formula:C24H21ClFNO6Purity:98.26% - 99.64%Color and Shape:SolidMolecular weight:473.88Ref: TM-T8842
1mg145.00€5mg311.00€10mg533.00€25mg775.00€50mg938.00€100mg1,320.00€1mL*10mM (DMSO)325.00€CDK-IN-10
CAS:CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.Formula:C18H18N4O2Purity:97.07%Color and Shape:SolidMolecular weight:322.36SP-96
CAS:SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.Formula:C25H20FN7OPurity:99.52%Color and Shape:SolidMolecular weight:453.47Ref: TM-T41256
1mg73.00€5mg160.00€10mg250.00€25mg445.00€50mg625.00€100mg909.00€200mg1,216.00€1mL*10mM (DMSO)170.00€Valacyclovir hydrochloride
CAS:Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an acyclovir prodrug that inhibits viral DNA replication after metabolization.Formula:C13H20N6O4·HClPurity:100% - ≥95%Color and Shape:White To Off-White Crystalline PowerMolecular weight:360.8Ref: TM-T1087
1g299.00€10mg47.00€25mg69.00€50mg85.00€100mg97.00€200mg127.00€500mg202.00€1mL*10mM (DMSO)47.00€Netivudine
CAS:Netivudine, a potent NRTI with anti-varicella activity, treats HIV by inhibiting reverse transcriptase, reducing viral load.Formula:C12H14N2O6Purity:99.83%Color and Shape:SolidMolecular weight:282.25GW779439X
CAS:GW779439X is an inhibitor of CDK.Formula:C22H21F3N8Purity:97.87%Color and Shape:SolidMolecular weight:454.45Ref: TM-T8866
1mg62.00€2mg87.00€5mg119.00€10mg188.00€25mg425.00€50mg625.00€100mg892.00€1mL*10mM (DMSO)131.00€Rinatabart
Rinatabart is a humanized IgG1κ antibody that targets FOLR1. The corresponding isotype control is HumanIgG1kappa, Isotype Control.Color and Shape:Odour LiquidTHZ2
CAS:THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).Formula:C31H28ClN7O2Purity:98%Color and Shape:SolidMolecular weight:566.05RWJ 50271
CAS:RWJ 50271 inhibits LFA-1/ICAM-1 interaction with IC50 5.0 μM in HL60 cells.Formula:C18H17F3N4O2SPurity:99.09%Color and Shape:SolidMolecular weight:410.41Ref: TM-T12783
1mg127.00€5mg311.00€10mg472.00€25mg747.00€50mg1,017.00€100mg1,311.00€200mg1,786.00€1mL*10mM (DMSO)344.00€Etrolizumab
CAS:MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Purity:95% - 95%Color and Shape:LiquidBMS202 hydrochloride (1675203-84-5(free base))
CAS:BMS202 hydrochloride (1675203-84-5) is a potent PD-1/PD-L1 inhibitor (IC50: 18 nM) that promotes PD-L1 dimerization, blocking PD1 binding.Formula:C25H30ClN3O3Purity:99.47%Color and Shape:SolidMolecular weight:455.97Ref: TM-T4696
1mg51.00€2mg63.00€5mg100.00€10mg160.00€25mg306.00€50mg548.00€100mg785.00€1mL*10mM (DMSO)100.00€CDK9/PARP-IN-1
CAS:CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.Formula:C38H34F2N8O3Color and Shape:SolidMolecular weight:688.725αvβ6-IN-2
αvβ6-IN-2 (compound 20) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 7.8. It shows potential for use in research on idiopathic pulmonary fibrosis.Formula:C25H30F3N3O3Color and Shape:SolidMolecular weight:477.52Elarofiban TFA
CAS:Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.Formula:C26H34F6N4O8Purity:100%Color and Shape:SoildMolecular weight:644.56Ribociclib succinate hydrate
CAS:Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively).Formula:C27H38N8O6Purity:98%Color and Shape:SolidMolecular weight:570.651CCT244747
CAS:CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Formula:C20H24N8O2Purity:99.17%Color and Shape:SolidMolecular weight:408.46CDK6-IN-1
CAS:CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.Formula:C30H23N5Color and Shape:SolidMolecular weight:453.5411α-O-Tigloyl-12β-O-acetyltenacigenin B
CAS:11α-O-Tigloyl-12β-O-acetyltenacigenin B, an ester derivative isolated from Garcinia cambogia (MTC), modulates the antitumor effects of Aurora-A in lymphomaFormula:C28H40O7Purity:98%Color and Shape:SolidMolecular weight:488.61Ara-G
CAS:Ara-G, a deoxyguanosine analog, inhibits DNA synthesis, targeting T cell leukemia by converting to araGTP.Formula:C10H13N5O5Purity:99.93%Color and Shape:Slightly Off White To White PowderMolecular weight:283.24Sorivudine
CAS:Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.Formula:C11H13BrN2O6Purity:97.33%Color and Shape:SolidMolecular weight:349.13Apcin A HCL
CAS:Apcin A HCL is an Apcin-derived APC inhibitor that binds Cdc20 and hinders ubiquitination, useful for synthesizing PROTAC CP5V.Formula:C10H15Cl4N5O2Purity:99.59%Color and Shape:SolidMolecular weight:379.07AUZ 454
CAS:AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50/18.6/15.4/9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.Formula:C24H26F3N7O2Purity:99.59%Color and Shape:SolidMolecular weight:501.5Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Formula:C23H28N8OSPurity:99.99%Color and Shape:SolidMolecular weight:464.59AS-136A
CAS:AS-136A is an orally active MV RdRp inhibitor with antiviral activity that inhibits measles virus and blocks viral RNA synthesis.Formula:C17H19F3N4O3SPurity:99.96%Color and Shape:SolidMolecular weight:416.42WRN inhibitor 16
WRN inhibitor 16 (Example 83) is an orally active WRN inhibitor. In a SW48 xenograft mouse tumor model, WRN inhibitor 16 did not cause tumor regression.Formula:C31H30F4N4O5SColor and Shape:SolidMolecular weight:646.65CDK9-IN-7
CAS:CDK9-IN-7: selective, oral CDK9/cyclin T inhibitor with 11 nM IC50, stronger than CDK4/6.Formula:C29H37N7O2SPurity:98.19%Color and Shape:SolidMolecular weight:547.71Ref: TM-T10745
1mg116.00€5mg298.00€10mg432.00€25mg652.00€50mg900.00€100mg1,206.00€500mg2,432.00€1mL*10mM (DMSO)325.00€Penpulimab
CAS:Penpulimab is a monoclonal antibody targeting PD-1 with antitumor activity, used in studies of pancreatic cancer.Purity:95% - 95%Color and Shape:LiquidTadocizumab
CAS:Tadocizumab (C4G1) is a humanized monoclonal antibody targeting integrin αIIbβ3 with antiplatelet and antithrombotic effects.Color and Shape:LiquidAurora B inhibitor 1
CAS:Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.Formula:C25H26ClF2N7O2Purity:98.37%Color and Shape:SolidMolecular weight:529.97
