Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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TY-011
CAS:TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.Formula:C18H16ClN5Color and Shape:SolidMolecular weight:337.81T025
CAS:T025 inhibits CLK1-4 (Kds: 0.074-6.5 nM), shows anti-cancer effects (IC50: 30-300 nM), useful for MYC-related disease research.Formula:C21H18N8Purity:98.08%Color and Shape:SolidMolecular weight:382.42Ref: TM-T13058
1mg143.00€5mg354.00€10mg528.00€25mg852.00€50mg1,159.00€100mg1,568.00€500mg3,125.00€1mL*10mM (DMSO)378.00€Empesertib
CAS:Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.Formula:C29H26FN5O4SPurity:97.45% - 98.44%Color and Shape:SolidMolecular weight:559.61Ref: TM-T8487
1mg90.00€5mg183.00€10mg275.00€25mg449.00€50mg615.00€100mg848.00€200mg1,121.00€1mL*10mM (DMSO)245.00€CDK2 degrader 4
CAS:CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.Formula:C23H26ClN3O5Color and Shape:SolidMolecular weight:459.923Adebrelimab
CAS:Adebrelimab (SHR-1316) is a humanized monoclonal antibody targeting PD-L1 with antitumor activity for the study of solid tumors.Purity:95% - 95%Color and Shape:LiquidCHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Formula:C18H19BrClN7O2Purity:98.02%Color and Shape:SoildMolecular weight:480.75BT100
BT100, an aptamer, impedes the interaction of von Willebrand factor (VWF) with platelet glycoprotein GPIb, thus obstructing arterial thrombosis [1].Purity:98%Color and Shape:Odour Solid2'-Amino-2'-deoxy-b-D-arabino-5-methyl uridine
CAS:2'-Amino-2'-deoxy-b-D-arabino-5-methyl uridine is a purine nucleoside analog with potential antitumor activity.Formula:C10H15N3O5Purity:96.76%Color and Shape:SolidMolecular weight:257.24AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Formula:C19H23N7O2Purity:99.83% - 99.98%Color and Shape:SolidMolecular weight:381.43Ref: TM-T3068
1mg47.00€2mg60.00€5mg95.00€10mg170.00€25mg299.00€50mg499.00€100mg723.00€1mL*10mM (DMSO)97.00€CCT241736
CAS:CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3Formula:C22H23Cl2N7Purity:96.2% - 99.88%Color and Shape:SolidMolecular weight:456.37Cdk1/2 Inhibitor III
CAS:Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.Formula:C15H13F2N7O2S2Purity:100%Color and Shape:SolidMolecular weight:425.44Ref: TM-T14914
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€CRT-0105950
CAS:CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Formula:C21H16ClN3OSPurity:99.78% - 99.86%Color and Shape:SolidMolecular weight:393.89Ref: TM-T23917
1mg65.00€5mg140.00€10mg216.00€25mg439.00€50mg707.00€100mg1,130.00€1mL*10mM (DMSO)156.00€IRE1α kinase-IN-9
CAS:IRE1α kinase-IN-9 (compound 2) is a potent inhibitor of IRE-1α, demonstrating an average IC50 value of less than 0.1 μM.Formula:C24H24N2O6Purity:98%Color and Shape:SolidMolecular weight:436.46Isoguanine
CAS:Isoguanine is a purine base that is an isomer of guanine. A building block in organic synthesis.Formula:C5H5N5OPurity:99.90%Color and Shape:SolidMolecular weight:151.13Vidarabine
CAS:Vidarabine is a nucleoside antibiotic from Streptomyces with antiviral properties, effective against herpes and other DNA viruses.Formula:C10H13N5O4Purity:100%Color and Shape:White To Off-White Crystalline PowderMolecular weight:267.24Rac1 Inhibitor F56, control peptide acetate
Rac1 Inhibitor F56, control peptide acetate is a control peptide version of Rac1 Inhibitor; comprises residues 45-60 of Rac1 with Trp56 replaced by Phe.Formula:C74H120N18O25SPurity:98%Color and Shape:SolidMolecular weight:1692.94Lon-TK
Lon-TK is a glycolysis inhibitor of LTB, linked with a linker conjugate. LTB is an intelligent responsive prodrug, comprised of Lonidamine (Lon) and a PD-L1 inhibitor (BMS-1), which are connected through a thioketal linkage. It effectively inhibits glycolytic metabolism in tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK holds potential for use in photodynamic-enhanced immunotherapy research.Formula:C24H28Cl2N2O3S2Color and Shape:SolidMolecular weight:527.53rel-(2S,3R)-Voruciclib hydrochloride
CAS:Rel-(2S,3R)-Voruciclib hydrochloride is an enantiomer of Voruciclib hydrochloride, an orally active cyclin-dependent kinase (CDK) inhibitor.Formula:C22H20Cl2F3NO5Purity:98%Color and Shape:SolidMolecular weight:506.3CVT-313
CAS:CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.Formula:C20H28N6O3Purity:97.46% - 97.97%Color and Shape:SolidMolecular weight:400.47Ref: TM-T3195
1mg44.00€2mg55.00€5mg88.00€10mg118.00€25mg208.00€50mg380.00€100mg565.00€1mL*10mM (DMSO)88.00€Prolgolimab
CAS:Prolgolimab (BCD-100) is an anti-PD-1 antibody used in melanoma research.Purity:>95%Color and Shape:Liquid6-O-Methyl Guanosine
CAS:6-O-Methyl Guanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.Formula:C11H15N5O5Purity:97.50%Color and Shape:SolidMolecular weight:297.27Lysidine
CAS:Lysidine (2-Methyl-2-iMidazoline) is a nucleoside rarely seen outside of tRNA. Lysidine has better translation fidelity.Formula:C4H8N2Purity:98%Color and Shape:Light Yellow To Off-White CrystallineMolecular weight:84.12Trifluridine
CAS:Trifluridine is a fluorinated thymidine analog with antineoplastic and antiviral properties, disrupting DNA and protein synthesis, leading to apoptosis.Formula:C10H11F3N2O5Purity:99.39% - 99.82%Color and Shape:White Crystalline PowderMolecular weight:296.2Haspin-IN-3
CAS:Haspin-IN-3 is a potent haspin inhibitor with an IC50 of 14 nM.Haspin-IN-3 has anticancer activity.Formula:C16H10N2O3Purity:98.78%Color and Shape:SolidMolecular weight:278.261-Methylcytosine
CAS:1-Methylcytosine (4-amino-1-methylpyrimidin-2(1H)-one) is a methylated form of the cytosine and can be used as the nucleobase of hachimoji DNA paired withFormula:C5H7N3OPurity:100%Color and Shape:SolidMolecular weight:125.13MM41
CAS:MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.Formula:C44H66N10O6Purity:97.13%Color and Shape:SolidMolecular weight:831.06Ref: TM-T60028
1mg52.00€5mg116.00€10mg178.00€25mg293.00€50mg393.00€100mg520.00€200mg712.00€1mL*10mM (DMSO)160.00€Kira8
CAS:Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity (IC50: 5.9 nM).Formula:C31H29ClN6O3SPurity:98.07%Color and Shape:SolidMolecular weight:601.12Ref: TM-T11762L
1mg87.00€5mg202.00€10mg305.00€25mg567.00€50mg810.00€100mg1,111.00€1mL*10mM (DMSO)269.00€SCH-1473759 hydrochloride
CAS:SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).Formula:C20H27ClN8OSPurity:98.29%Color and Shape:SolidMolecular weight:463Didox
CAS:Didox (NSC-324360), a synthetic RR inhibitor, lowers oxidative injury markers in HIV-related dementia.Formula:C7H7NO4Purity:96.85%Color and Shape:SolidMolecular weight:169.13DMTr-LNA-5MeU-3-CED-phosphoramidite
CAS:DMTr-LNA-5MeU-3-CED-phosphoramidite is a derivative of nucleoside.Formula:C41H49N4O9PPurity:98.28%Color and Shape:SolidMolecular weight:772.82HMN-214
CAS:HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.Formula:C22H20N2O5SPurity:100% - 98.63%Color and Shape:SolidMolecular weight:424.47Ref: TM-T2438
1mg40.00€2mg52.00€5mg85.00€10mg124.00€25mg219.00€50mg350.00€100mg505.00€500mg1,121.00€1mL*10mM (DMSO)92.00€Durvalumab
CAS:Durvalumab is a humanized antibody for cancer, inhibiting PD-L1/PD-1 and CD80 interactions at very low concentrations.Purity:SDS-PAGE:97.2%;SEC-HPLC:95.3%Color and Shape:LiquidMolecular weight:146.03 kDaILK-IN-2
CAS:ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.Formula:C30H30F3N5OPurity:99.30%Color and Shape:SolidMolecular weight:533.59Ref: TM-T5488
1mg48.00€5mg97.00€10mg128.00€25mg162.00€50mg192.00€100mg281.00€200mg408.00€1mL*10mM (DMSO)137.00€Tibremciclib
CAS:Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].Formula:C28H32F2N8Purity:98%Color and Shape:SolidMolecular weight:518.6MLS-573151
CAS:MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Formula:C21H19N3O2SPurity:98.80%Color and Shape:SolidMolecular weight:377.46Ref: TM-T22106
2mg35.00€5mg52.00€10mg90.00€25mg170.00€50mg259.00€100mg383.00€200mg545.00€1mL*10mM (DMSO)58.00€DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Formula:C26H35N7O5Color and Shape:SolidMolecular weight:525.6BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Formula:C29H28N4O2Purity:97.13% - 97.54%Color and Shape:SolidMolecular weight:464.56Ref: TM-T6785
1mg49.00€5mg97.00€10mg153.00€25mg296.00€50mg445.00€100mg660.00€200mg917.00€1mL*10mM (DMSO)97.00€CASIN
CAS:CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).Formula:C20H22N2OPurity:100% - 99.86%Color and Shape:SolidMolecular weight:306.4Ref: TM-T3971
1mg38.00€2mg49.00€5mg74.00€10mg120.00€25mg188.00€50mg283.00€100mg435.00€500mg938.00€1mL*10mM (DMSO)74.00€Kaempferitrin
CAS:Kaempferitrin has antidepressant effects via 5-HT1A, targets HeLa cells, promotes glucose control, and boosts immune function, including NK cells.Formula:C27H30O14Purity:98% - 99.59%Color and Shape:SolidMolecular weight:578.52Ref: TM-T3386
1mg50.00€5mg123.00€10mg207.00€25mg349.00€50mg515.00€100mg735.00€500mg1,483.00€1mL*10mM (DMSO)156.00€Nolatrexed
CAS:Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.Formula:C14H12N4OSPurity:97.91%Color and Shape:SolidMolecular weight:284.34Ref: TM-T4228
1mg42.00€2mg50.00€5mg90.00€10mg148.00€25mg240.00€50mg430.00€100mg633.00€1mL*10mM (DMSO)96.00€BMH-21
CAS:BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.Formula:C21H20N4O2Purity:98.87% - 99.53%Color and Shape:SolidMolecular weight:360.41Reozalimab
CAS:Rezilimab is a bispecific antibody that targets PD-1/PD-L1 and mediates antibody-dependent cell cytotoxicity (ADCC) in cancer research [1] [2].Purity:98%Color and Shape:LiquidN1-Methylpseudouridine-5'-triphosphate
CAS:N1-Methylpseudouridine-5'-triphosphate is a modified nucleotide and can replace UTP in synthesis thereby improving RNA stability and reducing immunogenicity.Formula:C10H17N2O15P3Purity:98.18%Color and Shape:SolidMolecular weight:498.17BMS-5
CAS:BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.Formula:C17H14Cl2F2N4OSPurity:95.83% - 99.88%Color and Shape:SolidMolecular weight:431.29Ref: TM-T4598
1mg43.00€2mg55.00€5mg84.00€10mg123.00€25mg198.00€50mg298.00€100mg444.00€1mL*10mM (DMSO)92.00€Fialuridine
CAS:Fialuridine (DRG-0098), a DNA polymerase inhibitor, shows strong anti-HBV effects both in vitro and in vivo.Formula:C9H10FIN2O5Purity:99.71% - 99.90%Color and Shape:Less Crystals Colourless CrystalsMolecular weight:372.09Ref: TM-T7655
1mg35.00€5mg74.00€10mg116.00€25mg235.00€50mg373.00€100mg562.00€500mg1,216.00€1mL*10mM (DMSO)82.00€CDK4/6-IN-24
CAS:CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.Formula:C32H41N7O3Color and Shape:SolidMolecular weight:571.713Carotegrast methyl
CAS:Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Formula:C28H26Cl2N4O5Purity:99.40%Color and Shape:SolidMolecular weight:569.44Ref: TM-T30751
10g9,508.00€1mg74.00€5mg160.00€10mg264.00€25mg528.00€50mg785.00€100mg1,130.00€200mg1,549.00€1mL*10mM (DMSO)170.00€1ACTA
CAS:1ACTA (IRE1αS-nitrosylation inhibitor) is a compound that helps maintain the endoplasmic reticulum stress response under conditions of nitrosative stress.Formula:C14H16N2O2Color and Shape:SolidMolecular weight:244.29NRTT-IN-1
CAS:NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.Formula:C28H24FN5O5Color and Shape:SolidMolecular weight:529.519PND-1186
CAS:PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).Formula:C25H26F3N5O3Purity:99.14% - 99.75%Color and Shape:SolidMolecular weight:501.5
