Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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Carmofur
CAS:Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.Formula:C11H16FN3O3Purity:98.59% - 99.48%Color and Shape:SolidMolecular weight:257.265-Ethynyluridine
CAS:5-Ethynyluridine marks new RNA for RICK, capturing proteins on various RNAs, even nonpolyadenylated types.Formula:C11H12N2O6Purity:100%Color and Shape:SolidMolecular weight:268.22Ref: TM-T36971
5mg51.00€10mg88.00€25mg145.00€50mg250.00€100mg363.00€200mg545.00€1mL*10mM (DMSO)57.00€CDK2/4-IN-2
CAS:CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.Formula:C18H20F3N7O3S2Color and Shape:SolidMolecular weight:503.52Abemaciclib
CAS:Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.Formula:C27H32F2N8Purity:99.39% - 99.87%Color and Shape:SolidMolecular weight:506.595-(Methoxycarbonyl)methyluridine
CAS:5-(Methoxycarbonyl)methyluridine is an important modifying nucleotide in tRNAs, and the lack of the mcm5U modification leads to increased protein aggregation.Formula:C12H16N2O8Purity:99.71%Color and Shape:SolidMolecular weight:316.26GSK-1520489A
CAS:GSK-1520489A is an active PKMYT1 inhibitor.Formula:C21H23N5O3SPurity:97.25%Color and Shape:SolidMolecular weight:425.5D5B
D5B is an effective and selective PD-L1 inhibitor that has been modified with DBCO. It degrades PD-L1 in 4T1 and B16-F10 tumor cells with EC50 values of 5.4 μM and 6.2 μM, respectively. D5B can block the PD-L1/PD-1 interaction and exhibits antitumor activity.Formula:C58H66N2O12Color and Shape:SolidMolecular weight:983.15TH287 hydrochloride
CAS:TH287 inhibits MTH1 (IC50: 0.8 nM), causing DNA damage in cancer cells through oxidized dNTP incorporation, leading to cytotoxicity in mouse xenografts.Formula:C11H11Cl3N4Purity:99.5%Color and Shape:SolidMolecular weight:305.59ANI-7
CAS:ANI-7, an AhR pathway activator, selectively impedes MCF-7 breast cancer cell growth (GI50: 0.56 μM).Formula:C13H8Cl2N2Purity:99.21%Color and Shape:SolidMolecular weight:263.12CDK4/6-IN-3
CAS:CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.Formula:C25H31FN8Purity:98%Color and Shape:SolidMolecular weight:462.57Danusertib
CAS:Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Formula:C26H30N6O3Purity:97.88% - 98.44%Color and Shape:White PowderMolecular weight:474.55Ref: TM-T2094
1mg59.00€2mg85.00€5mg116.00€10mg188.00€25mg365.00€50mg555.00€100mg795.00€500mg1,605.00€1mL*10mM (DMSO)120.00€DNA polymerase-IN-2
DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, demonstrates inhibitory activity towards Taq DNA polymerase, with an IC50 value of 48.25 μM, and holdsFormula:C14H12O5SPurity:98%Color and Shape:SolidMolecular weight:292.31TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formula:C23H22Cl2FN5O3Purity:98.69%Color and Shape:SolidMolecular weight:506.36Ref: TM-T34787
1mg97.00€5mg235.00€10mg378.00€25mg748.00€50mg1,169.00€100mg1,644.00€1mL*10mM (DMSO)261.00€ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Formula:C21H25N7Purity:97.63% - ≥95%Color and Shape:SolidMolecular weight:375.47Ref: TM-T2358
1mg51.00€2mg72.00€5mg105.00€10mg159.00€25mg279.00€50mg462.00€100mg648.00€1mL*10mM (DMSO)116.00€Mefenidil
CAS:Mefenidil (McN-2378), a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.Formula:C12H11N3Purity:98.17%Color and Shape:SolidMolecular weight:197.24Volociximab
CAS:Volociximab (M200) is an IgG4 monoclonal antibody targeting the α5β1 integrin , with antiangiogenic, antitumor and anticancer activity, inhibits the growth of rabbit VX2 tumors and is used to study solid tumors.Purity:95%Color and Shape:LiquidPKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Formula:C24H26FN5O2Color and Shape:SolidMolecular weight:435.49MKC3946
CAS:MKC3946 is an effective and soluble IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines.Formula:C21H20N2O3SPurity:99.65%Color and Shape:SolidMolecular weight:380.46Ref: TM-TQ0101
1mg66.00€5mg170.00€10mg265.00€25mg444.00€50mg653.00€100mg929.00€1mL*10mM (DMSO)157.00€ML216
CAS:ML216 (CID-49852229) inhibits BLM helicase (IC50: 1.8 μM), 28-fold selective over RECQ1, RECQ5, and UvrD (IC50s > 50 μM).Formula:C15H9F4N5OSPurity:98.12%Color and Shape:SolidMolecular weight:383.323'-Deoxy-3'-fluoroguanosine
CAS:3'-Deoxy-3'-fluoroguanosine is a nucleoside phosphorylase inhibitor that inhibits RNA replication by binding replons.Formula:C10H12FN5O4Purity:99.33%Color and Shape:SolidMolecular weight:285.23
