Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Products of "Cell Cycle/Checkpoint"
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Antiviral agent 36
Antiviral agent 36 (compound 27), a potent inhibitor of both dengue (DENV) and Zika (ZIKV) viruses, demonstrates replication inhibition with EC50 values of 100Formula:C30H32N4O3Purity:98%Color and Shape:SolidMolecular weight:496.6m-Se3
CAS:m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].Formula:C29H23IN2SePurity:98%Color and Shape:SolidMolecular weight:605.37CDK2-IN-4
CAS:CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A.Formula:C23H18N6O2SPurity:97.24% - 99.10%Color and Shape:SolidMolecular weight:442.49Ref: TM-T14916
1mg87.00€5mg202.00€10mg321.00€25mg550.00€50mg753.00€100mg1,074.00€1mL*10mM (DMSO)240.00€Bersiporocin
CAS:Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.Formula:C15H19Cl2N3OPurity:100% - 98.88%Color and Shape:SolidMolecular weight:328.24ON-013100
CAS:ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Formula:C19H22O7SPurity:98.27%Color and Shape:SolidMolecular weight:394.44Ref: TM-T16391
1mg50.00€5mg74.00€10mg105.00€25mg182.00€50mg283.00€100mg425.00€200mg602.00€1mL*10mM (DMSO)64.00€ICAM-1-IN-1
CAS:ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.Formula:C15H11BrN2O2SPurity:99.34%Color and Shape:SolidMolecular weight:363.23Ref: TM-T13147
1mg185.00€5mg393.00€10mg587.00€25mg935.00€50mg1,264.00€100mg1,700.00€500mg3,410.00€1mL*10mM (DMSO)432.00€CDK2-IN-40
CAS:CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.Formula:C16H21N7O2Color and Shape:SolidMolecular weight:343.384MYCi361
CAS:MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).Formula:C26H16ClF9N2O2Purity:99.52%Color and Shape:SolidMolecular weight:594.86Dimethylenastron
CAS:Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.Formula:C16H18N2O2SPurity:98.07%Color and Shape:SolidMolecular weight:302.39Ref: TM-T3118
1mg35.00€2mg48.00€5mg62.00€10mg87.00€25mg156.00€50mg235.00€100mg354.00€1mL*10mM (DMSO)67.00€Ribociclib succinate
CAS:Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Formula:C27H36N8O5Purity:99.90%Color and Shape:SolidMolecular weight:552.63Ref: TM-T15732
2mg35.00€5mg51.00€10mg73.00€25mg97.00€50mg115.00€100mg168.00€200mg271.00€500mg484.00€1mL*10mM (DMSO)64.00€HAMNO
CAS:HAMNO (NSC-111847) is a protein interaction inhibitor of replication protein A (RPA).Formula:C17H13NO2Purity:99.96%Color and Shape:SolidMolecular weight:263.29BML-259
CAS:BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.Formula:C14H16N2OSPurity:99.68%Color and Shape:SolidMolecular weight:260.35Ref: TM-T36964
5mg50.00€10mg85.00€25mg169.00€50mg279.00€100mg487.00€500mg1,035.00€1mL*10mM (DMSO)52.00€WRN inhibitor 14
WRN inhibitor 14 (compound S35) is an orally administered WRN inhibitor with anticancer properties. It effectively suppresses tumor growth in the SW48 xenograft model in BALB/c nude mice.Formula:C35H40F4N10O5Color and Shape:SolidMolecular weight:756.75Bimosiamose disodium
CAS:Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.Formula:C46H52Na2O16Purity:98%Color and Shape:SolidMolecular weight:906.888-Bromoadenosine
CAS:8-Bromoadenosine is an adenosine derivative. 8-Br-Adenosine inhibitis mitochondrial membrane potential, cytoplasmic Ca²⁺ levels, and RNA and protein synthesis.Formula:C10H12BrN5O4Purity:99.11%Color and Shape:SolidMolecular weight:346.14SEL120-34A
CAS:SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Formula:C15H18Br2N4Purity:100% - 99.7%Color and Shape:SolidMolecular weight:414.14NSAH
CAS:NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-Formula:C18H14N2O3Purity:99.27%Color and Shape:SolidMolecular weight:306.32Ref: TM-T8800
5mg70.00€10mg111.00€25mg216.00€50mg354.00€100mg567.00€500mg1,198.00€1mL*10mM (DMSO)77.00€CDK8-IN-1
CAS:CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).Formula:C11H8F3N3OPurity:97.09%Color and Shape:SolidMolecular weight:255.2Ref: TM-T10740
1mg87.00€5mg216.00€10mg311.00€25mg525.00€50mg707.00€100mg944.00€1mL*10mM (DMSO)240.00€Rifalazil
CAS:Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.Formula:C51H64N4O13Purity:98%Color and Shape:SolidMolecular weight:941.07GTSE1-IN-1
CAS:GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.Formula:C21H24FN7Color and Shape:SolidMolecular weight:393.46
