Ferroptosis
Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides and iron-dependent oxidative stress. Unlike apoptosis, ferroptosis is not driven by caspases but rather by the failure of cellular antioxidant defenses, leading to cell death. Ferroptosis inhibitors and inducers are critical for studying this unique cell death pathway, which is implicated in various diseases, including cancer, neurodegeneration, and ischemia-reperfusion injury. At CymitQuimica, we offer a wide range of high-quality ferroptosis modulators to support your research in cell death mechanisms, oxidative stress, and disease pathology.
Products of "Ferroptosis"
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Anticancer agent 147
CAS:Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROSFormula:C32H40BrN3O2Purity:98%Color and Shape:SolidMolecular weight:578.58BAY 87-2243
CAS:BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).Formula:C26H26F3N7O2Purity:98% - 99.77%Color and Shape:SolidMolecular weight:525.53Lapatinib
CAS:Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.Formula:C29H26ClFN4O4SPurity:99.00% - 99.81%Color and Shape:PowderMolecular weight:581.06JKE-1674
CAS:JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210.Cost-effective and quality-assured.Formula:C20H20Cl2N4O4Purity:97.12% - 98.72%Color and Shape:SolidMolecular weight:451.3Ref: TM-T37314
1mg52.00€5mg111.00€10mg173.00€25mg298.00€50mg464.00€100mg747.00€200mg1,017.00€1mL*10mM (DMSO)124.00€Artesunate
CAS:Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.Formula:C19H28O8Purity:99.53% - 99.91%Color and Shape:White Crystalline PowderMolecular weight:384.42ML-210
CAS:ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor. ML-210 has antitumor activity and induces ferroptosis. Cost-effective and quality-assured.Formula:C22H20Cl2N4O4Purity:96.7% - 99.03%Color and Shape:SolidMolecular weight:475.32Ref: TM-T8375
1mg40.00€2mg52.00€5mg87.00€10mg140.00€25mg246.00€50mg415.00€100mg597.00€200mg847.00€500mg1,254.00€1mL*10mM (DMSO)90.00€2-(10-hydroxydecyl)-6-methoxy-3-methyl-5-(trideuteriomethoxy)cyclohexa-2,5-diene-1,4-dione
CAS:Formula:C19H30O5Purity:98%Color and Shape:SolidMolecular weight:338.4385Ref: IN-DA00396N
1g29.00€5g45.00€15g93.00€1kgTo inquire25g112.00€2kgTo inquire5kgTo inquire100g177.00€Coenzyme Q10
CAS:Coenzyme Q10 (CoQ10) (ubiquinone) is a naturally occurring compound, acting as the electron carrier in the mitochondrial respiratory chain.Formula:C59H90O4Purity:99.62% - 99.88%Color and Shape:DrypowderMolecular weight:863.34Ammonium iron(III) citrate
CAS:Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload and iron death.Formula:C24H32Fe3N3O28Purity:98%Color and Shape:Ferric Ammonium Citrate Is A Yellowish Brown To Red Solid With A Faint Odor Of AmmoniaMolecular weight:978.05Butylhydroxyanisole
CAS:BHA is an antioxidant with two isomers: 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole.Formula:C11H16O2Purity:99.42% - 99.63%Color and Shape:White Solid WaxyMolecular weight:180.25iFSP1
CAS:iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverseFormula:C20H13N5Purity:98.74% - 99.74%Color and Shape:SolidMolecular weight:323.35GPX4-IN-13
CAS:GPX4-IN-13 (compound 16), a GPX4 inhibitor, exhibits anticancer properties by diminishing the expression of GPX4, thereby reducing thyroid cell proliferation and inducing ferroptosis. Additionally, this compound effectively inhibits the growth of three distinct thyroid cancer cell lines: N-thy-ori-3-1 (IC 50 =8.39 μM), MDA-T32 (IC 50 =10.28 μM), and MDA-T41 (IC 50 =8.18 μM).Formula:C23H15NO3Color and Shape:SolidMolecular weight:353.37(-)-Apomorphine hydrochloride hydrate
CAS:(-)-Apomorphine hydrochloride hydrate is a broad-spectrum dopamine agonist and ferroptosis inhibitor.Formula:C17H17NO2HClXH2OColor and Shape:SolidMolecular weight:303.8MMRi62
CAS:MMRi62, a MDM2-MDM4 inhibitor, induces ferroptosis and autophagy in PDAC, degrades FTH1 and mutant p53, and inhibits KRAS/TP53 mutant PDAC in mice.Formula:C21H15Cl2N3OPurity:99.7%Color and Shape:SoildMolecular weight:396.27Ref: TM-T60202
1mg35.00€5mg70.00€10mg104.00€25mg202.00€50mg329.00€100mg525.00€500mg1,121.00€1mL*10mM (DMSO)78.00€Curcumin
CAS:Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity.Formula:C21H20O6Purity:95% - 98.98%Color and Shape:Orange-Yellow Crystal Powder; Gives Brownish-Red Color With Alkali; Light-Yellow Color With Acids Physical Description Orange-Yellow Needles (Ntp 1992)Molecular weight:368.3799Erastin
CAS:View and buy Erastin from TargetMol.Erastin is a ferroptosis activator acting on mitochondrial VDAC.Formula:C30H31ClN4O4Purity:98% - 99.75%Color and Shape:SolidMolecular weight:547.04Matrine
CAS:Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.Formula:C15H24N2OPurity:100% - 97.16%Color and Shape:SolidMolecular weight:248.36Butylated hydroxytoluene
CAS:Butylated hydroxytoluene (BHT FCC/NF) is an organic chemical composed of 4-methylphenol modified with tert-butyl groups at positions 2 and 6.Formula:C15H24OPurity:99.72%Color and Shape:Colourless Solid PowderMolecular weight:220.35UAMC-4821
UAMC-4821 is a ferroptosis inhibitor with an IC50 of 5.2 nM. It effectively scavenges free radicals, inhibits lipid peroxidation, and prevents ML162-induced ferroptosis, providing protective effects on HT-1080 cells. With favorable pharmacokinetic properties in mice, UAMC-4821 presents an oral bioavailability of 63% and demonstrates blood-brain barrier permeability.Formula:C15H19N3OColor and Shape:SolidMolecular weight:257.33Levobupivacaine hydrochloride
CAS:Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.Formula:C18H28N2O·HClPurity:99.74%Color and Shape:White Crystalline PowderMolecular weight:324.89Ferroptocide
CAS:Ferroptocide is a thioredoxin inhibitor that induces iron death in cancer cells and can be used in breast cancer research.Formula:C30H36ClN3O7Color and Shape:SolidMolecular weight:586.08Eugenol
CAS:Eugenol (Allylguaiacol) is a Standardized Chemical Allergen.Formula:C10H12O2Purity:99.72%Color and Shape:Colorless Or Pale Yellow Liquid Pungent Taste (Ntp 1992)Molecular weight:164.2NA-Ir
CAS:NA-Ir is a ferroptosis (Ferroptosis) inducer that targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to stimulate ferritin autophagy (). It also induces the production of reactive oxygen species (ROS) through photodynamic therapy (PDT), depletes glutathione (GSH), and downregulates glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and ferroptosis. NA-Ir exhibits enhanced anticancer activity under light exposure and selectively inhibits cancer cells with high H2S content.Formula:C49H36F6IrN8O4PColor and Shape:SolidMolecular weight:1138.04UAMC-3203
CAS:UAMC-3203 is a potent and selective Ferroptosis inhibitor (IC50: 12 nM).Formula:C25H37N5O2SPurity:100% - 98.81%Color and Shape:SolidMolecular weight:471.66L-BUTHIONINE-(S,R)-SULFOXIMINE
CAS:L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase that induces oxidative stress by depleting GSH.Formula:C8H18N2O3SPurity:97.07% - ≥98%Color and Shape:White Fine PowderMolecular weight:222.31Pseudolaric Acid B
CAS:Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.Formula:C23H28O8Purity:99.19% - 99.68%Color and Shape:SolidMolecular weight:432.46Ferroptosis-IN-16
Ferroptosis-IN-16 (Compound 13l) acts as a specific inhibitor of ferroptosis, demonstrating EC50 values of 0.7 nM in ES-2 cells and 0.9 nM in LX-2 cells. It effectively alleviates acute liver injury induced by Acetaminophen in mouse models and shows excellent metabolic stability in mouse liver microsomes.Formula:C26H23N5OColor and Shape:SolidMolecular weight:421.49Pifithrin-β hydrobromide
CAS:Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis.Formula:C16H17BrN2SPurity:99.24% - 99.74%Color and Shape:SolidMolecular weight:349.29U-73122
CAS:U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.Formula:C29H40N2O3Purity:97.50%Color and Shape:Solid Off-WhiteMolecular weight:464.64Necrostatin-1
CAS:Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity.Formula:C13H13N3OSPurity:100% - 99.81%Color and Shape:SolidMolecular weight:259.33Ref: TM-T1847
5mg35.00€10mg49.00€25mg82.00€50mg113.00€100mg170.00€200mg250.00€500mg419.00€1mL*10mM (DMSO)52.00€Pioglitazone hydrochloride
CAS:Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplasticFormula:C19H20N2O3S·HClPurity:100% - 99.66%Color and Shape:White Crystals Or Crystalline PowderMolecular weight:392.9Setanaxib
CAS:Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.Formula:C21H19ClN4O2Purity:93.468% - 99.66%Color and Shape:SolidMolecular weight:394.85Ref: TM-T6099
1g1,359.00€2mg40.00€5mg60.00€10mg96.00€25mg177.00€50mg319.00€100mg507.00€500mg1,093.00€1mL*10mM (DMSO)66.00€Bardoxolone Methyl
CAS:Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-Formula:C32H43NO4Purity:97.81% - 99.09%Color and Shape:SolidMolecular weight:505.69Ref: TM-T6165
10mg47.00€25mg65.00€50mg88.00€100mg119.00€200mg187.00€500mg424.00€1mL*10mM (DMSO)50.00€Atorvastatin hemicalcium salt
CAS:Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an orally HMG-CoA reductase inhibitor that lowers cholesterol. Cost-effective and quality-assured.Formula:C33H34FN2O5CaPurity:99.27% - 99.89%Color and Shape:White Crystalline PowderMolecular weight:577.67CQ-ER
CQ-ER is a Coumarin-quinazolinone-based photosensitizer targeting the endoplasmic reticulum (ER). It induces ferroptosis, thereby enhancing photodynamic therapy (PDT).Formula:C33H33N7O6SColor and Shape:SolidMolecular weight:655.72Ferroptosis-IN-6
CAS:Ferroptosis-IN-6 is an efficient ferroptosis inhibitor, protecting cells from cell death induced by ferroptosis inducers, and inhibiting STY-BODIPY oxidation.Formula:C15H17NOPurity:99.84%Color and Shape:SolidMolecular weight:227.3Ref: TM-T86417
1mg59.00€5mg127.00€10mg188.00€25mg395.00€50mg635.00€100mg1,017.00€200mg1,359.00€1mL*10mM (DMSO)139.00€(E)-Ferulic acid
CAS:(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression ofFormula:C10H10O4Purity:99.63%Color and Shape:SolidMolecular weight:194.186-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
CAS:Formula:C14H18O4Purity:98%Color and Shape:SolidMolecular weight:250.2903Deferiprone
CAS:Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.Formula:C7H9NO2Purity:99.58% - ≥95%Color and Shape:White NeedlesMolecular weight:139.15α-Vitamin E
CAS:α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.Formula:C29H50O2Purity:98% - 99.89%Color and Shape:Light Yellow LiquidMolecular weight:430.71GPX4-IN-14
GPX4-IN-14 (compound 2c) acts as a GPX4 inhibitor, exhibiting both free radical scavenging activity (with a maximum scavenging rate of 72.52%) and anti-tumor proliferation activity in vitro. This compound targets GPX4 protein, elevating lipid peroxide and intracellular Reactive Oxygen Species (ROS) levels, which induces ferroptosis and contributes to its anti-tumor proliferation effects.Formula:C26H39NO8SeColor and Shape:SolidMolecular weight:572.55Alogliptin
CAS:Alogliptin (SYR-322)(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9Formula:C18H21N5O2Purity:99.63%Color and Shape:SolidMolecular weight:339.39Ref: TM-T6192
2mg35.00€5mg50.00€10mg66.00€25mg89.00€50mg97.00€100mg144.00€200mg207.00€1mL*10mM (DMSO)56.00€Ferroptosis inducer-6
CAS:Ferroptosisinducer 6 (6d) is an inducer of ferroptosis (ferroptosis) that exhibits potent potential for Type I/II photodynamic therapy by inducing ROS production, oxidative stress, and mitochondrial damage. Additionally, it demonstrates antitumor activity.Formula:C69H78F12N12P2RuColor and Shape:SolidMolecular weight:1466.44ML162
CAS:ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces ferroptosis. ML162 has antitumor activity. Cost-effective and quality-assured.Formula:C23H22Cl2N2O3SPurity:98.42% - 99.78%Color and Shape:SolidMolecular weight:477.4TOFA-Plasmalogen
TOFA-Plasmalogen (compound 1), a derivative of glyceraldehyde, exhibits ferroptosis-inducing properties. This compound promotes lipid peroxidation in cell membranes, leading to cytotoxic effects with an inhibition concentration (IC 50 = 32.87 μM).Formula:C33H62NO7PColor and Shape:SolidMolecular weight:615.82Baicalein
CAS:Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor.Formula:C15H10O5Purity:95.79% - 97.25%Color and Shape:Yellow Crystalline SolidMolecular weight:270.24DL-Glutamine
CAS:DL-Glutamine, a non-essential amino acid, is abundant in the body, aids metabolism, carries nitrogen, and fuels cells.Formula:C5H10N2O3Purity:99.89%Color and Shape:White Crystalline Powder White Crystalline PowderMolecular weight:146.14Troglitazone
CAS:Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.Formula:C24H27NO5SPurity:98% - 99.62%Color and Shape:Yellow SolidMolecular weight:441.54Ref: TM-T3170
2mg42.00€5mg62.00€10mg88.00€25mg172.00€50mg305.00€100mg558.00€500mg1,169.00€1mL*10mM (DMSO)85.00€(-)-Epicatechin
CAS:(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localizationFormula:C15H14O6Purity:97.34% - 98.55%Color and Shape:SolidMolecular weight:290.27Eprenetapopt
CAS:Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells.Formula:C10H17NO3Purity:98.75% - 99.57%Color and Shape:SolidMolecular weight:199.25Ref: TM-T4414
5mg73.00€10mg105.00€25mg207.00€50mg368.00€100mg652.00€500mg1,320.00€1mL*10mM (DMSO)81.00€Ferroptosis-IN-1
Ferroptosis-IN-1, a diterpene derived from A.Formula:C22H34O5Purity:98%Color and Shape:SolidMolecular weight:378.5Levobupivacaine
CAS:Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide.Formula:C18H28N2OPurity:99.72%Color and Shape:SolidMolecular weight:288.43Ref: TM-T1787
5mg48.00€10mg63.00€25mg93.00€50mg136.00€100mg188.00€200mg283.00€500mg487.00€1mL*10mM (DMSO)49.00€Coenzyme Q9
CAS:Formula:C54H82O4Purity:>98.0%(HPLC)Color and Shape:Light yellow to Yellow to Orange powder to crystalMolecular weight:795.25PRIMA-1
CAS:PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.Formula:C9H15NO3Purity:99.22%Color and Shape:SolidMolecular weight:185.22Ref: TM-T6954
5mg51.00€10mg73.00€25mg140.00€50mg207.00€100mg368.00€200mg547.00€500mg877.00€1mL*10mM (DMSO)57.00€Baicalein
CAS:Formula:C15H10O5Purity:>98.0%(T)Color and Shape:Light yellow to Amber to Dark green powder to crystalMolecular weight:270.24CAR-2
CAS:CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LD). It exhibits phototoxicity against breast cancer cells with an IC50 of 0.01-0.02 μM and demonstrates antitumor efficacy in a 4T1 xenograft mouse model.Formula:C27H23BF2I2N4O2Color and Shape:SolidMolecular weight:738.114RSL3
CAS:View and buy RSL3 from TargetMol.RSL3 is a VDAC-independent ferroptosis activator.Cited in 10 publications.Formula:C23H21ClN2O5Purity:98% - 99.96%Color and Shape:SolidMolecular weight:440.88Ref: TM-T3646
1g1,359.00€1mg39.00€2mg51.00€5mg79.00€10mg126.00€25mg258.00€50mg349.00€100mg459.00€500mg1,026.00€1mL*10mM (DMSO)74.00€Idebenone
CAS:Formula:C19H30O5Purity:>98.0%(T)(HPLC)Color and Shape:Light yellow to Brown powder to crystalMolecular weight:338.44Lapatinib ditosylate monohydrate
CAS:Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.Formula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPurity:98% - 99.41%Color and Shape:Colourless To Light-Yellow CrystalMolecular weight:943.47Fluvastatin sodium
CAS:Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterolFormula:C24H25FNNaO4Purity:98.54% - 99.46%Color and Shape:Light Yellow Solid PowderMolecular weight:433.45TfR-1-IN-1
CAS:TfR-1-IN-1 is a TfR-1 inhibitor, also a Fe(III) salivary phenol complex, inducing apoptosis and inhibiting tumor and normal cell growth.Formula:C20H12ClF2FeN2O2Purity:96.96%Color and Shape:SolidMolecular weight:441.62Erastin2
CAS:Erastin2 is an iron death inducer that induces cell death by binding to the lipophilic free radical trapping antioxidant ferrostatin-1 or the iron chelator DFO.Formula:C36H35ClN4O4Purity:99.63%Color and Shape:SolidMolecular weight:623.14Ref: TM-T35994
1mg73.00€5mg160.00€10mg250.00€25mg424.00€50mg620.00€100mg800.00€200mg1,074.00€1mL*10mM (DMSO)224.00€GPX4 activator 2
CAS:GPX4 Activator 2 (Compound C3) serves as an activator of GPX4 and exhibits cardioprotective effects by inhibiting cellular iron death (ferroptosis) with an efficacy concentration (EC50) of 7.8 μM. It is used in the study of myocardial damage.Formula:C20H26N6O2SColor and Shape:SolidMolecular weight:414.52Cerivastatin
CAS:Cerivastatin is an HMG-CoA reductase inhibitor with anticancer and lipid-lowering effects and can be used to study primary hyperlipidemia.Formula:C26H34FNO5Purity:98.93% - 99.31%Color and Shape:SolidMolecular weight:459.55Ferroptosis-IN-15
CAS:Ferroptosis-IN-15 (compound 12) serves as an effective inhibitor of ferroptosis, exhibiting EC50 values of 0.76 μM and 0.67 μM in A375 cells and 786-O cells, respectively. It acts as a potential iron chelator and radical-scavenging antioxidant.Formula:C17H14O5Color and Shape:SolidMolecular weight:298.29Acetylcysteine
CAS:Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent.Formula:C5H9NO3SPurity:100% - 99.95%Color and Shape:Crystals From Water SolidMolecular weight:163.19
