Ferroptosis
Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides and iron-dependent oxidative stress. Unlike apoptosis, ferroptosis is not driven by caspases but rather by the failure of cellular antioxidant defenses, leading to cell death. Ferroptosis inhibitors and inducers are critical for studying this unique cell death pathway, which is implicated in various diseases, including cancer, neurodegeneration, and ischemia-reperfusion injury. At CymitQuimica, we offer a wide range of high-quality ferroptosis modulators to support your research in cell death mechanisms, oxidative stress, and disease pathology.
Products of "Ferroptosis"
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L-Glutathione reduced
CAS:L-Glutathione reduced (Glutathione) is a naturally occurring tripeptide found in cells as an endogenous antioxidant that scavenges oxygen free radicals.Formula:C10H17N3O6SPurity:97.37% - 99.97%Color and Shape:SolidMolecular weight:307.32Tagitinin C
CAS:Tagitinin C is a sesquiterpene compound isolated from Tithonia diversifolia, an inducer of ferroptosis with anti-cancer activity.Formula:C19H24O6Color and Shape:SolidMolecular weight:348.39TBHQ
CAS:TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Formula:C10H14O2Purity:99.17% - 99.53%Color and Shape:White Solid PowderMolecular weight:166.22Cycloheximide
CAS:Cycloheximide (Naramycin A) is an antimitotic compound and an inhibitor of DNA and protein synthesis.Formula:C15H23NO4Purity:95.08% - 99.95%Color and Shape:SolidMolecular weight:281.35L-Glutamic Acid
CAS:Formula:C5H9NO4Purity:>99.0%(T)Color and Shape:White powder to crystalMolecular weight:147.13Ferroptosis-IN-3
Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM).Purity:98%Color and Shape:Odour SolidTrigonelline
CAS:Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.Formula:C7H7NO2Purity:98% - 99.49%Color and Shape:Prisms Aqueous From Alcohol + Water SolidMolecular weight:137.14GDCNF-11
CAS:GDCNF-11, an HSP90-based HIM-PROTACGPX4 degrader, facilitates the ubiquitination and degradation of GPX4 through the HSP90 chaperone complex. This reduction in endogenous GPX4 induces ferroptosis in HT-1080 cells, with a DC50 value of 0.08 μM.Formula:C48H53Cl2N13O5SColor and Shape:SolidMolecular weight:994.99CDDO-Im
CAS:CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).Formula:C34H43N3O3Purity:100% - 98.3%Color and Shape:SolidMolecular weight:541.72Ref: TM-TQ0120
1mg37.00€5mg79.00€10mg111.00€25mg210.00€50mg338.00€100mg512.00€500mg1,093.00€1mL*10mM (DMSO)94.00€Rosiglitazone
CAS:Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity.Formula:C18H19N3O3SPurity:98.61% - 99.87%Color and Shape:White To Off-White Crystalline PowderMolecular weight:357.43Gallic acid
CAS:Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.Formula:C7H6O5Purity:99.57%Color and Shape:White Solid Solid Particulate/PowderMolecular weight:170.12Ciclopirox
CAS:Ciclopirox is an antifungal that chelates Fe3+ and Al3+, inhibiting enzymes and has antibacterial and anti-inflammatory effects.Formula:C12H17NO2Purity:97.72% - 99.41%Color and Shape:SolidMolecular weight:207.27FA16
FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16Formula:C22H27F3N4O2SPurity:99.75%Color and Shape:SolidMolecular weight:468.54Bay 11-7085
CAS:Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).Formula:C13H15NO2SPurity:99.76% - 99.83%Color and Shape:White SolidMolecular weight:249.33Ref: TM-T1934
2mg35.00€5mg50.00€10mg66.00€25mg85.00€50mg124.00€100mg197.00€200mg255.00€1mL*10mM (DMSO)62.00€Piperlongumine
CAS:Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.Formula:C17H19NO5Purity:97.03% - 99.89%Color and Shape:SolidMolecular weight:317.34Vamifeport
CAS:Vamifeport (VIT-2763), an inhibitor targeting iron transport proteins, improves anemia and erythropoiesis and can be studied β-thalassemiaFormula:C21H21FN6O2Purity:99.26%Color and Shape:SolidMolecular weight:408.43Ref: TM-T39520
1mg115.00€5mg274.00€10mg432.00€25mg730.00€50mg1,026.00€100mg1,378.00€1mL*10mM (DMSO)303.00€(-)-Epigallocatechin Gallate
CAS:(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase.Formula:C22H18O11Purity:98.08% - 99.43%Color and Shape:Yellow PowderMolecular weight:458.37NADPH tetrasodium salt
CAS:NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety ofFormula:C21H26N7Na4O17P3Purity:100% - 99.65%Color and Shape:SolidMolecular weight:833.35CP-24879 hydrochloride
CAS:CP-24879 HCl, a Δ5D/Δ6D dual-inhibitor, reduces liver lipid buildup and inflammation.Formula:C11H18ClNOPurity:98.78%Color and Shape:SolidMolecular weight:215.72Ref: TM-T27061
1mg49.00€5mg92.00€10mg145.00€25mg274.00€50mg472.00€100mg687.00€500mg1,444.00€1mL*10mM (DMSO)96.00€GPX4-IN-7
GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment.Formula:C25H23ClN4O4Purity:98%Color and Shape:SolidMolecular weight:478.93SRS11-92
CAS:SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1Formula:C22H28N2O2Purity:98.58%Color and Shape:SolidMolecular weight:352.47Ref: TM-T8922
1mg46.00€5mg80.00€10mg116.00€25mg227.00€50mg359.00€100mg550.00€500mg1,159.00€1mL*10mM (DMSO)105.00€FSEN1
CAS:FSEN1 is a novel and highly effective non-competitive FSP1 inhibitor with an IC50 value of 313 nM.Formula:C22H22BrN5OSPurity:98.56%Color and Shape:SolidMolecular weight:484.41Pro-GA
CAS:Pro-GA is a γ-glutamyl cyclotransferase (GGCT) inhibitor with cell permeability, acting as a diester prodrug with anticancer properties. GGCT is a key enzyme in glutathione metabolism and is involved in the ferroptosis pathway. Pro-GA exhibits an IC50 value of 57 μM against the bladder cancer cell line T24, making it useful for cancer research.Formula:C12H19NO7Color and Shape:SolidMolecular weight:289.28NYY-6a
NYY-6a is a ferroptosis (Ferroptosis) inhibitor, demonstrating significant suppression of RSL3-induced ferroptosis in 786-O and HT-1080 cells, with EC50 values of 52 nM and 50 nM, respectively. As a radical-trapping antioxidant (RTA), NYY-6a effectively reduces lipid peroxidation, comparable to ferrostatin-1 and liproxstatin-1, making it useful for research into ferroptosis-related pathologies.Formula:C23H22N2O3Color and Shape:SolidMolecular weight:374.43DL-Buthionine-(S,R)-sulfoximine
CAS:DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.Formula:C8H18N2O3SPurity:98% - 98.32%Color and Shape:White Fine PowderMolecular weight:222.31Rosiglitazone maleate
CAS:Rosiglitazone maleate (BRL 49653) is an oral antidiabetic and potential anticancer agent.Formula:C22H23N3O7SPurity:99.33% - 99.51%Color and Shape:Off-White SolidMolecular weight:473.5Zileuton
CAS:Zileuton (A 64077) inhibits 5-lipoxygenase, reduces leukotrienes, aids bronchodilation, lessens mucus/edema, and helps manage asthma symptoms.Formula:C11H12N2O2SPurity:98.72% - 99.43%Color and Shape:Crystalline SolidMolecular weight:236.29Pravastatin sodium
CAS:Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.Formula:C23H35NaO7Purity:97.14%Color and Shape:White Crystalline PowderMolecular weight:446.52Nordihydroguaiaretic acid
CAS:Nordihydroguaiaretic acid (NDGA) is a natural lipoxygenase (5-LOX) inhibitor. Nordihydroguaiaretic acid has antioxidant effect. Cost-effective and quality-assured.Formula:C18H22O4Purity:97.82% - 99.91%Color and Shape:SolidMolecular weight:302.36Hemin
CAS:Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer.Formula:C34H32ClFeN4O4Purity:98.29% - 99.59%Color and Shape:Dark Purple Crystalline PowderMolecular weight:651.94Photosensitizer-5
Photosensitizer-5, a photodynamic agent, exhibits cytotoxicity towards HeLa and HepG2 cells, with IC50 values of 10.4 nM and 6.9 nM, respectively. It induces cell death through lipid peroxidation via an iron-independent ferroptosis pathway. Additionally, Photosensitizer-5 displays antitumor activity in HeLa-tumor-bearing mice.Formula:C35H26BF2IN4O2Color and Shape:SolidMolecular weight:710.32Ferrostatin-1
CAS:Formula:C15H22N2O2Purity:>98.0%(HPLC)Color and Shape:White to Amber to Dark purple powder to crystalMolecular weight:262.35Roxadustat
CAS:Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.Formula:C19H16N2O5Purity:99% - 99.82%Color and Shape:SolidMolecular weight:352.34CIL56
CAS:CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS).Formula:C23H27N3O5S2Purity:99.46% - 99.91%Color and Shape:SolidMolecular weight:489.61Ref: TM-T4309
1mg37.00€2mg52.00€5mg79.00€10mg115.00€25mg188.00€50mg299.00€100mg459.00€1mL*10mM (DMSO)86.00€Cetzole
CAS:Cetzole (Compound 1) acts as an inducer of ferroptosis (iron-dependent cell death) through the accumulation of ROS, leading to cell death. The compound exhibits varying half-maximal cytotoxic concentrations (CC50) against several cell lines: 2.56 μM in NCI-H522, 10.31 μM in NCI-H522 GFP-SCL7A11 #8, 2.71 μM in NCI-H522 RV-GFP, 3.07 μM in HT-1080, 14.9 μM in NARF2, and 6.28 μM in MDA-MB-231. This highlights Cetzole's potential for research in cancer therapeutics.Formula:C11H11NOSColor and Shape:SolidMolecular weight:205.28Dopamine hydrochloride
CAS:Dopamine hydrochloride (ASL279) is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine andFormula:C8H12ClNO2Purity:99.56% - 99.76%Color and Shape:SolidMolecular weight:189.639Arteannuin B
CAS:1. Arteannuin B has potent antimalarial activity.Formula:C15H20O3Purity:98% - 99.8%Color and Shape:SolidMolecular weight:248.32L-Cystine
CAS:L-Cystine (Cystine Acid) is not considered one of the 20 amino acids, L-Cystine (Cystine Acid) is a sulfur-containing derivative obtained from oxidation ofFormula:C6H12N2O4S2Purity:99.59% - 99.85%Color and Shape:White Solid PowderMolecular weight:240.3Sorafenib
CAS:Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57Formula:C21H16ClF3N4O3Purity:98% - 99.89%Color and Shape:SolidMolecular weight:464.82Sulfasalazine
CAS:Formula:C18H14N4O5SPurity:98%Color and Shape:SolidMolecular weight:398.3925599999999ZX782
ZX782 acts as a GPX4 protein degrader and an inducer of ferroptosis (Ferroptosis), targeting GPX4 for destruction via both the ubiquitin-proteasome system and the autophagy-lysosome pathway. Following the degradation of GPX4 induced by ZX782, there is a significant increase in the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells.Formula:C39H48ClN5O8Color and Shape:SolidMolecular weight:750.28Linagliptin
CAS:Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.Formula:C25H28N8O2Purity:99.15% - 99.95%Color and Shape:SolidMolecular weight:472.54Simvastatin
CAS:Formula:C25H38O5Purity:>97.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:418.57Artemisinin
CAS:Artemisinin (Qinghaosu) is a natural sesquiterpene lactone. Artemisinin has anti-malarial, neuroprotective and anti-tumor effects. Cost-effective and quality-assured.Formula:C15H22O5Purity:100% - 99.87%Color and Shape:Crystalline SolidMolecular weight:282.33Vildagliptin
CAS:Vildagliptin (LAF237), an oral DPP-4 inhibitor with hypoglycemic effects, is metabolized and excreted in urine.Formula:C17H25N3O2Purity:100% - 99.03%Color and Shape:White Crystalline PowderMolecular weight:303.4Gallic Acid Monohydrate
CAS:Gallic Acid Monohydrate, a natural polyhydroxyphenol, which inhibits the free radical scavenging effect of COX-2,antioxidant, anti-tumor, and antibacterial.Formula:C7H8O6Purity:98.02%Color and Shape:SolidMolecular weight:188.14Pioglitazone
CAS:Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes.Formula:C19H20N2O3SPurity:95% - 99.57%Color and Shape:White PowderMolecular weight:356.44D-glutamine
CAS:D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.Formula:C5H10N2O3Purity:99.99%Color and Shape:White Or Off-White PowderMolecular weight:146.14WITHAFERIN A
CAS:WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/Formula:C28H38O6Purity:97.41% - 99.83%Color and Shape:SolidMolecular weight:470.6Ref: TM-T5687
1mg85.00€5mg265.00€10mg393.00€25mg653.00€50mg929.00€100mg1,254.00€500mg2,517.00€1mL*10mM (DMSO)304.00€Ebselen
CAS:Formula:C13H9NOSePurity:>98.0%(GC)Color and Shape:Light orange to Yellow to Green powder to crystalMolecular weight:274.18
