Ferroptosis
Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides and iron-dependent oxidative stress. Unlike apoptosis, ferroptosis is not driven by caspases but rather by the failure of cellular antioxidant defenses, leading to cell death. Ferroptosis inhibitors and inducers are critical for studying this unique cell death pathway, which is implicated in various diseases, including cancer, neurodegeneration, and ischemia-reperfusion injury. At CymitQuimica, we offer a wide range of high-quality ferroptosis modulators to support your research in cell death mechanisms, oxidative stress, and disease pathology.
Products of "Ferroptosis"
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DihydroarteMisinic acid
CAS:DihydroarteMisinic acid (Dihydro-Artmisinic Acid) is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinalFormula:C15H24O2Purity:99.06% - 99.17%Color and Shape:SolidMolecular weight:236.3584-B10
CAS:84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.Formula:C25H22F3NO5Purity:99.76%Color and Shape:SolidMolecular weight:473.44Ref: TM-T75268
1mg52.00€5mg97.00€10mg169.00€25mg321.00€50mg494.00€100mg742.00€200mg1,008.00€1mL*10mM (DMSO)105.00€BODIPY 581/591 C11
CAS:BODIPY 581/591 C11 is a fluorescent radioactive probe used to indicate lipid peroxidation and antioxidant efficacy in model membrane systems and living cells.Formula:C30H35BF2N2O2Purity:98.83% - 98.90%Color and Shape:SolidMolecular weight:504.42L-Glutamic acid monosodium salt
CAS:L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.Formula:C5H8NO4·NaPurity:99.93%Color and Shape:White Solid CrystallineMolecular weight:169.11Ferrostatin-1
CAS:View and buy Ferrostatin-1 from TargetMol.Ferrostatin-1 is a potent ferroptosis inhibitor (EC50: 60 nM).Cited in 49 publications.Formula:C15H22N2O2Purity:96.1% - 99.68%Color and Shape:SolidMolecular weight:262.35Simvastatin
CAS:Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity.Formula:C25H38O5Purity:98.54% - 99.13%Color and Shape:SolidMolecular weight:418.57Ref: TM-T0687
10mg43.00€25mg58.00€50mg69.00€100mg106.00€200mg140.00€500mg270.00€1mL*10mM (DMSO)47.00€PRLX-93936 HCL
CAS:PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.Formula:C21H26Cl2N4O2Purity:100% - 99.78%Color and Shape:SolidMolecular weight:437.37Sorafenib tosylate
CAS:Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).Formula:C21H16ClF3N4O3·C7H8O3SPurity:99.2% - 99.94%Color and Shape:White To Off-White Crystalline PowderMolecular weight:637.03Piperazine Erastin
CAS:Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.Formula:C35H41ClN6O4Purity:97.74%Color and Shape:SolidMolecular weight:645.19Ref: TM-T16540
1mg96.00€5mg168.00€10mg283.00€25mg567.00€50mg929.00€100mg1,225.00€200mg1,681.00€500mg2,498.00€1mL*10mM (DMSO)240.00€Liproxstatin-1
CAS:Liproxstatin-1 is a potent and selective inhibitor of iron death (IC50=22 nM).Formula:C19H21ClN4Purity:97.11% - 99.9%Color and Shape:SolidMolecular weight:340.85Ref: TM-T2376
2mg52.00€5mg88.00€10mg137.00€25mg255.00€50mg411.00€100mg522.00€200mg750.00€1mL*10mM (DMSO)88.00€ML385
CAS:ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity.Formula:C29H25N3O4SPurity:100% - 99.98%Color and Shape:SolidMolecular weight:511.59Ref: TM-T4360
5mg51.00€10mg79.00€25mg153.00€50mg243.00€100mg376.00€200mg562.00€500mg899.00€1mL*10mM (DMSO)59.00€Cerivastatin sodium
CAS:Cerivastatin sodium (BAY W 6228 sodium) is an HMG-CoA reductase inhibitor with lipid-lowering activity that reduces LDL cholesterol levels.Formula:C26H33FNNaO5Purity:98%Color and Shape:SolidMolecular weight:481.53Ref: TM-T10767
1mg52.00€5mg136.00€10mg235.00€25mg565.00€50mg1,045.00€100mg1,890.00€1mL*10mM (DMSO)612.00€Dp44mT
CAS:Dp44mT, a effective iron chelator, has selective antitumor activity.Formula:C14H15N5SPurity:100% - 98.68%Color and Shape:SolidMolecular weight:285.37FINO2
CAS:FINO2, a strong ferroptosis trigger, blocks GPX4, oxidizes Fe2+, stable in different pH, causes lipid peroxidation.Formula:C15H28O3Purity:97.27%Color and Shape:SoildMolecular weight:256.38Imidazole ketone erastin
CAS:View and buy Imidazole ketone erastin from TargetMol.Imidazole ketone erastin (IKE) is an inducer of ferroptosis. It has inhibition of the system Xc- cystine/glutamate transporter.Cited in 22 publications.Formula:C35H35ClN6O5Purity:98.98% - 99.87%Color and Shape:SolidMolecular weight:655.14Ref: TM-T5523
1mg78.00€2mg97.00€5mg169.00€10mg216.00€25mg373.00€50mg567.00€100mg747.00€1mL*10mM (DMSO)182.00€Chrysosplenetin
CAS:Chrysosplenetin is a metabolic inhibitor of artemisinin.Formula:C19H18O8Purity:97.43% - 98.53%Color and Shape:SolidMolecular weight:374.34Ref: TM-TJS1159
1mg60.00€5mg127.00€10mg188.00€25mg348.00€50mg512.00€100mg730.00€500mg1,483.00€1mL*10mM (DMSO)226.00€Ethylenediaminetetraacetic acid trisodium salt
CAS:Ethylenediaminetetraacetic acid trisodium salt (EDTA Trisodium) used to bind metal ions in the chelation therapy.Formula:C10H13N2Na3O8Purity:99.92% - 99.96%Color and Shape:White CrystalsMolecular weight:358.19Ciclopirox olamine
CAS:Ciclopirox olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities.Formula:C14H24N2O3Purity:100% - 99.16%Color and Shape:White To Yellow Solid Solid Particulate/PowderMolecular weight:268.35Alogliptin Benzoate
CAS:Alogliptin Benzoate, a potent DPP-4 inhibitor with >10,000-fold selectivity over DPP-8/9, may also curb TLR-4-induced inflammation.Formula:C25H27N5O4Purity:100% - 99.94%Color and Shape:White PowderMolecular weight:461.51Ferrostatin-1 diyne
CAS:Ferrostatin-1 diyne (Fer-1 diyne) (compound 2) serves as an inhibitor of ferroptosis, accumulating in cellular lysosomes, mitochondria, and the endoplasmic reticulum. It notably inhibits ferroptosis independently of lysosomal and mitochondrial activity.Formula:C18H22N2O2Color and Shape:SolidMolecular weight:298.38Brusatol
CAS:Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.Formula:C26H32O11Purity:99.35% - 99.82%Color and Shape:SolidMolecular weight:520.53Ref: TM-TQ0211
1mg39.00€5mg94.00€10mg160.00€25mg311.00€50mg502.00€100mg715.00€200mg938.00€1mL*10mM (DMSO)107.00€BCP-T.A
CAS:BCP-T.A is an iron death inducer that acts by binding to GPX4.Formula:C23H19Cl2N3OSPurity:99.49%Color and Shape:SolidMolecular weight:456.39L-Glutamine
CAS:L-Glutamine (L-Glutamic acid 5-amide) , a non-essential amino acid, is synthesized from glutamic acid and ammonia.Formula:C5H10N2O3Purity:99.66% - 99.98%Color and Shape:Solid CrystallineMolecular weight:146.14Erastin
CAS:Formula:C30H31ClN4O4Purity:>98.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:547.056-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid
CAS:Formula:C14H18O4Purity:>98.0%(GC)(T)Color and Shape:White to Orange to Green powder to crystalineMolecular weight:250.29Sulfasalazine
CAS:Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative. Sulfasalazine induces ferroptosis and inhibits NF-κB. Cost effective and quality assured.Formula:C18H14N4O5SPurity:98.00% - 99.28%Color and Shape:Minute Brownish-Yellow CrystalsMolecular weight:398.39Sulfasalazine
CAS:Formula:C18H14N4O5SPurity:>95.0%(T)(HPLC)Color and Shape:Light yellow to Amber to Dark green powder to crystalMolecular weight:398.39Ferroptosis inducer-4
Ferroptosisinducer-4 (Compound 5) is a phospholipid-based ferroptosis inducer featuring a terminal double bond at the sn-2 position. It exhibits significant cytotoxicity towards HT-1080 cells with an IC50 value of 18 μM. The toxicity mechanism involves the generation of lipid peroxides and oxidative damage to the cell membrane induced by the terminal double bond. Ferroptosisinducer-4 can be utilized in studies pertaining to the regulation of ferroptosis.Formula:C33H64NO7PColor and Shape:SolidMolecular weight:617.84L-Glutamic acid
CAS:L-Glutamic acid (Glutaminol) acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.Formula:C5H9NO4Purity:99.14% - 99.55%Color and Shape:White Solid CrystallineMolecular weight:147.13Siramesine hydrochloride
CAS:Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibitFormula:C30H32ClFN2OPurity:100% - 99.75%Color and Shape:SolidMolecular weight:491.04Ref: TM-T1885
1mg60.00€2mg88.00€5mg111.00€10mg173.00€25mg354.00€50mg528.00€100mg743.00€1mL*10mM (DMSO)120.00€Lapatinib Ditosylate
CAS:Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).Formula:C29H26ClFN4O4S·2C7H8O3SPurity:99.41%Color and Shape:Yellow SolidMolecular weight:925.46PD146176
CAS:PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.Formula:C15H11NSPurity:98.00%Color and Shape:SolidMolecular weight:237.32Lovastatin
CAS:Lovastatin (MK-803) is an HMG-CoA reductase inhibitor. Lovastatin lowers cholesterol and is used as a lipid-lowering agent. Cost-effective and quality-assured.Formula:C24H36O5Purity:99.59% - 99.72%Color and Shape:The Substance Is A White-Yellowish To Yellow Powder Solid PowderMolecular weight:404.54Cisplatin
CAS:Cisplatin (CDDP) is a DNA cross-linking agent.Formula:Cl2H6N2PtPurity:97.13% - 99.63%Color and Shape:Orange-Yellow To Deep Yellow Solid Or PowderMolecular weight:300.04SP600125
CAS:SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitiveFormula:C14H8N2OPurity:97.63% - 99.58%Color and Shape:SolidMolecular weight:220.23Coenzyme Q10
CAS:Formula:C59H90O4Purity:>98.0%(HPLC)Color and Shape:Light yellow to Yellow to Orange powder to crystalMolecular weight:863.37Trolox
CAS:Trolox is a vitamin E analogue, used in reducing oxidative stress or damage.Formula:C14H18O4Purity:98.84% - 99.80%Color and Shape:White To Fainly Beige Crystalline PowderMolecular weight:250.29Ferroptosis-IN-12
Ferroptosis-IN-12 (Cpd-A1) is an inhibitor of ferroptosis. It effectively suppresses ferroptosis in mouse renal tubular epithelial cells (mTECs) treated with Erastin and improves renal function in dose-dependent manners in mouse models of acute kidney injury (AKI) induced by ischemia/reperfusion (I/R) or cecal ligation and puncture (CLP). This compound also reduces renal tubular damage and eliminates inflammation. Exhibiting good plasma stability and high distribution in renal tissues during pharmacokinetic studies in mice, Ferroptosis-IN-12 shows promising potential for research in the field of AKI.Color and Shape:Odour SolidHDAC-IN-77
HDAC-IN-77 (HL-5s), an HDAC inhibitor, has the capability to induce ferroptosis and suppress the Nrf2/HO-1 signaling pathway. This compound is utilized in cancer research.Formula:C22H26N4O2SColor and Shape:SolidMolecular weight:410.53Rosiglitazone hydrochloride
CAS:Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.Formula:C18H19N3O3S·HClPurity:99.63% - 99.79%Color and Shape:SolidMolecular weight:393.89NADPH tetracyclohexanamine
CAS:NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.Formula:C45H82N11O17P3Purity:98.73% - 99.05%Color and Shape:SolidMolecular weight:1142.12Pifithrin-α hydrobromide
CAS:Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.Formula:C16H18N2OS·HBrPurity:100% - 98.54%Color and Shape:SolidMolecular weight:367.3DL-α-Tocopherol
CAS:DL-alpha-Tocopherol (Ephanyl) is a synthetic vitamin E that protects skin fibroblasts from the cytotoxic effects of UV light and has antioxidant properties.Formula:C29H50O2Purity:99.60%Color and Shape:Light Yellow Liquid ViscousMolecular weight:430.71SRS16-86
CAS:SRS16-86 is a novel third-generation ferrostatin, is an inhibitor of ferroptosis.Formula:C26H32N4O2Purity:99.85%Color and Shape:SolidMolecular weight:432.56Ref: TM-T9073
1mg37.00€2mg52.00€5mg77.00€10mg114.00€25mg215.00€50mg324.00€100mg484.00€1mL*10mM (DMSO)94.00€CuATSP
CAS:CuATSP is a potent free radical trapping antioxidant (RTA) and ferroptosis inhibitor inhibit lipid peroxidation, for (ALS) and Parkinson's disease.Formula:C18H18CuN6S2Purity:97.09%Color and Shape:SolidMolecular weight:446.05UAMC-3203 hydrochloride
CAS:UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.Formula:C25H38ClN5O2SPurity:99.62%Color and Shape:SolidMolecular weight:508.12Ref: TM-T8662
2mg49.00€5mg79.00€10mg111.00€25mg170.00€50mg202.00€100mg283.00€200mg420.00€1mL*10mM (DMSO)88.00€Deferasirox
CAS:Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.Formula:C21H15N3O4Purity:98.79% - 99.4%Color and Shape:SolidMolecular weight:373.36Lepadin H
CAS:Lepadin H, a marine alkaloid and ferroptosis inducer, exhibits significant cytotoxicity by promoting p53 expression, escalating ROS production, and enhancingFormula:C26H45NO3Purity:98%Color and Shape:SolidMolecular weight:419.64FIN56
CAS:FIN56 is a specific inducer of ferroptosis.Formula:C25H31N3O5S2Purity:98.39% - 99.78%Color and Shape:SolidMolecular weight:517.66
