CDK
CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.
Products of "CDK"
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AM5992
CAS:AM5992 (example 195) is a potent CDK4 and CDK6 inhibitor (CDK4, IC50= 0.013 μM). AM5992 can be used for the research of CDK4-mediated disorders.Formula:C27H33FN8OPurity:98%Color and Shape:SoildMolecular weight:504.6P18IN011
CAS:P18IN011 (P18IN011 - CAS 77408-67-4 - Calbiochem) is a novel inhibitor of p18(INK4C).Formula:C15H12N2O5SPurity:97.63%Color and Shape:SolidMolecular weight:332.33Ref: TM-T8576
1mg88.00€5mg170.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)178.00€LDC000067
CAS:LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.Formula:C18H18N4O3SPurity:98.08% - 99.07%Color and Shape:SolidMolecular weight:370.43Cucurbitacin E
CAS:Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Formula:C32H44O8Purity:98.88% - 99.19%Color and Shape:SolidMolecular weight:556.69Ref: TM-T5S1467
1mg59.00€5mg115.00€10mg177.00€25mg300.00€50mg445.00€100mg643.00€1mL*10mM (DMSO)140.00€Riviciclib hydrochloride
CAS:Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3.Formula:C21H20ClNO5·HClPurity:99.36%Color and Shape:SolidMolecular weight:438.3XPW1
CAS:XPW1 is a CDK9 inhibitor with antitumor activity, inhibits DNA repair procedures, and can be used for the research of clear cell renal cell carcinoma.Formula:C36H39ClFN7O2Purity:98.08%Color and Shape:SoildMolecular weight:656.19SU9516
CAS:SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.Formula:C13H11N3O2Purity:100% - 99.68%Color and Shape:SolidMolecular weight:241.25Ref: TM-T6167
1mg35.00€2mg50.00€5mg73.00€10mg103.00€25mg208.00€50mg376.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)74.00€MC180295
CAS:MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.Formula:C17H18N4O3SPurity:99.84%Color and Shape:SolidMolecular weight:358.41Ref: TM-T5533
1mg56.00€5mg131.00€10mg187.00€25mg319.00€50mg449.00€100mg638.00€200mg842.00€1mL*10mM (DMSO)143.00€BS-181 hydrochloride
CAS:BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.Formula:C22H32N6·HClPurity:99.21%Color and Shape:SolidMolecular weight:416.99Ref: TM-T6162
1mg37.00€2mg52.00€5mg79.00€10mg126.00€25mg274.00€50mg454.00€100mg655.00€1mL*10mM (DMSO)87.00€CDK-IN-15
CAS:CDK-IN-15 (Compound 456) is an effective inhibitor of Cyclin A, exhibiting an IC50 value of 0.14 μM.Formula:C45H63Cl2F4N7O8Color and Shape:SolidMolecular weight:976.92CDK9-IN-2
CAS:CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Formula:C23H25ClFN5Purity:99%Color and Shape:SolidMolecular weight:425.93Ref: TM-T14918
1mg88.00€5mg187.00€10mg281.00€25mg487.00€50mg705.00€100mg998.00€1mL*10mM (DMSO)207.00€AG-024322
CAS:AG-024322 is a pan-CDK inhibitor with antitumor activity, induces apoptosis, and can be used in the study of metabolic diseases.Formula:C23H20F2N6Purity:98.53%Color and Shape:SolidMolecular weight:418.44TG003
CAS:TG003 is a Clk1/Sty inhibitor that inhibits Clk1 and Clk4, suppresses cancer cell growth, and induces apoptosis.Formula:C13H15NO2SPurity:99.46%Color and Shape:SolidMolecular weight:249.33Ref: TM-T60367
1mg50.00€5mg97.00€10mg159.00€25mg281.00€50mg465.00€100mg558.00€200mg810.00€1mL*10mM (DMSO)170.00€Avotaciclib hydrochloride
Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, includingFormula:C13H12ClN7OPurity:98%Color and Shape:SolidMolecular weight:317.73CDK9-IN-29
CAS:CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.Formula:C29H33F2N5O4Purity:98%Color and Shape:SolidMolecular weight:553.69-Isopropylolomoucine
CAS:9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.Formula:C17H22N6OPurity:100%Color and Shape:SolidMolecular weight:326.4Ref: TM-T23589
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€1mL*10mM (DMSO)642.00€CAN508
CAS:CAN508: potent CDK9/T1 inhibitor; IC50 0.35 μM, Cdk2/E; Ki 13.3 μM, IC50 20 μM; 38x selective; antitumor.Formula:C9H10N6OPurity:98.65%Color and Shape:SolidMolecular weight:218.22CDK9 ligand 3
CAS:CDK9ligand 3 is a ligand for CDK9 and can be utilized in the synthesis of PROTAC degraders, specifically PROTAC CDK9degrader-11.Formula:C18H18BrCl2N5O3Color and Shape:SolidMolecular weight:503.177SR-4835
CAS:SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (Formula:C21H20Cl2N10OPurity:100% - 98.87%Color and Shape:SolidMolecular weight:499.36Ref: TM-T8325
1mg56.00€2mg81.00€5mg119.00€10mg188.00€25mg389.00€50mg565.00€100mg822.00€500mg1,681.00€AT7519
CAS:AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.Formula:C16H17Cl2N5O2Purity:98.88% - 99.65%Color and Shape:SolidMolecular weight:382.24
