PLK
PLK (Polo-like Kinase) inhibitors target PLKs, a family of serine/threonine kinases that are essential for various stages of cell division, including mitotic entry, spindle assembly, and cytokinesis. PLKs are critical for the proper execution of the cell cycle, and their dysregulation is often associated with cancer. Inhibiting PLKs can induce cell cycle arrest and apoptosis in cancer cells, making these inhibitors important tools in cancer research and therapy. At CymitQuimica, we offer a range of high-quality PLK inhibitors to support your research in mitosis, cell cycle control, and oncology.
Products of "PLK"
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(1E)-CFI-400437 dihydrochloride
CAS:(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.Formula:C29H30Cl2N6O2Purity:98.36%Color and Shape:SolidMolecular weight:565.5Centrinone
CAS:Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).Formula:C26H25F2N7O6S2Purity:98.76%Color and Shape:SolidMolecular weight:633.65HMN-214
CAS:HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.Formula:C22H20N2O5SPurity:100% - 98.63%Color and Shape:SolidMolecular weight:424.47Ref: TM-T2438
1mg40.00€2mg52.00€5mg85.00€10mg124.00€25mg219.00€50mg350.00€100mg505.00€500mg1,121.00€1mL*10mM (DMSO)92.00€Ocifisertib(CFI-400945 free base)
CAS:Ocifisertib (CFI-400945 free base) is a potent, selective and orally active inhibitor of polo-like kinase 4.Cost-effective and quality-assured.Formula:C33H34N4O3Purity:97.56% - 98.53%Color and Shape:SolidMolecular weight:534.65TAK-960
CAS:TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.Formula:C27H34F3N7O3Purity:97.06%Color and Shape:SolidMolecular weight:561.6Ref: TM-T7200
1mg64.00€2mg89.00€5mg120.00€10mg170.00€25mg294.00€50mg490.00€100mg710.00€1mL*10mM (DMSO)170.00€(E/Z)-Rigosertib sodium
CAS:ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay).Formula:C21H24NNaO8SPurity:97.16% - 99.82%Color and Shape:SolidMolecular weight:473.473MB-PP1
CAS:3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.Formula:C17H21N5Purity:99.97%Color and Shape:White SolidMolecular weight:295.38Ref: TM-T21678
5mg52.00€10mg96.00€25mg170.00€50mg269.00€100mg394.00€500mgTo inquire1mL*10mM (DMSO)58.00€GSK461364
CAS:GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.Formula:C27H28F3N5O2SPurity:98.85% - 99.5%Color and Shape:SolidMolecular weight:543.6Ref: TM-T6282
1mg37.00€2mg52.00€5mg74.00€10mg124.00€25mg207.00€50mg374.00€100mg557.00€200mg797.00€500mg1,216.00€Centrinone-B
CAS:Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.Formula:C27H27F2N7O5S2Purity:98.71%Color and Shape:SolidMolecular weight:631.675-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS:5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.Formula:C8H13N3SPurity:99.03%Color and Shape:SolidMolecular weight:183.27Ro3280
CAS:Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Formula:C27H35F2N7O3Purity:100% - 98%Color and Shape:SolidMolecular weight:543.61Poloxin-2
CAS:Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.Formula:C16H15NO3Purity:99.59%Color and Shape:SolidMolecular weight:269.3Ref: TM-T25969
1mg333.00€5mg922.00€10mg1,140.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,664.00€LFM-A13
CAS:LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR,Formula:C11H8Br2N2O2Purity:99.9%Color and Shape:SolidMolecular weight:360T521
CAS:T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.Formula:C17H14FNO5S2Purity:99.65%Color and Shape:SolidMolecular weight:395.43Plogosertib
CAS:Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.Formula:C34H48N8O3Purity:99.15% - 99.85%Color and Shape:SolidMolecular weight:616.797Cyclapolin 9
CAS:Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.Formula:C9H4F3N3O4SPurity:99.5%Color and Shape:SolidMolecular weight:307.21Ref: TM-T22700
1mg92.00€5mg216.00€10mg338.00€25mg540.00€50mg747.00€100mg1,017.00€500mg2,043.00€1mL*10mM (DMSO)240.00€TC-S 7005
CAS:TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).Formula:C21H17N3O3Purity:99.68%Color and Shape:SolidMolecular weight:359.38Ref: TM-T17008
1mg57.00€2mg84.00€5mg125.00€10mg188.00€25mg354.00€50mg532.00€100mg712.00€500mgTo inquire1mL*10mM (DMSO)138.00€MLN0905
CAS:MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).Formula:C24H25F3N6SPurity:97.17% - 98%Color and Shape:SolidMolecular weight:486.56PLK1 Protein, Human, Recombinant (His)
PLK1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Purity:96.8%Color and Shape:Lyophilized PowderMolecular weight:70.5 kDa (predicted); 66 kDa (reducing conditions)PLK1 Protein, Mouse, Recombinant (His)
PLK1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Color and Shape:Lyophilized PowderMolecular weight:70.6 kDa (predicted); 65 kDa (reducing conditions)
![5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT8912.webp&w=3840&q=75)
