ROCK
ROCK (Rho-associated protein kinase) inhibitors target ROCK kinases, which are involved in the regulation of the cytoskeleton, cell shape, and motility. ROCK plays a significant role in the control of cell division, particularly in processes such as cytokinesis. Inhibiting ROCK can lead to changes in cell cycle dynamics, cell motility, and apoptosis, making these inhibitors valuable in cancer research, neurobiology, and cardiovascular studies. At CymitQuimica, we provide a selection of high-quality ROCK inhibitors to support your research in cell biology, cytoskeletal dynamics, and disease mechanisms.
Products of "ROCK"
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Belumosudil mesylate
CAS:Belumosudil mesylate (KD025 mesylate) is a ROCK2 inhibitor with antifibrotic activity, and can be used in chronic graft-versus-host disease research.Formula:C27H28N6O5SColor and Shape:SolidMolecular weight:548.61Ref: TM-T39555
1mg35.00€5mg74.00€10mg97.00€25mg172.00€50mg255.00€100mg376.00€200mg560.00€1mL*10mM (DMSO)94.00€AT13148
CAS:AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Formula:C17H16ClN3OPurity:98.04% - ≥95%Color and Shape:SolidMolecular weight:313.78GSK180736A
CAS:GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).Formula:C19H16FN5O2Purity:98.16% - 98.44%Color and Shape:SolidMolecular weight:365.36Ref: TM-T3513
1mg42.00€2mg52.00€5mg73.00€10mg88.00€25mg170.00€50mg306.00€100mg568.00€500mg1,225.00€1mL*10mM (DMSO)65.00€Rhodblock 6
CAS:Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.Formula:C12H13N3OPurity:98.27%Color and Shape:SolidMolecular weight:215.25GKI-1 HCl
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.Formula:C15H13Cl2N3Purity:98.44%Color and Shape:SoildMolecular weight:306.19Ref: TM-T11402L
1mg96.00€5mg225.00€10mg334.00€25mg533.00€50mg750.00€100mg1,064.00€200mg1,415.00€1mL*10mM (DMSO)251.00€CID-5056270
CAS:CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphomaFormula:C17H13N3O3SPurity:99.57%Color and Shape:SolidMolecular weight:339.37GSK-25
CAS:GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.Formula:C24H16Cl2F2N6OPurity:98.59%Color and Shape:SolidMolecular weight:513.33Ref: TM-T4488
1mg47.00€2mg59.00€5mg92.00€10mg117.00€25mg172.00€50mg271.00€100mg454.00€1mL*10mM (DMSO)95.00€Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formula:C14H18ClN3O2SPurity:100% - ≥95%Color and Shape:White SolidMolecular weight:327.83ROCK-IN-7
CAS:ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Formula:C17H17N3O2SPurity:98%Color and Shape:SolidMolecular weight:327.4Y-33075 dihydrochloride
CAS:Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).Formula:C16H18Cl2N4OPurity:98.88% - 99.1%Color and Shape:SolidMolecular weight:353.25Ref: TM-T13384L
1mg35.00€5mg70.00€10mg107.00€25mg202.00€50mg360.00€100mg538.00€200mg772.00€1mL*10mM (DMSO)82.00€CKI-7
CAS:CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Formula:C11H14Cl3N3O2SPurity:100.00% - 100.00%Color and Shape:SolidMolecular weight:358.67Ref: TM-T19913
1mg114.00€5mg217.00€10mg325.00€25mg525.00€50mg712.00€100mg959.00€200mg1,293.00€1mL*10mM (DMSO)239.00€HA-100
CAS:HA-100 is an inhibitor of protein kinaseFormula:C13H15N3O2SPurity:99.44%Color and Shape:Pale Yellow Crystalline SolidMolecular weight:277.34Neoprzewaquinone A
CAS:Neoprzewaquinone A (NEO), an active ingredient of S. miltiorrhiza, inhibits breast cancer cell migration and promotes smooth muscle relaxation by targeting PIM1 and blocking the ROCK2/STAT3 pathway.Formula:C36H28O6Purity:98%Color and Shape:SolidMolecular weight:556.6Narciclasine
CAS:Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.Formula:C14H13NO7Purity:98.79% - 99.58%Color and Shape:SolidMolecular weight:307.26LX-7101 hydrochloride
CAS:LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.Formula:C23H29N7O3xHClPurity:98.35%Color and Shape:SolidMolecular weight:487.99Afuresertib hydrochloride
CAS:Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)Formula:C18H18Cl3FN4OSPurity:99.96%Color and Shape:SolidMolecular weight:463.8Ref: TM-T7885
2mg52.00€5mg74.00€10mg95.00€25mg163.00€50mg253.00€100mg437.00€200mg568.00€1mL*10mM (DMSO)86.00€Hydroxyfasudil
CAS:Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Formula:C14H17N3O3SPurity:98.13%Color and Shape:SolidMolecular weight:307.37CRT0066854 hydrochloride
CAS:CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.Formula:C24H27Cl2N5SPurity:97.51%Color and Shape:SolidMolecular weight:488.48Y-27632 dihydrochloride
CAS:View and buy Y-27632 dihydrochloride from TargetMol.Y-27632 is a selective inhibitor of ROCKs.Cited in 10 publications.Formula:C14H21N3O·2HClPurity:97.96% - 99.98%Color and Shape:SolidMolecular weight:320.26Ref: TM-T1725
5mg47.00€10mg60.00€25mg99.00€50mg169.00€100mg273.00€200mg432.00€500mg715.00€1mL*10mM (DMSO)50.00€GSK269962A hydrochloride
CAS:GSK269962A hydrochloride (GSK 269962 hydrochloride) is a ROCK inhibitor with anti-inflammatory and vasodilatory effects and inhibits ROCK1 and ROCK2.Formula:C29H31ClN8O5Color and Shape:SolidMolecular weight:607.06
