HSP
HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.
Products of "HSP"
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Gamitrinib TPP
CAS:Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.Formula:C52H65N3O8PPurity:98%Color and Shape:SolidMolecular weight:891.078HSP70/SIRT2-IN-2
CAS:HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].Formula:C17H13N3S3Purity:98%Color and Shape:SolidMolecular weight:355.5Pifithrin-μ
CAS:Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Formula:C8H7NO2SPurity:99.33% - 99.79%Color and Shape:SolidMolecular weight:181.21ML346
CAS:ML346 is a novel activator of Hsp70.Formula:C14H12N2O4Purity:99.25% - 99.29%Color and Shape:SolidMolecular weight:272.26Ref: TM-T3594
1mg40.00€2mg52.00€5mg85.00€10mg115.00€25mg172.00€50mg274.00€100mg427.00€500mg938.00€1mL*10mM (DMSO)85.00€JG-98
CAS:JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).Formula:C24H21Cl2N3OS3Purity:99.13%Color and Shape:SolidMolecular weight:534.53VER-50589
CAS:VER-50589 is a potent HSP90 inhibitor.Formula:C19H17ClN2O5Purity:100% - 99.96%Color and Shape:SolidMolecular weight:388.8Ref: TM-T2258
1mg42.00€5mg97.00€10mg159.00€25mg264.00€50mg404.00€100mg588.00€200mg832.00€1mL*10mM (DMSO)97.00€PU-H71
CAS:PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.Formula:C18H21IN6O2SPurity:98.31%Color and Shape:SolidMolecular weight:512.37Hsp90-IN-34
CAS:Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.Formula:C22H14F2N6OColor and Shape:SolidMolecular weight:416.38EV206
CAS:EV206 is an effective inhibitor of Hsp70, exhibiting antiproliferative properties. This compound induces cell apoptosis (apoptosis) and enhances the protein expression of cleaved PARP and caspase-3. Additionally, EV206 demonstrates antitumor activity.Formula:C21H19N3OColor and Shape:SolidMolecular weight:329.40HA15
CAS:HA15 targets BiP/GRP78/HSPA5, showing anti-cancer effects on all tested melanoma cells, resistant or patient-derived.Formula:C23H22N4O3S2Purity:99.77% - 99.86%Color and Shape:SolidMolecular weight:466.58Ref: TM-T6855
1mg40.00€2mg51.00€5mg84.00€10mg96.00€25mg187.00€50mg329.00€100mg567.00€1mL*10mM (DMSO)84.00€DTHIB
CAS:DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.Formula:C13H9ClFN3O3Purity:98.86% - 99.29%Color and Shape:SolidMolecular weight:309.68Ref: TM-T8858
1mg35.00€5mg70.00€10mg104.00€25mg210.00€50mg338.00€100mg540.00€500mg1,130.00€1mL*10mM (DMSO)78.00€Zelavespib hydrochloride
Zelavespib (PU-H71) hydrochloride is a potent inhibitor of Hsp90, exhibiting an IC50 value of 51 nM in MDA-MB-468 cells.Purity:98%Color and Shape:Odour Solid
