Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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Apabetalone
CAS:Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary arteryFormula:C20H22N2O5Purity:100% - ≥98%Color and Shape:SolidMolecular weight:370.4CPUY074020
CAS:CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.Formula:C25H28N4O2Purity:99.07%Color and Shape:SolidMolecular weight:416.52GSK-690
CAS:GSK-690 is a potent, reversible and selective inhibitors of Lysine Specific Demethylase 1.Formula:C24H23N3OPurity:98.65%Color and Shape:SolidMolecular weight:369.46WDR5-47
CAS:WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.Formula:C19H20ClFN4O3Purity:98.08%Color and Shape:SoildMolecular weight:406.84Ref: TM-T67697
1mg115.00€5mg255.00€10mg375.00€25mg562.00€50mg787.00€100mg1,074.00€200mg1,444.00€1mL*10mM (DMSO)279.00€LEM-14-1189
CAS:LEM-14-1189 inhibits NSD1/2/3 (IC50: 418/111/60 μM), targets nuclear receptors, and may treat cancer and blood diseases.Formula:C35H34N6O5S2Purity:97.98%Color and Shape:SolidMolecular weight:682.81BRM/BRG1 ligand 1
CAS:BRM/BRG1 Ligand 1 is a BRM/BRG1 ligand utilized for the synthesis of PROTAC BRM/BRG1 degrader-1.Formula:C10H8BrN3OColor and Shape:SolidMolecular weight:266.09KSQ-4279 (gentisate)
CAS:KSQ-4279 (gentisate) (Compound Formula I) serves as an effective inhibitor of USP1 and a selective inhibitor of PARP1. This compound shows promise for use in cancer research.Formula:C34H31F3N8O5Color and Shape:SolidMolecular weight:688.66PHD-IN-1
CAS:PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.Formula:C24H23N7O2Purity:98%Color and Shape:SolidMolecular weight:441.49Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18PFI-90
CAS:PFI-90, a selective histone demethylase (KDM3B) inhibitor, targets PAX3-FOXO1 action and demonstrates potential antitumor activity.Formula:C11H10N4OPurity:99.46%Color and Shape:SolidMolecular weight:214.22HNHA
CAS:HNHA is an inhibitor of HDAC.Formula:C17H21NO2SPurity:98.04%Color and Shape:SolidMolecular weight:303.42Ref: TM-T21806
1mg44.00€5mg84.00€10mg135.00€25mg279.00€50mg445.00€100mg640.00€200mg879.00€1mL*10mM (DMSO)90.00€DY-46-2
CAS:DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.Formula:C19H22N6O5SPurity:99.12% - 99.12%Color and Shape:SolidMolecular weight:446.48GSK199
CAS:GSK199 is a selective PAD4 inhibitor(IC50 of 200 nM in the absence of calcium).Formula:C24H29ClN6O2Purity:99.44%Color and Shape:SolidMolecular weight:468.98Ref: TM-T8861
1mg65.00€5mg140.00€10mg226.00€25mg371.00€50mg520.00€100mg702.00€200mg944.00€1mL*10mM (DMSO)164.00€Baricitinib phosphate
CAS:Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.Formula:C16H20N7O6PSPurity:98.87% - 99.68%Color and Shape:SolidMolecular weight:469.41UPF 1069
CAS:UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.Formula:C17H13NO3Purity:98.80% - 99.88%Color and Shape:SolidMolecular weight:279.29MZP-54
CAS:MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)Formula:C55H66ClN7O9SPurity:98%Color and Shape:SolidMolecular weight:1036.67CM-272
CAS:CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.Formula:C28H38N4O3Purity:97.83%Color and Shape:SolidMolecular weight:478.63Ref: TM-T7194
1mg73.00€5mg160.00€10mg274.00€25mg512.00€50mg738.00€100mg1,035.00€1mL*10mM (DMSO)170.00€CDD-1102 HCl
CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.Formula:C32H31ClN6O3Purity:98.05%Color and Shape:SoildMolecular weight:583.08SK-575
CAS:SK-575 is a potent PARP1-degrading agent effective against BRCA1/2 mutant cancers, even at low doses, and enhances tumor inhibition in mice.Formula:C47H53FN8O8Purity:99.39%Color and Shape:SolidMolecular weight:876.97Cucurbitacin I
CAS:Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.Formula:C30H42O7Purity:96.69% - 98.2%Color and Shape:SolidMolecular weight:514.65Panaxadiol
CAS:Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.Formula:C30H52O3Purity:98% - 99.9%Color and Shape:SolidMolecular weight:460.73CFT8634
CAS:CFT8634 degrades BRD9, for synovial sarcoma and SMARCB1 tumor research, from patent WO2021178920A1.Formula:C37H45F3N6O5Color and Shape:SolidMolecular weight:710.79OXFBD04
CAS:OXFBD04: Potent BRD4 inhibitor, IC50=166nM, acts on BET bromodomains; moderate CREBBP affinity; anti-cancer properties.Formula:C17H16N2O3Purity:98.84%Color and Shape:SolidMolecular weight:296.32Ref: TM-T12338
1mg64.00€5mg140.00€10mg221.00€25mg411.00€50mg610.00€100mg827.00€200mg1,103.00€1mL*10mM (DMSO)156.00€P300-IN-4
P300-IN-4 (compound 6) is a histone acetyltransferase p300 inhibitor with an IC50 value of 12.2 μM.Formula:C29H28ClIN4O5Color and Shape:SolidMolecular weight:674.91ZM39923 hydrochloride
CAS:ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Formula:C23H25NO·HClPurity:98.05%Color and Shape:SolidMolecular weight:367.91MC4171
MC4171 is a selective KAT8 inhibitor with antiproliferative activity and can be used to study cancer.Formula:C21H15N3O3Purity:98.77%Color and Shape:SolidMolecular weight:357.36PROTAC BRD4 Degrader-5
CAS:PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.Formula:C50H62ClN9O8S2Color and Shape:SolidMolecular weight:1016.67OUL232
CAS:OUL232 is a potent single ARTs PARP7, PARP10, PARP11, PARP12, PARP14 and PARP15 inhibitor for cancer and tumour research.Formula:C10H10N4O2SPurity:99.04%Color and Shape:SolidMolecular weight:250.28Niraparib hydrochloride
CAS:Niraparib hydrochloride (MK-4827) is a PARP inhibitor with potential cancer treatment effects, causing DNA damage and apoptosis.Formula:C19H21ClN4OPurity:99.26%Color and Shape:SolidMolecular weight:356.85ABBV-712
CAS:ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseasesFormula:C24H28N4O5Purity:98%Color and Shape:SolidMolecular weight:452.5Bromosporine
CAS:Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.Formula:C17H20N6O4SPurity:99.4% - 99.65%Color and Shape:SolidMolecular weight:404.44Ref: TM-T6255
1mg52.00€5mg97.00€10mg180.00€25mg330.00€50mg560.00€100mg810.00€500mg1,605.00€1mL*10mM (DMSO)111.00€AS8351
CAS:AS8351 inhibits histone demethylase, used with various compounds to turn human lung fibroblasts into cardiomyocytes.Formula:C17H13N3O2Purity:99.54% - 99.72%Color and Shape:SolidMolecular weight:291.3Ref: TM-T4100
5mg50.00€10mg70.00€25mg116.00€50mg188.00€100mg350.00€200mg455.00€500mg745.00€1mL*10mM (DMSO)51.00€4-amino-1,8-Naphthalimide
CAS:4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nMFormula:C12H8N2O2Purity:95.13%Color and Shape:Yellow Solid PowderMolecular weight:212.2WHI-P97
CAS:WHI-P97 is a rationally designed potent inhibitor of JAK-3.Formula:C16H13Br2N3O3Purity:99.93%Color and Shape:SolidMolecular weight:455.1GS-626510
CAS:GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).Formula:C25H22N4OColor and Shape:SolidMolecular weight:394.47Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Color and Shape:Odour SolidLin281632
CAS:Lin281632 is an inhibitor of RNA binding protein Lin28 and bromodomain. Lin281632 promotes mESC differentiation.Formula:C15H15N5OPurity:99.8%Color and Shape:SolidMolecular weight:281.31Ref: TM-T27835
1mg35.00€5mg74.00€10mg106.00€25mg224.00€50mg359.00€100mg565.00€500mg1,206.00€1mL*10mM (DMSO)84.00€AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Formula:C28H32FN9O2Color and Shape:SolidMolecular weight:545.61Tazemetostat trihydrochloride
CAS:Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.Formula:C34H47Cl3N4O4Purity:98%Color and Shape:SolidMolecular weight:682.125-Hydroxy-7-acetoxy-8-methoxyflavone
CAS:5-Hydroxy-7-acetoxy-8-methoxyflavone is a flavonoid compound that inhibits lipid peroxidation and may have anti-influenza virus activity.Formula:C18H14O6Purity:≥98%Color and Shape:SolidMolecular weight:326.3JBJ-02-112-05
CAS:JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].Formula:C27H20N4O2SPurity:98%Color and Shape:SolidMolecular weight:464.54GSK2801
CAS:GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.Formula:C20H21NO4SPurity:97.78% - 99.5%Color and Shape:SolidMolecular weight:371.45TP-064
CAS:TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.Formula:C28H34N4O2Purity:97.85%Color and Shape:SolidMolecular weight:458.6Ref: TM-T28996
1mg38.00€2mg49.00€5mg79.00€10mg119.00€25mg245.00€50mg487.00€100mg710.00€1mL*10mM (DMSO)80.00€PU139
CAS:PU139 is a novel inhibitor of histone acetyltransferase (HAT).Formula:C12H7FN2OSPurity:97.61%Color and Shape:SolidMolecular weight:246.26SMI-16a
CAS:SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Formula:C13H13NO3SPurity:99.99%Color and Shape:SolidMolecular weight:263.31Ref: TM-T3989
1mg35.00€2mg48.00€5mg70.00€10mg87.00€25mg160.00€50mg235.00€100mg354.00€1mL*10mM (DMSO)92.00€Neogrifolin
CAS:Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OSFormula:C22H32O2Purity:98%Color and Shape:SolidMolecular weight:328.49BET-IN-27
CAS:BET-IN-27 (compound 6C) is an orally active BET inhibitor with IC50 values of 3.3 nM (BRD4-BD2), 3.4 nM (BRD4-BD1), 4.1 nM (BRD2-BD1), 20.4 nM (BRD3-BD1), and 42.0 nM (BRDT-BD1). It also exhibits antiproliferative activity.Formula:C21H23N5O3SColor and Shape:SolidMolecular weight:425.5JQEZ5
CAS:JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).Formula:C30H38N8O2Purity:98.14% - ≥98%Color and Shape:SolidMolecular weight:542.68GDC-9918
CAS:GDC-9918 (compound GDC-9918) is an inhibitor of Janus kinases.Formula:C20H18F2N6O5SColor and Shape:SolidMolecular weight:492.46JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Color and Shape:Odour SolidOICR-9429
CAS:OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.Formula:C29H32F3N5O3Purity:99.13% - 99.93%Color and Shape:SolidMolecular weight:555.59Ref: TM-T6916
1mg37.00€2mg52.00€5mg74.00€10mg111.00€25mg187.00€50mg311.00€100mg502.00€1mL*10mM (DMSO)97.00€YDR1
CAS:YDR1 is an effective PROTAC degrader of SMARCA2, featuring a DC50 value of 7.7 nM.Formula:C44H49FN10O5Color and Shape:SolidMolecular weight:816.92AMI-1 free acid
CAS:AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.Formula:C21H16N2O9S2Purity:97.8%Color and Shape:SolidMolecular weight:504.49HLCL-61
CAS:HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).Formula:C23H24N2OColor and Shape:SolidMolecular weight:344.45(S,R,S)-AHPC-Me-amide-C9-acid
CAS:(S,R,S)-AHPC-Me-amide-C9-acid is an E3 ligase ligand-linker conjugate utilized in synthesizing PROTACSMARCA2 degrader-31.Formula:C34H50N4O6SColor and Shape:SolidMolecular weight:642.85FM-381
CAS:FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.Formula:C24H24N6O2Purity:98.44%Color and Shape:SolidMolecular weight:428.49MAT2A-IN-10
CAS:MAT2A-IN-10 (Compound 28), an orally active inhibitor of MAT2A, exhibits an IC50 of 26 nM and is utilized in cancer research [1].Formula:C27H24F2N6O4Purity:98%Color and Shape:SolidMolecular weight:534.51SETD7-IN-1
SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitoryPurity:98%Color and Shape:Odour SolidGSK-J1
CAS:GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively.Formula:C22H23N5O2Purity:99.23% - 99.67%Color and Shape:SolidMolecular weight:389.45MOZ-IN-2
CAS:MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).Formula:C17H13FN4O3SPurity:99.17%Color and Shape:SolidMolecular weight:372.37Ref: TM-T12098
2mg37.00€5mg60.00€10mg96.00€25mg188.00€50mg283.00€100mg432.00€500mg938.00€1mL*10mM (DMSO)66.00€3-methyl-1,2-dihydroquinolin-2-one
CAS:3-methyl-1,2-dihydroquinolin-2-one is the first known micromolar inhibitors of the ATAD2 bromodomain.Formula:C10H9NOPurity:99.62%Color and Shape:SolidMolecular weight:159.18Ref: TM-T50035
1mg50.00€5mg103.00€10mg155.00€25mg255.00€50mg375.00€100mg535.00€200mg725.00€1mL*10mM (DMSO)93.00€Molibresib
CAS:Molibresib (GSK525762) is an inhibitor of BET proteins (IC50: about 35 nM).Formula:C22H22ClN5O2Purity:97.70% - 99.08%Color and Shape:SolidMolecular weight:423.9Ref: TM-T1906
1mg43.00€2mg57.00€5mg93.00€10mg125.00€25mg216.00€50mg359.00€100mg535.00€200mg752.00€500mg1,169.00€1mL*10mM (DMSO)93.00€RG108
CAS:RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).Formula:C19H14N2O4Purity:98% - 99.78%Color and Shape:SolidMolecular weight:334.33Ref: TM-T2038
5mg47.00€10mg69.00€25mg117.00€50mg205.00€100mg286.00€200mg401.00€500mg652.00€1mL*10mM (DMSO)56.00€KDM2B-IN-2
CAS:KDM2B-IN-2 is a potent histone demethylase (kdm2b) inhibitor.Formula:C21H26N4O2S2Purity:97.57%Color and Shape:SolidMolecular weight:430.59Ref: TM-T39389
1mg66.00€5mg144.00€10mg216.00€25mg406.00€50mg607.00€100mg845.00€500mg1,738.00€1mL*10mM (DMSO)159.00€PARP1-IN-5 dihydrochloride
CAS:PARP1-IN-5 dihydrochloride: oral, potent PARP-1 inhibitor (IC50=14.7 nM), for cancer research.Formula:C25H26Cl2N2O5SPurity:96.03%Color and Shape:SolidMolecular weight:537.46AMG 900
CAS:AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.Formula:C28H21N7OSPurity:98.35% - 98.9%Color and Shape:SolidMolecular weight:503.58Ref: TM-T6380
1mg52.00€5mg97.00€10mg166.00€25mg303.00€50mg467.00€100mg682.00€500mg1,415.00€1mL*10mM (DMSO)105.00€TNG-462
CAS:TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic & bladder).Formula:C28H36N6O2SPurity:98.7%Color and Shape:SolidMolecular weight:520.69WDR5-0103 hydrochloride[890190-22-4(free base)]
WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd:Formula:C21H26ClN3O4Purity:99.66%Color and Shape:SolidMolecular weight:419.9BET BD2-IN-1
BET BD2-IN-1 (compound 45) is a potent, selective inhibitor of BET BD2, exhibiting an IC50 value of 1.6 nM.Purity:98%Color and Shape:Odour SolidC646
CAS:C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).Formula:C24H19N3O6Purity:98% - 99.21%Color and Shape:SolidMolecular weight:445.42JNJ-42041935
CAS:JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.Formula:C12H6ClF3N4O3Purity:99.58% - ≥95%Color and Shape:SolidMolecular weight:346.65Ref: TM-T3180
1mg40.00€2mg52.00€5mg88.00€10mg119.00€25mg210.00€50mg354.00€100mg567.00€500mg1,198.00€1mL*10mM (DMSO)87.00€Zebularine
CAS:Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.Formula:C9H12N2O5Purity:100% - 99.84%Color and Shape:SolidMolecular weight:228.2PROTAC SMARCA2 degrader-20
CAS:PROTAC SMARCA2 degrader-20 (Compound I-40) is a potent degrader of PROTAC SMARCA2, showing potential for cancer research applications.Formula:C55H65N11O5SColor and Shape:SolidMolecular weight:992.24CPI-1205
CAS:CPI-1205 是一种高效的选择性 EZH2 抑制剂(IC50:0.002 μM,EC50:0.032 μM)。Formula:C27H33F3N4O3Purity:98.71% - 99.7%Color and Shape:SolidMolecular weight:518.57Effusanin E
CAS:Effusanin E inhibits bacterial growth, counters cancer by blocking p50/p65 and reducing COX-2, halting NPC cell proliferation and triggering cell death.Formula:C20H28O6Purity:98%Color and Shape:SolidMolecular weight:364.438UNC7096
UNC7096 is a potent, selective degrader of NSD2-PWWP1, exhibiting a dissociation constant (Kd) of 46 nM, and shows promise for treating NSD2-related diseases [1Formula:C61H87N7O18SPurity:98%Color and Shape:SolidMolecular weight:1238.44PROTAC BRD4 Degrader-29
PROTAC BRD4 Degrader-29 (compound 7a) is a potent BRD4 PROTAC degrader with a DC50 of 89.4 nM, playing a significant role in cancer research.Formula:C58H61ClN10O9S2Molecular weight:1141.75PARP-1-IN-13
PARP-1-IN-13 (Compound 19c) is a potent PARP-1 inhibitor with an IC50 of 26 nM, hindering DNA single-strand break repair and exacerbating DNA double-strandFormula:C20H17N5O2SPurity:98%Color and Shape:SolidMolecular weight:391.45J-147
CAS:J-147, a curcumin derivative, is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging.Formula:C18H17F3N2O2Purity:100% - 99.61%Color and Shape:SolidMolecular weight:350.33BRD4 Inhibitor-27
CAS:BRD4 Inhibitor-27 is a potent BRD4 inhibitor that inhibits BRD4 BD1 and BRD4 BD2 with IC50s of 9.6 and 11.3 μM, respectively.BRD4 Inhibitor-27 has anticancerFormula:C16H13F3N6Purity:99.22%Color and Shape:SolidMolecular weight:346.31JAK1-IN-16
JAK1-IN-16 (compound 4l) acts as an inhibitor of JAK1/STAT3 and effectively downregulates the expression of TLR4 protein.Formula:C20H15ClF3N3OSColor and Shape:SolidMolecular weight:437.87Tyk2-IN-22
CAS:Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.Formula:C16H16ClN5O2Color and Shape:SolidMolecular weight:345.78JAK-STAT-IN-1
CAS:JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.Formula:C21H21N5O2Purity:99.21%Color and Shape:SolidMolecular weight:375.42PROTAC BRD4 Degrader-27
CAS:PROTAC BRD4 Degrader-27 is a selective PROTAC targeting BRD4, distinguished from BRD2/BRD3. This compound is composed of the E3 ubiquitinase ligand Thalidomide-4-OH, the PROTAC Linker γ-Aminobutyric acid, and the PROTAC target protein ligand PROTAC BRD4 ligand-3. The active control for this target protein ligand is Mivebresib, while the conjugate of the E3 ubiquitin ligase ligand and Linker is identified as Pomalidomide 4'-alkylC3-acid.Formula:C37H30F2N6O7Color and Shape:SolidMolecular weight:708.67Bromodomain inhibitor-13
CAS:Bromodomain Inhibitor-13 (Compound 1), an analog of PFI-3, is a bromodomain-containing protein (BCP) inhibitor. It specifically targets the bromodomains of SMARCA2, SMARCA4, and the first and second bromodomains of PB1 [PB1(5) and PB1(2)], with dissociation constants (KD) of 37, 53, 30, and 190 nM, respectively.Formula:C21H22N4O2Color and Shape:SolidMolecular weight:362.43Antitumor agent-104
CAS:Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzymeFormula:C31H33FN6O3Purity:98%Color and Shape:SolidMolecular weight:556.633,6-Dihydroxyflavone
CAS:3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway.Formula:C15H10O4Purity:99.92%Color and Shape:SolidMolecular weight:254.24Dehydrocorydaline chloride
CAS:Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.Formula:C22H24ClNO4Purity:99.53%Color and Shape:SolidMolecular weight:401.88Ref: TM-T10990
1mg58.00€5mg111.00€10mg160.00€25mg264.00€50mg396.00€100mg563.00€1mL*10mM (DMSO)124.00€OG-L002
CAS:OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.Formula:C15H15NOPurity:97.05%Color and Shape:SolidMolecular weight:225.29Ref: TM-T6073
1mg42.00€5mg88.00€10mg137.00€25mg253.00€50mg416.00€100mg602.00€500mg1,254.00€1mL*10mM (DMSO)52.00€Diflunisal
CAS:Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.Formula:C13H8F2O3Purity:98.92% - 99.42%Color and Shape:SolidMolecular weight:250.2ORIC-944 TFA
ORIC-944 TFA is an orally bioavailable selective polycomb repressive complex 2 (PRC2) inhibitor with antitumor activity.Formula:C28H26F4N6O3Color and Shape:SoildMolecular weight:570.54EPZ032597
CAS:EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancerFormula:C20H23N7OPurity:99.41%Color and Shape:SolidMolecular weight:377.441,4-DPCA
CAS:1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibitingFormula:C13H8N2O3Purity:97.75%Color and Shape:SolidMolecular weight:240.21Ref: TM-T21653
5mg51.00€10mg84.00€25mg153.00€50mg235.00€100mg376.00€200mg553.00€500mg883.00€1mL*10mM (DMSO)57.00€SGC-SMARCA-BRDVIII
CAS:SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM,Formula:C19H25N5O3Purity:99.6% - 99.85%Color and Shape:SolidMolecular weight:371.43Ref: TM-T9568
1mg47.00€5mg70.00€10mg106.00€25mg235.00€50mg376.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)57.00€LSD1/HDAC-IN-1
CAS:LSD1/HDAC-IN-1 (compound 2) serves as an effective inhibitor of both HDAC and LSD1, demonstrating IC50 values of 0.125 nM, 0.373 nM, 0.0118 nM, 0.103 nM, and 0.571 μM for HDAC1, HDAC2, HDAC6, HDAC8, and LSD1 respectively. This compound plays a crucial role in cancer research.Formula:C18H18N2O4SColor and Shape:SolidMolecular weight:358.41Oroxylin A
CAS:Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.Formula:C16H12O5Purity:98.72% - 99.55%Color and Shape:SolidMolecular weight:284.26PT2399
CAS:PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.Formula:C17H10F5NO4SPurity:98.8% - 99.07%Color and Shape:SolidMolecular weight:419.32Ref: TM-T12675L
1mg99.00€5mg235.00€10mg354.00€25mg640.00€50mg944.00€100mg1,320.00€1mL*10mM (DMSO)259.00€JAK/HDAC-IN-4
JAK/HDAC-IN-4 (compound 11 i) is a dual inhibitor targeting both JAK2 and HDAC6, with IC50 values of 0.49 nM and 12 nM respectively. It inhibits cell proliferation and the production of nitric oxide. In a mouse model induced by Imiquimod, JAK/HDAC-IN-4 ameliorates psoriasiform skin lesions with low toxicity.Formula:C30H32N8O5SColor and Shape:SolidMolecular weight:616.69MS645
CAS:MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.Formula:C48H54Cl2N10O2S2Purity:98%Color and Shape:SolidMolecular weight:938.04WM-1119
CAS:WM-1119 is a highly potent, selective KAT6A/B inhibitorFormula:C18H13F2N3O3SPurity:96.59% - 98.18%Color and Shape:SolidMolecular weight:389.38
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