Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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BI-7273
CAS:BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.Formula:C20H23N3O3Purity:97.37% - 99.57%Color and Shape:SolidMolecular weight:353.41WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.Formula:C16H14Br2ClN3O3Purity:99.49%Color and Shape:SolidMolecular weight:491.56Procainamide
CAS:Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.Formula:C13H21N3OPurity:98.86%Color and Shape:SolidMolecular weight:235.33dAURK-4 hydrochloride
dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formula:C52H53Cl2FN8O12Purity:99.44%Color and Shape:SolidMolecular weight:1071.93dTRIM24
CAS:dTRIM24 is a selective bifunctional TRIM24 degradation agent based on PROTAC technology, consisting of the ligands von Hippel-Lindau and TRIM24.Formula:C55H68N8O13S2Purity:99.13%Color and Shape:SolidMolecular weight:1113.3EML 425
CAS:EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).Formula:C27H24N2O4Purity:97.60%Color and Shape:SolidMolecular weight:440.49Ref: TM-T15216
2mg38.00€5mg58.00€10mg92.00€25mg187.00€50mg280.00€100mg418.00€200mg590.00€1mL*10mM (DMSO)65.00€MAK683
CAS:MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).Formula:C20H17FN6OPurity:97.98% - 99.92%Color and Shape:SolidMolecular weight:376.39Ref: TM-T15201
1mg52.00€5mg107.00€10mg188.00€25mg411.00€50mg607.00€100mg847.00€500mg1,758.00€1mL*10mM (DMSO)95.00€WHI-P154
CAS:WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.Formula:C16H14BrN3O3Purity:98% - 99.6%Color and Shape:SolidMolecular weight:376.2Decitabine
CAS:Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.Formula:C8H12N4O4Purity:98.06% - 99.87%Color and Shape:Physical Description Fine White Crystalline Powder Used As A DrugMolecular weight:228.21FKBP12 PROTAC dTAG-13
CAS:dTAG-13: Degrades FKBP12F36V-fused proteins and BRD4 by connecting to E3 ligase CRBN.Formula:C57H68N4O15Purity:98%Color and Shape:SolidMolecular weight:1049.17γ-Oryzanol
CAS:γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in theFormula:C40H58O4Purity:mixture - mixtureColor and Shape:White Or White Crystalline Powder OdourlessMolecular weight:602.9GNE-272
CAS:GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.Formula:C22H25FN6O2Color and Shape:SolidMolecular weight:424.47UNC0646
CAS:UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.Formula:C36H59N7O2Purity:100%Color and Shape:SolidMolecular weight:621.9PRMT5-IN-28
CAS:PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processesFormula:C18H19ClN4O5Purity:98%Color and Shape:SolidMolecular weight:406.82Acaricide
Compound 7l, an acaricide, serves as an effective LSD1 inhibitor. It demonstrates substantial acaricidal activity against the eggs of T. cinnabarinus, with a lethal concentration 50 (LC50) of 0.0035 mg/L.Formula:C21H21F2NOS2Color and Shape:SolidMolecular weight:405.52AW68
CAS:AW68 is a potential small molecule BRD4 inhibitor that prevents and treats BRD4-related diseases and can be used in cancer research.Formula:C22H21ClN6Purity:98.52% - 99.92%Color and Shape:SoildMolecular weight:404.89TCS PIM-1 1
CAS:TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.Formula:C18H11BrN2O2Purity:97% - 99.64%Color and Shape:SolidMolecular weight:367.2Ref: TM-T2253
1mg35.00€5mg64.00€10mg88.00€25mg187.00€50mg284.00€100mg424.00€200mg612.00€1mL*10mM (DMSO)97.00€WM-8014
CAS:WM-8014 (MOZ-IN-3) is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.Formula:C20H17FN2O3SPurity:99.64%Color and Shape:SolidMolecular weight:384.42Ref: TM-T4362
1mg57.00€2mg82.00€5mg115.00€10mg170.00€25mg334.00€50mg497.00€100mg720.00€1mL*10mM (DMSO)136.00€PRMT4-IN-1
CAS:PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].Formula:C23H28FN3OPurity:98%Color and Shape:SolidMolecular weight:381.49MI-3
CAS:MI-3 (Menin-MLL Inhibitor) (Menin-MLL Inhibitor) is an effective inhibitor of Menin-MLL interaction (IC50: 648 nM).Formula:C18H25N5S2Purity:98.66% - 98.97%Color and Shape:SolidMolecular weight:375.55TCS-PIM-1-4a
CAS:SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Formula:C11H6F3NO2SPurity:99.89%Color and Shape:SolidMolecular weight:273.23YT117R
YT117R is a PROTAC that targets degradation of FKBP12 and BRD4.Formula:C50H52ClN9O7SColor and Shape:SolidMolecular weight:958.52F5446
CAS:F5446 is a selective small molecule SUV39H1 methyltransferase inhibitor, promotes apoptosis in colorectal cancer cells by inhibiting the deposition of H3K9me3.Formula:C26H17ClN2O8SPurity:98.56%Color and Shape:SolidMolecular weight:552.944β-Hydroxywithanolide E
CAS:4bHWE inhibits colon cancer growth, alters splicing, is anti-inflammatory, aids in diabetes/obesity, and may be chemopreventive.Formula:C28H38O8Purity:98%Color and Shape:SolidMolecular weight:502.604ZEN-3411
CAS:ZEN-3411 is an BET inhibitor that inhibits BRD4(BD1), BRD4(BD2), and BRD4(BD1BD2) and suppresses the growth of tumor cells overproducing BET proteins.Formula:C21H20N4O2Purity:97.42% - 97.77%Color and Shape:SolidMolecular weight:360.41GSK3368715 dihydrochloride
CAS:GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is a PRMTs inhibitor , with anticancer activity, for the study of advanced solid tumors.Formula:C20H40Cl2N4O2Purity:99.66% - 99.66%Color and Shape:SolidMolecular weight:439.46Acetyl Pentapeptide-1 acetate
Acetyl Pentapeptide-1 acetate is an histone deacetylase inhibitor.Formula:C34H55N9O12Purity:99.09%Color and Shape:SolidMolecular weight:781.86Ref: TM-T38318L
1mg87.00€2mg124.00€5mg187.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€200mg1,159.00€BET/Aurora kinase-IN-1
CAS:BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.Formula:C25H30FN7OColor and Shape:SolidMolecular weight:463.55LSD1-IN-30
CAS:LSD1-IN-30 is a lysine-specific demethylase 1 (LSD1) inhibitor with anticancer activity for the study of small cell lung cancer and acute myeloid leukemia.Formula:C15H14N2O3Purity:98.42%Color and Shape:SoildMolecular weight:270.28CFT-1297
CFT-1297 is a BET PROTAC degrader that targets BRD4 for degradation.Formula:C47H51N9O4Color and Shape:SolidMolecular weight:805.97LLY-283
CAS:LLY-283, PRMT5 inhibitor, IC50 22 nM, Kd 6 nM, oral, selective, with antitumor effects.Formula:C17H18N4O4Purity:98.79%Color and Shape:SolidMolecular weight:342.35PROTAC SMARCA2 degrader-24
CAS:PROTAC SMARCA2 degrader-24 (Compound 34) is a SMARCA2 PROTAC degrader with a DC50 of less than 0.1 µM in HeLa cells. It also degrades SMARCA4 in HeLa cells, exhibiting a DC50 greater than 10 µM.Formula:C45H56N10O5SColor and Shape:SolidMolecular weight:849.06OTS186935 FA
OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells.Formula:C26H28ClN5O4Purity:98.16%Color and Shape:SoildMolecular weight:509.98Ref: TM-T12344L1
1mg97.00€5mg235.00€10mg393.00€25mg710.00€50mg1,103.00€100mg1,539.00€500mg3,068.00€1mL*10mM (DMSO)269.00€JAK3/BTK-IN-1
CAS:JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two importantFormula:C25H28N8OPurity:97.89%Color and Shape:SolidMolecular weight:456.54L134
L134, an effective PROTAC BRD4 degrader, exhibits a DC50 value of 7.36 nM. The degradation of BRD4 by L134 is mediated through the ubiquitin-proteasome system in a DCAF11-dependent manner.Formula:C48H51ClF3N7O7SColor and Shape:SolidMolecular weight:962.47CBP/p300-IN-2
CAS:CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc).Formula:C27H29F2N7O2Purity:98%Color and Shape:SolidMolecular weight:521.56RBN-2397
CAS:RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.Formula:C20H23F6N7O3Purity:98.48% - 99.96%Color and Shape:SolidMolecular weight:523.43Ref: TM-T12695
1mg130.00€5mg311.00€10mg472.00€25mg753.00€50mg1,017.00€100mg1,311.00€1mL*10mM (DMSO)434.00€PFI-2 hydrochloride
CAS:PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM),Formula:C23H26ClF4N3O3SPurity:98.04% - 99.91%Color and Shape:SolidMolecular weight:535.98Ref: TM-T4583
1mg40.00€2mg51.00€5mg85.00€10mg117.00€25mg212.00€50mg378.00€100mg552.00€500mg1,169.00€1mL*10mM (DMSO)128.00€Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Formula:C9H6O4Purity:97.47% - 99.8%Color and Shape:SolidMolecular weight:178.14Ruxolitinib phosphate
CAS:Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.Formula:C17H21N6O4PPurity:100% - 99.91%Color and Shape:SolidMolecular weight:404.36Ref: TM-T3043
1g615.00€5mg52.00€10mg65.00€25mg82.00€50mg97.00€100mg145.00€200mg227.00€500mg418.00€1mL*10mM (DMSO)59.00€Pocenbrodib
CAS:Pocenbrodib (FT-7051) is a potent inhibitor of the bromodomain of the CBP/p300 family with potential antitumour activity and is palatable for cancer research.Formula:C28H32FN3O6Purity:98.44% - 98.48%Color and Shape:SolidMolecular weight:525.57PIM1-IN-4
CAS:PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.Formula:C27H25BrCl2CuN6OPurity:98%Color and Shape:SolidMolecular weight:663.88PIM-IN-2
CAS:PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .Formula:C19H22N4O2Purity:98%Color and Shape:SolidMolecular weight:338.4Procainamide hydrochloride
CAS:Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analogFormula:C13H21N3O·HClPurity:99.83% - 99.97%Color and Shape:White To Slightly Yellow PowderMolecular weight:271.79TCS7010
CAS:TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay.Formula:C31H31ClFN7O2Purity:98.49% - 99.62%Color and Shape:SolidMolecular weight:588.07(R)-HH2853
CAS:(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.Formula:C31H36F3N7O3Purity:100% - 97.14%Color and Shape:SolidMolecular weight:611.66NSC 694621
CAS:NSC 694621 is a PCAF inhibitor that forms a covalent bond with Cys574, irreversibly inhibiting its acetyltransferase activity, inhibit proliferation,anticancer.Formula:C13H10N2O2SPurity:99.7%Color and Shape:SolidMolecular weight:258.3NMS-P118
CAS:NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy.Formula:C20H24F3N3O2Purity:98.79%Color and Shape:SolidMolecular weight:395.42Deferoxamine Mesylate
CAS:Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Formula:C26H52N6O11SPurity:94.68% - 99.80%Color and Shape:SolidMolecular weight:656.79FL-411
CAS:FL-411 (BRD4-IN-1) is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.Formula:C18H19N3O2SPurity:96.23%Color and Shape:SolidMolecular weight:341.43Ref: TM-T4365
2mg35.00€5mg58.00€10mg96.00€25mg170.00€50mg284.00€100mg472.00€200mg655.00€1mL*10mM (DMSO)65.00€YCH1899
YCH1899, an orally active PARP inhibitor, demonstrates potent inhibition of PARP1/2 with an IC50 of less than 0.001 nM.Formula:C25H18BrFN6O3Purity:98%Color and Shape:SolidMolecular weight:549.35Chlorogenic Acid
CAS:Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.Formula:C16H18O9Purity:98.76% - 99.67%Color and Shape:SolidMolecular weight:354.31N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide
CAS:N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide is a racemic form of Cl-amidine (S enantiomer).Formula:C14H19ClN4O2Purity:97.66%Color and Shape:SolidMolecular weight:310.78KDM4D-IN-1
CAS:KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM).Formula:C11H7N5OPurity:100% - 99.51%Color and Shape:SolidMolecular weight:225.21Ref: TM-T4214
1mg77.00€5mg166.00€10mg259.00€25mg522.00€50mg838.00€100mg1,225.00€1mL*10mM (DMSO)177.00€TAK-632
CAS:TAK-632 is a potent pan-Raf inhibitor.Formula:C27H18F4N4O3SPurity:98% - 98.92%Color and Shape:SolidMolecular weight:554.52Oclacitinib maleate
CAS:Oclacitinib maleate is a selective JAK inhibitor (IC50: 10-99 nM; JAK1 cytokines: 36-249 nM), with no effect on 38 non-JAK kinases.Formula:C15H23N5O2S·C4H4O4Purity:99.17%Color and Shape:SolidMolecular weight:453.51Ref: TM-T6914
1mg39.00€2mg50.00€5mg79.00€10mg99.00€25mg170.00€50mg271.00€100mg457.00€1mL*10mM (DMSO)86.00€Corin
CAS:Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).Formula:C26H28N4O2Purity:98.22%Color and Shape:SolidMolecular weight:428.53Ref: TM-T10864
1mg170.00€5mg432.00€10mg638.00€25mg1,008.00€50mg1,359.00€100mg1,825.00€1mL*10mM (DMSO)465.00€Minocycline hydrochloride
CAS:Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.Formula:C23H28ClN3O7Purity:100% - 99.89%Color and Shape:Bright Yellow-Orange Amorphous Solid Crystalline YellowMolecular weight:493.94Glucosamine sulfate
CAS:Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.Formula:C6H13NO5·H2SO4Purity:99.64%Color and Shape:White CrystalMolecular weight:277.25Valemetostat
CAS:Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor, which can be used to study T-cell lymphoma.Cost-effective and quality-assured.Formula:C26H34ClN3O4Purity:98.38% - 99.08%Color and Shape:SolidMolecular weight:488.02Ref: TM-T13279L
1mg95.00€5mg187.00€10mg329.00€25mg550.00€50mg783.00€100mg1,035.00€1mL*10mM (DMSO)207.00€CCT077791
CAS:CCT077791 is a potent inhibitor of p300 and PCAF histone acetyltransferase activity for cancer research.Formula:C9H5ClN2O3SPurity:99.15%Color and Shape:SolidMolecular weight:256.67Hexamethylene bisacetamide
CAS:Hexamethylene bisacetamide inhibits BET Bromodomain Proteins.Formula:C10H20N2O2Purity:99.94%Color and Shape:White FlakesMolecular weight:200.28GSK-J1 lithium salt
CAS:GSK-J1 lithium salt is an effective inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with an IC 50 of 60 nM for KDM6B.Formula:C22H22LiN5O2Purity:98%Color and Shape:SolidMolecular weight:395.38ODM-207
CAS:ODM-207 (BET-IN-4) is a potent BRD4 inhibitor.Formula:C22H21N3O3Purity:99.73%Color and Shape:SolidMolecular weight:375.42Ref: TM-T10521
1mg47.00€5mg96.00€10mg140.00€25mg249.00€50mg359.00€100mg507.00€200mg697.00€1mL*10mM (DMSO)96.00€BET-IN-17
BET-IN-17, also known as compound 16, serves as a pan-inhibitor for BET, exhibiting inhibitory potencies (pIC50) of 7.8 for BET BD1 and 7.6 for BET BD2 [1].Formula:C30H36N4O2Purity:98%Color and Shape:SolidMolecular weight:484.63BY27
CAS:BY27 is a BET BD2 inhibitor with anticancer activity that inhibits BRD2, BRD3 and BRD4 and suppresses tumor growth.Formula:C22H21ClN6Purity:99.19% - 99.40%Color and Shape:SolidMolecular weight:404.89GNE-987
CAS:GNE-987 is a potent chimeric BET degrader, binding BRD4 BD1/BD2 at IC50: 4.7/4.4 nM & has a DC50: 0.03 nM in EOL-1 AML cells.Formula:C56H67F2N9O8S2Purity:98%Color and Shape:SolidMolecular weight:1096.31JAK2-IN-4
CAS:JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.Formula:C23H27N5O4SPurity:98%Color and Shape:SolidMolecular weight:469.56GSK046
CAS:GSK046 (iBET-BD2), potent oral BET BD2 inhibitor; IC50: BRD2 (264 nM), BRD3 (98 nM), BRD4 (49 nM), BRDT (214 nM); immunomodulatory.Formula:C23H27FN2O4Purity:99.97%Color and Shape:SolidMolecular weight:414.47Ref: TM-T8932
1mg113.00€5mg235.00€10mg378.00€25mg630.00€50mg898.00€100mg1,216.00€1mL*10mM (DMSO)259.00€PT-2385
CAS:PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).Formula:C17H12F3NO4SPurity:98.69% - 99.55%Color and Shape:SolidMolecular weight:383.34Ref: TM-T7848
1mg66.00€2mg87.00€5mg153.00€10mg258.00€25mg411.00€50mg610.00€100mg868.00€1mL*10mM (DMSO)126.00€ORY1001
CAS:ORY1001: Oral LSD1/KDM1A inhibitor, highly selective, IC50 <20 nM.Formula:C15H22N2·2HClPurity:99.4% - 99.96%Color and Shape:SolidMolecular weight:303.27Ref: TM-T6922
1mg59.00€2mg84.00€5mg134.00€10mg234.00€25mg452.00€50mg660.00€100mg939.00€500mg1,882.00€1mL*10mM (DMSO)134.00€Roxadustat
CAS:Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.Formula:C19H16N2O5Purity:99% - 99.82%Color and Shape:SolidMolecular weight:352.34PROTAC SMARCA2/4-degrader-25
PROTAC SMARCA2/4-degrader-25 is a PROTAC that targets SMARCA2/4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2/4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.Formula:C44H50N10O9S2Color and Shape:SolidMolecular weight:927.06Hydroxycitric acid tripotassium hydrate
CAS:Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.Formula:C6H7K3O8Purity:95%Color and Shape:White Solid CrystallineMolecular weight:324.41TNKS-2-IN-1
CAS:TNKS-2-IN-1 inhibits TNKS1/2 (IC50: 259/1100 nM), has antimicrobial effects on E. coli/S. aureus, and blocks NLRP3/IL-1β release (IC50: 5 μM).Formula:C14H9N3O3Purity:98.4%Color and Shape:SolidMolecular weight:267.24ZL0580
CAS:ZL0580 suppresses HIV by blocking Tat activation, halting transcription, and promoting repressive chromatin at the HIV promoter.Formula:C25H23F3N4O4SPurity:99.70%Color and Shape:SolidMolecular weight:532.53MK-5108
CAS:MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Formula:C22H21ClFN3O3SPurity:100%Color and Shape:SolidMolecular weight:461.94UNC3866
CAS:UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.Formula:C43H66N6O8Purity:88.06% - 99.47%Color and Shape:SolidMolecular weight:795.02JAK3-IN-1
CAS:JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.Formula:C26H30ClN7O2Color and Shape:SolidMolecular weight:508.02EZM 2302
CAS:EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.Formula:C29H37ClN6O5Purity:97.47% - ≥98%Color and Shape:SolidMolecular weight:585.09DR2313
CAS:DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.Formula:C8H10N2OSPurity:98.65%Color and Shape:SolidMolecular weight:182.24CW-3308
CW-3308 is an orally active PROTAC that targets BRD9. It is composed of the PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH, the linker 3-Azaspiro[5.5]undecane-9-methanol, and the E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine. The coupling of the E3 ubiquitin ligase ligand with the linker results in the conjugate Thalidomide-pyrrolidine-C-azaspiro.Formula:C45H48N6O8Color and Shape:SolidMolecular weight:800.9ZM-447439
CAS:ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.Formula:C29H31N5O4Purity:98.53% - 99.11%Color and Shape:Pale Yellow SolidMolecular weight:513.59MBM-17
CAS:MBM-17 is a potent inhibitor of NIMA-related kinase 2 (Nek2,IC50 of 3 nM).Formula:C28H28N6O2Purity:98%Color and Shape:SolidMolecular weight:480.56Birabresib
CAS:Birabresib (MK-8628) is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4Formula:C25H22ClN5O2SPurity:98.36% - 99.36%Color and Shape:SolidMolecular weight:491.99Ref: TM-T6032
2mg48.00€5mg73.00€10mg95.00€25mg150.00€50mg235.00€100mg396.00€200mg590.00€500mg943.00€1mL*10mM (DMSO)79.00€HDAC1-IN-9
HDAC1-IN-9 (13c) is an HDAC1 inhibitor. It inhibits the HDAC1 enzyme with an IC50 value of 1.07 µM. This compound exhibits the strongest antiproliferative activity against HT-29 (human colon adenocarcinoma cells), with an IC50 of 1.78 μM. In HCT-116 (human colon cancer cells), HDAC1-IN-9 significantly induces apoptosis. Additionally, HDAC1-IN-9 possesses antiangiogenic properties, reducing the expression levels of VEGFR-2 and phosphorylated VEGFR-2 (pVEGFR-2) by approximately 80%.Formula:C17H17N3O3Color and Shape:SolidMolecular weight:311.34MAK-683 hydrochloride
CAS:MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Formula:C20H18ClFN6OPurity:100% - 99.72%Color and Shape:SolidMolecular weight:412.85PARPi-FL
CAS:PARPi-FL (PARPiFL) is a fluorescent PARP1 inhibitor used for imaging glioblastoma and detecting oral cancer.Formula:C34H32BF3N6O3Purity:99.73%Color and Shape:SolidMolecular weight:640.46NEO2734
CAS:NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).Formula:C22H24F3N3O3Purity:98.72% - 98.80%Color and Shape:SolidMolecular weight:435.44Ref: TM-T8658
1mg114.00€5mg274.00€10mg454.00€25mg750.00€50mg1,026.00€100mg1,406.00€500mg2,822.00€1mL*10mM (DMSO)303.00€Ritlecitinib
CAS:Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.Formula:C15H19N5OPurity:98.82% - 99.92%Color and Shape:SolidMolecular weight:285.34Ref: TM-T5382
2mg47.00€5mg70.00€10mg111.00€25mg216.00€50mg329.00€100mg495.00€200mg705.00€500mg1,064.00€1mL*10mM (DMSO)77.00€dencichine
CAS:Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.Formula:C5H8N2O5Purity:≥95%Color and Shape:SolidMolecular weight:176.13Ref: TM-TL0001
1mg49.00€5mg97.00€10mg169.00€25mg349.00€50mg520.00€100mg748.00€200mg1,026.00€1mL*10mM (DMSO)106.00€PRMT5-MTA-IN-2
PRMT5-MTA-IN-2 (compound 1) is a synergistic inhibitor of PRMT5 with an IC50 of less than 1.5 nM.Formula:C30H25F2N7O2Color and Shape:SolidMolecular weight:553.56Ruxolitinib
CAS:Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.Formula:C17H18N6Purity:100% - 99.99%Color and Shape:SolidMolecular weight:306.36Ref: TM-T1829
5mg58.00€10mg74.00€25mg92.00€50mg116.00€100mg155.00€200mg245.00€500mg414.00€1mL*10mM (DMSO)65.00€MAT2A-IN-11
MAT2A Allosteric Inhibitor 1, also known as Compound 5, is a selective inhibitor of methionine adenosyltransferase (MAT) demonstrating potent activity with anFormula:C21H22N6OPurity:98%Color and Shape:SolidMolecular weight:374.44MS8511 HCl
MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the study of a variety of cancers including brain cancer.Formula:C28H42ClN5O3Purity:97.83% - 98.90%Color and Shape:SolidMolecular weight:532.12PROTAC BRD4 Degrader-21
CAS:PROTAC BRD4 Degrader-21 (Comp 74), a potent degrader of BRD4, has demonstrated substantial inhibition of tumor growth in mouse xenograft models, showing itsFormula:C47H54Cl2N10O4SPurity:98%Color and Shape:SolidMolecular weight:925.97PARP1-IN-35
PARP1-IN-35 (compound T26) is a selective, orally active PARP1 inhibitor that can cross the blood-brain barrier, with IC50 values of 0.2 nM for PARP1 and 122 nM for PARP2. It exhibits antiproliferative and anticancer activities and holds potential for breast cancer research.Formula:C22H21N5OMolecular weight:371.435NVP-BSK805
CAS:NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.Formula:C27H28F2N6OPurity:98%Color and Shape:SolidMolecular weight:490.55Amifostine trihydrate
CAS:Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.Formula:C5H15N2O3PS·3H2OPurity:99.71% - 99.80%Color and Shape:SolidMolecular weight:268.27MM-102 TFA
CAS:MM-102 TFA is a potent WDR5/MLL inhibitor with IC50 of 2.4 nM; it disrupts MLL1-WDR5 interaction, impeding H3K4 HMT activity.Formula:C37H50F5N7O6Purity:99.4% - 99.78%Color and Shape:SolidMolecular weight:783.83Ref: TM-T8768
1mg39.00€2mg51.00€5mg105.00€10mg168.00€25mg284.00€50mg420.00€100mg620.00€1mL*10mM (DMSO)149.00€
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