Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
Sort by
Ganoderic acid DM
CAS:Ganoderic acid DM inhibits osteoclastogenesis, targeting c-Fos, NFATc1, and reducing DC-STAMP expression, thus preventing osteoclast fusion.Formula:C30H44O4Purity:98%Color and Shape:SolidMolecular weight:468.67BET BD2-IN-3
CAS:BET BD2-IN-3 (compound I-58), a BET inhibitor specifically targeting the BD2 domain, can be radiolabeled with [11C] for use in positron emission tomography (PET) imaging. PET studies with [11C]BD2-IN-3 in mice have demonstrated appropriate biodistribution in peripheral organs and tissues.Formula:C29H30N4OColor and Shape:SolidMolecular weight:450.58Dbet57
CAS:dBET57: PROTAC-based BRD4BD1 degrader, DC50/5h at 500 nM, ineffective on BRD4BD2.Formula:C34H31ClN8O5SPurity:99.32% - 99.52%Color and Shape:SolidMolecular weight:699.18Ref: TM-T5440
1mg49.00€5mg97.00€10mg156.00€25mg279.00€50mg432.00€100mg625.00€500mg1,293.00€1mL*10mM (DMSO)170.00€EHP-101
CAS:EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.Formula:C28H35NO3Purity:99.22%Color and Shape:SolidMolecular weight:433.58Ref: TM-T13289
1mg107.00€5mg227.00€10mg378.00€25mg620.00€50mg868.00€100mg1,169.00€1mL*10mM (DMSO)250.00€UNC3866 TFA(1872382-47-2 free base)
CAS:UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.Formula:C45H67F3N6O10Purity:98.6%Color and Shape:SolidMolecular weight:909.04Ref: TM-T4021L
1mg38.00€2mg49.00€5mg74.00€10mg119.00€25mg229.00€50mg339.00€100mg472.00€200mg655.00€1mL*10mM (DMSO)155.00€PRMT5 ligand 1
CAS:PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.Formula:C20H26N6O2Color and Shape:SolidMolecular weight:382.459GSK3368715
CAS:GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50sFormula:C20H38N4O2Purity:98%Color and Shape:SolidMolecular weight:366.54YLIU-4-105-1
CAS:YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.Formula:C32H34F3N7O2Color and Shape:SolidMolecular weight:605.65TGP-377/421
CAS:TGP-377/421 (Targapre-miR-377/421) is a potent miR-377 and miR-421 dual inhibitor that inhibits miR-377 and miR-421 by binding to their functional sites.Formula:C20H16N6Purity:98.48%Color and Shape:SolidMolecular weight:340.38Ref: TM-T61085
1mg66.00€5mg144.00€10mg227.00€25mg454.00€50mg733.00€100mg1,026.00€500mg2,052.00€1mL*10mM (DMSO)159.00€2',3',5'-triacetyl-5-Azacytidine
CAS:2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.Formula:C14H18N4O8Purity:98.34%Color and Shape:SolidMolecular weight:370.31Ref: TM-T7840
2mg40.00€5mg52.00€10mg80.00€25mg129.00€50mg187.00€100mg281.00€200mg406.00€1mL*10mM (DMSO)64.00€PROTAC BRM/BRG1 degrader-1
CAS:PROTAC BRM/BRG1 degrader-1 is a chemical compound that acts as a degrader of PROTAC BRM/BRG1, exhibiting a DC50 range of 10-100 nM (BRM) and > 1 μM (BRG1). This compound is utilized in cancer research.Formula:C54H63N9O9SColor and Shape:SolidMolecular weight:1014.2KAT6-IN-2
KAT6-IN-2 is a potent inhibitor of KAT6, showing promise for use in cancer research.Color and Shape:Odour SolidPIN1 inhibitor API-1
CAS:API-1 is a Pin1 inhibitor (IC50: 72.3 nM), enhancing anticancer miRNA biogenesis and inhibiting hepatocellular carcinoma.Formula:C15H13F3N6O2Purity:98.48%Color and Shape:SolidMolecular weight:366.3Ref: TM-T16538
1mg60.00€5mg127.00€10mg235.00€25mg344.00€50mg512.00€100mg645.00€200mg898.00€500mg1,311.00€1mL*10mM (DMSO)140.00€Bobcat339
CAS:Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.Formula:C16H12ClN3OPurity:97.79% - 99.24%Color and Shape:SolidMolecular weight:297.74UMB298
CAS:UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.Formula:C27H31ClN4O2Purity:99.76%Color and Shape:SolidMolecular weight:479.01Ref: TM-T9194
1mg64.00€5mg140.00€10mg219.00€25mg378.00€50mg530.00€100mg723.00€200mg938.00€1mL*10mM (DMSO)148.00€CARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Formula:C27H35ClN6O3Color and Shape:SolidMolecular weight:527.06Itacitinib
CAS:Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.Formula:C26H23F4N9OPurity:96.4% - 99.01%Color and Shape:SolidMolecular weight:553.51Ref: TM-T3998
1mg49.00€2mg71.00€5mg111.00€10mg180.00€25mg325.00€50mg543.00€100mg780.00€500mg1,549.00€1mL*10mM (DMSO)137.00€Ilginatinib maleate
CAS:Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.Formula:C25H24FN7O4Purity:99.74% - 99.82%Color and Shape:SolidMolecular weight:505.5Ref: TM-T12266L
1mg64.00€5mg138.00€10mg187.00€25mg273.00€50mg393.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)153.00€E7449
CAS:E7449 is a potent inhibitor of PARP1, PARP2, TNKS1, and TNKS2 with IC50s of 2, 1, ~50, and ~50 nM respectively.Formula:C18H15N5OPurity:97.13%Color and Shape:SolidMolecular weight:317.34Ref: TM-T4471
1mg35.00€5mg93.00€10mg120.00€25mg188.00€50mg284.00€100mg420.00€200mg622.00€1mL*10mM (DMSO)94.00€(S)-CPI203
CAS:CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).Formula:C19H18ClN5OSPurity:98.96% - 99.36%Color and Shape:SolidMolecular weight:399.9Ref: TM-T6026
2mg35.00€5mg58.00€10mg94.00€25mg178.00€50mg284.00€100mg449.00€200mg627.00€1mL*10mM (DMSO)62.00€MAT2A-IN-9
CAS:MAT2A-IN-9, a 2-oxoquinazoline, inhibits MAT2A with antitumor effects on lymphomas and solid cancers.Formula:C14H8ClF3N4OPurity:98.53%Color and Shape:SolidMolecular weight:340.69PARP7-IN-16
CAS:PARP7-IN-16 (compound 36) is a potent, selective, and orally active PARP-1/2/7 inhibitor, exhibiting IC50 values of 0.94, 0.87, and 0.21 nM , respectively.Formula:C25H26FN4NaO4Purity:98%Color and Shape:SolidMolecular weight:488.49IOX4
CAS:IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)Formula:C15H16N6O3Purity:99.97%Color and Shape:SolidMolecular weight:328.33PROTAC BRM/BRG1 degrader-2
CAS:PROTAC BRM/BRG1 degrader-2 (Example.004) is a potent PROTAC BRM/BRG1 degrading agent exhibiting a DC50 of less than 10 nM and an IC50 of 15 nM in A549 cells.Formula:C50H60N12O5SColor and Shape:SolidMolecular weight:941.15GSK591
CAS:GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM).Formula:C22H28N4O2Purity:99.35% - 99.77%Color and Shape:SolidMolecular weight:380.48Ref: TM-T6853
1mg48.00€2mg62.00€5mg100.00€10mg144.00€25mg283.00€50mg487.00€100mg710.00€500mg1,483.00€1mL*10mM (DMSO)106.00€PARP1 Protein, Human, Recombinant (His)
PARP Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Purity:94.1%Color and Shape:Lyophilized PowderMolecular weight:114.5 kDa (predicted); 100-110 kDa (reducing conditions)GNE-781
CAS:GNE-781: potent CBP inhibitor (IC50: 0.94 nM), also targets BRET/BRD4(1) (IC50: 6.2/5100 nM).Formula:C27H33F2N7O2Purity:98.73% - 99.92%Color and Shape:SolidMolecular weight:525.59Ref: TM-T15405
1mg163.00€5mg354.00€10mg528.00€25mg852.00€50mg1,159.00€100mg1,568.00€1mL*10mM (DMSO)391.00€A-196
CAS:A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective overFormula:C18H16Cl2N4Purity:99.92%Color and Shape:SolidMolecular weight:359.25Ref: TM-T4343
2mg42.00€5mg62.00€10mg96.00€25mg169.00€50mg264.00€100mg426.00€200mg617.00€1mL*10mM (DMSO)62.00€LW6
CAS:LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.Formula:C26H29NO5Purity:98.1% - 99.10%Color and Shape:SolidMolecular weight:435.51Ref: TM-T3494
2mg47.00€5mg69.00€10mg89.00€25mg183.00€50mg298.00€100mg449.00€500mg938.00€1mL*10mM (DMSO)69.00€BRM/BRG1 ATP Inhibitor-2
CAS:BRM/BRG1 ATP Inhibitor-2 is an inhibitor of BRG1/BRM ATPase and can be used in studies about the treatment of BAF-related disorders.Formula:C20H20N4O2S2Purity:99.88%Color and Shape:SolidMolecular weight:412.53Ref: TM-T60032
1mg63.00€5mg137.00€10mg210.00€25mg424.00€50mg627.00€100mg893.00€500mg1,786.00€1mL*10mM (DMSO)153.00€AZD5153
CAS:AZD5153 is an orally active and selective BET/BRD4 bromodomain inhibitor with an IC50 value of 1.7nM for BRD4.Formula:C25H33N7O3Purity:99.25%Color and Shape:SolidMolecular weight:479.57PROTAC BET Degrader-1
CAS:PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.Formula:C44H45N11O9Purity:98%Color and Shape:SolidMolecular weight:871.9DS-103
DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 μM, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 μM. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 μM and 1.47 μM, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 μM and 2.23 μM. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.Formula:C28H33N5O3Color and Shape:SolidMolecular weight:487.59dBRD9 HCl
CAS:dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide .Formula:C40H47Cl2N7O10Purity:97% - 99.37%Color and Shape:SolidMolecular weight:856.75(+)-JQ-1
CAS:(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility.Formula:C23H25ClN4O2SPurity:97.57% - ≥95%Color and Shape:SolidMolecular weight:456.99Ref: TM-T2110
1mg35.00€2mg44.00€5mg60.00€10mg79.00€25mg96.00€50mg144.00€100mg188.00€200mg283.00€500mg512.00€1mL*10mM (DMSO)66.00€Fucosterol
CAS:Fucosterol, from E. stolonifera, has anti-diabetic, anti-adipogenic, anti-cancer properties; it affects PPARα and C/EBPα to control fat cell formation.Formula:C29H48OPurity:98.39% - 99.68%Color and Shape:White PowderMolecular weight:412.69MS31 trihydrochloride (2366264-12-0 free base)
MS31 trihydrochloride (2366264-12-0 free base) is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitorFormula:C20H30Cl3N3O2Purity:99.69%Color and Shape:SolidMolecular weight:450.83Ref: TM-T12111L
1mg195.00€5mg390.00€10mg572.00€25mg914.00€50mg1,216.00€100mg1,673.00€1mL*10mM (DMSO)399.00€MK-8745
CAS:MK-8745 is a potent and selective Aurora A inhibitor.Formula:C20H19ClFN5OSPurity:98.94% - 99.31%Color and Shape:SolidMolecular weight:431.91BRD4-IN-4
CAS:BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line andFormula:C17H18N2O3SPurity:100%Color and Shape:SolidMolecular weight:330.4Veliparib dihydrochloride
CAS:Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.Formula:C13H18Cl2N4OPurity:97.09% - 98%Color and Shape:SolidMolecular weight:317.21A-485
CAS:A-485 is a p300/CBP histone acetyltransferase (HAT) inhibitor that inhibits p300 and CBP. A-485 has antitumor effects. Cost effective and quality assured.Formula:C25H24F4N4O5Purity:100% - 98.32%Color and Shape:SolidMolecular weight:536.48Ref: TM-T14073
1mg87.00€2mg119.00€5mg170.00€10mg304.00€25mg378.00€50mg449.00€100mg777.00€1mL*10mM (DMSO)208.00€AZD1208
CAS:AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.Formula:C21H21N3O2SPurity:97.24% - 99.83%Color and Shape:SolidMolecular weight:379.48Ref: TM-T2300
2mg38.00€5mg51.00€10mg74.00€25mg118.00€50mg213.00€100mg378.00€200mg495.00€500mg792.00€1mL*10mM (DMSO)57.00€WM-586
CAS:WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.Formula:C20H20F3N5O3SPurity:98%Color and Shape:SolidMolecular weight:467.47T-3775440 hydrochloride
CAS:T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).Formula:C18H23ClN4OPurity:99.88%Color and Shape:SolidMolecular weight:346.85Ref: TM-T13055
1mg96.00€5mg202.00€10mg305.00€25mg550.00€50mg772.00€100mg1,074.00€1mL*10mM (DMSO)224.00€Menin-KMT2A-IN-1
Menin-KMT2A-IN-1 (Compound 20) is an inhibitor of menin-KMT2A, binding to menin with an IC50 of 8 nM, and disrupting the interaction between menin and lysine methyltransferase 2A (KMT2A). It inhibits hERG channels with an IC50 of 65 μM and suppresses MV4-11 cells with an IC50 of 74 nM. Furthermore, Menin-KMT2A-IN-1 exhibits favorable pharmacokinetic properties in CD-1 mice, with an oral bioavailability of 74%.Formula:C28H35FN6O3Color and Shape:SolidMolecular weight:522.61Lepzacitinib
CAS:Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Formula:C18H21N5O3Purity:99.85%Color and Shape:SolidMolecular weight:355.39Ref: TM-T78207
1mg52.00€5mg116.00€10mg178.00€25mg359.00€50mg533.00€100mg750.00€200mg1,064.00€1mL*10mM (DMSO)127.00€6-Thioguanine
CAS:6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.Formula:C5H5N5SPurity:100% - 98.75%Color and Shape:Odorless Or Almost Odorless Pale Yellow Crystalline PowderMolecular weight:167.19GNA002
CAS:GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).Formula:C42H55NO8Purity:98%Color and Shape:SolidMolecular weight:701.89MI-3454
CAS:MI-3454: potent, oral menin-MLL1 inhibitor, IC50 of 0.51 nM, halts leukemia cells, aids remission in mice.Formula:C32H35F3N8OSPurity:99.68%Color and Shape:SolidMolecular weight:636.73PARP1-IN-14
CAS:PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM.Formula:C28H24FN7O3Purity:98%Color and Shape:SolidMolecular weight:525.53PBIT
CAS:PBIT is a JARID1 inhibitor with IC50: 3 μM for JARID1B, 6 μM for JARID1A, and 4.9 μM for JARID1C.Formula:C14H11NOSPurity:99.61% - 99.83%Color and Shape:SolidMolecular weight:241.31Ref: TM-T16435
1mg40.00€5mg85.00€10mg116.00€25mg235.00€50mg379.00€100mg610.00€200mg840.00€1mL*10mM (DMSO)92.00€GSK778
CAS:GSK778 selectively inhibits BD1 bromodomains (BRD2, BRD3, BRD4, BRDT) and impedes cell growth, causing arrest and apoptosis.Formula:C30H33N5O3Purity:98.42%Color and Shape:SolidMolecular weight:511.61Ref: TM-T9703
1mg160.00€5mg311.00€10mg502.00€25mg1,008.00€50mg1,596.00€100mg2,213.00€1mL*10mM (DMSO)47.00€YM458
CAS:YM458 inhibits EZH2 (490 nM) and BRD4 (34 nM), curbing tumor cell growth and inducing apoptosis.Formula:C53H61ClN8O5SPurity:98%Color and Shape:SolidMolecular weight:957.62Seclidemstat
CAS:Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.Formula:C20H23ClN4O4SPurity:98.28% - 98.88%Color and Shape:SolidMolecular weight:450.94Ref: TM-T4527
5mg48.00€10mg72.00€25mg120.00€50mg187.00€100mg354.00€200mg528.00€500mg852.00€1mL*10mM (DMSO)49.00€Ru3
Ru3 is a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor that prompts apoptosis in MCF-7 cells through various mechanisms, including DNA damage induction,Purity:98%Color and Shape:Odour SolidUNC0224
CAS:UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.Formula:C26H43N7O2Purity:99.58%Color and Shape:SolidMolecular weight:485.67Ref: TM-T17203
1mg51.00€2mg73.00€5mg97.00€10mg159.00€25mg354.00€50mg558.00€100mg797.00€500mg1,634.00€1mL*10mM (DMSO)107.00€Sinefungin
CAS:Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viralFormula:C15H23N7O5Purity:98.12%Color and Shape:SolidMolecular weight:381.39BBDDL2059
CAS:BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against the EZH2-Y641F mutant.Formula:C27H36N4O4SPurity:98%Color and Shape:SolidMolecular weight:512.66RVX-297
CAS:RVX-297 selectively inhibits BD2 domains of BET bromodomains, binding preferentially to BET proteins.Formula:C24H29N3O4Purity:98.11%Color and Shape:SolidMolecular weight:423.5Ref: TM-T28628
2mg42.00€5mg65.00€10mg97.00€25mg187.00€50mg301.00€100mg487.00€200mg658.00€1mL*10mM (DMSO)71.00€Gusacitinib
CAS:Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).Formula:C24H28N8O2Purity:98.06% - 99.94%Color and Shape:SolidMolecular weight:460.53Ref: TM-T14331
1mg42.00€5mg88.00€10mg123.00€25mg188.00€50mg350.00€100mg522.00€200mg750.00€1mL*10mM (DMSO)116.00€(E/Z)-Zotiraciclib
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Formula:C23H24N4OPurity:97% - 98.03%Color and Shape:SolidMolecular weight:372.46Ref: TM-T21503
1mg46.00€2mg59.00€5mg87.00€10mg119.00€25mg210.00€50mg349.00€100mg507.00€1mL*10mM (DMSO)96.00€UNC1999
CAS:UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).Formula:C33H43N7O2Purity:100% - 99.49%Color and Shape:SolidMolecular weight:569.74Ref: TM-T3057
1mg37.00€2mg52.00€5mg71.00€10mg97.00€25mg177.00€50mg286.00€100mg515.00€500mg1,130.00€1mL*10mM (DMSO)89.00€PARP1-IN-8
CAS:PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM).Formula:C23H18ClN3O2Purity:98.26%Color and Shape:SolidMolecular weight:403.86NSD2-IN-4
NSD2-IN-4 is a potent, selective inhibitor of the NSD2-SET domain, showing promise for the treatment of diseases related to NSD2 [1].Formula:C18H14ClN3O3Purity:98%Color and Shape:SolidMolecular weight:355.78AMG-193
CAS:AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.Formula:C22H19F3N4O3Purity:99.52%Color and Shape:SolidMolecular weight:444.41Ref: TM-T85645
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€1mL*10mM (DMSO)588.00€JAK2-IN-11
CAS:JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with potent antitumor activity, exhibiting an IC50 of ≤10 nM against JH2 BIND WT/V617F. This compound effectively suppresses tumor growth.Formula:C31H31F3N8O4Color and Shape:SolidMolecular weight:639.64MR837
CAS:MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.Formula:C16H14N2OSPurity:99.77% - 99.85%Color and Shape:SolidMolecular weight:282.36Ref: TM-T8879
2mg40.00€5mg58.00€10mg96.00€25mg145.00€50mg255.00€100mg375.00€200mg530.00€1mL*10mM (DMSO)70.00€Momelotinib sulfate
CAS:Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.Formula:C23H26N6O10S2Purity:98%Color and Shape:SolidMolecular weight:610.62JAK-IN-26
CAS:JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormula:C22H24N6O3Purity:98%Color and Shape:SolidMolecular weight:420.46QL-1200186
CAS:QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production followingFormula:C26H27N7O3Purity:98%Color and Shape:SolidMolecular weight:485.54PBRM1-BD2-IN-3
CAS:PBRM1-BD2-IN-3 (compound 12) is a potent inhibitor of PBRM1-BD2, exhibiting an IC50 value of 1.1 μM, and is utilized in anticancer research.Formula:C14H11ClN2OPurity:99.91%Color and Shape:SoildMolecular weight:258.7Ref: TM-T60158
1mg115.00€5mg255.00€10mg375.00€25mg562.00€50mg792.00€100mg1,064.00€500mg2,147.00€1mL*10mM (DMSO)226.00€KAT6A-IN-1
CAS:KAT6A-IN-1 (compound 5) is an inhibitor of KAT6A.Formula:C23H27N5O5SColor and Shape:SolidMolecular weight:485.56CARM1 degrader-1
PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1).Formula:C71H98N12O8SPurity:98%Color and Shape:SolidMolecular weight:1279.68EB-47
CAS:EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).Formula:C24H27N9O6Purity:99.86%Color and Shape:SolidMolecular weight:537.53GSK620
CAS:GSK620, a selective pan-BD2 inhibitor, has anti-inflammatory properties and favorable oral pharmacokinetics.Formula:C18H19N3O3Purity:99.42% - 99.88%Color and Shape:SolidMolecular weight:325.36Ref: TM-T9020
2mg35.00€5mg50.00€10mg81.00€25mg150.00€50mg235.00€100mg349.00€200mg515.00€1mL*10mM (DMSO)92.00€EPZ020411 2HCl (1700663-41-7(free base))
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).Formula:C25H40Cl2N4O3Purity:98%Color and Shape:SolidMolecular weight:515.51JAK3i
CAS:JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.Formula:C18H15FN4O3Purity:98.61% - 99.81%Color and Shape:SolidMolecular weight:354.34Pyridone 6
CAS:Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).Formula:C18H16FN3OPurity:97.10% - 98.74%Color and Shape:SolidMolecular weight:309.34Ref: TM-T3080
1mg82.00€2mg106.00€5mg162.00€10mg221.00€25mg449.00€50mg658.00€100mg939.00€500mg1,882.00€1mL*10mM (DMSO)177.00€PIM-1 Inhibitor 2
CAS:PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.Formula:C17H11ClN4OPurity:98.81%Color and Shape:SolidMolecular weight:322.75PARP1-IN-17
PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis.Purity:98%Color and Shape:Odour SolidGSK-1070916
CAS:GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Formula:C30H33N7OPurity:99.73%Color and Shape:SolidMolecular weight:507.63PNZ5
CAS:PNZ5, an isoxazole-based pan-BET inhibitor, demonstrates potent activity and high selectivity comparable to the established (+)-JQ1, exhibiting a dissociationFormula:C20H18N2O2Purity:100% - 99.53%Color and Shape:SolidMolecular weight:318.37Ref: TM-T12513
1mg115.00€5mg255.00€10mg375.00€25mg562.00€50mg792.00€100mg1,064.00€200mg1,444.00€1mL*10mM (DMSO)253.00€NSC-636819
CAS:NSC-636819 is a novel inhibitor of KDM4A/KDM4B.Formula:C22H12Cl4N2O4Purity:98%Color and Shape:SolidMolecular weight:510.15GSK343
CAS:GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity againstFormula:C31H39N7O2Purity:98% - 99.9%Color and Shape:SolidMolecular weight:541.69MK-4827 Racemate
CAS:MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity forFormula:C19H20N4OPurity:99.47%Color and Shape:SolidMolecular weight:320.39Ref: TM-T22988
1mg49.00€2mg69.00€5mg87.00€10mg154.00€25mg283.00€50mg492.00€100mg663.00€1mL*10mM (DMSO)118.00€GSK8573
CAS:GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).Formula:C20H21NO3Purity:99.81%Color and Shape:SolidMolecular weight:323.39PARP Protein, Mouse, Recombinant (His)
PARP Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Color and Shape:Lyophilized PowderMolecular weight:115 kDa (predicted); 75 kDa (reducing conditions)A-366
CAS:A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.Formula:C19H27N3O2Purity:97.28% - 99.8%Color and Shape:SolidMolecular weight:329.44Ref: TM-T3624
1mg35.00€2mg50.00€5mg74.00€10mg90.00€25mg208.00€50mg359.00€100mg530.00€1mL*10mM (DMSO)82.00€LSD1-IN-27
CAS:LSD1-IN-27 inhibits LSD1 (IC50=13 nM), blocks gastric cancer cell stemness/migration, reduces PD-L1, and boosts T-cell response.Formula:C24H25N3Purity:98.65%Color and Shape:SoildMolecular weight:355.48Solcitinib
CAS:Solcitinib (GLPG-0778), a JAK1 inhibitor, may treat psoriasis, ulcerative colitis, and lupus.Formula:C22H23N5O2Purity:99.61% - 99.82%Color and Shape:SolidMolecular weight:389.45EBI-2511
CAS:EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).Formula:C34H48N4O4Purity:99.01%Color and Shape:SolidMolecular weight:576.77EPZ015666
CAS:EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.Formula:C20H25N5O3Purity:98% - 99.41%Color and Shape:SolidMolecular weight:383.44CYC-116
CAS:CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not activeFormula:C18H20N6OSPurity:96.6% - 97.59%Color and Shape:SolidMolecular weight:368.46Ref: TM-T6458
2mg39.00€5mg56.00€10mg78.00€25mg135.00€50mg217.00€100mg358.00€500mg908.00€1mL*10mM (DMSO)49.00€ZEN-2759
CAS:ZEN-2759 is a potent BET small molecule inhibitor of BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).Formula:C17H16N2O2Purity:99.36%Color and Shape:SolidMolecular weight:280.32HJB97
CAS:HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively).Formula:C26H28N8O3Purity:98%Color and Shape:SolidMolecular weight:500.55EZM0414
CAS:EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay.Formula:C22H29FN4O2Purity:98.9%Color and Shape:SolidMolecular weight:400.49Filgotinib
CAS:Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.Formula:C21H23N5O3SPurity:98.03% - ≥95%Color and Shape:SolidMolecular weight:425.5JAK-IN-29
JAK-IN-29 (Compound 3) is a potent inhibitor of Janus kinases (JAK) [1].Formula:C17H14ClN5O2Purity:98%Color and Shape:SolidMolecular weight:355.78JAK2 Inhibitor V
CAS:JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.Formula:C23H24N2OPurity:96.69% - 99.15%Color and Shape:SolidMolecular weight:344.45Ref: TM-T3042
2mg39.00€5mg57.00€10mg85.00€25mg157.00€50mg274.00€100mg505.00€500mg1,121.00€1mL*10mM (DMSO)63.00€
