Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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KDM2A/7A-IN-1
CAS:KDM2A/7A-IN-1 is a KDM2A/7A inhibitor with potential anti-tumour activity for the study of duodenal adenomas and ossifying fibromucoid tumours.Formula:C33H38N4OPurity:99.59%Color and Shape:SolidMolecular weight:506.68NI-42
CAS:NI-42, a BRPFs inhibitor: IC50(BRPF1/2/3)=7.9/48/260 nM, Kd(BRPF1/2/3)=40/210/940 nM; selective for class IV BRDs.Formula:C18H15N3O3SPurity:99.18%Color and Shape:SolidMolecular weight:353.39NSC 228155
CAS:NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.Formula:C11H6N4O4SPurity:99.84%Color and Shape:SolidMolecular weight:290.25Ref: TM-T6908
2mg35.00€5mg50.00€10mg66.00€25mg125.00€50mg205.00€100mg369.00€200mg495.00€1mL*10mM (DMSO)52.00€FY-21
FY-21 is a selective LSD1 inhibitor (IC50= 340 nM) that inhibits proliferation and colony formation of leukemia cells, decreases mRNA levels of the transcription factors HOXA9 and MEIS1, and can be used in the study of leukemia.Formula:C17H15F3N2O6Purity:99.86%Color and Shape:SolidMolecular weight:400.31CTB
CAS:CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.Formula:C16H13ClF3NO2Purity:99.80%Color and Shape:SolidMolecular weight:343.73GNE-375
CAS:GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.Formula:C25H29N3O5Purity:99.32%Color and Shape:SolidMolecular weight:451.51Ref: TM-T27423
1mg117.00€5mg279.00€10mg432.00€25mg707.00€50mg1,017.00€100mg1,491.00€1mL*10mM (DMSO)315.00€Niraparib
CAS:Niraparib (MK-4827) inhibits PARP1/PARP2 (IC50: 3.8/2.1 nM), effective on BRCA mutant cancers, 330x less effective on PARP3, V-PARP, Tank1.Formula:C19H20N4OPurity:98% - 99.91%Color and Shape:SolidMolecular weight:320.39Ref: TM-T3231
5mg60.00€10mg88.00€25mg111.00€50mg144.00€100mg216.00€200mg321.00€500mg543.00€1mL*10mM (DMSO)66.00€RK-287107
CAS:RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).Formula:C22H26F2N4O2Purity:99.64%Color and Shape:SolidMolecular weight:416.46SGC2085
CAS:SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).Formula:C19H24N2O2Purity:99.61% - 99.71%Color and Shape:SolidMolecular weight:312.41Ref: TM-T7089
1mg88.00€2mg119.00€5mg227.00€10mg341.00€25mg563.00€50mg820.00€100mg1,130.00€1mL*10mM (DMSO)160.00€GSK1324726A
CAS:GSK1324726A (I-BET726) is a greatly specific inhibitor of BET family proteins for BRD2(IC50=41 nM), BRD3(IC50=31 nM), and BRD4 (IC50=22 nM).Formula:C25H23ClN2O3Purity:98.34% - 99.74%Color and Shape:SolidMolecular weight:434.91HDAC6 ligand-3
HDAC6ligand-3 serves as a ligand for HDAC6 and can be utilized as a target protein ligand in the synthesis of [PROTAC] HDAC6 degrader4.Formula:C20H21N3O3Color and Shape:SolidMolecular weight:351.399Pinometostat
CAS:Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor. Pinometostat has antitumor activity. Cost effective and quality assured.Formula:C30H42N8O3Purity:99.19% - 99.86%Color and Shape:SolidMolecular weight:562.71LT052
CAS:LT052 is a BET BD1 inhibitor with anti-inflammatory activity. It mediates the BRD4/NF-κB/NLRP3 signaling inflammatory pathway.Formula:C22H19N5O4SPurity:98.87%Color and Shape:SolidMolecular weight:449.48SGC-CBP30
CAS:SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).Formula:C28H33ClN4O3Purity:99.03% - 99.05%Color and Shape:SolidMolecular weight:509.04Ref: TM-T6668
1mg49.00€2mg71.00€5mg88.00€10mg119.00€25mg210.00€50mg354.00€100mg528.00€1mL*10mM (DMSO)88.00€IACS-9571
CAS:IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).Formula:C32H42N4O8SPurity:98%Color and Shape:SolidMolecular weight:642.76AZ960
CAS:AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).Formula:C18H16F2N6Purity:96.02% - 98.51%Color and Shape:SolidMolecular weight:354.36Bromodomain inhibitor-12
CAS:Bromodomain Inhibitor-12 (example 303) is a research compound utilized in the study of autoimmune and inflammatory diseases [1].Formula:C28H38N4O5Purity:98%Color and Shape:SolidMolecular weight:510.63PROTAC BET degrader-3
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.Formula:C53H64N12O9SPurity:98%Color and Shape:SolidMolecular weight:1045.22G007-LK
CAS:G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.Formula:C25H16ClN7O3SPurity:97.63% - 98.17%Color and Shape:SolidMolecular weight:529.96Ref: TM-T6842
1mg49.00€2mg70.00€5mg99.00€10mg166.00€25mg334.00€50mg530.00€100mg745.00€1mL*10mM (DMSO)123.00€JG-2016
CAS:JG-2016, as a histone acetyltransferase 1 inhibitor, inhibits growth of human cancer cell lines and inhibits enzymatic activity in cellulose.Formula:C18H21ClN4O3Purity:99% - 99.37%Color and Shape:SolidMolecular weight:376.84Ref: TM-T82008
1mg116.00€5mg283.00€10mg455.00€25mg905.00€50mg1,454.00€100mg1,882.00€1mL*10mM (DMSO)310.00€Naphthol AS-E
CAS:Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.Formula:C17H12ClNO2Purity:99.33%Color and Shape:Grey Solid PowderMolecular weight:297.74VEGFR/PARP-IN-1
VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively.Formula:C29H27N9OPurity:98%Color and Shape:SolidMolecular weight:517.58PROTAC SMARCA2 degrader-29
CAS:PROTAC SMARCA2 degrader-29 (Example 87) is a potent PROTAC SMARCA2 (BRM) degrading agent with a DC50 ranging between 10-100 nM (BRM) and over 1 μM (BRG1, also known as SMARCA2).Formula:C47H54N8O5S2Color and Shape:SolidMolecular weight:875.11PROTAC BRD4 Degrader-1
CAS:PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).Formula:C40H37N9O8Purity:98%Color and Shape:SolidMolecular weight:771.78XU1
CAS:XU1(Benzo[c][1,8]naphthyridin-6(5h)-One) is an Aurora protein kinase inhibitor used for the treatment of diseases suitable for inhibition, regulation orFormula:C12H8N2OPurity:100% - 98.97%Color and Shape:SolidMolecular weight:196.2SMARCA2 degrader-17
CAS:SMARCA2 degrader-17 is a degrader of SMARCA2, exhibiting synergistic antiproliferative effects with Adagrasib in cancer cells and capable of inhibiting tumor growth.Formula:C47H58N10O6SColor and Shape:SolidMolecular weight:891.09PARP14 inhibitor H10
CAS:PARP14 inhibitor H10 is a selective inhibitor against PARP14 with IC50 of 490 nMFormula:C24H27N7O7SPurity:98%Color and Shape:SolidMolecular weight:557.58GSK-1268997
CAS:GSK-1268997 is a bio-active chemical.Formula:C21H23N7O3SPurity:99.78% - 99.81%Color and Shape:SolidMolecular weight:453.52Deucravacitinib
CAS:Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.Formula:C20H19D3N8O3Purity:100% - 99.43%Color and Shape:SolidMolecular weight:425.46Ref: TM-T14687
1mg70.00€5mg153.00€10mg274.00€25mg432.00€50mg638.00€100mg908.00€200mg1,225.00€500mg1,825.00€1mL*10mM (DMSO)166.00€SGC2085 HCl
CAS:SGC2085: potent, selective CARM1 inhibitor; IC50=50 nM; >100x selectivity vs other PRMTs; impacts cancer growth.Formula:C19H24N2O2·HClPurity:99.91%Color and Shape:SolidMolecular weight:348.87Ref: TM-T4013
1mg93.00€2mg150.00€5mg190.00€10mg343.00€25mg567.00€50mg825.00€100mg1,130.00€1mL*10mM (DMSO)244.00€Veliparib
CAS:Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.Formula:C13H16N4OPurity:98.66% - 99%Color and Shape:SolidMolecular weight:244.29Ref: TM-T2591
5mg57.00€10mg81.00€25mg127.00€50mg207.00€100mg331.00€200mg540.00€500mg852.00€1mL*10mM (DMSO)64.00€TRIM24/BRPF1-IN-2
CAS:TRIM24/BRPF1-IN-2 is a TRIM24/BRPF1 dual inhibitor with anticancer activity that inhibits the proliferation of prostate cancer cells.Formula:C20H22N2O4SPurity:98.69% - 99.13%Color and Shape:SoildMolecular weight:386.47TNG908
CAS:TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.Formula:C21H23N5O2SPurity:98.24% - 99.79%Color and Shape:SolidMolecular weight:409.51Hydralazine hydrochloride
CAS:Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.Formula:C8H9ClN4Purity:99.1% - 99.86%Color and Shape:Yellow Crystals White Crystalline SolidMolecular weight:196.64TIQ-A
CAS:TIQ-A blocks PARP1 to prevent excessive DNA damage response, implicated in ischemia, asthma, and atherosclerosis.Formula:C11H7NOSPurity:99.75%Color and Shape:SolidMolecular weight:201.24Ref: TM-T50098
1mg50.00€5mg97.00€10mg170.00€25mg306.00€50mg437.00€100mg562.00€200mg777.00€1mL*10mM (DMSO)101.00€M1001
CAS:M1001 is a HIF-2α agonist.Formula:C17H17N3O2SPurity:98.83%Color and Shape:SolidMolecular weight:327.4EPZ005687
CAS:EPZ005687 is a potent and selective inhibitor of EZH2.Formula:C32H37N5O3Purity:98% - 99.66%Color and Shape:SolidMolecular weight:539.67SGC707
CAS:SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.Formula:C16H18N4O2Purity:98.45% - 99.75%Color and Shape:SolidMolecular weight:298.34I-CBP112 hydrochloride
CAS:I-CBP112 selectively inhibits CBP/p300 bromodomains, with minimal effect on others, and reduces leukemia cell growth, enhancing JQ1 and doxorubicin's effects.Formula:C27H37ClN2O5Purity:99.69%Color and Shape:SolidMolecular weight:505.05Ref: TM-T4247
1mg90.00€2mg145.00€5mg236.00€10mg447.00€25mg735.00€50mg1,026.00€100mg1,388.00€1mL*10mM (DMSO)447.00€BYK204165
CAS:BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)Formula:C15H12N2O2Purity:99.61%Color and Shape:SolidMolecular weight:252.27MRTX9768
CAS:MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.Formula:C24H17FN6OPurity:98.48%Color and Shape:SolidMolecular weight:424.43GDC-0214
CAS:GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).Formula:C28H28ClF2N9O3Purity:98.54%Color and Shape:SolidMolecular weight:612.03Ref: TM-T9826
1mg87.00€5mg192.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€200mg1,159.00€1mL*10mM (DMSO)259.00€DC-BPi-11 hydrochloride
DC-BPi-11 hydrochloride is a BPTF (bromodomain PHD finger transcription factor) inhibitor with an IC50 value of 698 nM, demonstrating significant anti-Formula:C20H24ClN5O2SPurity:98%Color and Shape:SolidMolecular weight:433.95PROTAC BRD4 Degrader-22
PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based degrader targeting BRD4, exhibiting a pDC50 of 9.2 in MOLT4 cells over 24 hours [1].Purity:98%Color and Shape:Odour Solid(S)-HH2853
CAS:(S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.Formula:C31H36F3N7O3Purity:97.18% - 99.74%Color and Shape:SolidMolecular weight:611.66GNE-955
CAS:GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Formula:C22H24N8OPurity:98%Color and Shape:SolidMolecular weight:416.48DW71177
CAS:DW71177 is a BET inhibitor with potent anti-leukemic activity for the study of leukemia.Formula:C20H28N6O2Purity:98.13%Color and Shape:SoildMolecular weight:384.48SCR-7952
CAS:SCR-7952, a MAT2A inhibitor, is utilized in cancer research.Formula:C19H15ClN4OColor and Shape:SolidMolecular weight:350.80AMG-47a
CAS:AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Formula:C29H28F3N5O2Purity:98%Color and Shape:SolidMolecular weight:535.56Anticancer agent 126
Anticancer agent 126 (compound 12), a WDR5 inhibitor, exhibits anticancer properties by disrupting the WDR5-MYC interaction in cells, subsequently reducing MYCFormula:C25H11BBr2F2N2O3S4Purity:98%Color and Shape:SolidMolecular weight:724.23GSK3685032
CAS:GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM).Formula:C22H24N6OSPurity:98.56% - 99.49%Color and Shape:SolidMolecular weight:420.53Ref: TM-T9573
1mg93.00€5mg188.00€10mg303.00€25mg567.00€50mg810.00€100mg1,111.00€1mL*10mM (DMSO)200.00€Remodelin
CAS:Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.Formula:C15H14N4SPurity:99.39% - 99.78%Color and Shape:SolidMolecular weight:282.36Dehydrocorydaline nitrate
CAS:DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.Formula:C22H24N2O7Purity:99.79%Color and Shape:SolidMolecular weight:428.44ZL0454
CAS:ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).Formula:C18H22N4O3SPurity:98%Color and Shape:SolidMolecular weight:374.46EXQ-2d
EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.Formula:C18H17N3O3Color and Shape:SolidMolecular weight:323.35Naringenin triacetate
CAS:Naringenin Triacetate is a derivative of the flavonoid Naringenin with good binding affinity for the Nac binding site of the structural domain of the BRD4-BD1.Formula:C21H18O8Purity:99.90%Color and Shape:SolidMolecular weight:398.36MK-8617
CAS:MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).Formula:C24H21N5O4Purity:100% - 99.38%Color and Shape:SolidMolecular weight:443.45BRD4 Inhibitor-24
CAS:BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity.Formula:C13H14N2O4Purity:98.65%Color and Shape:SolidMolecular weight:262.26C-7280948
CAS:C-7280948 is a PRMT1 inhibitor.Formula:C14H16N2O2SPurity:98.68% - ≥95%Color and Shape:SolidMolecular weight:276.35Ref: TM-T2097
5mg48.00€10mg70.00€25mg115.00€50mg188.00€100mg283.00€200mg437.00€500mg705.00€1mL*10mM (DMSO)52.00€Metoprine
CAS:Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.Formula:C11H10Cl2N4Purity:98.42%Color and Shape:SolidMolecular weight:269.13Aurora inhibitor 1
CAS:Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).Formula:C23H25N9SPurity:98%Color and Shape:SolidMolecular weight:459.57PBRM1-BD2-IN-8
CAS:PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM).Formula:C15H13BrN2OPurity:99.48%Color and Shape:SoildMolecular weight:317.18Ref: TM-T60157
1mg97.00€5mg246.00€10mg358.00€25mg555.00€50mg735.00€100mg1,008.00€500mg2,023.00€1mL*10mM (DMSO)243.00€OUL35
CAS:OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.Formula:C14H12N2O3Purity:99.20%Color and Shape:SolidMolecular weight:256.26GSK2879552
CAS:GSK2879552: oral, irreversible LSD1 inhibitor with potential cancer-fighting properties.Formula:C23H28N2O2Purity:99.22%Color and Shape:SolidMolecular weight:364.483-Aminobenzamide
CAS:3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction duringFormula:C7H8N2OPurity:98.40% - 99.5%Color and Shape:White To Off-White PowderMolecular weight:136.15Chloramphenicol
CAS:Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.Formula:C11H12Cl2N2O5Purity:99.6% - 99.84%Color and Shape:Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidMolecular weight:323.13DC_517
CAS:DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).Formula:C33H35N3O2Color and Shape:SolidMolecular weight:505.65TC-A 2317 hydrochloride
CAS:TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Formula:C19H29ClN6OPurity:98%Color and Shape:SolidMolecular weight:392.93SHR0302
CAS:SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,Formula:C18H22N8O2SPurity:99.11%Color and Shape:SolidMolecular weight:414.48Ref: TM-T9195
1mg160.00€5mg393.00€10mg620.00€25mg1,035.00€50mg1,483.00€100mg1,882.00€1mL*10mM (DMSO)455.00€lirucitinib
CAS:Lirucitinib is a JAK inhibitor known for its anti-inflammatory properties.Formula:C16H25N5OSColor and Shape:SolidMolecular weight:335.468PROTAC BRM/BRG1 degrader-4
PROTAC BRM/BRG1 degrader-4 (example 047) is a potent degrader targeting both BRM and BRG1, demonstrating DC50 values of 0.21 nM and 3.4 nM respectively in SW1573 cells.Formula:C44H52N10O6SColor and Shape:SolidMolecular weight:849.01EZM0414 TFA
CAS:EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.Formula:C24H30F4N4O4Purity:96.2%Color and Shape:SolidMolecular weight:514.51GSK1379725A
CAS:GSK1379725A is a selective BPTF ligand (Kd = 2.8 μM).Formula:C23H23FN6O3Purity:99.59%Color and Shape:SolidMolecular weight:450.47Ref: TM-T15424
1mg73.00€5mg116.00€10mg188.00€25mg335.00€50mg470.00€100mg662.00€200mg892.00€1mL*10mM (DMSO)134.00€BET-IN-15
CAS:BET-IN-15 (compound 1) is a potent, orally active inhibitor of BET, demonstrating inhibitory IC50 values of 0.64 nM for BRD4-BD1 and 0.25 nM for BRD4-BD2.Formula:C21H18F2N4O3SPurity:98%Color and Shape:SolidMolecular weight:444.45AZD-9574
CAS:AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs.Formula:C21H22F2N6O2Purity:98.39% - 98.55%Color and Shape:SolidMolecular weight:428.44AKB-6899
CAS:AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treatedFormula:C14H11FN2O4Purity:97.11%Color and Shape:SolidMolecular weight:290.25Ref: TM-T29797
1mg74.00€5mg169.00€10mg263.00€25mg455.00€50mg652.00€100mg929.00€1mL*10mM (DMSO)178.00€JAK-IN-11
CAS:JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.Formula:C23H22FN5O4SPurity:99.57%Color and Shape:SolidMolecular weight:483.52Ilorasertib
CAS:Ilorasertib (ABT-348) inhibits Aurora kinases A/B/C & RET, PDGFRβ, Flt1 (IC50: 1-120 nM).Formula:C25H21FN6O2SPurity:96.17% - 98.03%Color and Shape:SolidMolecular weight:488.54DMOG
CAS:DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.Formula:C6H9NO5Purity:80.23% - 99.98%Color and Shape:SolidMolecular weight:175.14PROTAC BRD4 Degrader-3
CAS:PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.Formula:C55H65F2N9O9S2Purity:98%Color and Shape:SolidMolecular weight:1098.3SRX3177
CAS:SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.Formula:C31H32N6O4SPurity:99.16%Color and Shape:SolidMolecular weight:584.69Ref: TM-T69742
1mg77.00€5mg165.00€10mg240.00€25mg408.00€50mg562.00€100mg800.00€1mL*10mM (DMSO)208.00€Bobcat339 hydrochloride
CAS:Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.Formula:C16H13Cl2N3OPurity:99.22%Color and Shape:SolidMolecular weight:334.2Ref: TM-T61012
2mg35.00€5mg52.00€10mg85.00€25mg160.00€50mg250.00€100mg373.00€200mg547.00€1mL*10mM (DMSO)58.00€JNJ-64619178
CAS:JNJ-64619178: selective, oral, pseudo-irreversible PRMT5 inhibitor (IC50: 0.14 nM), effective in lung cancer.Formula:C22H23BrN6O2Purity:98.44% - 99.63%Color and Shape:SolidMolecular weight:483.36Ref: TM-T15624
1mg88.00€5mg170.00€10mg274.00€25mg567.00€50mg944.00€100mg1,659.00€1mL*10mM (DMSO)182.00€AZ505 ditrifluoroacetate
CAS:AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).Formula:C33H40Cl2F6N4O8Color and Shape:SolidMolecular weight:805.593-methyl-1,2,3,4-tetrahydroquinazolin-2-one
CAS:3-methyl-1,2,3,4-tetrahydroquinazolin-2-one is a inhibitor of BRD4 .Formula:C9H10N2OPurity:99.30% - 99.64%Color and Shape:SolidMolecular weight:162.19Ref: TM-T50006
2mg39.00€5mg55.00€10mg82.00€25mg126.00€50mg182.00€100mg273.00€500mg677.00€1mL*10mM (DMSO)59.00€UNC926 hydrochloride
CAS:UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.Formula:C16H22BrClN2OPurity:98.71%Color and Shape:SolidMolecular weight:373.72Ref: TM-T9221
1mg88.00€5mg172.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)177.00€WAY-620473
CAS:WAY-620473 is a potent PARP-1 inhibitor with antitumor activity and alters eukaryotic lifespan.Formula:C17H20N4O3Purity:97.04%Color and Shape:SolidMolecular weight:328.37Tofacitinib
CAS:Tofacitinib (Tasocitinib) is an orally Janus kinase inhibitor. Tofacitinib is used for the treatment of rheumatoid arthritis. Cost effective and quality assured.Formula:C16H20N6OPurity:100% - 99.71%Color and Shape:SolidMolecular weight:312.372'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS:2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.Formula:C9H13ClFN3O4Purity:99.69%Color and Shape:SolidMolecular weight:281.67BBC0403
CAS:BBC0403 is a BRD2 inhibitor, inhibiting BRD2 and BRD2, and suppresses NF-κB and MAPK signaling pathways.Formula:C21H22N2O5Purity:98.15%Color and Shape:SolidMolecular weight:382.41Ref: TM-T88118
1mg69.00€5mg145.00€10mg226.00€25mg469.00€50mg687.00€100mg938.00€200mg1,283.00€1mL*10mM (DMSO)155.00€Mivebresib
CAS:Mivebresib (ABBV-075) is a potent BET inhibitor with antitumor effects, disrupting gene expression and MYC, TMPRSS2-ETS proteins.Formula:C22H19F2N3O4SPurity:98.74% - 99.32%Color and Shape:SolidMolecular weight:459.47Ref: TM-T3712
1mg58.00€2mg82.00€5mg97.00€10mg159.00€25mg256.00€50mg462.00€100mg660.00€1mL*10mM (DMSO)99.00€lutidinic acid
CAS:lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.Formula:C7H5NO4Purity:98.06%Color and Shape:White To Off-White Crystalline PowderMolecular weight:167.12PRMT5-IN-31
PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 andFormula:C21H24N2O2Purity:98%Color and Shape:SolidMolecular weight:336.43CARM1 degrader-2
PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associatedFormula:C72H100N12O7SPurity:98%Color and Shape:SolidMolecular weight:1277.71JAK1/STAT3-IN-1
JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).Formula:C30H33FN4O3SColor and Shape:SolidMolecular weight:548.67AKI603
CAS:AKI603: Aurora A kinase blocker; IC50 12.3 nM; targets BCR-ABL-T315I resistance; halts leukemia cell growth.Formula:C19H23N9O2Purity:99.81%Color and Shape:SolidMolecular weight:409.45Ref: TM-T64338
1mg66.00€5mg145.00€10mg212.00€25mg380.00€50mg562.00€100mg792.00€200mg1,064.00€1mL*10mM (DMSO)160.00€K-756
CAS:K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).Formula:C24H27N5O3Purity:99.68%Color and Shape:SolidMolecular weight:433.5Ref: TM-T15639
1mg52.00€5mg96.00€10mg169.00€25mg316.00€50mg567.00€100mg810.00€500mg1,644.00€1mL*10mM (DMSO)114.00€ML367
CAS:ML367 inhibits ATAD5 stabilization with low micromolar activity, serving as a probe molecule.Formula:C19H12F2N4Purity:99.39%Color and Shape:SolidMolecular weight:334.32ZSNI-21
ZSNI-21 is a dual inhibitor targeting ADAM17 and HDAC2. It effectively suppresses the proliferation of Bel-7402 cells and exhibits significant anti-metastatic properties against HCC-LM3 cells, making it a promising candidate for hepatocellular carcinoma (HCC) research.Formula:C26H25N3O5Color and Shape:SolidMolecular weight:459.49MS0124
CAS:MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.Formula:C20H29N5O3Purity:99.56%Color and Shape:SolidMolecular weight:387.48
