Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
Sort by
LFM-A13
CAS:LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR,Formula:C11H8Br2N2O2Purity:99.9%Color and Shape:SolidMolecular weight:360BAZ1A-IN-1
CAS:BAZ1A-IN-1, a potent inhibitor, KD 0.52 μM against BAZ1A, is effective in high-BAZ1A cancer cells, not in low-BAZ1A ones.Formula:C16H12N4O3SPurity:99.91%Color and Shape:SolidMolecular weight:340.36Ref: TM-T9552
1mg92.00€5mg188.00€10mg296.00€25mg593.00€50mg852.00€100mg1,159.00€200mg1,549.00€1mL*10mM (DMSO)216.00€HIF1-IN-3
CAS:HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used inFormula:C26H24N2O3Purity:99.48%Color and Shape:SolidMolecular weight:412.48LSD1-IN-5
CAS:LSD1-IN-5, a reversible LSD1 inhibitor, boosts H3K4me2 without affecting LSD1 expression; IC50: 121 nM.Formula:C15H13BrN2O3Purity:98%Color and Shape:SolidMolecular weight:349.18INCB054329
CAS:INCB054329 is a BET inhibitor targeting BRD2/3/4 and BRDT with IC50s ranging from 1-119 nM.Formula:C19H16N4O3Purity:98.03%Color and Shape:SolidMolecular weight:348.36NU1025
CAS:NU1025 (NSC-696807) is a potent PARP inhibitor with IC50 of 400 nM.Formula:C9H8N2O2Purity:98.00%Color and Shape:SolidMolecular weight:176.17Ref: TM-T6912
2mg48.00€5mg71.00€10mg103.00€25mg188.00€50mg319.00€100mg502.00€500mg1,121.00€1mL*10mM (DMSO)71.00€Procaine hydrochloride
CAS:Procaine HCl is a benzoic acid derivative used as a local anesthetic, blocking nerve impulses and sensation.Formula:C13H20N2O2·HClPurity:100.00% - 99.22%Color and Shape:White Crystalline PowderMolecular weight:272.77Lin28-let-7a antagonist 1
CAS:Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.Formula:C31H29N5O7Purity:99.91%Color and Shape:SolidMolecular weight:583.59Ref: TM-T11851
1mg92.00€5mg216.00€10mg329.00€25mg593.00€50mg893.00€100mg1,311.00€1mL*10mM (DMSO)281.00€PROTAC SMARCA2 degrader-31
CAS:PROTAC SMARCA2-degrader-36 (compound 38) is an SMARCA2 degrader that achieves a 99% degradation rate at 100 nM in H929 cells. It possesses antiproliferative activity and is used in cancer research.Formula:C48H65N9O6SColor and Shape:SolidMolecular weight:896.15ZL0590
CAS:ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.Formula:C23H27F3N4O4SPurity:99.95%Color and Shape:SoildMolecular weight:512.55Ref: TM-T60072
1mg74.00€5mg160.00€10mg235.00€25mg424.00€50mg635.00€100mg935.00€1mL*10mM (DMSO)177.00€BRD4 Inhibitor-20
CAS:BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity.Formula:C18H18N2O4SPurity:100%Color and Shape:SolidMolecular weight:358.41Ref: TM-T61318
2mg39.00€5mg62.00€10mg90.00€25mg170.00€50mg255.00€100mg359.00€200mg487.00€1mL*10mM (DMSO)77.00€PARP7-IN-16 free base
CAS:PARP7-IN-16 free base is the freebase form of PARP7-IN-16. As a selective oral inhibitor of PARP-1/2/7, it demonstrates IC50 values of 0.94, 0.87, and 0.21 nM, respectively. This compound is utilized in the research of breast and prostate cancer.Formula:C25H27FN4O4Color and Shape:SolidMolecular weight:466.50AZD-1897
CAS:AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.Formula:C18H23N3O3SPurity:99.49%Color and Shape:SolidMolecular weight:361.46Fluzoparib
CAS:Fluzoparib (SHR3162) is a novel, potent, and orally available inhibitor of PARP, potentially for the treatment of solid tumours.Formula:C22H16F4N6O2Purity:98.29% - 98.74%Color and Shape:SolidMolecular weight:472.4Ref: TM-T8806
1mg60.00€2mg88.00€5mg124.00€10mg197.00€25mg389.00€50mg565.00€100mg822.00€500mg1,681.00€1mL*10mM (DMSO)145.00€KRH102140
CAS:KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.Formula:C25H24FNOPurity:98.31% - 99.61%Color and Shape:SolidMolecular weight:373.46Glucosamine
CAS:Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids.Formula:C6H13NO5Purity:99.80% - 99.80%Color and Shape:CoaMolecular weight:179.17AZD-1480
CAS:AZD1480: JAK2 inhibitor, IC50 0.26 nM; selective vs Tyk2, JAK3; less on JAK1. Used in solid tumors, PPV, PMF, ET trials.Formula:C14H14ClFN8Purity:97.5% - 98.55%Color and Shape:SolidMolecular weight:348.77KAT6A-IN-2
CAS:KAT6A-IN-2 (compound 7) is an inhibitor of KAT6A.Formula:C23H29N5O5SColor and Shape:SolidMolecular weight:487.57PJ34
CAS:PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.Formula:C17H17N3O2Purity:95.05% - 99.85%Color and Shape:SolidMolecular weight:295.34TG101209
CAS:TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.Formula:C26H35N7O2SPurity:100% - 99.36%Color and Shape:SolidMolecular weight:509.67JAK-IN-27
CAS:JAK-IN-27, also known as compound 1, is an orally active, potent inhibitor of the JAKS family kinases, displaying inhibitory concentrations (IC50s) of 3.0 nMFormula:C20H21F2N7OPurity:98%Color and Shape:SolidMolecular weight:413.42TCIP 1
TCIP 1 is a small molecule in the category of transcriptional/epigenetic covalent inhibitor probes (TCIPs) that forms covalent bonds with molecules targetingFormula:C50H58Cl2N12O6SPurity:98%Color and Shape:SolidMolecular weight:1026.04DBr-1
DBr-1 is a potent degrader of BRD9 [1].Formula:C55H68ClN9O5Purity:98%Color and Shape:SolidMolecular weight:970.64Kgp-IN-1
CAS:Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.Formula:C19H24F4N4O3Purity:98%Color and Shape:SolidMolecular weight:432.41ATF3 inducer 1
CAS:ATF3 inducer 1 is an ATF3 inducer with lipid-lowering activity, alleviating glucose intolerance and insulin resistance induced by high-fat diet (HFD).Formula:C12H10N2O3Purity:99.04%Color and Shape:SoildMolecular weight:230.22YUKA1
CAS:YUKA1 inhibits Lysine demethylase 5A (IC50: 2.66 μM), weaker on KDM5C (IC50: 7.12 μM), inactive on KDM5B, KDM6A/B.Formula:C13H16N4O2SPurity:98%Color and Shape:SolidMolecular weight:292.36JQAD1
CAS:JQAD1, a potent EP300 degrader (DC50≤31.6 nM), induces apoptosis, suppresses tumor growth, and selectively downregulates CRC and MYCN without affecting CBP.Formula:C48H52F4N6O9Purity:99.75%Color and Shape:SolidMolecular weight:932.95Bleximenib oxalate
CAS:Bleximenib oxalate (Menin-MLL inhibitor 24 oxalate) is a menin-MLL inhibitor that blocks the binding of the menin-KMT2A complex to chromatin at gene promoters.Formula:C34H52FN7O7Purity:98%Color and Shape:SolidMolecular weight:689.82BAY1238097
CAS:BAY1238097 is a BET inhibitor with anticancer activity and antiproliferative activity for the study of advanced refractory malignancies.Formula:C25H33N5O3Purity:98.10% - 99.96%Color and Shape:SolidMolecular weight:451.56Ref: TM-T12660L
1mg52.00€5mg114.00€10mg183.00€25mg404.00€50mg702.00€100mg1,111.00€200mg1,501.00€1mL*10mM (DMSO)125.00€Danusertib
CAS:Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Formula:C26H30N6O3Purity:97.88% - 98.44%Color and Shape:White PowderMolecular weight:474.55Ref: TM-T2094
1mg59.00€2mg85.00€5mg116.00€10mg188.00€25mg365.00€50mg555.00€100mg795.00€500mg1,605.00€1mL*10mM (DMSO)120.00€Vadadustat
CAS:Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.Formula:C14H11ClN2O4Purity:99.09% - 99.4%Color and Shape:SolidMolecular weight:306.7TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formula:C23H22Cl2FN5O3Purity:98.69%Color and Shape:SolidMolecular weight:506.36Ref: TM-T34787
1mg97.00€5mg235.00€10mg378.00€25mg748.00€50mg1,169.00€100mg1,644.00€1mL*10mM (DMSO)261.00€ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Formula:C21H25N7Purity:97.63% - ≥95%Color and Shape:SolidMolecular weight:375.47Ref: TM-T2358
1mg51.00€2mg72.00€5mg105.00€10mg159.00€25mg279.00€50mg462.00€100mg648.00€1mL*10mM (DMSO)116.00€KAT modulator-1
CAS:KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].Formula:C20H36O2Purity:98%Color and Shape:SolidMolecular weight:308.5Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Formula:C27H36N6O3SPurity:98.23% - 99.96%Color and Shape:SolidMolecular weight:524.68Ref: TM-T1995
1g625.00€5mg49.00€10mg69.00€50mg113.00€100mg134.00€200mg216.00€500mg472.00€1mL*10mM (DMSO)57.00€EZH2-IN-15
CAS:A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.Formula:C32H44N4O4Purity:98.85%Color and Shape:SolidMolecular weight:548.72ZG-2033
CAS:ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.Formula:C15H14N2O2SColor and Shape:SolidMolecular weight:286.35Nesuparib
CAS:Nesuparib, a potent PARP/TNKS1 inhibitor, has antitumor properties and potential for treating various diseases.Formula:C23H24N6OPurity:99.71%Color and Shape:SolidMolecular weight:400.48Ref: TM-T61932
1mg88.00€5mg210.00€10mg338.00€25mg605.00€50mg825.00€100mg1,121.00€1mL*10mM (DMSO)233.00€CBP/p300-IN-21
CAS:CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibitsFormula:C19H16ClNO4Purity:98%Color and Shape:SolidMolecular weight:357.79Anacardic Acid
CAS:Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases.Formula:C22H36O3Purity:97.47% - 99.72%Color and Shape:SolidMolecular weight:348.52VZ185
CAS:VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).Formula:C53H67FN8O8SPurity:98%Color and Shape:SolidMolecular weight:995.21HSP90/LSD1-IN-1
HSP90/LSD1-IN-1 (compound 6) is a dual inhibitor of HSP90 and LSD1. This compound effectively inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI50 values of 0.24 μM and 0.30 μM, respectively.Color and Shape:Odour SolidGSK737
CAS:GSK737 is a dual inhibitor of BRD4 BD1 and BD2, exhibiting pIC50 values of 5.3 and 7.3, respectively.Formula:C20H21N5O2Purity:98%Color and Shape:SolidMolecular weight:363.41NSC243928 mesylate
CAS:NSC243928 mesylate binds to human lymphocyte antigen 6 (LY6), a cell growth inhibitor with anticancer activity.Formula:C23H25N3O6S2Purity:99.39%Color and Shape:SolidMolecular weight:503.59MY-1B
CAS:MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.Formula:C22H18BrN3O2Purity:100% - 100%Color and Shape:SoildMolecular weight:436.3Tyk2-IN-20
CAS:Tyk2-IN-20 (Example 289) is an effective inhibitor of Tyk2 with an IC50 value below 5 nM. Additionally, it inhibits JAK1, JAK2, and JAK3 with IC50 values under 100 nM. This compound is utilized for the research of inflammatory diseases.Formula:C24H25N7O2Color and Shape:SolidMolecular weight:443.50Brepocitinib
CAS:Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).Formula:C18H21F2N7OPurity:99.8%Color and Shape:SolidMolecular weight:389.4Ref: TM-TQ0010
1mg35.00€5mg74.00€10mg110.00€25mg226.00€50mg411.00€100mg660.00€200mg917.00€1mL*10mM (DMSO)81.00€PKC β pseudosubstrate acetate
PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.Purity:95.01%Color and Shape:SoildCM-579
CAS:CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.Formula:C29H40N4O3Purity:99.62%Color and Shape:SolidMolecular weight:492.65Ref: TM-T10840L
1mg55.00€5mg96.00€10mg138.00€25mg217.00€50mg319.00€100mg472.00€1mL*10mM (DMSO)124.00€BRD4 Inhibitor-10
CAS:BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).Formula:C25H27N5O2Purity:98.98%Color and Shape:SolidMolecular weight:429.51Ref: TM-T14776
1mg47.00€5mg97.00€10mg156.00€25mg301.00€50mg437.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)105.00€RO8191
CAS:RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Formula:C14H5F6N5OPurity:98.85% - ≥98%Color and Shape:SolidMolecular weight:373.21Baricitinib
CAS:Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Formula:C16H17N7O2SPurity:100% - 99.79%Color and Shape:SolidMolecular weight:371.42Ref: TM-T2485
5mg50.00€10mg73.00€25mg90.00€50mg115.00€100mg144.00€200mg188.00€500mg311.00€1mL*10mM (DMSO)69.00€KDM5-C70
CAS:KDM5-C70 is an ethyl ester derivative of KDM5-C49.Formula:C17H28N4O3Purity:97.63% - 99.12%Color and Shape:SolidMolecular weight:336.43Ref: TM-T15648
2mg44.00€5mg62.00€10mg88.00€25mg140.00€50mg245.00€100mg490.00€200mg700.00€500mg1,074.00€1mL*10mM (DMSO)73.00€JAK1-IN-4
CAS:JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).Formula:C26H32FN9O2Purity:98%Color and Shape:SolidMolecular weight:521.59Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formula:C19H15N3O2SPurity:99.47%Color and Shape:SolidMolecular weight:349.41BAY-299
CAS:BAY-299 inhibits BRPF2, TAF1, and TAF1L with IC50s of 67, 8, and 106 nM.Formula:C25H23N3O4Purity:97.5%Color and Shape:SolidMolecular weight:429.47MS37452
CAS:MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).Formula:C22H26N2O5Purity:99.39% - 99.39%Color and Shape:SolidMolecular weight:398.45Ref: TM-T21767
5mg51.00€10mg88.00€25mg170.00€50mg305.00€100mg527.00€500mg1,121.00€1mL*10mM (DMSO)57.00€Hellebrigenin
CAS:Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt.Formula:C24H32O6Purity:98%Color and Shape:SolidMolecular weight:416.51Glucosamine hydrochloride
CAS:Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.Formula:C6H13NO5·HClPurity:99.77%Color and Shape:White Solid CrystallineMolecular weight:215.63AJI-214
CAS:AJI-214 functions as a dual-target inhibitor that specifically blocks Aurora kinase A and JAK2. By directly inhibiting Aurora kinase A, AJI-214 prevents mitotic progression and cell polarity in T cells while concurrently suppressing JAK2 activation to reduce STAT3 phosphorylation. This inhibition decreases the differentiation of TH1 and TH17 cells. AJI-214 is utilized in research focused on the modulation of immune responses and the prevention of graft-versus-host disease (GVHD).Formula:C17H13ClFN5OColor and Shape:SolidMolecular weight:357.77MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Formula:C15H26Cl2N2OPurity:99.9%Color and Shape:SolidMolecular weight:321.28HDAC11-IN-1
HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.Formula:C43H63F3N6O6S2Color and Shape:SolidMolecular weight:881.12DPP
CAS:DPP, a Platinum(IV) complex with a pterostilbene-derived axial ligand, inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, demonstratingFormula:C36H40Cl2N2O10PtPurity:98%Color and Shape:SolidMolecular weight:926.7Euchrestaflavanone B
CAS:Euchrestaflavanone B has antibacterial effects on Gram-positive bacteria and may inhibit cancer by targeting protein kinase CKII.Formula:C25H28O6Purity:98%Color and Shape:SolidMolecular weight:424.49PRMT5-IN-25
CAS:PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1Formula:C24H21F3N6OPurity:98%Color and Shape:SolidMolecular weight:466.46CM-579 trihydrochloride (1846570-40-8 free base)
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wideFormula:C29H43Cl3N4O3Purity:98%Color and Shape:SolidMolecular weight:602.04FKBP12 PROTAC dTAG-7
CAS:dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.Formula:C63H79N5O19Purity:98%Color and Shape:SolidMolecular weight:1210.32AJI-100
CAS:AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD).Formula:C17H14FN5OColor and Shape:SolidMolecular weight:323.32CTX-0124143
CAS:CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.Formula:C17H13FN2O3SPurity:99.16%Color and Shape:SolidMolecular weight:344.36EZH2-IN-13
CAS:EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.Formula:C34H45N5O3Purity:98.3%Color and Shape:SolidMolecular weight:571.75TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Formula:C27H25F3N4O4Purity:≥98%Color and Shape:SolidMolecular weight:526.51UNC0379
CAS:UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.Formula:C23H35N5O2Purity:94.41% - 99.97%Color and Shape:SolidMolecular weight:413.56ZG-2305
ZG-2305 is an effective, selective, and orally active inhibitor of FIH (factor inhibiting hypoxia-inducible factor (FIH)), with Ki values of 79.6 nM for FIH and 2786 nM for PHD2. This compound enhances the expression of the EGLN3 gene, reduces cellular triglyceride levels, and decreases lipid accumulation. ZG-2305 holds potential for research into obesity and fatty liver disease.Formula:C17H11Cl2N3O5Color and Shape:SolidMolecular weight:408.19LSD1-IN-37
LSD1-IN-37 (Compound 5g) is an inhibitor of lysine-specific demethylase 1 (LSD1), developed through an efficient synthesis strategy incorporating a hexafluoroisopropyl group. This approach does not require metal catalysts and offers excellent reaction stability and adaptability. LSD1-IN-37 exhibits outstanding LSD1 inhibitory activity and has potential for further research.Formula:C15H13F2N5Color and Shape:SolidMolecular weight:301.29Niraparib metabolite M1 HCl
Niraparib metabolite M1 HCl, a PARP1/2 inhibitor, used in the study of ovarian cancer, fallopian tube cancer and primary peritoneal cancer.Formula:C19H20ClN3O2Color and Shape:SolidMolecular weight:357.83Ref: TM-T12229L
1mg171.00€5mg364.00€10mg547.00€25mg929.00€50mg1,391.00€100mg2,087.00€1mL*10mM (DMSO)245.00€PROTAC SMARCA2 degrader-18
CAS:PROTAC SMARCA2 degrader-18 (Example144) is a PROTAC SMARCA2 degrader with potential for researching non-small cell lung cancer (NSCLC).Formula:C40H41N9O3Color and Shape:SolidMolecular weight:695.81SMYD3-IN-1
CAS:SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).Formula:C28H31ClN4O3Purity:98%Color and Shape:SolidMolecular weight:507.02GSK2879552 2HCl (1401966-69-5(free base))
GSK2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.Formula:C23H30Cl2N2O2Purity:98.08% - ≥95%Color and Shape:SolidMolecular weight:437.41Ref: TM-T4418
1mg59.00€2mg86.00€5mg109.00€10mg175.00€25mg293.00€50mg411.00€100mg610.00€500mg1,301.00€PROTAC SMARCA2/4-degrader-26
PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.Formula:C38H47N9O5SColor and Shape:SolidMolecular weight:741.9Phoenixin-20 TFA
Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide that exerts hormone-like effects in vertebrates, stimulating hypothalamo-pituitary-gonadal hormones andFormula:C101H153N25O29·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:2181.45 (free base)Y06036
CAS:Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).Formula:C16H15BrN2O5SPurity:98.95%Color and Shape:SolidMolecular weight:427.27P3FI-63
CAS:P3FI-63 is a selective KDM3B inhibitor (IC50: 7 μM) with antitumor activity for the study of fusion-positive rhabdomyosarcoma and other transcriptionally addictive cancers.Formula:C15H15N3O2Purity:99.16%Color and Shape:SoildMolecular weight:269.3PROTAC SMARCA2/4-degrader-31
CAS:PROTAC SMARCA2/4-degrader-31 (Compound I-280) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in A549 cells and SMARCA4 in MV411 cells, both with a degradation concentration (DC50) of less than 100 nM.Formula:C44H51N11O4Color and Shape:SolidMolecular weight:797.95CP2
CP2 is a useful organic compound for research related to life sciences and the catalog number is T35338.Purity:98%Color and Shape:SolidMAT2A inhibitor 4
CAS:MAT2A Inhibitor 4 acts as an inhibitor targeting the catalytic subunit of methionine S-adenosyltransferase-2 (MAT2A), offering potential utility in cancerFormula:C16H15ClFNPurity:98.86%Color and Shape:SolidMolecular weight:275.75Ref: TM-T9262
1mg52.00€5mg116.00€10mg182.00€25mg315.00€50mg449.00€100mg610.00€200mg822.00€1mL*10mM (DMSO)128.00€Inobrodib
CAS:Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain.Formula:C30H32F2N4O3Purity:98.91% - 99.18%Color and Shape:SolidMolecular weight:534.6Ref: TM-T10717
1mg70.00€2mg92.00€5mg153.00€10mg264.00€25mg557.00€50mg797.00€100mg1,074.00€1mL*10mM (DMSO)173.00€MZP-55
CAS:MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)Formula:C57H70ClN7O10SPurity:98%Color and Shape:SolidMolecular weight:1080.73Anti-PARP1 Antibody (8I163)
Anti-PARP1 Antibody (8I163) is a Mouse antibody targeting PARP1. Anti-PARP1 Antibody (8I163) can be used in IHC-P.Color and Shape:Odour LiquidCBP/EP300-IN-1
CAS:CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.Formula:C23H23FN2O5Purity:99.05%Color and Shape:SolidMolecular weight:426.44PCAF-IN-1
CAS:PCAF-IN-1 is a highly selective PCAF inhibitor with potential anti-tumor, anti-inflammatory, and anti-heart disease effects.Formula:C15H11ClN6Color and Shape:SolidMolecular weight:310.74Protosappanin A
CAS:Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.Formula:C15H12O5Purity:100% - 99.42%Color and Shape:SolidMolecular weight:272.25Ref: TM-TJS1779
1mg87.00€5mg216.00€10mg354.00€25mg582.00€50mg825.00€100mg1,111.00€1mL*10mM (DMSO)197.00€Dot1L-IN-2
CAS:Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectivelyFormula:C27H24N8OPurity:98%Color and Shape:SolidMolecular weight:476.53Dihydro-5-azacytidine FA
Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.Formula:C9H16N4O7Purity:100%Color and Shape:SolidMolecular weight:292.25LSQ-28
LSQ-28 is an orally active HDAC3 inhibitor with an IC50 of 42 nM, demonstrating significant anticancer, antiproliferative, anti-migration, anti-invasion, and anti-wound healing activities. LSQ-28 is suitable for cancer research.Formula:C31H27N5OMolecular weight:485.579QC6352
CAS:QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).Formula:C24H25N3O2Purity:98%Color and Shape:SolidMolecular weight:387.47Momelotinib
CAS:Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Formula:C23H22N6O2Purity:97.47% - 99.56%Color and Shape:SolidMolecular weight:414.46Ref: TM-T1849
1mg38.00€2mg49.00€5mg81.00€10mg95.00€25mg166.00€50mg259.00€100mg406.00€200mg625.00€1mL*10mM (DMSO)88.00€PROTAC SMARCA2/4-degrader-30
CAS:Compound I-291, also known as PROTAC SMARCA2/4-degrader-30, targets the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. It effectively degrades SMARCA2 in A549 and MV411 cells, as well as SMARCA4 in MV411 cells, with a degradation concentration (DC50) of less than 100 nM.Formula:C44H51N11O4Color and Shape:SolidMolecular weight:797.95BMS-P5 free base
CAS:BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor.Formula:C27H32N6O2Purity:99.88%Color and Shape:SolidMolecular weight:472.58CBP/p300-IN-3
CAS:CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase.Formula:C24H29N7OPurity:97.35% - 97.38%Color and Shape:SolidMolecular weight:431.53Ref: TM-T12345
1mg92.00€5mg187.00€10mg311.00€25mg562.00€50mg810.00€100mg1,121.00€500mg2,232.00€1mL*10mM (DMSO)215.00€
