Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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NSD2-PWWP1-IN-1
CAS:NSD2-PWWP1-IN-1 (compound 31) is a potent inhibitor of NSD2-PWWP1 with an IC50 value of 0.64 µM, demonstrating potential applications in cancer research.Formula:C28H30N4Color and Shape:SolidMolecular weight:422.565WWL0245
CAS:WWL0245 is a potent and selective BRD4-targeting PROTAC that exhibits sub-nanomolar degradation efficiency (DC50 < 1 nM) for BRD4 over BRD2/3 and PLK1 (DC50 > 1Formula:C45H51N11O8Purity:98%Color and Shape:SolidMolecular weight:873.963-pyridine toxoflavin
CAS:3-pyridine toxoflavin is a potent KDM4C inhibitor, IC50=19nM.Formula:C12H10N6O2Purity:99.83%Color and Shape:SoildMolecular weight:270.25Ref: TM-T67738
1mg185.00€5mg426.00€10mg627.00€25mg938.00€50mg1,320.00€100mg1,786.00€500mg3,591.00€1mL*10mM (DMSO)378.00€EPZ020411
CAS:EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).Formula:C25H38N4O3Color and Shape:SolidMolecular weight:442.6Tulmimetostat
CAS:Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advancedFormula:C28H36ClN3O5SPurity:98.04%Color and Shape:SolidMolecular weight:562.12XAV-939
CAS:XAV-939 (NVP-XAV939) shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assay).Formula:C14H11F3N2OSPurity:97.47% - 99.04%Color and Shape:SolidMolecular weight:312.31ZINC13466751
CAS:ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).Formula:C20H21N5O2Purity:99.94%Color and Shape:SolidMolecular weight:363.41Ref: TM-T13398
1mg48.00€5mg97.00€10mg160.00€25mg255.00€50mg353.00€100mg452.00€200mg630.00€1mL*10mM (DMSO)105.00€653-47 hydrochloride
CAS:653-47 hydrochloride boosts CREB inhibition by 666-15 and weakly inhibits CREB itself (IC50: 26.3 μM).Formula:C20H20Cl2N2O3Purity:99.14%Color and Shape:SolidMolecular weight:407.29Ref: TM-T8890
1mg92.00€5mg187.00€10mg354.00€25mg597.00€50mg852.00€100mg1,159.00€500mg2,327.00€1mL*10mM (DMSO)215.00€Olaparib
CAS:View and buy Olaparib from TargetMol.Olaparib is a small molecule inhibitor of PARP1/PARP2.Cited in 10 publications.Formula:C24H23FN4O3Purity:100% - 99.90%Color and Shape:SolidMolecular weight:434.46PROTAC SMARCA2/4-degrader-34
PROTAC SMARCA2/4-degrader-34 (compound 38) serves as an effective degrader of both SMARCA2 and SMARCA4. It demonstrates binding affinity to PXR with a DC50 value of 85.1 nM and reduces the protein expression of 3xFLAG-PXR.Formula:C58H78N8O13SColor and Shape:SolidMolecular weight:1127.35HJ-PI01
CAS:HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.Formula:C14H11NO2Purity:99.55%Color and Shape:SolidMolecular weight:225.24Ref: TM-T9583
1mg35.00€5mg80.00€10mg116.00€25mg259.00€50mg383.00€100mg545.00€200mg740.00€1mL*10mM (DMSO)77.00€C-82
CAS:C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.Formula:C33H34N6O4Purity:98.86% - 99.66%Color and Shape:SolidMolecular weight:578.66JAK1-IN-10
CAS:JAK1-IN-10 (compound 9), a cyano-substituted cyclic hydrazine derivative, functions as a potent and selective inhibitor of JAK1 [1].Formula:C15H17N7Purity:98%Color and Shape:SolidMolecular weight:295.34Tankyrase-IN-5
CAS:Tankyrase-IN-5 (Compound 30f), structurally related to MSC2504877, effectively inhibits tankyrase isoforms TNKS1 and TNKS2, with half-maximal inhibitoryFormula:C17H18N2O2Purity:98%Color and Shape:SolidMolecular weight:282.34AZD5305
CAS:AZD5305 is a potent, selective and oral active PARP inhibitor.Formula:C22H26N6O2Purity:98.68% - 99.19%Color and Shape:SolidMolecular weight:406.48Ref: TM-T9165
1mg113.00€5mg235.00€10mg378.00€25mg630.00€50mg898.00€100mg1,216.00€1mL*10mM (DMSO)259.00€Hinokitiol
CAS:Hinokitiol prevents UVB-caused cell death, boosts antioxidant activity, and hinders breast cancer growth.Formula:C10H12O2Purity:99.49% - 99.67%Color and Shape:SolidMolecular weight:164.2ICG001
CAS:ICG001 antagonizes Wnt signaling, binds CBP with 3 μM IC50, not p300.Formula:C33H32N4O4Purity:99.06% - 99.95%Color and Shape:SolidMolecular weight:548.63Ref: TM-T2237
1mg35.00€5mg70.00€10mg106.00€25mg207.00€50mg360.00€100mg558.00€500mg1,198.00€1mL*10mM (DMSO)86.00€EPZ011989
CAS:EPZ011989: potent, selective oral EZH2 inhibitor, Ki < 3 nM, 15x more selective than EZH1, >3000x over other HMTases.Formula:C35H51N5O4Purity:98% - 99.81%Color and Shape:SolidMolecular weight:605.81GSK8814
CAS:GSK8814 is a selective and ATAD2/2B bromodomain chemical probe and inhibitor (binding constant pKd=8.1 and a pKi=8.9 in BROMOscan).Formula:C28H35F2N5O3Purity:98%Color and Shape:SolidMolecular weight:527.61BRD9 Degrader-1
BRD9 Degrader-1 functions as a BRD9 degrader, demonstrating micromolar binding affinity towards BRD9 and nanomolar affinity for the ternary complex involvingPurity:98%Color and Shape:Odour SolidMM-102
CAS:MM-102 (HMTase Inhibitor IX) is a potent inhibitor of WDR5/MLL interaction with IC50 of 2.4 nM and Ki of less than 1 nM in a WDR5 binding assay.Cost-effective and quality-assured.Formula:C35H49F2N7O4Purity:98.77% - 99.08%Color and Shape:SolidMolecular weight:669.8Ref: TM-T6333
1mg39.00€2mg51.00€5mg105.00€10mg168.00€25mg351.00€50mg543.00€100mg777.00€1mL*10mM (DMSO)156.00€PHD-1-IN-1
CAS:PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).Formula:C13H8N4Purity:99.78%Color and Shape:SolidMolecular weight:220.23Aurora A inhibitor 3
Aurora A Inhibitor 3 (Compound 5h) effectively inhibits Aurora-A kinase, exhibiting an IC50 of 0.78 μM, and demonstrates cytotoxicity against MCF-7 and MDA-MB-Purity:98%Color and Shape:Odour SolidKW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Formula:C20H20N4OPurity:98.43% - 99.89%Color and Shape:SolidMolecular weight:332.4Tranylcypromine (2-PCPA) hydrochloride
CAS:Tranylcypromine (2-PCPA) HCl, a MAO inhibitor, treats major, dysthymic, and atypical depression.Formula:C9H11N·HClPurity:99.48% - 99.86%Color and Shape:SolidMolecular weight:169.66B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormula:C20H17ClN4O3Purity:99.14%Color and Shape:SolidMolecular weight:396.83LIN28 inhibitor LI71
CAS:LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.Formula:C21H21NO3Purity:95.88%Color and Shape:SolidMolecular weight:335.4Ref: TM-T11850
1mg137.00€5mg329.00€10mg494.00€25mg822.00€50mg1,121.00€100mg1,539.00€1mL*10mM (DMSO)360.00€PARP-1-IN-2
CAS:PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity againstFormula:C22H15Cl2N3O2Purity:98.82%Color and Shape:SolidMolecular weight:424.28Ref: TM-T62281
1mg65.00€5mg145.00€10mg226.00€25mg379.00€50mg538.00€100mg730.00€200mg938.00€1mL*10mM (DMSO)155.00€NHWD-870
CAS:NHWD-870 selectively inhibits BET bromodomains BRD2-4, BRDT; potent anti-cancer effect by inducing apoptosis, halting cell growth.Formula:C29H29N7OPurity:98%Color and Shape:SolidMolecular weight:491.59MG 149
CAS:MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).Formula:C22H28O3Purity:98.28% - 99.1%Color and Shape:SolidMolecular weight:340.46Ref: TM-T6584
1mg52.00€2mg74.00€5mg96.00€10mg170.00€25mg324.00€50mg518.00€100mg747.00€1mL*10mM (DMSO)114.00€AZD5153 6-Hydroxy-2-naphthoic acid
CAS:AZD5153 6-Hydroxy-2-naphthoic acid (AZD5153) is a potent triazolopyridazine-based Bromodomain (BRD4) and Extraterminal (BET) inhibitor used in cancer treatmentsFormula:C25H33N7O3·C11H8O3Purity:100% - ≥95%Color and Shape:SolidMolecular weight:667.75MM-589 TFA
CAS:MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Formula:C30H45F3N8O7Purity:98%Color and Shape:SolidMolecular weight:686.72MIV-6R
CAS:MIV-6R inhibits Menin-MLL interaction (IC50: 56 nM) and can be used to study leukemia.Formula:C27H35N3OPurity:100.00% - 99.88%Color and Shape:SolidMolecular weight:417.59Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Formula:C15H18O2Purity:97.55% - 99.83%Color and Shape:SolidMolecular weight:230.3SNS-314 Mesylate
CAS:SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Formula:C18H15ClN6OS2·CH4O3SPurity:99.44% - 99.92%Color and Shape:SolidMolecular weight:527.04BMS-P5
CAS:BMS-P5 is a specific and orally active Peptidylarginine Deiminase 4 (PAD4) inhibitor.Formula:C27H33ClN6O2Purity:99.61%Color and Shape:SolidMolecular weight:509.04Ref: TM-T22277
2mg47.00€5mg90.00€10mg143.00€25mg283.00€50mg505.00€100mg802.00€200mg1,074.00€1mL*10mM (DMSO)92.00€CCT 137690
CAS:CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM).Formula:C26H31BrN8OPurity:98.51% - 99.82%Color and Shape:SolidMolecular weight:551.48CEP-9722
CAS:CEP-9722 is a PARP-1 and PARP-2 inhibitor with anticancer activity and is used in the study of ovarian cancer.Formula:C24H26N4O3Purity:99.40% - 99.64%Color and Shape:SolidMolecular weight:418.49GSK J5
CAS:GSK J5: schistosome, helminth inhibitor; trematode insecticide; boosts schistosome death dose/time-wise.Formula:C24H27N5O2Purity:100%Color and Shape:SolidMolecular weight:417.5TAK-418
CAS:TAK-418 is an orally active LSD1/KDM1A inhibitor with a 2.9 nM IC50, potential for autism therapy.Formula:C17H25ClN2O2SPurity:98.87%Color and Shape:SolidMolecular weight:356.91Ref: TM-T39252
1mg138.00€5mg329.00€10mg520.00€25mg1,064.00€50mg1,434.00€100mg1,920.00€200mg2,593.00€1mL*10mM (DMSO)386.00€PRMT5-IN-29
CAS:PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].Formula:C18H20Cl3N5O5Purity:98%Color and Shape:SolidMolecular weight:492.74Palmatine
CAS:Palmatine, also known as Burasaine, inhibits dopamine production and may treat flavivirus, jaundice, dysentery, hypertension, and liver issues.Formula:C21H22NO4Purity:96.28% - 99.49%Color and Shape:SolidMolecular weight:352.4HIF-2α-IN-4
CAS:HIF-2a translation inhibitor is a compound used as a molecular building block.Formula:C9H9N3O4S2Purity:≥98%Color and Shape:SolidMolecular weight:287.32T-448
CAS:T-448 is a lysine-specific demethylase 1 inhibitor (IC50: 22 nM) that improves learning function in mice.T-448 can be used to study memory deficits.Formula:C19H22N4O3SPurity:97% - 98.63%Color and Shape:SolidMolecular weight:386.47SNDX-5613
CAS:Revumenib (SNDX-5613) is a potent and selective oral inhibitor of menin-KMT2A interaction.Cost-effective and quality-assured.Formula:C32H47FN6O4SPurity:99.12% - 99.12%Color and Shape:SolidMolecular weight:630.82Ref: TM-T12943
1mg73.00€2mg97.00€5mg160.00€10mg274.00€25mg542.00€50mg778.00€100mg1,074.00€1mL*10mM (DMSO)217.00€S2101
CAS:S 2101 is an inhibitor of lysine-specific demethylase 1 (LSD1)(IC50 of 0.99 μM, Ki of 0.61 μM and Kinact/Ki of 4560 M/s).Formula:C16H16ClF2NOPurity:98%Color and Shape:SolidMolecular weight:311.75PFI-3
CAS:PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.Formula:C19H19N3O2Purity:99.71% - 99.94%Color and Shape:SolidMolecular weight:321.37Ref: TM-T6939
1mg38.00€2mg49.00€5mg78.00€10mg103.00€25mg210.00€50mg319.00€100mg474.00€1mL*10mM (DMSO)78.00€HDAC3-IN-T247
CAS:HDAC3-IN-T247 (HDAC3 inhibitor T247) is a histone deacetylase 3 (HDAC3) inhibitor with antiviral activity that inhibits the proliferation of cancer cells.Formula:C21H19N5OSPurity:98.11% - 98.94%Color and Shape:SolidMolecular weight:389.47Ref: TM-T24131
1mg92.00€5mg188.00€10mg311.00€25mg643.00€50mg914.00€100mg1,216.00€1mL*10mM (DMSO)215.00€Ifidancitinib
CAS:Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.Formula:C20H18FN5O3Purity:98.05%Color and Shape:SolidMolecular weight:395.39O6BTG-C8-αGlu
CAS:O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.Formula:C24H34BrN5O7SColor and Shape:SolidMolecular weight:616.525GNE-049
CAS:GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay).Formula:C27H32F2N6O2Color and Shape:SolidMolecular weight:510.58PBRM1-BD2-IN-2
CAS:PBRM1-BD2-IN-2 selectively inhibits PBRM1 with Kd 9.3μM & IC50 1.0μM, useful in cancer research.Formula:C14H9Cl2FN2OPurity:100%Color and Shape:SoildMolecular weight:311.14Ref: TM-T60156
1mg115.00€5mg255.00€10mg375.00€25mg562.00€50mg787.00€100mg1,074.00€500mg2,157.00€1mL*10mM (DMSO)245.00€JAK-IN-10
CAS:JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.Formula:C20H18FN5O3SPurity:98.88%Color and Shape:SolidMolecular weight:427.45Ref: TM-T13571
1mg87.00€5mg177.00€10mg260.00€25mg429.00€50mg605.00€100mg815.00€500mg1,624.00€1mL*10mM (DMSO)188.00€WDR5-IN-6
CAS:WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6Formula:C13H8Cl2N2O2SPurity:99.69%Color and Shape:SoildMolecular weight:327.19PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Color and Shape:Odour SolidJAK kinase-IN-1
CAS:JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32Formula:C17H19F2N7OSPurity:98%Color and Shape:SolidMolecular weight:407.441-benzyl-2-ethyl-4,5,6,7-tetrahydro-1H-indol-4-one
CAS:1-benzyl-2-ethyl-4,5,6,7-tetrahydro-1H-indol-4-one is an inhibitor Bromodomain-containing protein 4 (human).Formula:C17H19NOPurity:99.08%Color and Shape:SolidMolecular weight:253.34Ref: TM-T8601
1mg88.00€5mg170.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)164.00€ITK inhibitor 2
CAS:ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor , with an IC50 of 2 nM.Formula:C25H33N5O2Color and Shape:SolidMolecular weight:435.56UNC 669
CAS:UNC 669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.Formula:C15H20BrN3OPurity:97.38%Color and Shape:SolidMolecular weight:338.24Nicotinamide riboside
CAS:Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-Formula:C11H15N2O5Purity:98.61% - 99.58%Color and Shape:SolidMolecular weight:255.25G-631
CAS:G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.Formula:C19H22F2N6O3Color and Shape:SolidMolecular weight:420.41PROTAC HDAC6 degrader 2
PROTAC HDAC6 degrader 2 (Compound 1) is an HDAC6 PROTAC degrader with an IC50 value of 0.643 μM. It facilitates the ubiquitination and degradation of HDAC6 and is applicable in research on hematological and solid cancers.Formula:C34H33F2N9O8Molecular weight:733.678PJ34 hydrochloride
CAS:PJ34 hydrochloride (PJ34 HCl) is a potent specific inhibitor of PARPl/2.Formula:C17H18ClN3O2Purity:98.87% - ≥95%Color and Shape:SolidMolecular weight:331.8Rucaparib
CAS:Rucaparib (PF-01367338) is a orally PARP inhibitor and a H6PD inhibitor. Rucaparib exhibits antitumor activity against CRPC. Cost-effective and quality-assured.Formula:C19H18FN3OPurity:98.37% - 99.80%Color and Shape:SolidMolecular weight:323.36Ref: TM-T4463
2mg48.00€5mg73.00€10mg115.00€25mg173.00€50mg235.00€100mg364.00€200mg540.00€500mg869.00€1mL*10mM (DMSO)81.00€W4275
CAS:W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity and an IC50 of 17 nM. It exhibits antiproliferative activity, with an IC50 of 230 nM against RS411 cells, and significantly inhibits tumor growth in an RS411 tumor xenograft model. Pharmacokinetic analysis in mice shows that W4275 has a favorable oral bioavailability (F is 27.34%). W4275 holds potential for use in cancer research.Formula:C25H36N6O3Color and Shape:SolidMolecular weight:468.59YD23
CAS:YD23 is a PROTAC that induces SMARCA2 degradation, has anticancer activity, and selectively inhibits the growth of SMARCA4 mutant lung cancer cells in vitro.Formula:C38H39FN8O7Purity:99.11%Color and Shape:SolidMolecular weight:738.76Curcumin
CAS:Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity.Formula:C21H20O6Purity:95% - 98.98%Color and Shape:Orange-Yellow Crystal Powder; Gives Brownish-Red Color With Alkali; Light-Yellow Color With Acids Physical Description Orange-Yellow Needles (Ntp 1992)Molecular weight:368.3799OF-1
CAS:OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.Formula:C17H18BrN3O4SPurity:98.55% - ≥95%Color and Shape:SolidMolecular weight:440.31Ref: TM-T2127
1mg38.00€5mg79.00€10mg130.00€25mg254.00€50mg406.00€100mg628.00€200mg879.00€1mL*10mM (DMSO)79.00€LLY-507
CAS:LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.Formula:C36H42N6OPurity:99.56% - 99.93%Color and Shape:SolidMolecular weight:574.76Ref: TM-T6879
1mg44.00€2mg55.00€5mg85.00€10mg138.00€25mg304.00€50mg552.00€100mg787.00€1mL*10mM (DMSO)110.00€Nudifloramide
CAS:Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD).Formula:C7H8N2O2Purity:99.49% - ≥95%Color and Shape:SolidMolecular weight:152.15Eleven-Nineteen-Leukemia Protein IN-1
CAS:ENL-IN-1: Potent ENL YEATS domain inhibitor with 14.5 nM IC50, enhances thermal stability in vitro.Formula:C27H33N7O2Purity:98%Color and Shape:SolidMolecular weight:487.6Ilginatinib hydrochloride
CAS:Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Formula:C21H21ClFN7Purity:99.55%Color and Shape:SolidMolecular weight:425.89Ref: TM-T12266L2
1mg77.00€5mg165.00€10mg240.00€25mg408.00€50mg562.00€100mg800.00€200mg1,074.00€1mL*10mM (DMSO)177.00€TM11
TM11, a tanshinone analog, serves as an effective inhibitor of HuR, preventing the formation of HuR-RNA complexes. It also reduces LPS-induced inflammatory responses in murine macrophages.Formula:C19H12O5SColor and Shape:SolidMolecular weight:352.36SMD-3040
SMD-3040 is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM), which consists of an SMARCA2/4 ligand, a linker, and a VHL ligand.Formula:C52H66N10O5SPurity:98%Color and Shape:SolidMolecular weight:943.21EML741
CAS:EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.Formula:C31H49N5O2Purity:98%Color and Shape:SolidMolecular weight:523.75BI-9321 trihydrochloride
CAS:BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.Formula:C22H24Cl3FN4Purity:99.12% - 99.96%Color and Shape:SolidMolecular weight:469.81JAK-IN-31
CAS:JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,Formula:C21H19N7O2S2Purity:98%Color and Shape:SolidMolecular weight:465.55HIF-1α-IN-2 hydrochloride
HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM inFormula:C21H20ClN3OSPurity:98%Color and Shape:SolidMolecular weight:397.92G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formula:C22H19F2NO3Purity:97.30%Color and Shape:SolidMolecular weight:383.39Ref: TM-T8742
1mg50.00€5mg97.00€10mg145.00€25mg259.00€50mg374.00€100mg523.00€200mg710.00€1mL*10mM (DMSO)105.00€Niraparib tosylate
CAS:Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.Formula:C19H20N4O·C7H8O3SPurity:99.34% - 99.87%Color and Shape:SolidMolecular weight:492.59Ref: TM-T6892
2mg46.00€5mg66.00€10mg93.00€25mg117.00€50mg147.00€100mg230.00€500mg563.00€1mL*10mM (DMSO)72.00€VTP50469
CAS:VTP50469 is a highly selective and orally active small molecule inhibitor of the Menin-MLL protein-protein interaction.Cost-effective and quality-assured.Formula:C32H47FN6O4SPurity:98.31% - 98.92%Color and Shape:SolidMolecular weight:630.82Ref: TM-T13336
1mg167.00€5mg354.00€10mg424.00€25mg592.00€50mg755.00€100mg1,017.00€1mL*10mM (DMSO)492.00€EML734
CAS:EML734 is a potent, selective inhibitor of PRMT7 and PRMT9, demonstrating inhibitory concentration 50 (IC50) values of 315 nM for PRMT7 and 0.89 μM for PRMT9.Formula:C27H32N10O7Purity:98%Color and Shape:SolidMolecular weight:608.61AMPK activator 16
CAS:AMPK activator16 (compound 6) functions as an AMP-activated protein kinase (AMPK) inhibitor. It interacts effectively with crucial AMPK residues, significantly activating the enzyme. In N2a cells, AMPK activator16 enhances the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) and phosphorylated raptor (p-raptor).Formula:C23H20ClNO5SColor and Shape:SolidMolecular weight:457.927GSK 690 Hydrochloride
CAS:GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd value of 9 nM and IC 50 of 37 nM.Formula:C24H24ClN3OPurity:98%Color and Shape:SolidMolecular weight:405.92RO495
CAS:RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assaysFormula:C17H14Cl2N6OPurity:97.94%Color and Shape:SolidMolecular weight:389.24Ref: TM-T22416
1mg64.00€2mg87.00€5mg117.00€10mg183.00€25mg354.00€50mg520.00€100mg702.00€200mg944.00€1mL*10mM (DMSO)140.00€E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formula:C21H30O6Purity:98.83%Color and Shape:SolidMolecular weight:378.46Ref: TM-T6823
1mg50.00€2mg72.00€5mg107.00€10mg167.00€25mg304.00€50mg500.00€100mg725.00€200mg1,017.00€500mg1,510.00€1mL*10mM (DMSO)88.00€Ivangustin
CAS:Ivangustin is derived from Inula britannica and exhibits significant cytotoxicity against human cancer cell lines.Formula:C15H20O3Purity:99.86%Color and Shape:SolidMolecular weight:248.32Ref: TM-TN4340
1mg183.00€5mg457.00€10mg652.00€25mg1,026.00€50mg1,406.00€100mg1,890.00€1mL*10mM (DMSO)465.00€MOZ-IN-3
MOZ-IN-3 (Compound 6j), a potent KAT6A (MOZ) acetyltransferase inhibitor with an IC50 of 30 nM, exhibits antitumor activity against multiple myeloid leukemiaFormula:C17H13FN2O3SPurity:98%Color and Shape:SolidMolecular weight:344.36Menin-MLL inhibitor 34
Menin-MLL inhibitor 34 (Compound 37) is a selective and potent inhibitor of Menin-MLL, exhibiting an IC50 of 18.21 nM against Menin. This compound effectively reduces Menin protein levels and downregulates MEN1 transcription, demonstrating sustained anti-leukemia effects.Formula:C40H54FN9O4SColor and Shape:SolidMolecular weight:775.98MicroRNA-21-IN-2
CAS:MicroRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. MicroRNA-21-IN-2 can be used to study cancer.Formula:C17H15N3O3SPurity:99.2%Color and Shape:SolidMolecular weight:341.38DCLX069
CAS:DCLX069: PRMT1 inhibitor, IC50=17.9µM, targets SAM pocket, inhibits breast/liver cancer, and AML cell growth.Formula:C20H25N3O2Purity:97.76%Color and Shape:SolidMolecular weight:339.43Ref: TM-T27133
1mg38.00€2mg49.00€5mg79.00€10mg111.00€25mg187.00€50mg305.00€100mg487.00€500mg1,035.00€1mL*10mM (DMSO)92.00€KDM5A-IN-1
CAS:KDM5A-IN-1 is a pan-histidine lysine demethylase 5 KDM5 inhibitor that inhibits KDM5A, KDM5B, and KDM5C.Can be used in the study of cancer.Formula:C15H22N4O2Purity:99.8%Color and Shape:SolidMolecular weight:290.36JAK-IN-5 hydrochloride
CAS:JAK-IN-5 hydrochloride is a JAK inhibitor [1].Formula:C27H32ClFN6OColor and Shape:SolidMolecular weight:511.03Palmatine chloride
CAS:Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Formula:C21H22ClNO4Purity:97.9% - 99.47%Color and Shape:SolidMolecular weight:387.8573-deazaneplanocin A HCl
CAS:3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor.Formula:C12H15ClN4O3Purity:93.24% - 98.34%Color and Shape:SolidMolecular weight:298.73Cenacitinib
CAS:Cenacitinib is an effective inhibitor of Janus kinase (Janus kinase) and possesses anti-inflammatory activity.Formula:C19H19F2N7O3Color and Shape:SolidMolecular weight:431.40SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Formula:C20H22F3N5OPurity:100% - 99.84%Color and Shape:SolidMolecular weight:405.42WDR5-0102
CAS:WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 other HMTs.Formula:C18H19ClN4O3Purity:97.16%Color and Shape:SolidMolecular weight:374.82Ref: TM-T67947
1mg77.00€5mg169.00€10mg274.00€25mg550.00€50mg792.00€100mg1,093.00€500mg2,175.00€1mL*10mM (DMSO)215.00€Nimucitinib
CAS:Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.Formula:C25H26F2N6O2Purity:98.71%Color and Shape:SoildMolecular weight:480.51Ref: TM-T67907
1mg96.00€2mg139.00€5mg227.00€10mg354.00€25mg653.00€50mg938.00€100mg1,454.00€500mg2,822.00€HDACs/EZH2-IN-1
HDACs/EZH2-IN-1 (Compound 22a) is a dual inhibitor of HDACs and EZH2, exhibiting potent inhibitory activity, with EZH2 Y641N being suppressed by 98% at 50 nM. It selectively targets HDAC1 and HDAC6, with IC50 values of 0.23 μM and 0.07 μM, respectively. HDACs/EZH2-IN-1 effectively inhibits the proliferation of diffuse large B-cell lymphoma cells harboring EZH2 mutations and various acute myeloid leukemia cells. Additionally, this compound has the capability to induce cellular differentiation and apoptosis (Apoptosis).Formula:C29H36BrN7O4Color and Shape:SolidMolecular weight:626.54
