Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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Ganoderic acid DM
CAS:Ganoderic acid DM inhibits osteoclastogenesis, targeting c-Fos, NFATc1, and reducing DC-STAMP expression, thus preventing osteoclast fusion.Formula:C30H44O4Purity:98%Color and Shape:SolidMolecular weight:468.67BET BD2-IN-3
CAS:BET BD2-IN-3 (compound I-58), a BET inhibitor specifically targeting the BD2 domain, can be radiolabeled with [11C] for use in positron emission tomography (PET) imaging. PET studies with [11C]BD2-IN-3 in mice have demonstrated appropriate biodistribution in peripheral organs and tissues.Formula:C29H30N4OColor and Shape:SolidMolecular weight:450.58Dbet57
CAS:dBET57: PROTAC-based BRD4BD1 degrader, DC50/5h at 500 nM, ineffective on BRD4BD2.Formula:C34H31ClN8O5SPurity:99.32% - 99.52%Color and Shape:SolidMolecular weight:699.18Ref: TM-T5440
1mg49.00€5mg97.00€10mg156.00€25mg279.00€50mg432.00€100mg625.00€500mg1,293.00€1mL*10mM (DMSO)170.00€EHP-101
CAS:EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.Formula:C28H35NO3Purity:99.22%Color and Shape:SolidMolecular weight:433.58Ref: TM-T13289
1mg107.00€5mg227.00€10mg378.00€25mg620.00€50mg868.00€100mg1,169.00€1mL*10mM (DMSO)250.00€UNC3866 TFA(1872382-47-2 free base)
CAS:UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.Formula:C45H67F3N6O10Purity:98.6%Color and Shape:SolidMolecular weight:909.04Ref: TM-T4021L
1mg38.00€2mg49.00€5mg74.00€10mg119.00€25mg229.00€50mg339.00€100mg472.00€200mg655.00€1mL*10mM (DMSO)155.00€PRMT5 ligand 1
CAS:PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.Formula:C20H26N6O2Color and Shape:SolidMolecular weight:382.459GSK3368715
CAS:GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50sFormula:C20H38N4O2Purity:98%Color and Shape:SolidMolecular weight:366.54YLIU-4-105-1
CAS:YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.Formula:C32H34F3N7O2Color and Shape:SolidMolecular weight:605.65TGP-377/421
CAS:TGP-377/421 (Targapre-miR-377/421) is a potent miR-377 and miR-421 dual inhibitor that inhibits miR-377 and miR-421 by binding to their functional sites.Formula:C20H16N6Purity:98.48%Color and Shape:SolidMolecular weight:340.38Ref: TM-T61085
1mg66.00€5mg144.00€10mg227.00€25mg454.00€50mg733.00€100mg1,026.00€500mg2,052.00€1mL*10mM (DMSO)159.00€2',3',5'-triacetyl-5-Azacytidine
CAS:2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.Formula:C14H18N4O8Purity:98.34%Color and Shape:SolidMolecular weight:370.31Ref: TM-T7840
2mg40.00€5mg52.00€10mg80.00€25mg129.00€50mg187.00€100mg281.00€200mg406.00€1mL*10mM (DMSO)64.00€PROTAC BRM/BRG1 degrader-1
CAS:PROTAC BRM/BRG1 degrader-1 is a chemical compound that acts as a degrader of PROTAC BRM/BRG1, exhibiting a DC50 range of 10-100 nM (BRM) and > 1 μM (BRG1). This compound is utilized in cancer research.Formula:C54H63N9O9SColor and Shape:SolidMolecular weight:1014.2KAT6-IN-2
KAT6-IN-2 is a potent inhibitor of KAT6, showing promise for use in cancer research.Color and Shape:Odour SolidPIN1 inhibitor API-1
CAS:API-1 is a Pin1 inhibitor (IC50: 72.3 nM), enhancing anticancer miRNA biogenesis and inhibiting hepatocellular carcinoma.Formula:C15H13F3N6O2Purity:98.48%Color and Shape:SolidMolecular weight:366.3Ref: TM-T16538
1mg60.00€5mg127.00€10mg235.00€25mg344.00€50mg512.00€100mg645.00€200mg898.00€500mg1,311.00€1mL*10mM (DMSO)140.00€Bobcat339
CAS:Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.Formula:C16H12ClN3OPurity:97.79% - 99.24%Color and Shape:SolidMolecular weight:297.74UMB298
CAS:UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.Formula:C27H31ClN4O2Purity:99.76%Color and Shape:SolidMolecular weight:479.01Ref: TM-T9194
1mg64.00€5mg140.00€10mg219.00€25mg378.00€50mg530.00€100mg723.00€200mg938.00€1mL*10mM (DMSO)148.00€CARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Formula:C27H35ClN6O3Color and Shape:SolidMolecular weight:527.06Itacitinib
CAS:Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.Formula:C26H23F4N9OPurity:96.4% - 99.01%Color and Shape:SolidMolecular weight:553.51Ref: TM-T3998
1mg49.00€2mg71.00€5mg111.00€10mg180.00€25mg325.00€50mg543.00€100mg780.00€500mg1,549.00€1mL*10mM (DMSO)137.00€Ilginatinib maleate
CAS:Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.Formula:C25H24FN7O4Purity:99.74% - 99.82%Color and Shape:SolidMolecular weight:505.5Ref: TM-T12266L
1mg64.00€5mg138.00€10mg187.00€25mg273.00€50mg393.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)153.00€E7449
CAS:E7449 is a potent inhibitor of PARP1, PARP2, TNKS1, and TNKS2 with IC50s of 2, 1, ~50, and ~50 nM respectively.Formula:C18H15N5OPurity:97.13%Color and Shape:SolidMolecular weight:317.34Ref: TM-T4471
1mg35.00€5mg93.00€10mg120.00€25mg188.00€50mg284.00€100mg420.00€200mg622.00€1mL*10mM (DMSO)94.00€(S)-CPI203
CAS:CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).Formula:C19H18ClN5OSPurity:98.96% - 99.36%Color and Shape:SolidMolecular weight:399.9Ref: TM-T6026
2mg35.00€5mg58.00€10mg94.00€25mg178.00€50mg284.00€100mg449.00€200mg627.00€1mL*10mM (DMSO)62.00€MAT2A-IN-9
CAS:MAT2A-IN-9, a 2-oxoquinazoline, inhibits MAT2A with antitumor effects on lymphomas and solid cancers.Formula:C14H8ClF3N4OPurity:98.53%Color and Shape:SolidMolecular weight:340.69PARP7-IN-16
CAS:PARP7-IN-16 (compound 36) is a potent, selective, and orally active PARP-1/2/7 inhibitor, exhibiting IC50 values of 0.94, 0.87, and 0.21 nM , respectively.Formula:C25H26FN4NaO4Purity:98%Color and Shape:SolidMolecular weight:488.49IOX4
CAS:IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)Formula:C15H16N6O3Purity:99.97%Color and Shape:SolidMolecular weight:328.33PROTAC BRM/BRG1 degrader-2
CAS:PROTAC BRM/BRG1 degrader-2 (Example.004) is a potent PROTAC BRM/BRG1 degrading agent exhibiting a DC50 of less than 10 nM and an IC50 of 15 nM in A549 cells.Formula:C50H60N12O5SColor and Shape:SolidMolecular weight:941.15GSK591
CAS:GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM).Formula:C22H28N4O2Purity:99.35% - 99.77%Color and Shape:SolidMolecular weight:380.48Ref: TM-T6853
1mg48.00€2mg62.00€5mg100.00€10mg144.00€25mg283.00€50mg487.00€100mg710.00€500mg1,483.00€1mL*10mM (DMSO)106.00€PARP1 Protein, Human, Recombinant (His)
PARP Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Purity:94.1%Color and Shape:Lyophilized PowderMolecular weight:114.5 kDa (predicted); 100-110 kDa (reducing conditions)GNE-781
CAS:GNE-781: potent CBP inhibitor (IC50: 0.94 nM), also targets BRET/BRD4(1) (IC50: 6.2/5100 nM).Formula:C27H33F2N7O2Purity:98.73% - 99.92%Color and Shape:SolidMolecular weight:525.59Ref: TM-T15405
1mg163.00€5mg354.00€10mg528.00€25mg852.00€50mg1,159.00€100mg1,568.00€1mL*10mM (DMSO)391.00€A-196
CAS:A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective overFormula:C18H16Cl2N4Purity:99.92%Color and Shape:SolidMolecular weight:359.25Ref: TM-T4343
2mg42.00€5mg62.00€10mg96.00€25mg169.00€50mg264.00€100mg426.00€200mg617.00€1mL*10mM (DMSO)62.00€LW6
CAS:LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.Formula:C26H29NO5Purity:98.1% - 99.10%Color and Shape:SolidMolecular weight:435.51Ref: TM-T3494
2mg47.00€5mg69.00€10mg89.00€25mg183.00€50mg298.00€100mg449.00€500mg938.00€1mL*10mM (DMSO)69.00€BRM/BRG1 ATP Inhibitor-2
CAS:BRM/BRG1 ATP Inhibitor-2 is an inhibitor of BRG1/BRM ATPase and can be used in studies about the treatment of BAF-related disorders.Formula:C20H20N4O2S2Purity:99.88%Color and Shape:SolidMolecular weight:412.53Ref: TM-T60032
1mg63.00€5mg137.00€10mg210.00€25mg424.00€50mg627.00€100mg893.00€500mg1,786.00€1mL*10mM (DMSO)153.00€AZD5153
CAS:AZD5153 is an orally active and selective BET/BRD4 bromodomain inhibitor with an IC50 value of 1.7nM for BRD4.Formula:C25H33N7O3Purity:99.25%Color and Shape:SolidMolecular weight:479.57PROTAC BET Degrader-1
CAS:PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.Formula:C44H45N11O9Purity:98%Color and Shape:SolidMolecular weight:871.9DS-103
DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 μM, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 μM. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 μM and 1.47 μM, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 μM and 2.23 μM. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.Formula:C28H33N5O3Color and Shape:SolidMolecular weight:487.59dBRD9 HCl
CAS:dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide .Formula:C40H47Cl2N7O10Purity:97% - 99.37%Color and Shape:SolidMolecular weight:856.75(+)-JQ-1
CAS:(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility.Formula:C23H25ClN4O2SPurity:97.57% - ≥95%Color and Shape:SolidMolecular weight:456.99Ref: TM-T2110
1mg35.00€2mg44.00€5mg60.00€10mg79.00€25mg96.00€50mg144.00€100mg188.00€200mg283.00€500mg512.00€1mL*10mM (DMSO)66.00€Fucosterol
CAS:Fucosterol, from E. stolonifera, has anti-diabetic, anti-adipogenic, anti-cancer properties; it affects PPARα and C/EBPα to control fat cell formation.Formula:C29H48OPurity:98.39% - 99.68%Color and Shape:White PowderMolecular weight:412.69MS31 trihydrochloride (2366264-12-0 free base)
MS31 trihydrochloride (2366264-12-0 free base) is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitorFormula:C20H30Cl3N3O2Purity:99.69%Color and Shape:SolidMolecular weight:450.83Ref: TM-T12111L
1mg195.00€5mg390.00€10mg572.00€25mg914.00€50mg1,216.00€100mg1,673.00€1mL*10mM (DMSO)399.00€MK-8745
CAS:MK-8745 is a potent and selective Aurora A inhibitor.Formula:C20H19ClFN5OSPurity:98.94% - 99.31%Color and Shape:SolidMolecular weight:431.91BRD4-IN-4
CAS:BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line andFormula:C17H18N2O3SPurity:100%Color and Shape:SolidMolecular weight:330.4Veliparib dihydrochloride
CAS:Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.Formula:C13H18Cl2N4OPurity:97.09% - 98%Color and Shape:SolidMolecular weight:317.21A-485
CAS:A-485 is a p300/CBP histone acetyltransferase (HAT) inhibitor that inhibits p300 and CBP. A-485 has antitumor effects. Cost effective and quality assured.Formula:C25H24F4N4O5Purity:100% - 98.32%Color and Shape:SolidMolecular weight:536.48Ref: TM-T14073
1mg87.00€2mg119.00€5mg170.00€10mg304.00€25mg378.00€50mg449.00€100mg777.00€1mL*10mM (DMSO)208.00€AZD1208
CAS:AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.Formula:C21H21N3O2SPurity:97.24% - 99.83%Color and Shape:SolidMolecular weight:379.48Ref: TM-T2300
2mg38.00€5mg51.00€10mg74.00€25mg118.00€50mg213.00€100mg378.00€200mg495.00€500mg792.00€1mL*10mM (DMSO)57.00€WM-586
CAS:WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.Formula:C20H20F3N5O3SPurity:98%Color and Shape:SolidMolecular weight:467.47T-3775440 hydrochloride
CAS:T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).Formula:C18H23ClN4OPurity:99.88%Color and Shape:SolidMolecular weight:346.85Ref: TM-T13055
1mg96.00€5mg202.00€10mg305.00€25mg550.00€50mg772.00€100mg1,074.00€1mL*10mM (DMSO)224.00€Menin-KMT2A-IN-1
Menin-KMT2A-IN-1 (Compound 20) is an inhibitor of menin-KMT2A, binding to menin with an IC50 of 8 nM, and disrupting the interaction between menin and lysine methyltransferase 2A (KMT2A). It inhibits hERG channels with an IC50 of 65 μM and suppresses MV4-11 cells with an IC50 of 74 nM. Furthermore, Menin-KMT2A-IN-1 exhibits favorable pharmacokinetic properties in CD-1 mice, with an oral bioavailability of 74%.Formula:C28H35FN6O3Color and Shape:SolidMolecular weight:522.61Lepzacitinib
CAS:Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Formula:C18H21N5O3Purity:99.85%Color and Shape:SolidMolecular weight:355.39Ref: TM-T78207
1mg52.00€5mg116.00€10mg178.00€25mg359.00€50mg533.00€100mg750.00€200mg1,064.00€1mL*10mM (DMSO)127.00€6-Thioguanine
CAS:6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.Formula:C5H5N5SPurity:100% - 98.75%Color and Shape:Odorless Or Almost Odorless Pale Yellow Crystalline PowderMolecular weight:167.19GNA002
CAS:GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).Formula:C42H55NO8Purity:98%Color and Shape:SolidMolecular weight:701.89MI-3454
CAS:MI-3454: potent, oral menin-MLL1 inhibitor, IC50 of 0.51 nM, halts leukemia cells, aids remission in mice.Formula:C32H35F3N8OSPurity:99.68%Color and Shape:SolidMolecular weight:636.73PARP1-IN-14
CAS:PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM.Formula:C28H24FN7O3Purity:98%Color and Shape:SolidMolecular weight:525.53PBIT
CAS:PBIT is a JARID1 inhibitor with IC50: 3 μM for JARID1B, 6 μM for JARID1A, and 4.9 μM for JARID1C.Formula:C14H11NOSPurity:99.61% - 99.83%Color and Shape:SolidMolecular weight:241.31Ref: TM-T16435
1mg40.00€5mg85.00€10mg116.00€25mg235.00€50mg379.00€100mg610.00€200mg840.00€1mL*10mM (DMSO)92.00€GSK778
CAS:GSK778 selectively inhibits BD1 bromodomains (BRD2, BRD3, BRD4, BRDT) and impedes cell growth, causing arrest and apoptosis.Formula:C30H33N5O3Purity:98.42%Color and Shape:SolidMolecular weight:511.61Ref: TM-T9703
1mg160.00€5mg311.00€10mg502.00€25mg1,008.00€50mg1,596.00€100mg2,213.00€1mL*10mM (DMSO)47.00€YM458
CAS:YM458 inhibits EZH2 (490 nM) and BRD4 (34 nM), curbing tumor cell growth and inducing apoptosis.Formula:C53H61ClN8O5SPurity:98%Color and Shape:SolidMolecular weight:957.62Seclidemstat
CAS:Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.Formula:C20H23ClN4O4SPurity:98.28% - 98.88%Color and Shape:SolidMolecular weight:450.94Ref: TM-T4527
5mg48.00€10mg72.00€25mg120.00€50mg187.00€100mg354.00€200mg528.00€500mg852.00€1mL*10mM (DMSO)49.00€Ru3
Ru3 is a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor that prompts apoptosis in MCF-7 cells through various mechanisms, including DNA damage induction,Purity:98%Color and Shape:Odour SolidUNC0224
CAS:UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.Formula:C26H43N7O2Purity:99.58%Color and Shape:SolidMolecular weight:485.67Ref: TM-T17203
1mg51.00€2mg73.00€5mg97.00€10mg159.00€25mg354.00€50mg558.00€100mg797.00€500mg1,634.00€1mL*10mM (DMSO)107.00€Sinefungin
CAS:Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viralFormula:C15H23N7O5Purity:98.12%Color and Shape:SolidMolecular weight:381.39BBDDL2059
CAS:BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against the EZH2-Y641F mutant.Formula:C27H36N4O4SPurity:98%Color and Shape:SolidMolecular weight:512.66RVX-297
CAS:RVX-297 selectively inhibits BD2 domains of BET bromodomains, binding preferentially to BET proteins.Formula:C24H29N3O4Purity:98.11%Color and Shape:SolidMolecular weight:423.5Ref: TM-T28628
2mg42.00€5mg65.00€10mg97.00€25mg187.00€50mg301.00€100mg487.00€200mg658.00€1mL*10mM (DMSO)71.00€Gusacitinib
CAS:Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).Formula:C24H28N8O2Purity:98.06% - 99.94%Color and Shape:SolidMolecular weight:460.53Ref: TM-T14331
1mg42.00€5mg88.00€10mg123.00€25mg188.00€50mg350.00€100mg522.00€200mg750.00€1mL*10mM (DMSO)116.00€(E/Z)-Zotiraciclib
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Formula:C23H24N4OPurity:97% - 98.03%Color and Shape:SolidMolecular weight:372.46Ref: TM-T21503
1mg46.00€2mg59.00€5mg87.00€10mg119.00€25mg210.00€50mg349.00€100mg507.00€1mL*10mM (DMSO)96.00€UNC1999
CAS:UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).Formula:C33H43N7O2Purity:100% - 99.49%Color and Shape:SolidMolecular weight:569.74Ref: TM-T3057
1mg37.00€2mg52.00€5mg71.00€10mg97.00€25mg177.00€50mg286.00€100mg515.00€500mg1,130.00€1mL*10mM (DMSO)89.00€PARP1-IN-8
CAS:PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM).Formula:C23H18ClN3O2Purity:98.26%Color and Shape:SolidMolecular weight:403.86NSD2-IN-4
NSD2-IN-4 is a potent, selective inhibitor of the NSD2-SET domain, showing promise for the treatment of diseases related to NSD2 [1].Formula:C18H14ClN3O3Purity:98%Color and Shape:SolidMolecular weight:355.78AMG-193
CAS:AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.Formula:C22H19F3N4O3Purity:99.52%Color and Shape:SolidMolecular weight:444.41Ref: TM-T85645
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€1mL*10mM (DMSO)588.00€JAK2-IN-11
CAS:JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with potent antitumor activity, exhibiting an IC50 of ≤10 nM against JH2 BIND WT/V617F. This compound effectively suppresses tumor growth.Formula:C31H31F3N8O4Color and Shape:SolidMolecular weight:639.64MR837
CAS:MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.Formula:C16H14N2OSPurity:99.77% - 99.85%Color and Shape:SolidMolecular weight:282.36Ref: TM-T8879
2mg40.00€5mg58.00€10mg96.00€25mg145.00€50mg255.00€100mg375.00€200mg530.00€1mL*10mM (DMSO)70.00€Momelotinib sulfate
CAS:Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.Formula:C23H26N6O10S2Purity:98%Color and Shape:SolidMolecular weight:610.62JAK-IN-26
CAS:JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormula:C22H24N6O3Purity:98%Color and Shape:SolidMolecular weight:420.46QL-1200186
CAS:QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production followingFormula:C26H27N7O3Purity:98%Color and Shape:SolidMolecular weight:485.54PBRM1-BD2-IN-3
CAS:PBRM1-BD2-IN-3 (compound 12) is a potent inhibitor of PBRM1-BD2, exhibiting an IC50 value of 1.1 μM, and is utilized in anticancer research.Formula:C14H11ClN2OPurity:99.91%Color and Shape:SoildMolecular weight:258.7Ref: TM-T60158
1mg115.00€5mg255.00€10mg375.00€25mg562.00€50mg792.00€100mg1,064.00€500mg2,147.00€1mL*10mM (DMSO)226.00€KAT6A-IN-1
CAS:KAT6A-IN-1 (compound 5) is an inhibitor of KAT6A.Formula:C23H27N5O5SColor and Shape:SolidMolecular weight:485.56CARM1 degrader-1
PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1).Formula:C71H98N12O8SPurity:98%Color and Shape:SolidMolecular weight:1279.68EB-47
CAS:EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).Formula:C24H27N9O6Purity:99.86%Color and Shape:SolidMolecular weight:537.53GSK620
CAS:GSK620, a selective pan-BD2 inhibitor, has anti-inflammatory properties and favorable oral pharmacokinetics.Formula:C18H19N3O3Purity:99.42% - 99.88%Color and Shape:SolidMolecular weight:325.36Ref: TM-T9020
2mg35.00€5mg50.00€10mg81.00€25mg150.00€50mg235.00€100mg349.00€200mg515.00€1mL*10mM (DMSO)92.00€EPZ020411 2HCl (1700663-41-7(free base))
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).Formula:C25H40Cl2N4O3Purity:98%Color and Shape:SolidMolecular weight:515.51JAK3i
CAS:JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.Formula:C18H15FN4O3Purity:98.61% - 99.81%Color and Shape:SolidMolecular weight:354.34Pyridone 6
CAS:Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).Formula:C18H16FN3OPurity:97.10% - 98.74%Color and Shape:SolidMolecular weight:309.34Ref: TM-T3080
1mg82.00€2mg106.00€5mg162.00€10mg221.00€25mg449.00€50mg658.00€100mg939.00€500mg1,882.00€1mL*10mM (DMSO)177.00€PIM-1 Inhibitor 2
CAS:PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.Formula:C17H11ClN4OPurity:98.81%Color and Shape:SolidMolecular weight:322.75PARP1-IN-17
PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis.Purity:98%Color and Shape:Odour SolidGSK-1070916
CAS:GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Formula:C30H33N7OPurity:99.73%Color and Shape:SolidMolecular weight:507.63PNZ5
CAS:PNZ5, an isoxazole-based pan-BET inhibitor, demonstrates potent activity and high selectivity comparable to the established (+)-JQ1, exhibiting a dissociationFormula:C20H18N2O2Purity:100% - 99.53%Color and Shape:SolidMolecular weight:318.37Ref: TM-T12513
1mg115.00€5mg255.00€10mg375.00€25mg562.00€50mg792.00€100mg1,064.00€200mg1,444.00€1mL*10mM (DMSO)253.00€NSC-636819
CAS:NSC-636819 is a novel inhibitor of KDM4A/KDM4B.Formula:C22H12Cl4N2O4Purity:98%Color and Shape:SolidMolecular weight:510.15GSK343
CAS:GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity againstFormula:C31H39N7O2Purity:98% - 99.9%Color and Shape:SolidMolecular weight:541.69MK-4827 Racemate
CAS:MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity forFormula:C19H20N4OPurity:99.47%Color and Shape:SolidMolecular weight:320.39Ref: TM-T22988
1mg49.00€2mg69.00€5mg87.00€10mg154.00€25mg283.00€50mg492.00€100mg663.00€1mL*10mM (DMSO)118.00€GSK8573
CAS:GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).Formula:C20H21NO3Purity:99.81%Color and Shape:SolidMolecular weight:323.39PARP Protein, Mouse, Recombinant (His)
PARP Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Color and Shape:Lyophilized PowderMolecular weight:115 kDa (predicted); 75 kDa (reducing conditions)A-366
CAS:A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.Formula:C19H27N3O2Purity:97.28% - 99.8%Color and Shape:SolidMolecular weight:329.44Ref: TM-T3624
1mg35.00€2mg50.00€5mg74.00€10mg90.00€25mg208.00€50mg359.00€100mg530.00€1mL*10mM (DMSO)82.00€LSD1-IN-27
CAS:LSD1-IN-27 inhibits LSD1 (IC50=13 nM), blocks gastric cancer cell stemness/migration, reduces PD-L1, and boosts T-cell response.Formula:C24H25N3Purity:98.65%Color and Shape:SoildMolecular weight:355.48Solcitinib
CAS:Solcitinib (GLPG-0778), a JAK1 inhibitor, may treat psoriasis, ulcerative colitis, and lupus.Formula:C22H23N5O2Purity:99.61% - 99.82%Color and Shape:SolidMolecular weight:389.45EBI-2511
CAS:EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).Formula:C34H48N4O4Purity:99.01%Color and Shape:SolidMolecular weight:576.77EPZ015666
CAS:EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.Formula:C20H25N5O3Purity:98% - 99.41%Color and Shape:SolidMolecular weight:383.44CYC-116
CAS:CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not activeFormula:C18H20N6OSPurity:96.6% - 97.59%Color and Shape:SolidMolecular weight:368.46Ref: TM-T6458
2mg39.00€5mg56.00€10mg78.00€25mg135.00€50mg217.00€100mg358.00€500mg908.00€1mL*10mM (DMSO)49.00€ZEN-2759
CAS:ZEN-2759 is a potent BET small molecule inhibitor of BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).Formula:C17H16N2O2Purity:99.36%Color and Shape:SolidMolecular weight:280.32HJB97
CAS:HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively).Formula:C26H28N8O3Purity:98%Color and Shape:SolidMolecular weight:500.55EZM0414
CAS:EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay.Formula:C22H29FN4O2Purity:98.9%Color and Shape:SolidMolecular weight:400.49Filgotinib
CAS:Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.Formula:C21H23N5O3SPurity:98.03% - ≥95%Color and Shape:SolidMolecular weight:425.5JAK-IN-29
JAK-IN-29 (Compound 3) is a potent inhibitor of Janus kinases (JAK) [1].Formula:C17H14ClN5O2Purity:98%Color and Shape:SolidMolecular weight:355.78JAK2 Inhibitor V
CAS:JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.Formula:C23H24N2OPurity:96.69% - 99.15%Color and Shape:SolidMolecular weight:344.45Ref: TM-T3042
2mg39.00€5mg57.00€10mg85.00€25mg157.00€50mg274.00€100mg505.00€500mg1,121.00€1mL*10mM (DMSO)63.00€KDM2A/7A-IN-1
CAS:KDM2A/7A-IN-1 is a KDM2A/7A inhibitor with potential anti-tumour activity for the study of duodenal adenomas and ossifying fibromucoid tumours.Formula:C33H38N4OPurity:99.59%Color and Shape:SolidMolecular weight:506.68NI-42
CAS:NI-42, a BRPFs inhibitor: IC50(BRPF1/2/3)=7.9/48/260 nM, Kd(BRPF1/2/3)=40/210/940 nM; selective for class IV BRDs.Formula:C18H15N3O3SPurity:99.18%Color and Shape:SolidMolecular weight:353.39NSC 228155
CAS:NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.Formula:C11H6N4O4SPurity:99.84%Color and Shape:SolidMolecular weight:290.25Ref: TM-T6908
2mg35.00€5mg50.00€10mg66.00€25mg125.00€50mg205.00€100mg369.00€200mg495.00€1mL*10mM (DMSO)52.00€FY-21
FY-21 is a selective LSD1 inhibitor (IC50= 340 nM) that inhibits proliferation and colony formation of leukemia cells, decreases mRNA levels of the transcription factors HOXA9 and MEIS1, and can be used in the study of leukemia.Formula:C17H15F3N2O6Purity:99.86%Color and Shape:SolidMolecular weight:400.31CTB
CAS:CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.Formula:C16H13ClF3NO2Purity:99.80%Color and Shape:SolidMolecular weight:343.73GNE-375
CAS:GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.Formula:C25H29N3O5Purity:99.32%Color and Shape:SolidMolecular weight:451.51Ref: TM-T27423
1mg117.00€5mg279.00€10mg432.00€25mg707.00€50mg1,017.00€100mg1,491.00€1mL*10mM (DMSO)315.00€Niraparib
CAS:Niraparib (MK-4827) inhibits PARP1/PARP2 (IC50: 3.8/2.1 nM), effective on BRCA mutant cancers, 330x less effective on PARP3, V-PARP, Tank1.Formula:C19H20N4OPurity:98% - 99.91%Color and Shape:SolidMolecular weight:320.39Ref: TM-T3231
5mg60.00€10mg88.00€25mg111.00€50mg144.00€100mg216.00€200mg321.00€500mg543.00€1mL*10mM (DMSO)66.00€RK-287107
CAS:RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).Formula:C22H26F2N4O2Purity:99.64%Color and Shape:SolidMolecular weight:416.46SGC2085
CAS:SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).Formula:C19H24N2O2Purity:99.61% - 99.71%Color and Shape:SolidMolecular weight:312.41Ref: TM-T7089
1mg88.00€2mg119.00€5mg227.00€10mg341.00€25mg563.00€50mg820.00€100mg1,130.00€1mL*10mM (DMSO)160.00€GSK1324726A
CAS:GSK1324726A (I-BET726) is a greatly specific inhibitor of BET family proteins for BRD2(IC50=41 nM), BRD3(IC50=31 nM), and BRD4 (IC50=22 nM).Formula:C25H23ClN2O3Purity:98.34% - 99.74%Color and Shape:SolidMolecular weight:434.91HDAC6 ligand-3
HDAC6ligand-3 serves as a ligand for HDAC6 and can be utilized as a target protein ligand in the synthesis of [PROTAC] HDAC6 degrader4.Formula:C20H21N3O3Color and Shape:SolidMolecular weight:351.399Pinometostat
CAS:Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor. Pinometostat has antitumor activity. Cost effective and quality assured.Formula:C30H42N8O3Purity:99.19% - 99.86%Color and Shape:SolidMolecular weight:562.71LT052
CAS:LT052 is a BET BD1 inhibitor with anti-inflammatory activity. It mediates the BRD4/NF-κB/NLRP3 signaling inflammatory pathway.Formula:C22H19N5O4SPurity:98.87%Color and Shape:SolidMolecular weight:449.48SGC-CBP30
CAS:SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).Formula:C28H33ClN4O3Purity:99.03% - 99.05%Color and Shape:SolidMolecular weight:509.04Ref: TM-T6668
1mg49.00€2mg71.00€5mg88.00€10mg119.00€25mg210.00€50mg354.00€100mg528.00€1mL*10mM (DMSO)88.00€IACS-9571
CAS:IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).Formula:C32H42N4O8SPurity:98%Color and Shape:SolidMolecular weight:642.76AZ960
CAS:AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).Formula:C18H16F2N6Purity:96.02% - 98.51%Color and Shape:SolidMolecular weight:354.36Bromodomain inhibitor-12
CAS:Bromodomain Inhibitor-12 (example 303) is a research compound utilized in the study of autoimmune and inflammatory diseases [1].Formula:C28H38N4O5Purity:98%Color and Shape:SolidMolecular weight:510.63PROTAC BET degrader-3
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.Formula:C53H64N12O9SPurity:98%Color and Shape:SolidMolecular weight:1045.22G007-LK
CAS:G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.Formula:C25H16ClN7O3SPurity:97.63% - 98.17%Color and Shape:SolidMolecular weight:529.96Ref: TM-T6842
1mg49.00€2mg70.00€5mg99.00€10mg166.00€25mg334.00€50mg530.00€100mg745.00€1mL*10mM (DMSO)123.00€JG-2016
CAS:JG-2016, as a histone acetyltransferase 1 inhibitor, inhibits growth of human cancer cell lines and inhibits enzymatic activity in cellulose.Formula:C18H21ClN4O3Purity:99% - 99.37%Color and Shape:SolidMolecular weight:376.84Ref: TM-T82008
1mg116.00€5mg283.00€10mg455.00€25mg905.00€50mg1,454.00€100mg1,882.00€1mL*10mM (DMSO)310.00€Naphthol AS-E
CAS:Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.Formula:C17H12ClNO2Purity:99.33%Color and Shape:Grey Solid PowderMolecular weight:297.74VEGFR/PARP-IN-1
VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively.Formula:C29H27N9OPurity:98%Color and Shape:SolidMolecular weight:517.58PROTAC SMARCA2 degrader-29
CAS:PROTAC SMARCA2 degrader-29 (Example 87) is a potent PROTAC SMARCA2 (BRM) degrading agent with a DC50 ranging between 10-100 nM (BRM) and over 1 μM (BRG1, also known as SMARCA2).Formula:C47H54N8O5S2Color and Shape:SolidMolecular weight:875.11PROTAC BRD4 Degrader-1
CAS:PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).Formula:C40H37N9O8Purity:98%Color and Shape:SolidMolecular weight:771.78XU1
CAS:XU1(Benzo[c][1,8]naphthyridin-6(5h)-One) is an Aurora protein kinase inhibitor used for the treatment of diseases suitable for inhibition, regulation orFormula:C12H8N2OPurity:100% - 98.97%Color and Shape:SolidMolecular weight:196.2SMARCA2 degrader-17
CAS:SMARCA2 degrader-17 is a degrader of SMARCA2, exhibiting synergistic antiproliferative effects with Adagrasib in cancer cells and capable of inhibiting tumor growth.Formula:C47H58N10O6SColor and Shape:SolidMolecular weight:891.09PARP14 inhibitor H10
CAS:PARP14 inhibitor H10 is a selective inhibitor against PARP14 with IC50 of 490 nMFormula:C24H27N7O7SPurity:98%Color and Shape:SolidMolecular weight:557.58GSK-1268997
CAS:GSK-1268997 is a bio-active chemical.Formula:C21H23N7O3SPurity:99.78% - 99.81%Color and Shape:SolidMolecular weight:453.52Deucravacitinib
CAS:Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.Formula:C20H19D3N8O3Purity:100% - 99.43%Color and Shape:SolidMolecular weight:425.46Ref: TM-T14687
1mg70.00€5mg153.00€10mg274.00€25mg432.00€50mg638.00€100mg908.00€200mg1,225.00€500mg1,825.00€1mL*10mM (DMSO)166.00€SGC2085 HCl
CAS:SGC2085: potent, selective CARM1 inhibitor; IC50=50 nM; >100x selectivity vs other PRMTs; impacts cancer growth.Formula:C19H24N2O2·HClPurity:99.91%Color and Shape:SolidMolecular weight:348.87Ref: TM-T4013
1mg93.00€2mg150.00€5mg190.00€10mg343.00€25mg567.00€50mg825.00€100mg1,130.00€1mL*10mM (DMSO)244.00€Veliparib
CAS:Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.Formula:C13H16N4OPurity:98.66% - 99%Color and Shape:SolidMolecular weight:244.29Ref: TM-T2591
5mg57.00€10mg81.00€25mg127.00€50mg207.00€100mg331.00€200mg540.00€500mg852.00€1mL*10mM (DMSO)64.00€TRIM24/BRPF1-IN-2
CAS:TRIM24/BRPF1-IN-2 is a TRIM24/BRPF1 dual inhibitor with anticancer activity that inhibits the proliferation of prostate cancer cells.Formula:C20H22N2O4SPurity:98.69% - 99.13%Color and Shape:SoildMolecular weight:386.47TNG908
CAS:TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.Formula:C21H23N5O2SPurity:98.24% - 99.79%Color and Shape:SolidMolecular weight:409.51Hydralazine hydrochloride
CAS:Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.Formula:C8H9ClN4Purity:99.1% - 99.86%Color and Shape:Yellow Crystals White Crystalline SolidMolecular weight:196.64TIQ-A
CAS:TIQ-A blocks PARP1 to prevent excessive DNA damage response, implicated in ischemia, asthma, and atherosclerosis.Formula:C11H7NOSPurity:99.75%Color and Shape:SolidMolecular weight:201.24Ref: TM-T50098
1mg50.00€5mg97.00€10mg170.00€25mg306.00€50mg437.00€100mg562.00€200mg777.00€1mL*10mM (DMSO)101.00€M1001
CAS:M1001 is a HIF-2α agonist.Formula:C17H17N3O2SPurity:98.83%Color and Shape:SolidMolecular weight:327.4EPZ005687
CAS:EPZ005687 is a potent and selective inhibitor of EZH2.Formula:C32H37N5O3Purity:98% - 99.66%Color and Shape:SolidMolecular weight:539.67SGC707
CAS:SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.Formula:C16H18N4O2Purity:98.45% - 99.75%Color and Shape:SolidMolecular weight:298.34I-CBP112 hydrochloride
CAS:I-CBP112 selectively inhibits CBP/p300 bromodomains, with minimal effect on others, and reduces leukemia cell growth, enhancing JQ1 and doxorubicin's effects.Formula:C27H37ClN2O5Purity:99.69%Color and Shape:SolidMolecular weight:505.05Ref: TM-T4247
1mg90.00€2mg145.00€5mg236.00€10mg447.00€25mg735.00€50mg1,026.00€100mg1,388.00€1mL*10mM (DMSO)447.00€BYK204165
CAS:BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)Formula:C15H12N2O2Purity:99.61%Color and Shape:SolidMolecular weight:252.27MRTX9768
CAS:MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.Formula:C24H17FN6OPurity:98.48%Color and Shape:SolidMolecular weight:424.43GDC-0214
CAS:GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).Formula:C28H28ClF2N9O3Purity:98.54%Color and Shape:SolidMolecular weight:612.03Ref: TM-T9826
1mg87.00€5mg192.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€200mg1,159.00€1mL*10mM (DMSO)259.00€DC-BPi-11 hydrochloride
DC-BPi-11 hydrochloride is a BPTF (bromodomain PHD finger transcription factor) inhibitor with an IC50 value of 698 nM, demonstrating significant anti-Formula:C20H24ClN5O2SPurity:98%Color and Shape:SolidMolecular weight:433.95PROTAC BRD4 Degrader-22
PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based degrader targeting BRD4, exhibiting a pDC50 of 9.2 in MOLT4 cells over 24 hours [1].Purity:98%Color and Shape:Odour Solid(S)-HH2853
CAS:(S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.Formula:C31H36F3N7O3Purity:97.18% - 99.74%Color and Shape:SolidMolecular weight:611.66GNE-955
CAS:GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Formula:C22H24N8OPurity:98%Color and Shape:SolidMolecular weight:416.48DW71177
CAS:DW71177 is a BET inhibitor with potent anti-leukemic activity for the study of leukemia.Formula:C20H28N6O2Purity:98.13%Color and Shape:SoildMolecular weight:384.48SCR-7952
CAS:SCR-7952, a MAT2A inhibitor, is utilized in cancer research.Formula:C19H15ClN4OColor and Shape:SolidMolecular weight:350.80AMG-47a
CAS:AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Formula:C29H28F3N5O2Purity:98%Color and Shape:SolidMolecular weight:535.56Anticancer agent 126
Anticancer agent 126 (compound 12), a WDR5 inhibitor, exhibits anticancer properties by disrupting the WDR5-MYC interaction in cells, subsequently reducing MYCFormula:C25H11BBr2F2N2O3S4Purity:98%Color and Shape:SolidMolecular weight:724.23GSK3685032
CAS:GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM).Formula:C22H24N6OSPurity:98.56% - 99.49%Color and Shape:SolidMolecular weight:420.53Ref: TM-T9573
1mg93.00€5mg188.00€10mg303.00€25mg567.00€50mg810.00€100mg1,111.00€1mL*10mM (DMSO)200.00€Remodelin
CAS:Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.Formula:C15H14N4SPurity:99.39% - 99.78%Color and Shape:SolidMolecular weight:282.36Dehydrocorydaline nitrate
CAS:DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.Formula:C22H24N2O7Purity:99.79%Color and Shape:SolidMolecular weight:428.44ZL0454
CAS:ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).Formula:C18H22N4O3SPurity:98%Color and Shape:SolidMolecular weight:374.46EXQ-2d
EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.Formula:C18H17N3O3Color and Shape:SolidMolecular weight:323.35Naringenin triacetate
CAS:Naringenin Triacetate is a derivative of the flavonoid Naringenin with good binding affinity for the Nac binding site of the structural domain of the BRD4-BD1.Formula:C21H18O8Purity:99.90%Color and Shape:SolidMolecular weight:398.36MK-8617
CAS:MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).Formula:C24H21N5O4Purity:100% - 99.38%Color and Shape:SolidMolecular weight:443.45BRD4 Inhibitor-24
CAS:BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity.Formula:C13H14N2O4Purity:98.65%Color and Shape:SolidMolecular weight:262.26C-7280948
CAS:C-7280948 is a PRMT1 inhibitor.Formula:C14H16N2O2SPurity:98.68% - ≥95%Color and Shape:SolidMolecular weight:276.35Ref: TM-T2097
5mg48.00€10mg70.00€25mg115.00€50mg188.00€100mg283.00€200mg437.00€500mg705.00€1mL*10mM (DMSO)52.00€Metoprine
CAS:Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.Formula:C11H10Cl2N4Purity:98.42%Color and Shape:SolidMolecular weight:269.13Aurora inhibitor 1
CAS:Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).Formula:C23H25N9SPurity:98%Color and Shape:SolidMolecular weight:459.57PBRM1-BD2-IN-8
CAS:PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM).Formula:C15H13BrN2OPurity:99.48%Color and Shape:SoildMolecular weight:317.18Ref: TM-T60157
1mg97.00€5mg246.00€10mg358.00€25mg555.00€50mg735.00€100mg1,008.00€500mg2,023.00€1mL*10mM (DMSO)243.00€OUL35
CAS:OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.Formula:C14H12N2O3Purity:99.20%Color and Shape:SolidMolecular weight:256.26GSK2879552
CAS:GSK2879552: oral, irreversible LSD1 inhibitor with potential cancer-fighting properties.Formula:C23H28N2O2Purity:99.22%Color and Shape:SolidMolecular weight:364.483-Aminobenzamide
CAS:3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction duringFormula:C7H8N2OPurity:98.40% - 99.5%Color and Shape:White To Off-White PowderMolecular weight:136.15Chloramphenicol
CAS:Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.Formula:C11H12Cl2N2O5Purity:99.6% - 99.84%Color and Shape:Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidMolecular weight:323.13DC_517
CAS:DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).Formula:C33H35N3O2Color and Shape:SolidMolecular weight:505.65TC-A 2317 hydrochloride
CAS:TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Formula:C19H29ClN6OPurity:98%Color and Shape:SolidMolecular weight:392.93SHR0302
CAS:SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,Formula:C18H22N8O2SPurity:99.11%Color and Shape:SolidMolecular weight:414.48Ref: TM-T9195
1mg160.00€5mg393.00€10mg620.00€25mg1,035.00€50mg1,483.00€100mg1,882.00€1mL*10mM (DMSO)455.00€lirucitinib
CAS:Lirucitinib is a JAK inhibitor known for its anti-inflammatory properties.Formula:C16H25N5OSColor and Shape:SolidMolecular weight:335.468PROTAC BRM/BRG1 degrader-4
PROTAC BRM/BRG1 degrader-4 (example 047) is a potent degrader targeting both BRM and BRG1, demonstrating DC50 values of 0.21 nM and 3.4 nM respectively in SW1573 cells.Formula:C44H52N10O6SColor and Shape:SolidMolecular weight:849.01EZM0414 TFA
CAS:EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.Formula:C24H30F4N4O4Purity:96.2%Color and Shape:SolidMolecular weight:514.51GSK1379725A
CAS:GSK1379725A is a selective BPTF ligand (Kd = 2.8 μM).Formula:C23H23FN6O3Purity:99.59%Color and Shape:SolidMolecular weight:450.47Ref: TM-T15424
1mg73.00€5mg116.00€10mg188.00€25mg335.00€50mg470.00€100mg662.00€200mg892.00€1mL*10mM (DMSO)134.00€BET-IN-15
CAS:BET-IN-15 (compound 1) is a potent, orally active inhibitor of BET, demonstrating inhibitory IC50 values of 0.64 nM for BRD4-BD1 and 0.25 nM for BRD4-BD2.Formula:C21H18F2N4O3SPurity:98%Color and Shape:SolidMolecular weight:444.45AZD-9574
CAS:AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs.Formula:C21H22F2N6O2Purity:98.39% - 98.55%Color and Shape:SolidMolecular weight:428.44AKB-6899
CAS:AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treatedFormula:C14H11FN2O4Purity:97.11%Color and Shape:SolidMolecular weight:290.25Ref: TM-T29797
1mg74.00€5mg169.00€10mg263.00€25mg455.00€50mg652.00€100mg929.00€1mL*10mM (DMSO)178.00€JAK-IN-11
CAS:JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.Formula:C23H22FN5O4SPurity:99.57%Color and Shape:SolidMolecular weight:483.52Ilorasertib
CAS:Ilorasertib (ABT-348) inhibits Aurora kinases A/B/C & RET, PDGFRβ, Flt1 (IC50: 1-120 nM).Formula:C25H21FN6O2SPurity:96.17% - 98.03%Color and Shape:SolidMolecular weight:488.54DMOG
CAS:DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.Formula:C6H9NO5Purity:80.23% - 99.98%Color and Shape:SolidMolecular weight:175.14PROTAC BRD4 Degrader-3
CAS:PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.Formula:C55H65F2N9O9S2Purity:98%Color and Shape:SolidMolecular weight:1098.3SRX3177
CAS:SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.Formula:C31H32N6O4SPurity:99.16%Color and Shape:SolidMolecular weight:584.69Ref: TM-T69742
1mg77.00€5mg165.00€10mg240.00€25mg408.00€50mg562.00€100mg800.00€1mL*10mM (DMSO)208.00€Bobcat339 hydrochloride
CAS:Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.Formula:C16H13Cl2N3OPurity:99.22%Color and Shape:SolidMolecular weight:334.2Ref: TM-T61012
2mg35.00€5mg52.00€10mg85.00€25mg160.00€50mg250.00€100mg373.00€200mg547.00€1mL*10mM (DMSO)58.00€JNJ-64619178
CAS:JNJ-64619178: selective, oral, pseudo-irreversible PRMT5 inhibitor (IC50: 0.14 nM), effective in lung cancer.Formula:C22H23BrN6O2Purity:98.44% - 99.63%Color and Shape:SolidMolecular weight:483.36Ref: TM-T15624
1mg88.00€5mg170.00€10mg274.00€25mg567.00€50mg944.00€100mg1,659.00€1mL*10mM (DMSO)182.00€AZ505 ditrifluoroacetate
CAS:AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).Formula:C33H40Cl2F6N4O8Color and Shape:SolidMolecular weight:805.593-methyl-1,2,3,4-tetrahydroquinazolin-2-one
CAS:3-methyl-1,2,3,4-tetrahydroquinazolin-2-one is a inhibitor of BRD4 .Formula:C9H10N2OPurity:99.30% - 99.64%Color and Shape:SolidMolecular weight:162.19Ref: TM-T50006
2mg39.00€5mg55.00€10mg82.00€25mg126.00€50mg182.00€100mg273.00€500mg677.00€1mL*10mM (DMSO)59.00€UNC926 hydrochloride
CAS:UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.Formula:C16H22BrClN2OPurity:98.71%Color and Shape:SolidMolecular weight:373.72Ref: TM-T9221
1mg88.00€5mg172.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)177.00€WAY-620473
CAS:WAY-620473 is a potent PARP-1 inhibitor with antitumor activity and alters eukaryotic lifespan.Formula:C17H20N4O3Purity:97.04%Color and Shape:SolidMolecular weight:328.37Tofacitinib
CAS:Tofacitinib (Tasocitinib) is an orally Janus kinase inhibitor. Tofacitinib is used for the treatment of rheumatoid arthritis. Cost effective and quality assured.Formula:C16H20N6OPurity:100% - 99.71%Color and Shape:SolidMolecular weight:312.372'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS:2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.Formula:C9H13ClFN3O4Purity:99.69%Color and Shape:SolidMolecular weight:281.67BBC0403
CAS:BBC0403 is a BRD2 inhibitor, inhibiting BRD2 and BRD2, and suppresses NF-κB and MAPK signaling pathways.Formula:C21H22N2O5Purity:98.15%Color and Shape:SolidMolecular weight:382.41Ref: TM-T88118
1mg69.00€5mg145.00€10mg226.00€25mg469.00€50mg687.00€100mg938.00€200mg1,283.00€1mL*10mM (DMSO)155.00€Mivebresib
CAS:Mivebresib (ABBV-075) is a potent BET inhibitor with antitumor effects, disrupting gene expression and MYC, TMPRSS2-ETS proteins.Formula:C22H19F2N3O4SPurity:98.74% - 99.32%Color and Shape:SolidMolecular weight:459.47Ref: TM-T3712
1mg58.00€2mg82.00€5mg97.00€10mg159.00€25mg256.00€50mg462.00€100mg660.00€1mL*10mM (DMSO)99.00€lutidinic acid
CAS:lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.Formula:C7H5NO4Purity:98.06%Color and Shape:White To Off-White Crystalline PowderMolecular weight:167.12PRMT5-IN-31
PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 andFormula:C21H24N2O2Purity:98%Color and Shape:SolidMolecular weight:336.43CARM1 degrader-2
PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associatedFormula:C72H100N12O7SPurity:98%Color and Shape:SolidMolecular weight:1277.71JAK1/STAT3-IN-1
JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).Formula:C30H33FN4O3SColor and Shape:SolidMolecular weight:548.67AKI603
CAS:AKI603: Aurora A kinase blocker; IC50 12.3 nM; targets BCR-ABL-T315I resistance; halts leukemia cell growth.Formula:C19H23N9O2Purity:99.81%Color and Shape:SolidMolecular weight:409.45Ref: TM-T64338
1mg66.00€5mg145.00€10mg212.00€25mg380.00€50mg562.00€100mg792.00€200mg1,064.00€1mL*10mM (DMSO)160.00€K-756
CAS:K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).Formula:C24H27N5O3Purity:99.68%Color and Shape:SolidMolecular weight:433.5Ref: TM-T15639
1mg52.00€5mg96.00€10mg169.00€25mg316.00€50mg567.00€100mg810.00€500mg1,644.00€1mL*10mM (DMSO)114.00€ML367
CAS:ML367 inhibits ATAD5 stabilization with low micromolar activity, serving as a probe molecule.Formula:C19H12F2N4Purity:99.39%Color and Shape:SolidMolecular weight:334.32ZSNI-21
ZSNI-21 is a dual inhibitor targeting ADAM17 and HDAC2. It effectively suppresses the proliferation of Bel-7402 cells and exhibits significant anti-metastatic properties against HCC-LM3 cells, making it a promising candidate for hepatocellular carcinoma (HCC) research.Formula:C26H25N3O5Color and Shape:SolidMolecular weight:459.49MS0124
CAS:MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.Formula:C20H29N5O3Purity:99.56%Color and Shape:SolidMolecular weight:387.48
