Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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LFM-A13
CAS:LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR,Formula:C11H8Br2N2O2Purity:99.9%Color and Shape:SolidMolecular weight:360BAZ1A-IN-1
CAS:BAZ1A-IN-1, a potent inhibitor, KD 0.52 μM against BAZ1A, is effective in high-BAZ1A cancer cells, not in low-BAZ1A ones.Formula:C16H12N4O3SPurity:99.91%Color and Shape:SolidMolecular weight:340.36Ref: TM-T9552
1mg92.00€5mg188.00€10mg296.00€25mg593.00€50mg852.00€100mg1,159.00€200mg1,549.00€1mL*10mM (DMSO)216.00€HIF1-IN-3
CAS:HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used inFormula:C26H24N2O3Purity:99.48%Color and Shape:SolidMolecular weight:412.48LSD1-IN-5
CAS:LSD1-IN-5, a reversible LSD1 inhibitor, boosts H3K4me2 without affecting LSD1 expression; IC50: 121 nM.Formula:C15H13BrN2O3Purity:98%Color and Shape:SolidMolecular weight:349.18INCB054329
CAS:INCB054329 is a BET inhibitor targeting BRD2/3/4 and BRDT with IC50s ranging from 1-119 nM.Formula:C19H16N4O3Purity:98.03%Color and Shape:SolidMolecular weight:348.36NU1025
CAS:NU1025 (NSC-696807) is a potent PARP inhibitor with IC50 of 400 nM.Formula:C9H8N2O2Purity:98.00%Color and Shape:SolidMolecular weight:176.17Ref: TM-T6912
2mg48.00€5mg71.00€10mg103.00€25mg188.00€50mg319.00€100mg502.00€500mg1,121.00€1mL*10mM (DMSO)71.00€Procaine hydrochloride
CAS:Procaine HCl is a benzoic acid derivative used as a local anesthetic, blocking nerve impulses and sensation.Formula:C13H20N2O2·HClPurity:100.00% - 99.22%Color and Shape:White Crystalline PowderMolecular weight:272.77Lin28-let-7a antagonist 1
CAS:Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.Formula:C31H29N5O7Purity:99.91%Color and Shape:SolidMolecular weight:583.59Ref: TM-T11851
1mg92.00€5mg216.00€10mg329.00€25mg593.00€50mg893.00€100mg1,311.00€1mL*10mM (DMSO)281.00€PROTAC SMARCA2 degrader-31
CAS:PROTAC SMARCA2-degrader-36 (compound 38) is an SMARCA2 degrader that achieves a 99% degradation rate at 100 nM in H929 cells. It possesses antiproliferative activity and is used in cancer research.Formula:C48H65N9O6SColor and Shape:SolidMolecular weight:896.15ZL0590
CAS:ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.Formula:C23H27F3N4O4SPurity:99.95%Color and Shape:SoildMolecular weight:512.55Ref: TM-T60072
1mg74.00€5mg160.00€10mg235.00€25mg424.00€50mg635.00€100mg935.00€1mL*10mM (DMSO)177.00€BRD4 Inhibitor-20
CAS:BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity.Formula:C18H18N2O4SPurity:100%Color and Shape:SolidMolecular weight:358.41Ref: TM-T61318
2mg39.00€5mg62.00€10mg90.00€25mg170.00€50mg255.00€100mg359.00€200mg487.00€1mL*10mM (DMSO)77.00€PARP7-IN-16 free base
CAS:PARP7-IN-16 free base is the freebase form of PARP7-IN-16. As a selective oral inhibitor of PARP-1/2/7, it demonstrates IC50 values of 0.94, 0.87, and 0.21 nM, respectively. This compound is utilized in the research of breast and prostate cancer.Formula:C25H27FN4O4Color and Shape:SolidMolecular weight:466.50AZD-1897
CAS:AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.Formula:C18H23N3O3SPurity:99.49%Color and Shape:SolidMolecular weight:361.46Fluzoparib
CAS:Fluzoparib (SHR3162) is a novel, potent, and orally available inhibitor of PARP, potentially for the treatment of solid tumours.Formula:C22H16F4N6O2Purity:98.29% - 98.74%Color and Shape:SolidMolecular weight:472.4Ref: TM-T8806
1mg60.00€2mg88.00€5mg124.00€10mg197.00€25mg389.00€50mg565.00€100mg822.00€500mg1,681.00€1mL*10mM (DMSO)145.00€KRH102140
CAS:KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.Formula:C25H24FNOPurity:98.31% - 99.61%Color and Shape:SolidMolecular weight:373.46Glucosamine
CAS:Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids.Formula:C6H13NO5Purity:99.80% - 99.80%Color and Shape:CoaMolecular weight:179.17AZD-1480
CAS:AZD1480: JAK2 inhibitor, IC50 0.26 nM; selective vs Tyk2, JAK3; less on JAK1. Used in solid tumors, PPV, PMF, ET trials.Formula:C14H14ClFN8Purity:97.5% - 98.55%Color and Shape:SolidMolecular weight:348.77KAT6A-IN-2
CAS:KAT6A-IN-2 (compound 7) is an inhibitor of KAT6A.Formula:C23H29N5O5SColor and Shape:SolidMolecular weight:487.57PJ34
CAS:PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.Formula:C17H17N3O2Purity:95.05% - 99.85%Color and Shape:SolidMolecular weight:295.34TG101209
CAS:TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.Formula:C26H35N7O2SPurity:100% - 99.36%Color and Shape:SolidMolecular weight:509.67JAK-IN-27
CAS:JAK-IN-27, also known as compound 1, is an orally active, potent inhibitor of the JAKS family kinases, displaying inhibitory concentrations (IC50s) of 3.0 nMFormula:C20H21F2N7OPurity:98%Color and Shape:SolidMolecular weight:413.42TCIP 1
TCIP 1 is a small molecule in the category of transcriptional/epigenetic covalent inhibitor probes (TCIPs) that forms covalent bonds with molecules targetingFormula:C50H58Cl2N12O6SPurity:98%Color and Shape:SolidMolecular weight:1026.04DBr-1
DBr-1 is a potent degrader of BRD9 [1].Formula:C55H68ClN9O5Purity:98%Color and Shape:SolidMolecular weight:970.64Kgp-IN-1
CAS:Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.Formula:C19H24F4N4O3Purity:98%Color and Shape:SolidMolecular weight:432.41ATF3 inducer 1
CAS:ATF3 inducer 1 is an ATF3 inducer with lipid-lowering activity, alleviating glucose intolerance and insulin resistance induced by high-fat diet (HFD).Formula:C12H10N2O3Purity:99.04%Color and Shape:SoildMolecular weight:230.22YUKA1
CAS:YUKA1 inhibits Lysine demethylase 5A (IC50: 2.66 μM), weaker on KDM5C (IC50: 7.12 μM), inactive on KDM5B, KDM6A/B.Formula:C13H16N4O2SPurity:98%Color and Shape:SolidMolecular weight:292.36JQAD1
CAS:JQAD1, a potent EP300 degrader (DC50≤31.6 nM), induces apoptosis, suppresses tumor growth, and selectively downregulates CRC and MYCN without affecting CBP.Formula:C48H52F4N6O9Purity:99.75%Color and Shape:SolidMolecular weight:932.95Bleximenib oxalate
CAS:Bleximenib oxalate (Menin-MLL inhibitor 24 oxalate) is a menin-MLL inhibitor that blocks the binding of the menin-KMT2A complex to chromatin at gene promoters.Formula:C34H52FN7O7Purity:98%Color and Shape:SolidMolecular weight:689.82BAY1238097
CAS:BAY1238097 is a BET inhibitor with anticancer activity and antiproliferative activity for the study of advanced refractory malignancies.Formula:C25H33N5O3Purity:98.10% - 99.96%Color and Shape:SolidMolecular weight:451.56Ref: TM-T12660L
1mg52.00€5mg114.00€10mg183.00€25mg404.00€50mg702.00€100mg1,111.00€200mg1,501.00€1mL*10mM (DMSO)125.00€Danusertib
CAS:Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Formula:C26H30N6O3Purity:97.88% - 98.44%Color and Shape:White PowderMolecular weight:474.55Ref: TM-T2094
1mg59.00€2mg85.00€5mg116.00€10mg188.00€25mg365.00€50mg555.00€100mg795.00€500mg1,605.00€1mL*10mM (DMSO)120.00€Vadadustat
CAS:Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.Formula:C14H11ClN2O4Purity:99.09% - 99.4%Color and Shape:SolidMolecular weight:306.7TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formula:C23H22Cl2FN5O3Purity:98.69%Color and Shape:SolidMolecular weight:506.36Ref: TM-T34787
1mg97.00€5mg235.00€10mg378.00€25mg748.00€50mg1,169.00€100mg1,644.00€1mL*10mM (DMSO)261.00€ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Formula:C21H25N7Purity:97.63% - ≥95%Color and Shape:SolidMolecular weight:375.47Ref: TM-T2358
1mg51.00€2mg72.00€5mg105.00€10mg159.00€25mg279.00€50mg462.00€100mg648.00€1mL*10mM (DMSO)116.00€KAT modulator-1
CAS:KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].Formula:C20H36O2Purity:98%Color and Shape:SolidMolecular weight:308.5Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Formula:C27H36N6O3SPurity:98.23% - 99.96%Color and Shape:SolidMolecular weight:524.68Ref: TM-T1995
1g625.00€5mg49.00€10mg69.00€50mg113.00€100mg134.00€200mg216.00€500mg472.00€1mL*10mM (DMSO)57.00€EZH2-IN-15
CAS:A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.Formula:C32H44N4O4Purity:98.85%Color and Shape:SolidMolecular weight:548.72ZG-2033
CAS:ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.Formula:C15H14N2O2SColor and Shape:SolidMolecular weight:286.35Nesuparib
CAS:Nesuparib, a potent PARP/TNKS1 inhibitor, has antitumor properties and potential for treating various diseases.Formula:C23H24N6OPurity:99.71%Color and Shape:SolidMolecular weight:400.48Ref: TM-T61932
1mg88.00€5mg210.00€10mg338.00€25mg605.00€50mg825.00€100mg1,121.00€1mL*10mM (DMSO)233.00€CBP/p300-IN-21
CAS:CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibitsFormula:C19H16ClNO4Purity:98%Color and Shape:SolidMolecular weight:357.79Anacardic Acid
CAS:Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases.Formula:C22H36O3Purity:97.47% - 99.72%Color and Shape:SolidMolecular weight:348.52VZ185
CAS:VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).Formula:C53H67FN8O8SPurity:98%Color and Shape:SolidMolecular weight:995.21HSP90/LSD1-IN-1
HSP90/LSD1-IN-1 (compound 6) is a dual inhibitor of HSP90 and LSD1. This compound effectively inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI50 values of 0.24 μM and 0.30 μM, respectively.Color and Shape:Odour SolidGSK737
CAS:GSK737 is a dual inhibitor of BRD4 BD1 and BD2, exhibiting pIC50 values of 5.3 and 7.3, respectively.Formula:C20H21N5O2Purity:98%Color and Shape:SolidMolecular weight:363.41NSC243928 mesylate
CAS:NSC243928 mesylate binds to human lymphocyte antigen 6 (LY6), a cell growth inhibitor with anticancer activity.Formula:C23H25N3O6S2Purity:99.39%Color and Shape:SolidMolecular weight:503.59MY-1B
CAS:MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.Formula:C22H18BrN3O2Purity:100% - 100%Color and Shape:SoildMolecular weight:436.3Tyk2-IN-20
CAS:Tyk2-IN-20 (Example 289) is an effective inhibitor of Tyk2 with an IC50 value below 5 nM. Additionally, it inhibits JAK1, JAK2, and JAK3 with IC50 values under 100 nM. This compound is utilized for the research of inflammatory diseases.Formula:C24H25N7O2Color and Shape:SolidMolecular weight:443.50Brepocitinib
CAS:Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).Formula:C18H21F2N7OPurity:99.8%Color and Shape:SolidMolecular weight:389.4Ref: TM-TQ0010
1mg35.00€5mg74.00€10mg110.00€25mg226.00€50mg411.00€100mg660.00€200mg917.00€1mL*10mM (DMSO)81.00€PKC β pseudosubstrate acetate
PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.Purity:95.01%Color and Shape:SoildCM-579
CAS:CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.Formula:C29H40N4O3Purity:99.62%Color and Shape:SolidMolecular weight:492.65Ref: TM-T10840L
1mg55.00€5mg96.00€10mg138.00€25mg217.00€50mg319.00€100mg472.00€1mL*10mM (DMSO)124.00€BRD4 Inhibitor-10
CAS:BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).Formula:C25H27N5O2Purity:98.98%Color and Shape:SolidMolecular weight:429.51Ref: TM-T14776
1mg47.00€5mg97.00€10mg156.00€25mg301.00€50mg437.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)105.00€RO8191
CAS:RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Formula:C14H5F6N5OPurity:98.85% - ≥98%Color and Shape:SolidMolecular weight:373.21Baricitinib
CAS:Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Formula:C16H17N7O2SPurity:100% - 99.79%Color and Shape:SolidMolecular weight:371.42Ref: TM-T2485
5mg50.00€10mg73.00€25mg90.00€50mg115.00€100mg144.00€200mg188.00€500mg311.00€1mL*10mM (DMSO)69.00€KDM5-C70
CAS:KDM5-C70 is an ethyl ester derivative of KDM5-C49.Formula:C17H28N4O3Purity:97.63% - 99.12%Color and Shape:SolidMolecular weight:336.43Ref: TM-T15648
2mg44.00€5mg62.00€10mg88.00€25mg140.00€50mg245.00€100mg490.00€200mg700.00€500mg1,074.00€1mL*10mM (DMSO)73.00€JAK1-IN-4
CAS:JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).Formula:C26H32FN9O2Purity:98%Color and Shape:SolidMolecular weight:521.59Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formula:C19H15N3O2SPurity:99.47%Color and Shape:SolidMolecular weight:349.41BAY-299
CAS:BAY-299 inhibits BRPF2, TAF1, and TAF1L with IC50s of 67, 8, and 106 nM.Formula:C25H23N3O4Purity:97.5%Color and Shape:SolidMolecular weight:429.47MS37452
CAS:MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).Formula:C22H26N2O5Purity:99.39% - 99.39%Color and Shape:SolidMolecular weight:398.45Ref: TM-T21767
5mg51.00€10mg88.00€25mg170.00€50mg305.00€100mg527.00€500mg1,121.00€1mL*10mM (DMSO)57.00€Hellebrigenin
CAS:Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt.Formula:C24H32O6Purity:98%Color and Shape:SolidMolecular weight:416.51Glucosamine hydrochloride
CAS:Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.Formula:C6H13NO5·HClPurity:99.77%Color and Shape:White Solid CrystallineMolecular weight:215.63AJI-214
CAS:AJI-214 functions as a dual-target inhibitor that specifically blocks Aurora kinase A and JAK2. By directly inhibiting Aurora kinase A, AJI-214 prevents mitotic progression and cell polarity in T cells while concurrently suppressing JAK2 activation to reduce STAT3 phosphorylation. This inhibition decreases the differentiation of TH1 and TH17 cells. AJI-214 is utilized in research focused on the modulation of immune responses and the prevention of graft-versus-host disease (GVHD).Formula:C17H13ClFN5OColor and Shape:SolidMolecular weight:357.77MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Formula:C15H26Cl2N2OPurity:99.9%Color and Shape:SolidMolecular weight:321.28HDAC11-IN-1
HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.Formula:C43H63F3N6O6S2Color and Shape:SolidMolecular weight:881.12DPP
CAS:DPP, a Platinum(IV) complex with a pterostilbene-derived axial ligand, inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, demonstratingFormula:C36H40Cl2N2O10PtPurity:98%Color and Shape:SolidMolecular weight:926.7Euchrestaflavanone B
CAS:Euchrestaflavanone B has antibacterial effects on Gram-positive bacteria and may inhibit cancer by targeting protein kinase CKII.Formula:C25H28O6Purity:98%Color and Shape:SolidMolecular weight:424.49PRMT5-IN-25
CAS:PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1Formula:C24H21F3N6OPurity:98%Color and Shape:SolidMolecular weight:466.46CM-579 trihydrochloride (1846570-40-8 free base)
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wideFormula:C29H43Cl3N4O3Purity:98%Color and Shape:SolidMolecular weight:602.04FKBP12 PROTAC dTAG-7
CAS:dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.Formula:C63H79N5O19Purity:98%Color and Shape:SolidMolecular weight:1210.32AJI-100
CAS:AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD).Formula:C17H14FN5OColor and Shape:SolidMolecular weight:323.32CTX-0124143
CAS:CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.Formula:C17H13FN2O3SPurity:99.16%Color and Shape:SolidMolecular weight:344.36EZH2-IN-13
CAS:EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.Formula:C34H45N5O3Purity:98.3%Color and Shape:SolidMolecular weight:571.75TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Formula:C27H25F3N4O4Purity:≥98%Color and Shape:SolidMolecular weight:526.51UNC0379
CAS:UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.Formula:C23H35N5O2Purity:94.41% - 99.97%Color and Shape:SolidMolecular weight:413.56ZG-2305
ZG-2305 is an effective, selective, and orally active inhibitor of FIH (factor inhibiting hypoxia-inducible factor (FIH)), with Ki values of 79.6 nM for FIH and 2786 nM for PHD2. This compound enhances the expression of the EGLN3 gene, reduces cellular triglyceride levels, and decreases lipid accumulation. ZG-2305 holds potential for research into obesity and fatty liver disease.Formula:C17H11Cl2N3O5Color and Shape:SolidMolecular weight:408.19LSD1-IN-37
LSD1-IN-37 (Compound 5g) is an inhibitor of lysine-specific demethylase 1 (LSD1), developed through an efficient synthesis strategy incorporating a hexafluoroisopropyl group. This approach does not require metal catalysts and offers excellent reaction stability and adaptability. LSD1-IN-37 exhibits outstanding LSD1 inhibitory activity and has potential for further research.Formula:C15H13F2N5Color and Shape:SolidMolecular weight:301.29Niraparib metabolite M1 HCl
Niraparib metabolite M1 HCl, a PARP1/2 inhibitor, used in the study of ovarian cancer, fallopian tube cancer and primary peritoneal cancer.Formula:C19H20ClN3O2Color and Shape:SolidMolecular weight:357.83Ref: TM-T12229L
1mg171.00€5mg364.00€10mg547.00€25mg929.00€50mg1,391.00€100mg2,087.00€1mL*10mM (DMSO)245.00€PROTAC SMARCA2 degrader-18
CAS:PROTAC SMARCA2 degrader-18 (Example144) is a PROTAC SMARCA2 degrader with potential for researching non-small cell lung cancer (NSCLC).Formula:C40H41N9O3Color and Shape:SolidMolecular weight:695.81SMYD3-IN-1
CAS:SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).Formula:C28H31ClN4O3Purity:98%Color and Shape:SolidMolecular weight:507.02GSK2879552 2HCl (1401966-69-5(free base))
GSK2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.Formula:C23H30Cl2N2O2Purity:98.08% - ≥95%Color and Shape:SolidMolecular weight:437.41Ref: TM-T4418
1mg59.00€2mg86.00€5mg109.00€10mg175.00€25mg293.00€50mg411.00€100mg610.00€500mg1,301.00€PROTAC SMARCA2/4-degrader-26
PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.Formula:C38H47N9O5SColor and Shape:SolidMolecular weight:741.9Phoenixin-20 TFA
Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide that exerts hormone-like effects in vertebrates, stimulating hypothalamo-pituitary-gonadal hormones andFormula:C101H153N25O29·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:2181.45 (free base)Y06036
CAS:Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).Formula:C16H15BrN2O5SPurity:98.95%Color and Shape:SolidMolecular weight:427.27P3FI-63
CAS:P3FI-63 is a selective KDM3B inhibitor (IC50: 7 μM) with antitumor activity for the study of fusion-positive rhabdomyosarcoma and other transcriptionally addictive cancers.Formula:C15H15N3O2Purity:99.16%Color and Shape:SoildMolecular weight:269.3PROTAC SMARCA2/4-degrader-31
CAS:PROTAC SMARCA2/4-degrader-31 (Compound I-280) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in A549 cells and SMARCA4 in MV411 cells, both with a degradation concentration (DC50) of less than 100 nM.Formula:C44H51N11O4Color and Shape:SolidMolecular weight:797.95CP2
CP2 is a useful organic compound for research related to life sciences and the catalog number is T35338.Purity:98%Color and Shape:SolidMAT2A inhibitor 4
CAS:MAT2A Inhibitor 4 acts as an inhibitor targeting the catalytic subunit of methionine S-adenosyltransferase-2 (MAT2A), offering potential utility in cancerFormula:C16H15ClFNPurity:98.86%Color and Shape:SolidMolecular weight:275.75Ref: TM-T9262
1mg52.00€5mg116.00€10mg182.00€25mg315.00€50mg449.00€100mg610.00€200mg822.00€1mL*10mM (DMSO)128.00€Inobrodib
CAS:Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain.Formula:C30H32F2N4O3Purity:98.91% - 99.18%Color and Shape:SolidMolecular weight:534.6Ref: TM-T10717
1mg70.00€2mg92.00€5mg153.00€10mg264.00€25mg557.00€50mg797.00€100mg1,074.00€1mL*10mM (DMSO)173.00€MZP-55
CAS:MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)Formula:C57H70ClN7O10SPurity:98%Color and Shape:SolidMolecular weight:1080.73Anti-PARP1 Antibody (8I163)
Anti-PARP1 Antibody (8I163) is a Mouse antibody targeting PARP1. Anti-PARP1 Antibody (8I163) can be used in IHC-P.Color and Shape:Odour LiquidCBP/EP300-IN-1
CAS:CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.Formula:C23H23FN2O5Purity:99.05%Color and Shape:SolidMolecular weight:426.44PCAF-IN-1
CAS:PCAF-IN-1 is a highly selective PCAF inhibitor with potential anti-tumor, anti-inflammatory, and anti-heart disease effects.Formula:C15H11ClN6Color and Shape:SolidMolecular weight:310.74Protosappanin A
CAS:Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.Formula:C15H12O5Purity:100% - 99.42%Color and Shape:SolidMolecular weight:272.25Ref: TM-TJS1779
1mg87.00€5mg216.00€10mg354.00€25mg582.00€50mg825.00€100mg1,111.00€1mL*10mM (DMSO)197.00€Dot1L-IN-2
CAS:Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectivelyFormula:C27H24N8OPurity:98%Color and Shape:SolidMolecular weight:476.53Dihydro-5-azacytidine FA
Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.Formula:C9H16N4O7Purity:100%Color and Shape:SolidMolecular weight:292.25LSQ-28
LSQ-28 is an orally active HDAC3 inhibitor with an IC50 of 42 nM, demonstrating significant anticancer, antiproliferative, anti-migration, anti-invasion, and anti-wound healing activities. LSQ-28 is suitable for cancer research.Formula:C31H27N5OMolecular weight:485.579QC6352
CAS:QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).Formula:C24H25N3O2Purity:98%Color and Shape:SolidMolecular weight:387.47Momelotinib
CAS:Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Formula:C23H22N6O2Purity:97.47% - 99.56%Color and Shape:SolidMolecular weight:414.46Ref: TM-T1849
1mg38.00€2mg49.00€5mg81.00€10mg95.00€25mg166.00€50mg259.00€100mg406.00€200mg625.00€1mL*10mM (DMSO)88.00€PROTAC SMARCA2/4-degrader-30
CAS:Compound I-291, also known as PROTAC SMARCA2/4-degrader-30, targets the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. It effectively degrades SMARCA2 in A549 and MV411 cells, as well as SMARCA4 in MV411 cells, with a degradation concentration (DC50) of less than 100 nM.Formula:C44H51N11O4Color and Shape:SolidMolecular weight:797.95BMS-P5 free base
CAS:BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor.Formula:C27H32N6O2Purity:99.88%Color and Shape:SolidMolecular weight:472.58CBP/p300-IN-3
CAS:CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase.Formula:C24H29N7OPurity:97.35% - 97.38%Color and Shape:SolidMolecular weight:431.53Ref: TM-T12345
1mg92.00€5mg187.00€10mg311.00€25mg562.00€50mg810.00€100mg1,121.00€500mg2,232.00€1mL*10mM (DMSO)215.00€Phoenixin-20
CAS:Phoenixin-20 (PNX-20) is a vertebrate bioactive peptide exhibiting hormone-like actions, stimulating the hypothalamo-pituitary-gonadal axis to regulateFormula:C101H153N25O29Purity:98%Color and Shape:SolidMolecular weight:2181.45Ruxolitinib (S enantiomer)
CAS:Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Formula:C17H18N6Purity:99.37% - 99.79%Color and Shape:SolidMolecular weight:306.36NI-57
CAS:NI-57 inhibits BRPF family proteins: BRPF1 (IC50=3.1nM), BRPF2 (IC50=46nM), BRPF3 (IC50=140nM).Formula:C19H17N3O4SPurity:100% - 99.87%Color and Shape:SolidMolecular weight:383.42UNC 1021
CAS:UNC 1021 is a selective L3MBTL3 inhibitor (IC50 = 0.048 μM).Formula:C26H38N4O2Purity:99.86%Color and Shape:SoildMolecular weight:438.61PROTAC BRM/BRG1 degrader-3
CAS:PROTAC BRM/BRG1 degrader-3 (compound 304) is a PROTAC-based degrader of BRM/BRG1. In SW1573 cells, it degrades BRM with a DC50 of less than 1 nM and BRG1 with a DC50 greater than 1 nM. PROTAC BRM/BRG1 degrader-3 exhibits antitumor activity and inhibits the proliferation of A549 cells with an IC50 of 0.6 nM.Formula:C50H63N11O5SColor and Shape:SolidMolecular weight:930.17JAK2-IN-9
CAS:Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 nM.Formula:C20H24N6O2SPurity:98%Color and Shape:SolidMolecular weight:412.51SMARCA-BD ligand 1 for Protac dihydrochloride
CAS:SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.Formula:C14H19Cl2N5OPurity:99.01%Color and Shape:SolidMolecular weight:344.24Senaparib
CAS:Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity.Formula:C24H20F2N6O3Purity:99.41%Color and Shape:SolidMolecular weight:478.45Ref: TM-T9593
1mg46.00€2mg59.00€5mg87.00€10mg153.00€25mg274.00€50mg432.00€100mg638.00€1mL*10mM (DMSO)96.00€BET-IN-14
CAS:BET-IN-14 is a pan BET inhibitor with an IC50 of 5.35 nM, demonstrating oral activity and anticancer properties [1].Formula:C30H37N7O2Purity:98%Color and Shape:SolidMolecular weight:527.66PF-06726304
CAS:PF-06726304: potent EZH2 inhibitor, effective against tumors, Kis at 0.7 nM (wild-type) and 3.0 nM (Y641N mutant).Formula:C22H21Cl2N3O3Purity:98.19% - 99.54%Color and Shape:SolidMolecular weight:446.33Ref: TM-T12428L
1mg39.00€2mg50.00€5mg81.00€10mg125.00€25mg279.00€50mg505.00€100mg730.00€1mL*10mM (DMSO)88.00€DDO-8926
DDO-8926 is a potent, selective BET inhibitor shown to markedly diminish mechanical hypersensitivity in neuropathic pain research by suppressing pro-Formula:C20H21FN6O2SPurity:98%Color and Shape:SolidMolecular weight:428.48KG-501
CAS:KG-501 (Naphthol AS-E phosphate) is a cAMP response element-binding protein (CREB) inhibitor(IC50 : 6.89 μM).Formula:C17H13ClNO5PPurity:≥95%Color and Shape:SolidMolecular weight:377.72PARP/HDAC-IN-1
PARP/HDAC-IN-1 is a PARP and HDAC inhibitor that inhibits PARP1, PARP2, and HDAC1, and may be used to study pancreatic cancer.Formula:C36H32F2N6O3Purity:95%Color and Shape:SolidMolecular weight:634.67M-110
CAS:M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).Formula:C22H28ClN5O3Purity:98.30%Color and Shape:SolidMolecular weight:445.943-Methoxybenzamide
CAS:3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase.Formula:C8H9NO2Purity:98.52%Color and Shape:SolidMolecular weight:151.16PROTAC SMARCA2 degrader-30
CAS:PROTAC SMARCA2 degrader-30 (example 85) is a potent PROTAC SMARCA2 degrader, exhibiting a DC50 of less than 100 nM in H1299 cells.Formula:C47H54N10O3Color and Shape:SolidMolecular weight:807EPZ031686
CAS:EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.Formula:C26H34ClF3N4O4SPurity:97.91%Color and Shape:SolidMolecular weight:591.09Ref: TM-TQ0263
1mg111.00€5mg250.00€10mg376.00€25mg748.00€50mg1,074.00€100mg1,444.00€1mL*10mM (DMSO)341.00€AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purity:98.6% - 99.39%Color and Shape:Yellow SolidMolecular weight:294.3Trotabresib
CAS:Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.Formula:C21H21NO4SPurity:99.03%Color and Shape:SolidMolecular weight:383.46Ref: TM-T36395
1mg92.00€5mg188.00€10mg311.00€25mg528.00€50mg755.00€100mg1,017.00€1mL*10mM (DMSO)215.00€TTK21
CAS:TTK21 is an activator of CBP/p300 histone acetyltransferase activity.Formula:C17H15ClF3NO2Purity:98.43%Color and Shape:SolidMolecular weight:357.75Ref: TM-T8778
1mg60.00€5mg111.00€10mg166.00€25mg324.00€50mg487.00€100mg730.00€500mg1,483.00€1mL*10mM (DMSO)120.00€PF-9363
CAS:PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.Formula:C20H20N4O6SPurity:99.03%Color and Shape:SolidMolecular weight:444.46AG-270
CAS:AG-270 is an allosteric and orally active inhibitor of MAT2A.Formula:C30H27N5O2Purity:98.2% - 98.28%Color and Shape:SolidMolecular weight:489.57SC-43
CAS:SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).Formula:C21H13ClF3N3O2Purity:98.44%Color and Shape:SolidMolecular weight:431.8BD750
CAS:BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFormula:C14H13N3OSPurity:99.02%Color and Shape:SolidMolecular weight:271.34GLPG0634 analog
CAS:GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.Formula:C23H18N6O2Purity:100% - 99.22%Color and Shape:SolidMolecular weight:410.43Ref: TM-T3076
1mg40.00€2mg52.00€5mg88.00€10mg144.00€25mg264.00€50mg465.00€100mg658.00€500mg1,378.00€1mL*10mM (DMSO)87.00€IOX1
CAS:IOX1, a broad-spectrum 2OG oxygenase inhibitor, IC50: KDM4A - 0.6uM, KDM3A - 0.1uM.Formula:C10H7NO3Purity:99.38%Color and Shape:SolidMolecular weight:189.17TB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.Color and Shape:Odour SolidAG14361
CAS:AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).Formula:C19H20N4OPurity:97.65% - 99.73%Color and Shape:SolidMolecular weight:320.39Ref: TM-T6339
1mg51.00€2mg71.00€5mg139.00€10mg246.00€25mg477.00€50mg697.00€100mg938.00€1mL*10mM (DMSO)139.00€Zavondemstat
CAS:Zavondemstat (QC8222 free base) is a KDM4 inhibitor with anticancer and antitumor activity for the study of triple-negative and breast cancers.Formula:C26H29N3O3Purity:99.62% - 99.78%Color and Shape:SolidMolecular weight:431.53BET-IN-16
CAS:BET-IN-16 (Comp I), a bromodomain and extra-terminal (BET) inhibitor, demonstrates anticancer activity by impeding the growth of prostate cancer cells.Formula:C31H25N5O3Purity:98%Color and Shape:SolidMolecular weight:515.56BRM/BRG1 ligand 2
CAS:BRM/BRG1 ligand 2 serves as a target protein ligand for the synthesis of PROTAC BRM/BRG1 degrader-2.Formula:C16H18N6OColor and Shape:SolidMolecular weight:310.35BAZ2-ICR
CAS:BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains.Formula:C20H19N7Purity:98%Color and Shape:SolidMolecular weight:357.41Fedratinib hydrochloride hydrate
CAS:Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.Formula:C27H40Cl2N6O4SPurity:98.96% - 99.46%Color and Shape:SolidMolecular weight:615.61SMARCA2-IN-2
CAS:Compound I-25, also known as SMARCA2-IN-2, is a SMARCA2 inhibitor (IC 50: 101-500 μM) with applications in cancer research.Formula:C16H17N3Color and Shape:SolidMolecular weight:251.33KC7F2
CAS:KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.Formula:C16H16Cl4N2O4S4Purity:98% - 99.11%Color and Shape:SolidMolecular weight:570.385,7,4'-Trimethoxyflavone
CAS:5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.Formula:C18H16O5Purity:97.53%Color and Shape:SolidMolecular weight:312.32CD532
CAS:CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.Formula:C26H25F3N8OPurity:99.49%Color and Shape:SolidMolecular weight:522.52EPZ020411 hydrochloride
CAS:EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM.Formula:C25H39ClN4O3Purity:100%Color and Shape:SolidMolecular weight:479.05Ref: TM-T22325
1mg60.00€5mg131.00€10mg215.00€25mg369.00€50mg563.00€100mg805.00€1mL*10mM (DMSO)145.00€XL019
CAS:XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.Formula:C25H28N6O2Purity:99.19%Color and Shape:SolidMolecular weight:444.53Alisertib
CAS:Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Formula:C27H20ClFN4O4Purity:100% - 99.82%Color and Shape:SolidMolecular weight:518.92Ref: TM-T2241
5mg55.00€10mg96.00€25mg155.00€50mg226.00€100mg354.00€200mg454.00€500mg743.00€1mL*10mM (DMSO)63.00€Iniparib
CAS:Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).Formula:C7H5IN2O3Purity:98.93%Color and Shape:SolidMolecular weight:292.03Ref: TM-T6224
5mg50.00€10mg77.00€25mg126.00€50mg229.00€100mg359.00€200mg570.00€500mg912.00€1mL*10mM (DMSO)55.00€JAK-IN-3
CAS:JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.Formula:C18H20N4O3Purity:98.04% - 98.19%Color and Shape:SolidMolecular weight:340.38Ref: TM-T11704
1mg133.00€2mg188.00€5mg321.00€10mg518.00€25mg1,035.00€50mg1,644.00€100mg2,680.00€200mg3,591.00€1mL*10mM (DMSO)354.00€SAR-20347
CAS:SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).Formula:C21H18ClFN4O4Purity:99.35% - 99.77%Color and Shape:SolidMolecular weight:444.84Ref: TM-T4210
1mg35.00€5mg80.00€10mg116.00€25mg227.00€50mg354.00€100mg588.00€200mg818.00€1mL*10mM (DMSO)88.00€MN-64
CAS:MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.Formula:C18H16O2Purity:99.36% - 99.93%Color and Shape:SolidMolecular weight:264.32PARP1-IN-16
PARP1-IN-16 (compound 12a) serves as a potent PARP1 inhibitor, exhibiting an IC50 value of 1.89 nM.Purity:98%Color and Shape:Odour SolidSarmustine
CAS:SarCNU is an alkylating anticancer drug targeting prostate cancer through p53 pathways and selects P140K MGMT-transduced CD34(+) cells.Formula:C6H11ClN4O3Purity:100% - 99.71%Color and Shape:SolidMolecular weight:222.63HIF-1α-IN-6
HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively.Purity:98%Color and Shape:Odour SoliddBET6
CAS:dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.Formula:C42H45ClN8O7SPurity:97.57% - 99.12%Color and Shape:SolidMolecular weight:841.37Ref: TM-T5130
1mg52.00€5mg97.00€10mg169.00€25mg306.00€50mg492.00€100mg712.00€200mg898.00€500mg1,311.00€1mL*10mM (DMSO)157.00€TC-E 5003
CAS:TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.Formula:C16H14Cl2N2O4SPurity:97.01%Color and Shape:SolidMolecular weight:401.26Pulrodemstat benzenesulfonate
CAS:Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally inhibitor of lysine specific demethylase-1 (LSD1) with anticancer effect.Formula:C30H29F2N5O5SPurity:97.67%Color and Shape:SolidMolecular weight:609.64Ref: TM-T11882
1mg60.00€2mg86.00€5mg124.00€10mg188.00€25mg329.00€50mg490.00€100mg710.00€1mL*10mM (DMSO)170.00€Rucaparib Phosphate
CAS:Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.Formula:C19H18FN3O·H3PO4Purity:99.1%Color and Shape:SolidMolecular weight:421.36Ref: TM-T6127
1mg38.00€2mg49.00€5mg79.00€10mg115.00€25mg188.00€50mg248.00€100mg393.00€200mg585.00€1mL*10mM (DMSO)79.00€ZEN-3862
CAS:ZEN-3862, a BET inhibitor, blocks BRD4(BD1) at 0.16 μM & BRD4(BD2) at 0.13 μM; usable in PROTACs for BRD4 degradation.Formula:C19H17FN2O3Purity:97.1%Color and Shape:SolidMolecular weight:340.35NP213
CAS:NP213 is a rapidly acting synthetic antimicrobial peptide (AMP).Formula:C42H84N28O7Purity:98%Color and Shape:SolidMolecular weight:1093.3Momelotinib Mesylate
CAS:Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.Formula:C24H26N6O5SPurity:98%Color and Shape:SolidMolecular weight:510.57Amifostine
CAS:Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.Formula:C5H15N2O3PSPurity:99.88%Color and Shape:White SolidMolecular weight:214.22NCGC00244536
CAS:NCGC00244536 (KDM4B Inhibitor B3) is a potent KDM4B inhibitor (IC50: 10 nM).Formula:C25H22N2O2Purity:97.20% - 99.72%Color and Shape:SolidMolecular weight:382.45Ref: TM-TQ0050
1mg96.00€5mg310.00€10mg472.00€25mg753.00€50mg1,074.00€100mg1,444.00€1mL*10mM (DMSO)259.00€Procaine
CAS:Procaine (Vitamin H3) is a slow-acting ester local anesthetic with a short effect, used for infiltration, nerve, and spinal blocks.Formula:C13H20N2O2Purity:99.57% - 99.73%Color and Shape:Anhydrous Plates Tables From Ligroin Or Ether SolidMolecular weight:236.31PHA-680632
CAS:PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.Formula:C28H35N7O2Purity:98.20%Color and Shape:SolidMolecular weight:501.62SD49-7
CAS:SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.Formula:C18H14N2O3Purity:99.36%Color and Shape:SoildMolecular weight:306.32Ref: TM-T67781
1mg60.00€5mg131.00€10mg188.00€25mg379.00€50mg550.00€100mg785.00€500mg1,568.00€1mL*10mM (DMSO)149.00€BIX-01294
CAS:BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).Formula:C28H38N6O2Purity:99.31% - 99.64%Color and Shape:SolidMolecular weight:490.64Ref: TM-T7697
1mg40.00€2mg51.00€5mg85.00€10mg117.00€25mg207.00€50mg350.00€100mg518.00€200mg740.00€1mL*10mM (DMSO)131.00€Rucaparib monocamsylate
CAS:Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor. Rucaparib Camsylate also displays binding affinity to eight other PARP domains.Formula:C29H34FN3O5SPurity:99.82%Color and Shape:SolidMolecular weight:555.66Ref: TM-T16807
5mg60.00€10mg96.00€25mg160.00€50mg235.00€100mg354.00€200mg522.00€1mL*10mM (DMSO)74.00€PROTAC BRD9 Degrader-1
CAS:PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM.Formula:C42H45N7O12S2Purity:98%Color and Shape:SolidMolecular weight:903.98Reversine
CAS:Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formula:C21H27N7OPurity:98% - 99.75%Color and Shape:SolidMolecular weight:393.49Ref: TM-T1825
1mg38.00€2mg49.00€5mg70.00€10mg88.00€25mg164.00€50mg224.00€100mg393.00€1mL*10mM (DMSO)70.00€Physachenolide C
CAS:Physachenolide C, a selective BET inhibitor, induces apoptosis and arrests the cell cycle at the G0-G1 phase, exhibiting antitumor activity [1].Formula:C30H40O9Purity:98%Color and Shape:SolidMolecular weight:544.63Delgocitinib
CAS:Delgocitinib is a potent JAK inhibitor (IC50: 2.8-58 nM), treats inflammatory diseases, and is the first topical drug for atopic dermatitis.Formula:C16H18N6OPurity:99.90%Color and Shape:SolidMolecular weight:310.35Ref: TM-T15096
1mg169.00€5mg311.00€10mg487.00€25mg929.00€50mg1,415.00€100mg2,062.00€200mg2,775.00€1mL*10mM (DMSO)349.00€UNC1079
CAS:UNC1079 is an selective L3MBTL3 domain inhibitorFormula:C28H42N4O2Purity:99.48%Color and Shape:SolidMolecular weight:466.66HDAC11-IN-2
CAS:HDAC11-IN-2 (compound B6) is a highly selective inhibitor of Histone Deacetylase 11 (HDAC11). It demonstrates IC50 values of 51.1 ×10^-3 μM for HDAC11 and 5 μM for HDAC8. HDAC11-IN-2 reduces de novo lipogenesis (DNL) and enhances fatty acid oxidation, which alleviates hepatic lipid accumulation and pathological symptoms in MASLD mice. By inhibiting HDAC11, HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at the Thr172 site, thereby modulating de novo lipogenesis and fatty acid oxidation in the liver.Formula:C25H35N3O3Color and Shape:SolidMolecular weight:425.564Sageone
CAS:Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 humanFormula:C19H24O3Purity:98%Color and Shape:SolidMolecular weight:300.39GSK503
CAS:GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.Formula:C31H38N6O2Purity:98% - 99.74%Color and Shape:SolidMolecular weight:526.67Ref: TM-T1775
1mg37.00€2mg52.00€5mg79.00€10mg111.00€25mg208.00€50mg376.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)92.00€JQKD82
CAS:JQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma.Formula:C27H40N4O5Purity:100.00%Color and Shape:SolidMolecular weight:500.635,7-Dihydroxychromone
CAS:1.Formula:C9H6O4Purity:99.73% - ≥95%Color and Shape:SolidMolecular weight:178.14Ref: TM-T5S1805
1mg47.00€5mg88.00€10mg126.00€25mg208.00€50mg309.00€100mg462.00€500mg1,008.00€1mL*10mM (DMSO)80.00€Nicotinamide riboside chloride
CAS:NR, also SRT647, is a B3 vitamin form; precursor to NAD+.Formula:C11H15ClN2O5Purity:98.92% - 99.86%Color and Shape:SolidMolecular weight:290.7BRD4 Inhibitor-38
BRD4 Inhibitor-38 (Compound 25) is an orally active BRD4 inhibitor, exhibiting IC50 values of 3.64 μM for BRD4 BD1 and 0.12 μM for BRD4 BD2. It also demonstrates anti-inflammatory properties, with an IC50 value of 1.98 μM for nitric oxide (NO) production.Formula:C19H18N2O4Molecular weight:338.357CHZ868
CAS:CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.Formula:C22H19F2N5O2Purity:99.38%Color and Shape:SolidMolecular weight:423.42BAY 87-2243
CAS:BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).Formula:C26H26F3N7O2Purity:98% - 99.77%Color and Shape:SolidMolecular weight:525.53CP-352664
CAS:CP-352664 is a JAK inhibitor with potency against JAK3, exhibiting an EC50 value of 210 nM. It holds potential for use in research related to organ transplant rejection and autoimmune diseases, such as rheumatoid arthritis.Formula:C18H18N4Color and Shape:SolidMolecular weight:290.36MS023 trihydrochloride
CAS:MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.Formula:C17H28Cl3N3OPurity:99.81%Color and Shape:SolidMolecular weight:396.78AS-85
CAS:AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.Formula:C26H28F3N5O3S2Purity:98.96%Color and Shape:SolidMolecular weight:579.66GSK121
CAS:GSK121 is an inhibitor of selective PAD4.Formula:C25H26F3N5O3Purity:98.92%Color and Shape:SolidMolecular weight:501.51Cedrusin
CAS:Cedrusin shows a cytotoxic effect on A375 and HeLa cells.Formula:C19H22O6Purity:98%Color and Shape:SolidMolecular weight:346.37Levetiracetam
CAS:Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onsetFormula:C8H14N2O2Purity:98.37% - 99.67%Color and Shape:White Crystalline PowderMolecular weight:170.21LY3295668
CAS:LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Formula:C24H26ClF2N5O2Purity:99.44%Color and Shape:SolidMolecular weight:489.95BRD9539
CAS:BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μMFormula:C24H21N3O3Purity:98% - 99.44%Color and Shape:SolidMolecular weight:399.44Bisdemethoxycurcumin
CAS:Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. Bisdemethoxycurcumin is a potent activator of macrophage phagocytosis.Formula:C19H16O4Purity:99.34% - 99.42%Color and Shape:SolidMolecular weight:308.33XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurity:99.07%Color and Shape:SolidMolecular weight:437.54Ref: TM-T17267
1mg56.00€2mg78.00€5mg99.00€10mg149.00€25mg258.00€50mg393.00€100mg582.00€1mL*10mM (DMSO)110.00€PFI-4
CAS:PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.Formula:C21H24N4O3Purity:99.53% - ≥95%Color and Shape:SolidMolecular weight:380.44BET bromodomain inhibitor 3
CAS:BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT.Formula:C18H17N3O4Purity:98%Color and Shape:SolidMolecular weight:339.35UNC8153 TFA
CAS:UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating aFormula:C35H38F3N5O7Purity:96.44%Color and Shape:SolidMolecular weight:697.7GSK217
CAS:GSK217 is a potent and selective inhibitor of the bromo and extraterminal domain (BET) second bromodomain (BD2) with high solubility, utilized in oncology andFormula:C20H20N6OPurity:98%Color and Shape:SolidMolecular weight:360.41Anti-PARP1 Antibody (9E313)
Anti-PARP1 Antibody (9E313) is a Mouse antibody targeting PARP1. Anti-PARP1 Antibody (9E313) can be used in IHC-P.Color and Shape:Odour LiquidI-BRD9
CAS:I-BRD9 (GSK602) is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.Formula:C22H22F3N3O3S2Purity:98.16% - 99.28%Color and Shape:SolidMolecular weight:497.55Ref: TM-T6859
1mg40.00€2mg51.00€5mg74.00€10mg113.00€25mg215.00€50mg411.00€100mg610.00€1mL*10mM (DMSO)84.00€Pulrodemstat HCl
CAS:Pulrodemstat HCl is an LSD1 inhibitor and a KDM1A inhibitor with anticancer anti, proliferative activity.Formula:C24H24ClF2N5O2Purity:97.87% - 99.29%Color and Shape:SoildMolecular weight:487.93FHT-1015
CAS:FHT-1205 is a potent inhibitor (IC50 ≤ 10 nM) of SMARCA4/SMARCA2 ATPase (BRG1 and BRM).Formula:C25H25N5O4S3Purity:≥98%Color and Shape:SolidMolecular weight:555.69Ref: TM-T63925
1mg99.00€2mg144.00€5mg235.00€10mg354.00€25mg747.00€50mg1,017.00€100mg1,359.00€500mg2,737.00€1mL*10mM (DMSO)335.00€Pamiparib
CAS:Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor. It has potent PARP trapping, and capability to penetrate the brain.Formula:C16H15FN4OPurity:99.69%Color and Shape:SolidMolecular weight:298.31KDM4C-IN-1
CAS:KDM4C-IN-1 is aKDM4C inhibitor withial anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.Formula:C15H14N4O3Purity:99.33%Color and Shape:SolidMolecular weight:298.3A-966492
CAS:A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively.Formula:C18H17FN4OPurity:98.53% - 99.27%Color and Shape:SolidMolecular weight:324.35Ref: TM-T6366
2mg35.00€5mg50.00€10mg89.00€25mg172.00€50mg275.00€100mg394.00€200mg560.00€1mL*10mM (DMSO)56.00€DC-BPi-03
CAS:DC-BPi-03 is a potent BPTF-BRD inhibitor with an IC 50 of 698.3 nM and a K d of 2.81 μM .Formula:C14H14N4O2SPurity:98.96%Color and Shape:SolidMolecular weight:302.35Ref: TM-T73288
1mg210.00€5mg492.00€10mg787.00€25mg1,444.00€50mg1,882.00€100mg2,537.00€1mL*10mM (DMSO)325.00€SCH-1473759
CAS:SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Formula:C20H26N8OSPurity:98%Color and Shape:SolidMolecular weight:426.54YF-2
CAS:YF-2 activates histone acetyltransferases (H3, CBP, PCAF, GCN5) across the blood-brain barrier; EC50s: 2.75-49.31 μM.Formula:C20H22ClF3N2O3Purity:99.33%Color and Shape:SolidMolecular weight:430.85
