Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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BI 2536
CAS:BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.Formula:C28H39N7O3Purity:98% - 99.88%Color and Shape:SolidMolecular weight:521.65Ref: TM-T6173
1mg46.00€2mg59.00€5mg87.00€10mg103.00€25mg124.00€50mg197.00€100mg350.00€500mg840.00€1mL*10mM (DMSO)97.00€JBJ-04-125-02
CAS:JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.Formula:C29H26FN5O3SPurity:98%Color and Shape:SolidMolecular weight:543.61(R)-CR8
CAS:(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.Formula:C24H29N7OPurity:98.41%Color and Shape:SolidMolecular weight:431.53Ref: TM-T12617L
1mg66.00€5mg144.00€10mg210.00€25mg356.00€50mg525.00€100mg747.00€1mL*10mM (DMSO)159.00€JANEX-1
CAS:JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.Formula:C16H15N3O3Purity:98% - 99.73%Color and Shape:SolidMolecular weight:297.31Ref: TM-T2045
1mg44.00€2mg55.00€5mg92.00€10mg150.00€25mg248.00€50mg444.00€100mg652.00€500mg1,378.00€1mL*10mM (DMSO)92.00€JAK3-IN-7
CAS:JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction afterFormula:C17H20N6OPurity:98.81%Color and Shape:SolidMolecular weight:324.384'-Methoxychalcone
CAS:4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.Formula:C16H14O2Purity:99.86%Color and Shape:SolidMolecular weight:238.28CPI-455
CAS:CPI-455 is a specific KDM5 inhibitor.Formula:C16H14N4OPurity:97.87% - 99.03%Color and Shape:SolidMolecular weight:278.31Ref: TM-T3552
1mg44.00€2mg55.00€5mg87.00€10mg131.00€25mg284.00€50mg452.00€100mg645.00€500mg1,311.00€1mL*10mM (DMSO)87.00€666-15
CAS:666-15 is a selective CREB inhibitor with an IC50 of 81 nM. 666-15 can effectively inhibit the growth of breast cancer.Cost-effective and quality-assured.Formula:C33H31Cl2N3O5Purity:99.41% - 99.77%Color and Shape:SolidMolecular weight:620.52EED226
CAS:EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.Formula:C17H15N5O3SPurity:98.14% - 99.33%Color and Shape:SolidMolecular weight:369.4MM-589
CAS:MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Formula:C28H44N8O5Purity:98%Color and Shape:SolidMolecular weight:572.70UNC926
CAS:UNC926 inhibits L3MBTL1 (IC50: 3.9 μM), has affinity for L3MBTL3, blocks 3xMBT-H4K20me1 interactions, doesn't affect 53BP1-H4K20me1 binding.Formula:C16H21BrN2OPurity:97.22%Color and Shape:SolidMolecular weight:337.25Quercetagetin
CAS:Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.Formula:C15H10O8Purity:99.65% - 99.76%Color and Shape:SolidMolecular weight:318.24Ref: TM-T8114
1mg88.00€5mg202.00€10mg303.00€25mg510.00€50mg733.00€100mg998.00€500mg1,985.00€1mL*10mM (DMSO)213.00€Niraparib (R-enantiomer)
CAS:Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM).Formula:C19H20N4OPurity:99.83%Color and Shape:SolidMolecular weight:320.39Ref: TM-T12064
1mg52.00€5mg105.00€10mg177.00€25mg306.00€50mg444.00€100mg620.00€200mg835.00€1mL*10mM (DMSO)116.00€Ilorasertib hydrochloride
CAS:Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Formula:C25H22ClFN6O2SPurity:98.34%Color and Shape:SolidMolecular weight:525PARP-1-IN-4
CAS:PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.Formula:C22H15Cl2N3O2Purity:99.82%Color and Shape:SolidMolecular weight:424.28Daprodustat
CAS:Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.Formula:C19H27N3O6Purity:97% - 99.82%Color and Shape:SolidMolecular weight:393.43Ref: TM-T3197
1mg39.00€5mg75.00€10mg111.00€25mg177.00€50mg296.00€100mg439.00€200mg645.00€1mL*10mM (DMSO)90.00€DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Formula:C26H35N7O5Color and Shape:SolidMolecular weight:525.6PF-06726304 acetate
CAS:PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.Formula:C24H25Cl2N3O5Purity:98%Color and Shape:SolidMolecular weight:506.38Crebinostat
CAS:Crebinostat: potent HDAC inhibitor, boosts synapsin-1 in neurons, enhances memory and gene Egr1 expression in mice.Formula:C20H23N3O3Purity:95%Color and Shape:SolidMolecular weight:353.41Ref: TM-T27083
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€Povorcitinib phosphate
CAS:Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.Formula:C23H25F5N7O5PPurity:97.71%Color and Shape:SolidMolecular weight:605.45Ref: TM-T39113L
1mg65.00€2mg95.00€5mg145.00€10mg212.00€25mg359.00€50mg512.00€100mg695.00€200mg937.00€SIRT-IN-6
CAS:SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of >50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.Formula:C7H4ClN3OSColor and Shape:SolidMolecular weight:213.644L-2-Hydroxyglutaric acid disodium
CAS:L-2-Hydroxyglutaric acid disodium may affect epigenetics and contribute to renal cancer, inhibiting Mi-CK (Km 2.52 mM, Ki 11.13 mM).Formula:C5H6Na2O5Purity:≥98%Color and Shape:SolidMolecular weight:192.08NU6140
CAS:NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).Formula:C23H30N6O2Purity:98.33%Color and Shape:SolidMolecular weight:422.52Ref: TM-T16359
2mg42.00€5mg64.00€10mg97.00€25mg187.00€50mg301.00€100mg437.00€200mg612.00€1mL*10mM (DMSO)71.00€PROTAC SMARCA2 degrader-26
CAS:PROTAC SMARCA2 degrader-26 (compound 45) is an effective degrader of SMARCA2 using the PROTAC technology. It induces degradation of SMARCA2 and SMARCA4 in VCaP cells, with degradation percentages of 94% and 57%, respectively. Additionally, PROTAC SMARCA2 degrader-26 demonstrates antiproliferative activity.Formula:C46H54N8O5SColor and Shape:SolidMolecular weight:831.04KF 13218
CAS:KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.Formula:C20H20N2O3Purity:98%Color and Shape:SolidMolecular weight:336.38MS402
CAS:MS402 is a novel BD1-selective BET BrD inhibitor.Formula:C20H19ClN2O3Purity:99.72%Color and Shape:SolidMolecular weight:370.83Ref: TM-T12112
5mg47.00€10mg65.00€25mg117.00€50mg177.00€100mg304.00€200mg437.00€1mL*10mM (DMSO)49.00€BD-9136
BD-9136, a highly selective BRD4 degrader, demonstrates the capability to inhibit tumor growth without inducing adverse effects in mice, showing potential forFormula:C44H44N10O5SPurity:98%Color and Shape:SolidMolecular weight:824.95JAK-IN-33
JAK-IN-33 (Compound 3 (R)) is a selective inhibitor of the Janus kinase (JAK) family [1].Purity:98%Color and Shape:Odour SolidDW14800
CAS:DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.Formula:C31H36N4O3Purity:97.26% - 99.12%Color and Shape:SolidMolecular weight:512.64Ref: TM-T11131
1mg87.00€2mg130.00€5mg216.00€10mg378.00€25mg717.00€50mg948.00€100mg1,415.00€1mL*10mM (DMSO)245.00€NSC 694623
CAS:NSC 694623: Potent HAT inhibitor, IC50=15.9 μM against PCAF, anti-cancer properties.Formula:C16H16N2OSPurity:99.87%Color and Shape:SolidMolecular weight:284.38CPI-455 HCl
CAS:CPI-455: specific KDM5A inhibitor, IC50=10±1nM, increases H3K4me3, reduces DTPs in cancer cells.Formula:C16H15ClN4OPurity:98%Color and Shape:SolidMolecular weight:314.77KDM5-IN-1
CAS:KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.Formula:C17H20N6OPurity:98.08%Color and Shape:SolidMolecular weight:324.38Ref: TM-T15649
1mg64.00€5mg187.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€500mgTo inquire1mL*10mM (DMSO)137.00€GSK9311 hydrochloride
CAS:GSK9311 hydrochloride is a less active GSK6853 analog, serving as a negative control, inhibiting BRPF1/2 (pIC50: 6.0/4.3).Formula:C24H32ClN5O3Purity:98%Color and Shape:SolidMolecular weight:474AZ9482
CAS:AZ9482, a potent PARP inhibitor with 2-piperazinyl-3-cyano-pyridine linkage, causes centrosome declustering in HeLa cells with an EC50 < 18 nM.Formula:C26H22N6O2Purity:99.86%Color and Shape:SolidMolecular weight:450.49Ref: TM-T22264
1mg57.00€5mg131.00€10mg205.00€25mg389.00€50mg565.00€100mg822.00€1mL*10mM (DMSO)140.00€Chiauranib
CAS:Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Formula:C27H21N3O3Purity:96.25%Color and Shape:SolidMolecular weight:435.47Ref: TM-T35570
1mg90.00€5mg187.00€10mg305.00€25mg520.00€50mg748.00€100mg1,026.00€1mL*10mM (DMSO)215.00€RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purity:97.29% - 99.91%Color and Shape:SolidMolecular weight:545.63Peficitinib
CAS:Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Formula:C18H22N4O2Purity:98.67% - 99.4%Color and Shape:SolidMolecular weight:326.39Ref: TM-T6933
2mg40.00€5mg66.00€10mg104.00€25mg182.00€50mg283.00€100mg439.00€200mg645.00€1mL*10mM (DMSO)73.00€Aurora kinase inhibitor-2
CAS:Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).Formula:C23H20N4O3Purity:98.66%Color and Shape:SolidMolecular weight:400.43Ref: TM-T9040
1mg66.00€5mg145.00€10mg212.00€25mg380.00€50mg562.00€100mg832.00€200mg1,121.00€1mL*10mM (DMSO)167.00€FLLL32
CAS:FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formula:C28H32O6Purity:96.39% - 97.90%Color and Shape:SolidMolecular weight:464.55Ref: TM-T6838
2mg46.00€5mg66.00€10mg93.00€25mg124.00€50mg197.00€100mg350.00€500mg840.00€1mL*10mM (DMSO)72.00€Tazemetostat
CAS:Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.Formula:C34H44N4O4Purity:98.24% - ≥95%Color and Shape:SolidMolecular weight:572.74Ref: TM-T1788
2mg38.00€5mg55.00€10mg78.00€25mg96.00€50mg97.00€100mg160.00€500mg404.00€1mL*10mM (DMSO)70.00€SJ46420
SJ46420, a potent and selective precursor variant of SJ46421, functions as a BRD3 PROTAC degrader through a KLHDC2-dependent mechanism. This compound specifically degrades BRD3, which concurrently results in the partial reduction of BRD2 or BRD4 levels.Formula:C43H43ClN8O5S2Color and Shape:SolidMolecular weight:851.44HDAC/JAK/BRD4-IN-1
CAS:HDAC/JAK/BRD4-IN-1 (compound 25ap) is a potent triple inhibitor targeting HDAC, JAK, and BRD4.Formula:C24H28N6O3Purity:98%Color and Shape:SolidMolecular weight:448.52Daminozide
CAS:Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.Formula:C6H12N2O3Purity:99.86%Color and Shape:White Crystalline Solid Physical Description Odorless White Crystals Or Powder (Ntp 1992)Molecular weight:160.17Cerdulatinib hydrochloride
CAS:Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.Formula:C20H28ClN7O3SPurity:99.23%Color and Shape:SolidMolecular weight:482SGC0946
CAS:SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.Formula:C28H40BrN7O4Purity:98% - 99.82%Color and Shape:SolidMolecular weight:618.57MI-463
CAS:MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).Formula:C24H23F3N6SPurity:100% - 99.18%Color and Shape:SolidMolecular weight:484.54UNC10142
UNC10142 (Compound 44) is a small-molecule antagonist of CHD1, with a binding IC50 value of 1.7 μM. It induces a dose-dependent reduction in the viability of PTEN-deficient prostate cancer cells.Formula:C33H52N6O3Color and Shape:SolidMolecular weight:580.8PX-478
CAS:PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.Formula:C13H20Cl4N2O3Purity:97% - ≥98%Color and Shape:SolidMolecular weight:394.12Pim-1/2 kinase inhibitor 1
CAS:Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Formula:C11H9NO3SPurity:99.89%Color and Shape:SolidMolecular weight:235.26GSK6853
CAS:GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.Formula:C22H27N5O3Purity:98.71% - 99.08%Color and Shape:SolidMolecular weight:409.48TD-428
TD-428: BRD4 degrader (DC50=0.32 nM), BET PROTAC, merges TD-106 with JQ1 to degrade BET proteins effectively.Formula:C43H43ClN10O7SPurity:98%Color and Shape:SolidMolecular weight:879.38PRMT5-IN-48
CAS:PRMT5-IN-48 (compound D3) is an orally active PRMT5 inhibitor with an IC50 of 20.7 nM, displaying antitumor activity. It effectively suppresses the growth of various cancer cells, induces apoptosis, and causes cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is applicable for research in non-Hodgkin's lymphoma (NHL).Formula:C30H37N5O3Color and Shape:SolidMolecular weight:515.646PROTAC SMARCA2 degrader-19
CAS:PROTAC SMARCA2 degrader-19 (Compound 46) acts as a degrader of SMARCA2, demonstrating degradation capabilities in A549 and MV411 cells with a DC50 of less than 100 nM. Additionally, this compound degrades SMARCA4 in MV411 cells, but with a significantly higher DC50 of over 1000 nM.Formula:C50H58N10O5SColor and Shape:SolidMolecular weight:911.13FT001
CAS:FT001: Oral BET Bromodomain inhibitor, IC50=0.46μM, suppresses MYC, anti-cancer, effective in vitro/vivo.Formula:C25H29N3O4SPurity:100%Color and Shape:SolidMolecular weight:467.58Ref: TM-T27392
1mg115.00€2mg172.00€5mg255.00€10mg374.00€25mg562.00€50mg787.00€100mg1,074.00€500mg2,147.00€1mL*10mM (DMSO)299.00€IV-255
IV-255 is a selective small molecule inhibitor of the BRG1 bromodomain, heightening DNA damage when administered with Temozolomide and Bleomycin.Formula:C19H19F2N3O2Purity:98%Color and Shape:SolidMolecular weight:359.37Guadecitabine sodium
CAS:Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .Formula:C18H24N9NaO10PPurity:98%Color and Shape:SolidMolecular weight:580.407GSK-3484862
CAS:Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.Formula:C19H19N5OSPurity:100% - 97.83%Color and Shape:SolidMolecular weight:365.45Ref: TM-T11469
1mg50.00€5mg119.00€10mg187.00€25mg335.00€50mg512.00€100mg730.00€500mg1,473.00€1mL*10mM (DMSO)215.00€PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formula:C22H25N7O2Purity:98.34% - 99.62%Color and Shape:SolidMolecular weight:419.48LSD1-IN-25
CAS:LSD1-IN-25: potent, selective oral LSD1 inhibitor; IC50=46 nM, Ki=30.3 nM; induces cancer cell apoptosis.Formula:C32H33ClN6O3SPurity:98%Color and Shape:SolidMolecular weight:617.16Cerdulatinib
CAS:Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Formula:C20H27N7O3SPurity:98.74% - 99.49%Color and Shape:SolidMolecular weight:445.54Ref: TM-T2487
1mg44.00€2mg55.00€5mg79.00€10mg106.00€25mg185.00€50mg283.00€100mg432.00€200mg605.00€500mg938.00€1mL*10mM (DMSO)86.00€Tofacitinib Citrate
CAS:Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Formula:C22H28N6O8Purity:99.19% - 99.75%Color and Shape:SolidMolecular weight:504.49SP-146
SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).Formula:C25H20FN7OPurity:97.82%Color and Shape:SolidMolecular weight:453.47Ref: TM-T8685
1mg88.00€5mg170.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)177.00€Tranylcypromine hemisulfate
CAS:Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset ofFormula:C9H11N1H2SO4Purity:98% - 99.94%Color and Shape:SolidMolecular weight:182.23FG-2216
CAS:FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Formula:C12H9ClN2O4Purity:100% - 99%Color and Shape:SolidMolecular weight:280.66ARV-771
CAS:ARV-771 is an effective BET degrader based on PROTAC technology.Cost-effective and quality-assured.Formula:C49H60ClN9O7S2Purity:99.69%Color and Shape:SolidMolecular weight:986.64PFI-6-COOH
CAS:PFI-6-COOH (Compound 18) is a ligand for the eleven-nineteen leukemia (ENL) protein, and is utilized in the synthesis of the ENL PROTAC degrader MS41.Formula:C23H21N3O6Color and Shape:SolidMolecular weight:435.43BAY-850
CAS:BAY-850 is ainhibitor of adenosine triphosphatase family protein 2 that inhibits ovarian cancer growth and metastasis in in vitro and in vivo models.Formula:C38H44ClN5O3Purity:98% - 98%Color and Shape:SolidMolecular weight:654.24(S)-JQ-35
CAS:(S)-JQ-35 (TEN-010) is a BET bromodomain inhibitor with anti-tumor activity, particularly in breast cancer research.Formula:C27H34ClN7OSPurity:98.55%Color and Shape:SolidMolecular weight:540.12TAK-901
CAS:TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among othersFormula:C28H32N4O3SPurity:97.38% - 99.1%Color and Shape:SolidMolecular weight:504.64GSK-LSD1 dihydrochloride
CAS:GSK-LSD1 dihydrochloride: potent LSD1 inhibitor, >1000x selective over MAO-A/B, LSD2, IC50: 16 nM.Formula:C14H22Cl2N2Purity:100% - 98.72%Color and Shape:SolidMolecular weight:289.24Ref: TM-T2315
1mg40.00€2mg52.00€5mg71.00€10mg103.00€25mg210.00€50mg319.00€100mg522.00€500mg1,111.00€1mL*10mM (DMSO)71.00€JMJD7-IN-1
CAS:JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM.Formula:C16H8Cl2N2O4Purity:99.66%Color and Shape:SolidMolecular weight:363.15AZ6102
CAS:AZ6102: Potent TNKS1/2 inhibitor, 100x selective over PARPs, IC50 = 5 nM in DLD-1 Wnt pathway.Formula:C25H28N6OPurity:97.98% - 99.91%Color and Shape:SolidMolecular weight:428.53PROTAC SMARCA2/4-degrader-27
CAS:PROTAC SMARCA2/4-degrader-27 (PROTAC 2) serves as a targeted degrader, utilizing PROTAC technology to degrade both SMARCA2 and SMARCA4.Formula:C49H58FN9O6SColor and Shape:SolidMolecular weight:920.11ME0328
CAS:ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.Formula:C19H19N3O2Purity:99.22%Color and Shape:SolidMolecular weight:321.37(2R)-Octyl-α-hydroxyglutarate
CAS:(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.Formula:C13H24O5Color and Shape:SolidMolecular weight:260.33GeA-69
CAS:GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).Formula:C20H16N2OPurity:99.85%Color and Shape:SolidMolecular weight:300.35M-89
CAS:M-89, a potent menin inhibitor (Kd 1.4 nM), disrupts Menin-MLL interaction, offering possible MLL leukemia treatment.Formula:C37H47N5O4SPurity:98.38%Color and Shape:SolidMolecular weight:657.87Ref: TM-T11925
1mg166.00€5mg406.00€10mg562.00€25mg825.00€50mg1,121.00€100mg1,549.00€1mL*10mM (DMSO)568.00€Brevilin A
CAS:Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Formula:C20H26O5Purity:100% - 99.74%Color and Shape:SolidMolecular weight:346.42Ref: TM-T4672
1mg96.00€5mg215.00€10mg369.00€25mg610.00€50mg840.00€100mg1,130.00€500mg2,308.00€1mL*10mM (DMSO)235.00€KAT6-IN-3
KAT6-IN-3 (compound 10) competitively targets and binds to KAT6A and KAT6B.Formula:C20H17N5O6SColor and Shape:SolidMolecular weight:455.44iso-Azalansta
CAS:(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.Formula:C22H24ClN3O2SPurity:100% - 99.40%Color and Shape:SoildMolecular weight:429.96Ref: TM-T25127L
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€200mg2,555.00€DDP-38003 dihydrochloride
CAS:DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM).Formula:C21H28Cl2N4OPurity:99.5%Color and Shape:SolidMolecular weight:423.38(Z)-SMI-4a
CAS:(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.Formula:C11H6F3NO2SPurity:97.66% - 99.44%Color and Shape:SolidMolecular weight:273.232,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS:2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.Formula:C16H13Cl2N3O2Purity:98.77%Color and Shape:SolidMolecular weight:350.2Anti-PARP Antibody (1W26)
Anti-PARP Antibody (1W26) is a Mouse antibody targeting PARP. Anti-PARP Antibody (1W26) can be used in WB,IHC-P,IP.Color and Shape:Odour Liquid6-Bromo-3-methyl-1,4-dihydroquinazolin-2-one
CAS:CHEMBRDG-BB 7118966 is an inhibitor of Bromodomain-containing protein 4 (human).Formula:C9H9BrN2OPurity:99.28%Color and Shape:SolidMolecular weight:241.08Ref: TM-T8609
1mg88.00€5mg170.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)162.00€JAK-IN-14
CAS:JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.Formula:C19H15FN4OPurity:98.27%Color and Shape:SolidMolecular weight:334.35Ref: TM-T9764
1mg139.00€5mg330.00€10mg492.00€25mg797.00€50mg1,103.00€100mg1,491.00€200mg1,985.00€1mL*10mM (DMSO)340.00€CARM1-IN-3
CAS:CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM forFormula:C24H32N4O2Purity:98%Color and Shape:SolidMolecular weight:408.54SJ1461
CAS:SJ1461 is a potent, orally active inhibitor of the BET family, selectively targeting and inhibiting BRD2 (BD1), BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) withFormula:C21H18ClN7OS2Purity:98%Color and Shape:SolidMolecular weight:484Alobresib
CAS:Alobresib (Vorolanib) is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.Formula:C26H23N5O2Purity:97.63%Color and Shape:SolidMolecular weight:437.49Ref: TM-T8495
1mg73.00€2mg93.00€5mg144.00€10mg274.00€25mg535.00€50mg753.00€100mg1,035.00€1mL*10mM (DMSO)159.00€RBN012759
CAS:RBN012759 inhibits PARP14 protein and is more than 300-fold selective over all PARP family members.Cost-effective and quality-assured.Formula:C19H23FN2O3SPurity:98.87% - 99.96%Color and Shape:SolidMolecular weight:378.46Ref: TM-T22414
1mg105.00€5mg250.00€10mg432.00€25mg645.00€50mg938.00€100mg1,311.00€1mL*10mM (DMSO)346.00€1,5-Isoquinolinediol
CAS:1,5-Isoquinolinediol, a PARP1 inhibitor (IC50: 0.39 μM), is used in DNA repair and cell death studies.Formula:C9H7NO2Purity:99.21% - 99.43%Color and Shape:Of White To White PowderMolecular weight:161.16PROTAC SMARCA2/4-degrader-29
CAS:PROTAC SMARCA2/4-degrader-29 (Compound I-279) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. In A549 cells, this compound effectively degrades SMARCA2 with a DC50 value of less than 100 nM, and similarly degrades SMARCA4 in MV411 cells with a DC50 under 100 nM.Formula:C44H51N11O4Color and Shape:SolidMolecular weight:797.95CPI-0610 carboxylic acid
CAS:CPI-0610 carboxylic acid is a selective BET protein inhibitor with potential anticancer effects.Formula:C20H15ClN2O3Purity:98.62%Color and Shape:SolidMolecular weight:366.8Dot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Color and Shape:Odour SolidJAK3-IN-6
CAS:JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFormula:C19H18N4O3Purity:97.46% - 99.94%Color and Shape:SolidMolecular weight:350.37BRD4 Inhibitor-28
CAS:BRD4 Inhibitor-28 (Compound 18), an orally active molecule, selectively inhibits the bromodomains of BRD4 (BRD4-BD1 and BRD4-BD2) with IC50 values of 15 and 55Formula:C23H21N3O3Purity:98%Color and Shape:SolidMolecular weight:387.43PARP-1/HDAC-IN-1
CAS:PARP-1/HDAC-IN-1 is a PARP-1 and HDAC6 inhibitor with anticancer, antimigratory, and antiangiogenic activities and is used in tumor research.Formula:C22H18N4O4Purity:95.94%Color and Shape:SolidMolecular weight:402.4A-395
CAS:A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.Formula:C26H35FN4O2SPurity:97.82%Color and Shape:SolidMolecular weight:486.65JAK/HDAC-IN-2
JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations.Formula:C28H38N6O5SPurity:98%Color and Shape:SolidMolecular weight:570.7PARP1-IN-33
CAS:PARP1-IN-33 (Example 6) is a PARP1 inhibitor with an IC50 of 0.41 nM. It demonstrates protective effects on retinal cells, exhibiting an EC50 of 0.02 nM in inhibiting hydrogen peroxide-induced MTS activity in human retinal pigment epithelial cells.Formula:C23H24ClFN4OColor and Shape:SolidMolecular weight:426.91GSK3326595
CAS:GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.).Formula:C24H32N6O3Purity:97.43% - 97.7%Color and Shape:SolidMolecular weight:452.55LSD1-IN-35
CAS:LSD1-IN-35 (Compound Z-1) is a selective inhibitor of LSD1, exhibiting an IC50 of 108 nM. This compound inhibits the demethylation of H3K4me1/2 and acts as an immunomodulator. Additionally, LSD1-IN-35 enhances the responsiveness of gastric cancer cells to T-cell killing by reducing PD-L1 expression, thereby weakening the PD-1/PD-L1 interaction.Formula:C25H26N4O2SColor and Shape:SolidMolecular weight:446.57EZH2-IN-22
CAS:EZH2-IN-22 (example 92) is a potent EZH2 inhibitor, exhibiting IC50 values of <0.00051 µM for EZH2(Y641N) and EZH2(Y641F), and 0.00052 µM for EZH2 (wt). Additionally, EZH2-IN-22 demonstrates antiproliferative activity.Formula:C36H50N4O8Color and Shape:SolidMolecular weight:666.8Antitumor agent-101
CAS:Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of 8.5 nM for G9a and 5.5 nM forFormula:C26H38N6O3Purity:98%Color and Shape:SolidMolecular weight:482.62Tazemetostat hydrobromide
CAS:Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) & EZH1 (IC50: 392 nM).Formula:C34H45BrN4O4Purity:99.03%Color and Shape:SolidMolecular weight:653.65Ref: TM-T17002
2mg43.00€5mg60.00€10mg81.00€50mg96.00€100mg159.00€200mg230.00€500mg378.00€1mL*10mM (DMSO)84.00€PROTAC SMARCA2/4-degrader-28
CAS:PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.Formula:C54H68ClN9O11S2Color and Shape:SolidMolecular weight:1118.75Talazoparib
CAS:Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).Formula:C19H14F2N6OPurity:98% - 99.92%Color and Shape:SolidMolecular weight:380.35Ref: TM-T6253
2mg42.00€5mg62.00€10mg88.00€25mg135.00€50mg187.00€100mg311.00€200mg429.00€500mg697.00€1mL*10mM (DMSO)67.00€JAK2-IN-6
CAS:JAK2-IN-6: A potent JAK2-specific inhibitor (IC50=22.86μg/mL), blocks JAK2 signaling, has anticancer properties, and is inactive against JAK1/3.Formula:C14H10ClN3OS2Purity:99.38%Color and Shape:SolidMolecular weight:335.83GSK3368715 3HCl
CAS:GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81Formula:C20H41Cl3N4O2Purity:98%Color and Shape:SolidMolecular weight:475.92WDR5-0103
CAS:WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).Formula:C21H25N3O4Purity:98% - 99.61%Color and Shape:SolidMolecular weight:383.44Izencitinib
CAS:Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.Formula:C22H26N8Purity:99.82%Color and Shape:SolidMolecular weight:402.50Ref: TM-T35898
1mg88.00€5mg187.00€10mg298.00€25mg597.00€50mg938.00€100mg1,510.00€200mg2,072.00€1mL*10mM (DMSO)207.00€SGC-iMLLT
CAS:SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular targetFormula:C22H24N6OPurity:99.21%Color and Shape:SolidMolecular weight:388.47VB1080
VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5 µM for PIM1, 4996 µM for PIM2, and 9.88 µM for PIM3. Additionally, VB1080 exhibits cytotoxic properties and possesses anthelmintic activity.Formula:C27H27N3O3Molecular weight:441.522SMARCA2-IN-6
CAS:SMARCA2-IN-6 is a potent inhibitor of SMARCA2 (also known as BRM), exhibiting an IC50 of less than 5 nM against both SMARCA2 and SMARCA4. Additionally, this compound suppresses the expression of the KRT80 gene in H1299 cells with an IC50 of 26 nM and inhibits the proliferation of SKMEL5 cells carrying a BRG1 mutation with an IC50 value of 13 nM.Formula:C10H8ClF2N5OSColor and Shape:SolidMolecular weight:319.72(R)-UT-155
CAS:(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.Formula:C20H15F4N3O2Color and Shape:SolidMolecular weight:405.35Enarodustat
CAS:Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.Formula:C17H16N4O4Purity:99.14% - 99.61%Color and Shape:SolidMolecular weight:340.33Ref: TM-T15219
1mg39.00€2mg50.00€5mg79.00€10mg115.00€25mg188.00€50mg311.00€100mg462.00€1mL*10mM (DMSO)90.00€SP-96
CAS:SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.Formula:C25H20FN7OPurity:99.52%Color and Shape:SolidMolecular weight:453.47Ref: TM-T41256
1mg73.00€5mg160.00€10mg250.00€25mg445.00€50mg625.00€100mg909.00€200mg1,216.00€1mL*10mM (DMSO)170.00€ML324
CAS:ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).Formula:C21H23N3O2Purity:98.22% - 98.57%Color and Shape:SolidMolecular weight:349.43Anti-PARP1 Antibody (8S756)
Anti-PARP1 Antibody (8S756) is an antibody targeting PARP1. Anti-PARP1 Antibody (8S756) can be used in ELISA, WB, IHC, IF, FCM.Color and Shape:Odour LiquidValemetostat tosylate
CAS:Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.Formula:C33H42ClN3O7SPurity:98%Color and Shape:SolidMolecular weight:660.22Lomeguatrib
CAS:Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .Formula:C10H8BrN5OSPurity:99.26% - 99.62%Color and Shape:SolidMolecular weight:326.17AGI-25696
CAS:AGI-25696 inhibits MATA2, blocking MTAP-deleted tumor growth, potential for cancer research.Formula:C27H18N4OPurity:99.08% - 99.74%Color and Shape:SolidMolecular weight:414.46PARP1-IN-29
CAS:PARP1-IN-29 is an orally active PARP-1 inhibitor with an IC50 of 6.3 nM. When labeled with [18F], PARP1-IN-29 can be utilized for positron emission tomography (PET) imaging, specifically targeting PARP-1 in tumors. This compound is useful in oncology and imaging studies, particularly for detecting PARP-1 activity in cancer.Formula:C18H16FN3O2Color and Shape:SolidMolecular weight:325.34Isomaltotriose
CAS:Isomaltotriose is a sugar compound derived from the enzymic hydrolyzates of dextran obtained from the Leuconostoc mesenteroides NRRL B-512.Formula:C18H32O16Purity:98%Color and Shape:Lyophilized PowderMolecular weight:504.44HIV-IN-7
Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.Formula:C32H61N3O10P2Purity:98%Color and Shape:SolidMolecular weight:709.79BRD4 degrader AT1
CAS:BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.Formula:C48H58ClN9O5S3Purity:98%Color and Shape:SolidMolecular weight:972.68BAY-598
CAS:BAY 598 is a potent and selective competitive inhibitor of SMYD2, exhibiting >100-fold selectivity over SMYD3, SUV420H1, and SUV420H2. Cost-effective and quality-assured.Formula:C22H20Cl2F2N6O3Purity:98.68% - 99.18%Color and Shape:SolidMolecular weight:525.34HIF-2α-IN-9
CAS:HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes withinFormula:C12H13F5O4S2Purity:98%Color and Shape:SolidMolecular weight:380.35SRI-42127
CAS:SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR that inhibits tumor growth and reduces neuropathic pain following nerve injury.Formula:C19H20N6OPurity:99.66%Color and Shape:SolidMolecular weight:348.4JAK-IN-30
CAS:JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50Formula:C19H26N8SPurity:98%Color and Shape:SolidMolecular weight:398.53GS-829845
CAS:GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-lifeFormula:C17H19N5O2SPurity:99.78%Color and Shape:SolidMolecular weight:357.43Brepocitinib P-Tosylate
CAS:Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).Formula:C25H29F2N7O4SPurity:99.82% - 99.97%Color and Shape:SolidMolecular weight:561.6PROTAC SMARCA2 degrader-21
CAS:PROTAC SMARCA2 degrader-21 (Compound I-5) acts as a degrader of SMARCA2 in A549 cells, with a DC50 range of 10-50 nM, and additionally degrades both SMARCA2 and SMARCA4 in MV411 cells, with respective DC50 values of <1 nM and >100 nM.Formula:C54H66N12O5SColor and Shape:SolidMolecular weight:995.24CeMMEC1
CAS:CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).Formula:C19H16N2O4Purity:100% - 99.26%Color and Shape:SolidMolecular weight:336.34CPI203
CAS:CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).Formula:C19H18ClN5OSPurity:99.13% - 99.71%Color and Shape:SolidMolecular weight:399.911α-O-Tigloyl-12β-O-acetyltenacigenin B
CAS:11α-O-Tigloyl-12β-O-acetyltenacigenin B, an ester derivative isolated from Garcinia cambogia (MTC), modulates the antitumor effects of Aurora-A in lymphomaFormula:C28H40O7Purity:98%Color and Shape:SolidMolecular weight:488.61JAK-IN-25
CAS:JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.Formula:C19H17N5O4Purity:98%Color and Shape:SolidMolecular weight:379.37T-448 free base
CAS:T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).Formula:C17H20N4OSPurity:98%Color and Shape:SolidMolecular weight:328.43ORIC-944
CAS:ORIC-944 is an orally available, selective variant of PRC2 with anticancer activity for the study of prostate cancer.Formula:C26H25FN6OPurity:98.08%Color and Shape:SolidMolecular weight:456.52PARP-1/2-IN-2
PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repairFormula:C25H23IN8O3Purity:98%Color and Shape:SolidMolecular weight:610.41AZ505
CAS:AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).Formula:C29H38Cl2N4O4Purity:98.18%Color and Shape:SolidMolecular weight:577.54Ref: TM-TQ0100
1mg64.00€5mg137.00€10mg188.00€25mg311.00€50mg487.00€100mg658.00€1mL*10mM (DMSO)168.00€GN44028
CAS:GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.Formula:C18H15N3O2Purity:98.20%Color and Shape:SolidMolecular weight:305.33Ref: TM-T15396
1mg70.00€5mg135.00€10mg188.00€25mg325.00€50mg465.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)149.00€KDM4-IN-4
CAS:KDM4-IN-4 is a KDM4 inhibitor with anticancer activity that inhibits the KDM4A-Tudor structural domain for cancer research.Formula:C16H23NOPurity:99.61%Color and Shape:SolidMolecular weight:245.36
